Ultrahigh-pressure liposome dispersing device

Abstract

The utility model discloses an ultrahigh pressure lipidosome dispersing device which comprises a homogenizer discharge pipe, a sealing sleeve and an electric push rod for driving the sealing sleeve to switch between a first state and a second state are sleeved on the homogenizer discharge pipe, a plugging plate is fixedly arranged on the inner wall of an upper shell, a plurality of communicating ports distributed in the circumferential direction are arranged on the plugging plate, and the communicating ports are communicated with the sealing sleeve. The extruder further comprises a plugging seat, a plugging block used for plugging the communication opening is arranged on the plugging seat, a pushing assembly used for keeping the plugging seat in the first state is arranged in the upper shell, in the first state, the plugging block is inserted into the communication opening to plug the communication opening, the extruder shell can be driven by the driving mechanism to rotate, and then the position of the filtering assembly is changed; and then the electric push rod is used for driving the sealing sleeve to switch between the first state and the second state, so that automatic connection or automatic disassembly of the discharging pipe of the homogenizer and the filtering assembly is realized, and the switching efficiency of the filtering assembly is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of high-pressure homogenization equipment, and particularly to an ultra-high pressure liposome dispersion device. Background Art

[0002] Liposomes are the core materials of nano-drugs. In the pharmaceutical process, strict requirements are imposed on the particle size of liposomes, and precise control of the particle size of liposomes is required.

[0003] Generally, during the liposome preparation process, it is necessary to first process through a high-pressure homogenizer and then filter through a low-pressure filter.

[0004] Among them, the high-pressure homogenizer and the high-pressure extruder operate separately. During the liposome preparation process, it is necessary to transfer from the high-pressure homogenizer to the high-pressure extruder. The low-pressure filter needs to replace the filter membrane assembly under different production conditions, so it is necessary to stop the machine, reducing the production efficiency of liposomes.

[0005] The existing utility model patent with the authorized announcement number CN211586440U discloses a high-pressure homogenization device for preparing liposomes, in which the outlet pipe of the homogenizer is placed directly above the high-pressure extruder. Among them, there are multiple groups of filter pipes on the high-pressure extruder, and the specifications of the filter membrane assemblies in each group of filter pipes are different. When the particle size requirement of liposomes changes, it is only necessary to switch the filter pipe connected to the outlet pipe of the high-pressure homogenizer. Among them, the connection between the outlet pipe of the high-pressure homogenizer and the filter pipe needs to be manually operated, and the filter pipe above is exposed to the air, and the filter membrane assembly in the filter pipe not connected to the outlet pipe of the high-pressure homogenizer is easily affected by external dust, which will affect the cleanliness of liposome preparation.

[0006] Therefore, how to design an ultra-high pressure liposome dispersion device has become a technical problem that needs to be solved urgently by those skilled in the art. Summary of the Utility Model

[0007] In order to solve at least one technical problem mentioned in the background art, the purpose of the present utility model is to provide an ultra-high pressure liposome dispersion device to solve the problem that the outlet pipe of the high-pressure homogenizer and the connecting pipe need to be manually installed and avoid the problem that the filter membrane assembly in the filter pipe is polluted by external dust.

[0008] To achieve the above purpose, the present utility model provides the following technical solutions:

[0009] A super-high pressure liposome dispersion device includes an extruder housing and a driving mechanism for driving the rotation of the extruder housing. The extruder housing is provided with a number of circumferentially distributed filter components. The filter component includes a lower housing, an upper housing threadedly connected to the lower housing, and a filter membrane component located between the upper housing and the lower housing. Above the extruder housing, there is a homogenizer discharge pipe located above one of the filter components. A sealing sleeve is sleeved on the homogenizer discharge pipe, and an electric push rod for driving the sealing sleeve to switch between a first state and a second state is provided. A blocking plate is fixedly provided on the inner wall of the upper housing. The blocking plate is provided with a number of circumferentially distributed communication ports. A blocking seat is also included. The blocking seat is provided with a blocking block for blocking the communication ports. A top-pushing component for holding the blocking seat in the first state is provided inside the upper housing. In the first state, the blocking block is inserted into the communication port to block the communication port.

[0010] Further, the top-pushing component includes a positioning seat fixed in the inner cavity of the upper housing. The positioning seat is provided with a vertically upward extending positioning sleeve. The bottom wall of the blocking seat is provided with a vertically downwardly provided guiding sleeve. The guiding sleeve is sleeved on the outside of the positioning sleeve and is slidably connected to the outer wall of the positioning sleeve. A compression spring installed in the positioning sleeve is also included. One end of the compression spring abuts against the positioning seat, and the other end of the compression spring abuts against the bottom wall of the blocking seat.

