Microscopic imaging device and visible component detection device
By designing a microscopic imaging device that can perform distance adjustment, using dual camera modules and distance fine-tuning components, the problem of inflexible image acquisition in the prior art is solved, efficient and flexible image acquisition is achieved, and the timeliness of detection is improved.
Patent Information
- Application Number
- CN202421897079.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-07
- Publication Date
- 2025-06-10
- Estimated Expiration
- 2034-08-07
AI Technical Summary
In the prior art, the image acquisition of the microscopic imaging device is not flexible enough, resulting in a large number of images at different positions or focal surfaces need to be taken at high magnification, which affects the detection timeliness.
A micro-imaging device that can perform distance adjustment is designed, using a dual-camera module and a distance fine-tuning component. Through the combination of a motor, a screw and a sliding table, the movement of the camera module in the optical path direction and the magnification adjustment are achieved.
It improves the flexibility and efficiency of image acquisition, and can flexibly adjust the magnification under different target species to obtain clear images and shorten the image acquisition time.
Smart Images
Figure CN222965488U_ABST
Abstract
Description
Technical Field
[0001] This application belongs to the field of microscopic imaging image technology, and particularly relates to a microscopic imaging device and a formed element detection device. Background Art
[0002] The pixel points of the image sensor in a digital microscope are fixed. During the microscopic imaging process, the larger the magnification, the smaller the field of view of the digital camera. When using a 40x magnifying glass, the area captured by the digital camera is approximately in the range of 0.2 mm wide and 0.3 mm long. If the height of the accommodation cavity for the detection chip is 0.2 mm, the volume captured in one picture is 0.012 cubic millimeters. In most detection scenarios, there are requirements for the sample volume of the detection object. Therefore, many pictures at different positions or different focal planes need to be taken. Often, the number of pictures that need to be taken exceeds 1000, which takes a long time and seriously affects the timeliness of detection. Often, for the target objects in the detection sample, such as cells, bacteria, etc., there are requirements for the detection duration. Beyond the set time, the cell membrane may rupture, resulting in incorrect measurement of the sample.
[0003] In the prior art, during the formed element analysis process, most image acquisitions are carried out in the form of a single imaging module with a fixed magnification. Although the consistency of the acquired images is good, it is not flexible enough and the image acquisition efficiency is not high. Summary of the Invention
[0004] In this application, the problem that the formed element analysis image acquisition device in the prior art is not flexible enough is solved. A microscopic imaging device capable of adjusting the distance is designed, which can adjust the magnification and, at the same time, adopts the form of a dual imaging module, greatly improving the image acquisition efficiency.
[0005] The technical solution of this application to solve the above technical problems is a microscopic imaging device, including imaging module A, distance fine-tuning component A, and support component; the support component is used for installation and support; the distance fine-tuning component A is used to drive imaging module A to move in the optical path direction and is used to adjust the distance during the microscopic imaging process; the distance fine-tuning component A includes a motor, a screw rod, and a sliding table, and imaging module A is mechanically connected to the sliding table; the output shaft of the motor is connected to the screw rod, the motor rotates to drive the screw rod to rotate, the screw rod drives the sliding table to move, and the sliding table drives imaging module A to move in the optical path direction.
[0006] The imaging optical path is split by beam splitter A into two optical paths, and imaging module A forms an image on one optical path; imaging module B forms an image on the other optical path.
[0007] The distance fine-tuning component B is used to drive the imaging module B to move in the optical path direction for adjusting the distance during the microscopic imaging process. The distance fine-tuning component B includes a motor, a screw rod, and a sliding table. The imaging module B is mechanically connected to the sliding table. The output shaft of the motor is connected to the screw rod. When the motor rotates, it drives the screw rod to rotate, and the screw rod drives the sliding table to move, and the sliding table drives the imaging module B to move in the optical path direction.
[0008] The described microscopic imaging device further includes a light guide barrel. One end of the light guide barrel is mechanically connected to the sliding table, and the other end of the light guide barrel is mechanically connected to the imaging module A or the imaging module B. The light guide barrel is mechanically connected to the sliding table. When the motor rotates, it drives the screw rod to rotate, the screw rod drives the sliding table to move, and the sliding table drives the light guide barrel to move.
[0009] The distance fine-tuning component A or the distance fine-tuning component B further includes a guiding slide rail. The guiding slide rail is slidably connected to the sliding table, parallel to the screw rod, and together with the screw rod, it restricts the sliding table to move in a fixed direction.
[0010] The described microscopic imaging device further includes a position sensor, and the position sensor is used to detect the position of the sliding table.
[0011] The described microscopic imaging device further includes a beam splitter B and a marker light component. The beam splitter B splits one optical path into a marker optical path. The marker light component emits marker light, which forms a marker pattern on the detection target through the marker optical path. The marker pattern passes through the imaging optical path and is imaged on the imaging module A or the imaging module B to form a marker image.
