Chromatographic column prepared through impurity separation

Abstract

The utility model relates to the technical field of chromatographic columns, in particular to a chromatographic column prepared by separating impurities, which comprises a column body, two ends of the column body are respectively and movably connected with a first joint and a connecting cylinder, the inner wall of the column body is provided with a wear-resistant coating made of ceramic materials, the outer surface of the connecting cylinder is provided with external threads, and the first joint is connected with the connecting cylinder. One end of the external thread is in threaded connection with a second connector, the inner surface of the connecting cylinder is provided with an internal thread, the internal thread is in threaded connection with the outer surface of the column body, the connecting cylinder is internally provided with a filtering piece, the column body is internally filled with filler, and protection of the inner wall of the column body is achieved through protection of a wear-resistant coating; the inner wall of the chromatographic column is prevented from being corroded by the filler, metal on the inner wall of the chromatographic column is changed into ions to be dissolved into a reagent of the filler, and filler pollution is caused, the filter piece is installed in the connecting cylinder, the connecting cylinder can be unscrewed from the column body and replaced with a new connecting cylinder after the chromatographic column is used for a period of time, and the convenience of replacement of the filter piece is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatographic columns, and particularly relates to a chromatographic column for impurity separation and preparation. Background Technique

[0002] A liquid chromatographic column is a device used in liquid chromatographic analysis instruments. During operation, the mobile phase in the reservoir is pumped into the system by a high-pressure pump. The sample solution enters the mobile phase through an injector and is carried into the chromatographic column (stationary phase) by the mobile phase. Since the components in the sample solution have different partition coefficients in the two phases, during the relative movement in the two phases, after repeated adsorption-desorption distribution processes, there are significant differences in the moving speeds of the components, and they are separated into individual components and flow out of the column in sequence.

[0003] However, in the prior art, chromatographic columns are usually made of metal, and their interiors in contact with the packing are also composed of directly exposed metal walls. In this way, when the chromatographic column is in use, if the reagent of the packing is corrosive, it is easy to cause the metal on the inner wall of the chromatographic column to become ions and dissolve into the reagent of the packing, resulting in packing contamination. As the use time increases, there will be more and more metal ions inside, thus having a greater impact on the composition of the packing.

[0004] Therefore, it is necessary to provide a chromatographic column for impurity separation and preparation to solve the above technical problems. Content of the Utility Model

[0005] To solve the above technical problems, the utility model provides a chromatographic column for impurity separation and preparation.

[0006] A chromatographic column for impurity separation and preparation provided by the utility model includes: a column body, both ends of the column body are movably connected to a first joint and a connection cylinder respectively, the inner wall of the column body is provided with a wear-resistant coating made of ceramic material, both ends of the outer surface of the column body are respectively provided with a first external thread and a second external thread, one end of the first external thread is threadedly connected to the inner surface of the first joint, the inner surface of the connection cylinder is provided with a second internal thread matching the second external thread, a filter sheet is installed inside the connection cylinder, and the inside of the column body is filled with packing.

[0007] Preferably, one end of the first external thread is threadedly connected to the inner surface of a first protective cylinder, the other end of the inner surface of the first protective cylinder is movably connected to the outer surface of the connection cylinder, one end of the second external thread is threadedly connected to the inner surface of a second protective cylinder, and the other end of the inner surface of the second protective cylinder is movably connected to the outer surface of a second joint.

[0008] Preferably, a first connection pad is adhered to the inner wall of one end of the first protective cylinder facing the connection cylinder, a second protective pad is adhered to the inner wall of one end of the second protective cylinder facing the second joint, and the materials of the first connection pad and the second connection pad are rubber materials.

[0009] Preferably, first limiting rings and second limiting rings are respectively connected to the inner walls of the connecting cylinders on both sides of the filter sheet.

[0010] Preferably, the number of the filter sheets is multiple, and the filter sheets are equidistantly placed inside the connecting cylinder.

[0011] Preferably, anti-slip lines are provided on the outer surface of the column body, and the anti-slip lines are located between the first external thread and the second external thread.

[0012] Compared with the related art, a chromatographic column for impurity separation and preparation provided by the present utility model has the following beneficial effects:

[0013] 1. By providing a wear-resistant coating made of ceramic material, when filling the filler into the column body, the inner wall of the column body can be protected through the protection of the wear-resistant coating, preventing the filler from corroding the inner wall, causing the metal on the inner wall of the chromatographic column to become ions and dissolve into the reagent of the filler, resulting in filler contamination. By providing a connecting cylinder threadedly connected to the column body and installing a filter sheet inside the connecting cylinder, after using for a period of time, the connecting cylinder can be unscrewed from the column body by rotation, and a new connecting cylinder with a filter sheet can be replaced, improving the convenience of replacing the filter sheet;

[0014] 2. By providing a first protective cylinder and a second protective cylinder, by rotating the protective cylinders, one end of the first protective cylinder can be connected to the connecting cylinder, and one end of the second protective cylinder can be connected to the second joint, so as to protect the connection between the connecting cylinder and one end of the column body, and the connection between the second joint and the other end of the column body, improving the sealing performance of the connection;

[0015] 3. By providing a first limiting ring and a second limiting ring, the stability of the placement of the filter sheet can be improved, and by providing multiple filter sheets, the filtering effect of the device can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic structural diagram of a preferred embodiment of a chromatographic column for impurity separation and preparation provided by the present utility model;

[0017] Figure 2 is Figure 1 a schematic structural diagram of the first external thread and the second external thread shown;

[0018] Figure 3 is Figure 1 a schematic structural diagram of the connecting cylinder shown;

[0019] Reference numerals in the figures: 1, column body; 2, first joint; 3, connecting cylinder; 4, first protective cylinder; 5, second protective cylinder; 6, anti-slip pattern; 7, first external thread; 8, second external thread; 9, second internal thread; 10, filter element; 11, first limiting ring; 12, second limiting ring. Detailed implementation manners

[0020] In order to make the objectives, technical solutions, and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Apparently, the described embodiments are some but not all of the embodiments of the present utility model. Usually, the components of the embodiments of the present utility model described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations.

[0021] Therefore, the following detailed description of the embodiments of the present utility model provided in the accompanying drawings is not intended to limit the scope of the claimed present utility model, but merely represents the selected embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0022] It should be noted that: Similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0023] In the description of the embodiments of the present utility model, it should be noted that if terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are used to indicate the orientation or positional relationship, it is based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the product of the present utility model is usually placed when in use. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be construed as a limitation of the present utility model. In addition, if terms such as "first", "second", "third", etc. are used only for distinguishing descriptions, they cannot be understood as indicating or implying relative importance.

[0024] In addition, if terms such as "horizontal", "vertical", "hanging" are used, it does not mean that the component is required to be absolutely horizontal or hanging, but can be slightly inclined. For example, "horizontal" only means that its direction is more horizontal relative to "vertical", and does not mean that the structure must be completely horizontal, but can be slightly inclined.

[0025] In the description of the embodiments of the present utility model, it should also be noted that unless otherwise clearly specified and defined, if the terms "set", "installed", "connected", and "connected" are used, they should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0026] The following describes in detail the specific implementation of a novel chromatographic column for impurity separation and preparation in combination with specific embodiments.

[0027] Reference Figures 1 to 3 , a chromatographic column for impurity separation and preparation provided by the present utility model includes: a column body 1, the two ends of the column body 1 are respectively movably connected to a first joint 2 and a connecting cylinder 3, the inner wall of the column body 1 is provided with a wear-resistant coating made of ceramic material, the two ends of the outer surface of the column body 1 are respectively provided with a first external thread 7 and a second external thread 8, one end of the first external thread 7 is threadedly connected to the inner surface of the first joint 2, the inner surface of the connecting cylinder 3 is provided with a second internal thread 9 that cooperates with the second external thread 8, a filter sheet 10 is installed inside the connecting cylinder 3, and the inside of the column body 1 is filled with packing.

[0028] It should be noted that: by setting a wear-resistant coating made of ceramic material, when filling the packing into the column body 1, the inner wall of the column body 1 can be protected through the protection of the wear-resistant coating, preventing the packing from corroding the inner wall, causing the metal on the inner wall of the chromatographic column to dissolve into the reagent of the packing as ions, resulting in packing pollution. And by setting a connecting cylinder 3 threadedly connected to the column body 1 and installing a filter sheet 10 inside the connecting cylinder 3, after using for a period of time, the connecting cylinder 3 can be unscrewed from the column body 1 by rotation, and a new connecting cylinder 3 with a filter sheet 10 can be replaced, improving the convenience of replacing the filter sheet 10.

[0029] In the embodiments of the present utility model, with reference to Figure 1 as shown, one end of the first external thread 7 is threadedly connected to the inner surface of the first protective cylinder 4, the other end of the inner surface of the first protective cylinder 4 is movably connected to the outer surface of the connecting cylinder 3, one end of the second external thread 8 is threadedly connected to the inner surface of the second protective cylinder 5, and the other end of the inner surface of the second protective cylinder 5 is movably connected to the outer surface of the second joint.

[0030] It should be noted that by setting the first protective cylinder 4 and the second protective cylinder 5, through the rotation of the protective cylinder, one end of the first protective cylinder 4 can be connected to the connecting cylinder 3 respectively, and one end of the second protective cylinder 5 can be connected to the second joint, so as to protect the connection between the connecting cylinder 3 and one end of the column body 1 and the connection between the second joint and the other end of the column body 1, and improve the sealing performance of the connection.