[0012] The support component includes a mounting hole for the marker light component, and the marker light component is connected to the marker optical path through the mounting hole.
[0013] The described microscopic imaging device further includes a lens module. The lens module includes a turntable and at least two groups of lenses. The lenses are mounted on the turntable. By rotating the turntable, different lenses are switched into the optical path.
[0014] The described microscopic imaging device further includes a lens module. The lens module is connected in series with the beam splitter A and the imaging module A in the vertical direction. The distance fine-tuning component A is used to drive the imaging module A to move in the vertical direction.
[0015] The described microscopic imaging device further includes a lens module. The lens module is connected in series with the beam splitter A and the imaging module B in the vertical direction. The distance fine-tuning component A is used to drive the imaging module A to move in the horizontal direction.
[0016] The lens module includes a motor A and a gear set A. The gear set A is respectively gear-connected to the motor A and the turntable, and the motor A drives the turntable to rotate through the gear set A.
[0017] The lens module further includes a position sensor for detecting the position of the turntable.
[0018] Another technical solution for the present application to solve the above technical problems may also be a formed component detection device, including the above microscopic imaging device.
[0019] The formed component detection device further includes a Z-axis moving assembly fixedly connected to the microscopic imaging device for driving the microscopic imaging device to move in the Z-axis direction.
[0020] The technical effects of the above technical solution include: being able to adjust the distance with the distance fine-tuning component A; when the types of target analytes are different and the magnification required for imaging needs to be adjusted, being able to respond flexibly and obtain clear images.
[0021] The technical effects of the above technical solution include: through the beam splitter A and the imaging module B, using multiple imaging modules to obtain images at different distances at the same position, and being able to provide richer image information at one time.
[0022] The technical effects of the above technical solution include: the distance fine-tuning component B enables the imaging module B to also adjust the distance, further flexibilizing the image acquisition mechanism.
[0023] The technical effects of the above technical solution include: the setting of the beam splitter B and the marker light component enables the imaging to introduce markers, facilitating subsequent positioning and calculation.
[0024] The technical effects of the above technical solution include: the marker light component mounting hole facilitates the access of different marker light components to meet the imaging requirements of different scenarios.
[0025] The technical effects of the above technical solution include: the lens module can switch different lenses into the optical path, meeting richer imaging requirements.
[0026] The technical effects of the above technical solution include: the distance fine-tuning component A is used to drive the imaging module A to move in the vertical direction. The distance fine-tuning component A is used to drive the imaging module A to move in the horizontal direction. It can flexibly set the movement in different directions to adapt to different scenarios.
[0027] The technical effects of the above technical solution include: the lens module can also be electrically controlled, which is the basis for realizing the automatic adjustment of the entire imaging process.
[0028] The technical effects of the above technical solution include: the electrical control of the distance fine-tuning component A enables the distance adjustment to achieve automatic adjustment.
[0029] The technical effects of the above technical solution include: the position sensor provides the position information for adjustment, making the control more accurate.
[0030] The technical effects of the above technical solution include: The formed element detection device based on the above microscopic imaging device can acquire images at multiple distances; at the same time, the multiple camera modules can acquire multiple images simultaneously, greatly improving the image acquisition efficiency, shortening the image acquisition time, and providing richer image information for subsequent image analysis. BRIEF DESCRIPTION OF THE DRAWINGS
[0031] Figures 1 to 3 is a schematic block diagram of a microscopic imaging device Figures 1 to 3 ;
[0032] Figures 4 to 6 is a partial schematic of a microscopic imaging device Figures 1 to 3 ;
[0033] Figures 7 to 9 is a schematic of a local part in a microscopic imaging device Figures 1 to 3 . DETAILED DESCRIPTION OF THE EMBODIMENTS
[0034] The following further details the content of the present application in conjunction with the respective drawings. It should be noted that the following is a description of the preferred embodiments of the present invention and does not constitute any limitation to the present invention. The description of the preferred embodiments of the present invention is only for the description of the general principles of the present invention. The numbers such as "first", "second" and "A", "B" involved in the present invention are only for the convenience of description and do not represent the order relationship in time or space. The combinations of letters and numbers "TA", "TB", "H" involved in the present invention are only for the convenience of description, and the specific meanings are determined by the specific words they represent.
[0035] A large number of images are required for analysis. To improve the image acquisition efficiency, a dual camera module form can be adopted. Usually, for the consistency of calculation, the two groups of camera modules can acquire images with the same fixed magnification of microscopic imaging. However, in some cases, during the analysis of formed elements, the image clarity of different targets is different at the same magnification. If a microscopic imaging device with the same magnification is used, the images of some targets are not clear enough. In order to better obtain clear images of different targets, the technical solution in the present application is designed.
[0036] For example Figure 1 , in an embodiment of a microscopic imaging device, it includes a camera module A110, a distance fine-tuning component A111, and a support component 150; the support component 150 is used to install and support the camera module A110 and the distance fine-tuning component A111. The distance fine-tuning component A111 is used to drive the camera module A110 to move in the optical path direction and is used to adjust the distance during microscopic imaging.
[0037] For example Figure 2, in an embodiment of a microscopic imaging device, the distance fine-tuning assembly A includes a motor 221, a screw 222, and a sliding table 223. The imaging module A210 is mechanically connected to the sliding table 223. The output shaft of the motor 221 is connected to the screw 222. When the motor 221 rotates, it drives the screw 222 to rotate. The screw 222 drives the sliding table 223 to move, and the sliding table 223 drives the imaging module A210 to move in the optical path direction.
[0038] As Figure 3 , in an embodiment of a microscopic imaging device, it includes an imaging module A110, a distance fine-tuning assembly A111, and a support assembly 150; it also includes a beam splitter A and an imaging module B. The imaging optical path is split by the beam splitter A131 into two optical paths. The imaging module A110 forms an image on one optical path; the imaging module B120 forms an image on the other optical path.
[0039] As Figure 3 , in an embodiment of a microscopic imaging device, it further includes a beam splitter B160 and a marker light assembly 250. The beam splitter B160 splits one optical path into a marker optical path. The marker light assembly 250 emits marker light, and through the marker optical path, a marker pattern is formed on the detection target. The marker pattern passes through the imaging optical path and forms a marker image on the imaging module A110 or the imaging module B120.
[0040] In an embodiment of the microscopic imaging device not shown in some of the drawings, it further includes a distance fine-tuning assembly B. The distance fine-tuning assembly B is used to drive the imaging module B to move in the optical path direction and is used to adjust the distance during the microscopic imaging process. The distance fine-tuning assembly B includes a motor, a screw, and a sliding table. The imaging module B is mechanically connected to the sliding table. The output shaft of the motor is connected to the screw. When the motor rotates, it drives the screw to rotate. The screw drives the sliding table to move, and the sliding table drives the imaging module B to move in the optical path direction.
[0041] As Figure 4 And Figure 5 , in an embodiment of a microscopic imaging device, the support assembly includes a marker light assembly mounting hole, and the marker light assembly is connected to the marker optical path through the mounting hole.
[0042] As Figure 4 And Figure 5 , in an embodiment of a microscopic imaging device, it further includes a lens module. The lens module includes a turntable and at least two groups of lenses. The lenses are mounted on the turntable. By rotating the turntable, different lenses are switched into the optical path.
[0043] In an embodiment of the microscopic imaging device not shown in some of the drawings, it further includes a lens module. The lens module is connected in series with the beam splitter A and the imaging module A in the vertical direction. The distance fine-tuning assembly A is used to drive the imaging module A to move in the vertical direction.
[0044] AsFigure 4 and Figure 5 In an embodiment of a microscopic imaging device, it further includes a lens module. The lens module is connected in series with the beam splitter A and the imaging module B in the vertical direction, and a fine-tuning component A is provided to drive the imaging module A to move in the horizontal direction.
[0045] Such as Figure 4 and Figure 5 In an embodiment of a microscopic imaging device, the lens module includes a motor A and a gear set A. The gear set A is respectively connected to the motor A and the turntable gear, and the motor A drives the turntable to rotate through the gear set A.
[0046] Such as Figure 4 and Figure 5 In an embodiment of a microscopic imaging device, the lens module further includes a position sensor, and the position sensor is used to detect the position of the turntable.
[0047] Such as Figure 6 and Figure 7 In an embodiment of a microscopic imaging device, it further includes a light guide barrel. One end of the light guide barrel is mechanically connected to the slide table 223, and the other end of the light guide barrel is mechanically connected to the imaging module A or the imaging module B; the light guide barrel is mechanically connected to the slide table 223. When the motor 221 rotates, it drives the screw 222 to rotate, the screw 222 drives the slide table 223 to move, and the slide table 223 drives the light guide barrel to move.
[0048] Such as Figure 8 and Figure 9 In an embodiment of a microscopic imaging device, the fine-tuning component A for distance or the fine-tuning component B for distance further includes a guide rail. The guide rail is slidably connected to the slide table, the guide rail is parallel to the screw, and the guide rail and the screw together restrict the slide table to move in a fixed direction.
[0049] Such as Figure 8 and Figure 9 In an embodiment of a microscopic imaging device, it further includes a position sensor, and the position sensor is used to detect the position of the slide table.
[0050] The motor in this application can be a stepper motor, a servo motor or other precision motors that can be precisely controlled to form. The imaging module A and the imaging module B include a CCD camera or other devices that can realize the acquisition of microscopic magnified images.