[0031] In an embodiment of the present invention, a first connection pad is adhesively bonded to the inner wall of one end of the first protective cylinder 4 facing the connecting cylinder 3, and a second protective pad is adhesively bonded to the inner wall of one end of the second protective cylinder 5 facing the second joint. The first connection pad and the second connection pad are made of rubber material.

[0032] It should be noted that by setting the first connection pad and the second connection pad made of rubber material, the elasticity of the first connection pad and the second connection pad can be utilized to effectively improve the sealing performance of the connection.

[0033] In an embodiment of the present invention, referring to Figure 3 as shown, a first limiting ring 11 and a second limiting ring 12 are respectively connected to the inner walls of the connecting cylinder 3 on both sides of the filter sheet 10.

[0034] In an embodiment of the present invention, referring to Figure 3 as shown, the number of the filter sheets 10 is multiple, and the filter sheets 10 are placed at equal intervals inside the connecting cylinder 3.

[0035] It should be noted that by setting the first limiting ring 11 and the second limiting ring 12, the placement stability of the filter sheet 10 can be improved, and by setting multiple filter sheets 10, the filtering effect of the device can be improved.

[0036] In an embodiment of the present invention, referring to Figure 1 as shown, anti-slip patterns 6 are provided on the outer surface of the column body 1, and the anti-slip patterns 6 are located between the first external thread 7 and the second external thread 8.

[0037] It should be noted that by setting the anti-slip patterns 6, when filling the column body 1 with filler and replacing the connecting cylinder 3, it is more convenient to hold the column body 1, and the holding stability is improved.

[0038] The working principle of a chromatographic column for impurity separation and preparation provided by the present invention is as follows:

[0039] By setting a wear-resistant coating made of ceramic material, when filling the inside of the column body 1 with packing material, the inner wall of the column body 1 can be protected through the protection of the wear-resistant coating, preventing the packing material from corroding the inner wall, causing the metal on the inner wall of the chromatographic column to turn into ions and dissolve into the reagent of the packing material, resulting in packing material pollution. And by setting a connecting cylinder 3 that is threadedly connected to the column body 1 and installing a filter sheet 10 inside the connecting cylinder 3, after using for a period of time, the connecting cylinder 3 can be unscrewed from the column body 1 by rotation, and a new connecting cylinder 3 with a filter sheet 10 can be replaced, improving the convenience of replacing the filter sheet 10.

[0040] The circuits and controls involved in the present utility model are all prior arts and will not be elaborated here too much.

[0041] The above are only the embodiments of the present utility model, and do not limit the patent scope of the present utility model accordingly. Any equivalent structure or equivalent process transformation made by using the content of the specification and drawings of the present utility model, or directly or indirectly applied to other related technical fields, shall be equally included in the patent protection scope of the present utility model.

Claims

1. A chromatographic column for separation and preparation of impurities, characterized in that: include: A column body (1), wherein the two ends of the column body (1) are movably connected to a first joint (2) and a connecting tube (3), respectively; the inner wall of the column body (1) is provided with a wear-resistant coating made of ceramic material; the two ends of the outer surface of the column body (1) are provided with a first external thread (7) and a second external thread (8), respectively; one end of the first external thread (7) is threadedly connected to the inner surface of the first joint (2); the inner surface of the connecting tube (3) is provided with a second internal thread (9) matched with the second external thread (8); a filter plate (10) is installed inside the connecting tube (3); and the interior of the column body (1) is filled with filler.

2. A chromatographic column for separation and preparation of impurities according to claim 1, characterized in that: The first external thread (7) is threadedly connected to one end of the inner surface of the first protective tube (4), and the other end of the inner surface of the first protective tube (4) is movably connected to the outer surface of the connecting tube (3). The second external thread (8) is threadedly connected to one end of the inner surface of the second protective tube (5), and the other end of the inner surface of the second protective tube (5) is movably connected to the outer surface of the second joint.

3. A chromatographic column for separation and preparation of impurities according to claim 2, characterized in that: A first connection pad is bonded to the inner wall of the first protective tube (4) at one end facing the connection tube (3), and a second protective pad is bonded to the inner wall of the second protective tube (5) at one end facing the second joint.

4. A chromatographic column for separation and preparation of impurities according to claim 3, characterized in that: The first connection pad and the second connection pad are made of rubber.

5. A chromatographic column for separation and preparation of impurities according to claim 1, characterized in that: The inner walls of the connecting tubes (3) on both sides of the filter plate (10) are respectively connected to a first limiting ring (11) and a second limiting ring (12).

6. A chromatographic column for separation and preparation of impurities according to claim 4, characterized in that: There are a plurality of filter sheets (10), and the filter sheets (10) are placed at equal distances inside the connecting cylinder (3).

7. A chromatographic column for separation and preparation of impurities according to claim 1, characterized in that: The outer surface of the column body (1) is provided with an anti-slip pattern (6), and the anti-slip pattern (6) is located between the first external thread (7) and the second external thread (8).

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