[0051] In an embodiment of a formed component detection device not shown in some drawings, it includes the above-mentioned microscopic imaging device. It further includes a Z-axis moving component. The Z-axis moving component is fixedly connected to the microscopic imaging device and is used to drive the microscopic imaging device to move in the Z-axis direction.
[0052] Although the present invention has been described and illustrated with reference to preferred embodiments and several alternatives, the invention is not limited to the specific description in this specification. Other additional alternatives or equivalent components may also be used to practice the present invention.
Claims
1. A microscopic imaging device, characterized in that: It includes a camera module A, a distance fine-tuning component A, and a supporting component; The support assembly is used to install the support; The phase distance fine adjustment component A is used to drive the camera module A to move in the direction of the optical path, and is used to adjust the phase distance during the microscopic imaging process; The phase distance fine adjustment component A includes a motor, a screw rod, and a slide table, and the camera module A is mechanically connected to the slide table; The output shaft of the motor is connected to the screw rod. The motor rotates to drive the screw rod to rotate. The screw rod drives the slide to move. The slide drives the camera module A to move in the direction of the optical path.
2. The microscopic imaging device according to claim 1, characterized in that: It also includes a beam splitter A and a camera module B; The imaging light path is split by the beam splitter A into two light paths. The camera module A forms an image on one light path, and the camera module B forms an image on the other light path.
3. The microscopic imaging device according to claim 2, characterized in that: Also includes a phase distance fine-tuning component B; The phase distance fine adjustment component B is used to drive the camera module B to move in the direction of the optical path, so as to adjust the phase distance during the microscopic imaging process; The phase distance fine adjustment component B includes a motor, a screw rod, and a slide table, and the camera module B is mechanically connected to the slide table; The output shaft of the motor is connected to the screw rod. The motor rotates to drive the screw rod to rotate. The screw rod drives the slide to move. The slide drives the camera module B to move in the direction of the optical path.
4. The microscopic imaging device according to any one of claims 1 to 3, characterized in that: It also includes a light guide lens barrel, one end of which is mechanically connected to the slide table, and the other end of which is mechanically connected to the camera module A or the camera module B; The light guide lens barrel is mechanically connected to the slide table. The motor rotates to drive the screw rod to rotate, the screw rod drives the slide table to move, and the slide table drives the light guide lens barrel to move.
5. The microscopic imaging device according to any one of claims 1 to 3, characterized in that: The distance fine-tuning component A or the distance fine-tuning component B also includes a guide rail, which is slidably connected to the slide table, and the guide rail is parallel to the screw rod. The guide rail and the screw rod together constrain the slide table to make directional movement.
6. The microscopic imaging device according to any one of claims 1 to 3, characterized in that: A position sensor is also included, and the position sensor is used to detect the position of the slide.
7. The microscopic imaging device according to any one of claims 1 to 3, characterized in that: It also includes a beam splitter B and a marking light assembly; Beam splitter B splits a light path into a marking light path. The marking light component emits marking light, which forms a marking pattern on the detection target through the marking light path. The marking pattern passes through the imaging light path and is imaged in the camera module A or the camera module B to form a marking image.
8. The microscopic imaging device according to claim 7, characterized in that: The supporting assembly comprises a marking light assembly mounting hole, and the marking light assembly is connected to the marking light path through the mounting hole.
9. The microscopic imaging device according to any one of claims 1 to 3, characterized in that: It also includes a lens module, which includes a turntable and at least two groups of lenses. The lenses are mounted on the turntable, and different lenses are switched to the light path when the turntable is rotated.
10. The microscopic imaging device according to claim 2, characterized in that: It also includes a lens module, which is connected in series with the beam splitter A and the camera module A in the vertical direction, and the distance fine-tuning component A is used to drive the camera module A to move in the vertical direction.
11. The microscopic imaging device according to claim 2, characterized in that: It also includes a lens module, which is connected in series with the beam splitter A and the camera module B in the vertical direction, and the distance fine-tuning component A is used to drive the camera module A to move in the horizontal direction.
12. The microscopic imaging device according to claim 9, characterized in that: The lens module includes a motor A and a gear set A. The gear set A is connected to the motor A and the turntable gear respectively. The motor A drives the turntable to rotate through the gear set A.
13. The microscopic imaging device according to claim 9, characterized in that: The lens module further includes a position sensor, and the position sensor is used to detect the position of the turntable.
14. A shaped component detection device, characterized in that: A microscopic imaging device comprising any one of claims 1 to 13.
15. The shaped component detection device according to claim 14, characterized in that: It also includes a Z-axis moving component, which is fixedly connected to the microscopic imaging device and is used to drive the microscopic imaging device to move in the Z-axis direction.