[0011] Further, the blocking plate is provided with a through hole penetrating up and down. The blocking seat is provided with a push rod extending upward through the through hole. A support rod corresponding to the push rod is fixedly provided on the inner wall of the sealing sleeve. In the first state, the support rod abuts against the push rod, and the top wall of the push rod is flush with the top wall of the blocking plate. In the second state, the support rod is disengaged from the push rod, and the top wall of the push rod is higher than the top wall of the blocking plate.

[0012] Further, the bottom of the homogenizer discharge pipe is provided with a bent edge bent outward. The bent edge and the outer wall of the homogenizer discharge pipe form a first sealing groove. A first sealing ring is provided in the first sealing groove. A blocking edge is provided in the sealing sleeve. In the first state, the blocking edge abuts against the first sealing ring.

[0013] Further, one end of the bent edge is curled out to form a curled edge retaining ring. The curled edge retaining ring abuts against the inner wall of the sealing sleeve.

[0014] Further, the longitudinal section of the bottom of the sealing sleeve is in an inverted Y shape. The bottom of the sealing sleeve is provided with an outwardly folded outer retaining edge and an inwardly folded inner retaining edge. A second sealing groove is formed between the outer retaining edge and the inner retaining edge. A second sealing ring is provided in the second sealing groove. In the first state, the second sealing ring abuts against the top wall of the upper housing. The outer retaining edge is inserted into the inside of the upper housing and abuts against the top wall of the blocking plate.

[0015] Further, a sealing ring groove is provided on the top wall of the plugging plate and is recessed downward. A sealing ring is provided in the sealing ring groove. A fitting groove is provided on the top wall of the upper housing. In the first state, the outer retaining edge abuts against the sealing ring, and the second sealing ring is buckled in the fitting groove.

[0016] Further, an annular supporting seat is provided on the inner wall of the lower housing. The filter membrane assembly includes a supporting plate, a filter plate, and a filter membrane that are sequentially arranged from bottom to top. The bottom wall of the supporting plate abuts against the top wall of the supporting seat.

[0017] Further, a pressing ring seat is provided on the upper housing and is arranged vertically downward. After the upper housing and the lower housing are installed, the bottom wall of the pressing ring seat abuts against the top wall of the filter membrane.

[0018] Further, a filtering discharge pipe communicating with the inner cavity of the lower housing is provided on the outer wall of the lower housing.

[0019] Compared with the prior art, the beneficial effects of the present utility model are as follows: The present utility model can drive the extruder casing to rotate by using the driving mechanism, thereby changing the position of the filtering component. Then, the electric push rod is used to drive the sealing sleeve to switch between the first state and the second state, so as to realize the automatic connection or disassembly of the homogenizer discharge pipe and the filtering component, and improve the switching efficiency of the filtering component.

[0020] The filtering component not connected to the homogenizer discharge pipe plugs the communication port on the plugging plate through the plugging seat, thereby preventing dust from contacting the filter membrane assembly and reducing the risk of the filter membrane assembly being polluted by dust. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 is a schematic diagram of the first state of the present utility model;

[0022] Figure 2 is a schematic diagram of the second state of the present utility model;

[0023] Figure 3 is a cross-sectional view of the first state;

[0024] Figure 4 is a cross-sectional view of the second state;

[0025] Figure 5 is Figure 4 an enlarged structural schematic diagram of A in

[0026] Figure 6 is an installation schematic diagram of the sealing sleeve;

[0027] Figure 7 is an installation schematic diagram of the filtering component;

[0028] Figure 8 is a cross-sectional view of the upper housing.

[0029] In the figure: 1. Extruder housing; 2. Filter assembly; 21. Lower housing; 211. Support seat; 212. Filter discharge pipe; 22. Upper housing; 221. Plugging plate; 2211. Sealing ring groove; 2212. Communication port; 2213. Through hole; 222. Positioning seat; 2221. Positioning sleeve; 223. Plugging seat; 2231. Guide sleeve; 2232. Push rod; 2233. Plugging block; 224. Compression spring; 225. Sealing ring; 226. Compression ring seat; 227. Fitting groove; 3. Homogenizer discharge pipe; 31. Bent edge; 311. Crimped retaining ring; 312. First sealing groove; 32. First sealing ring; 4. Sealing sleeve; 41. Plugging retaining edge; 42. Outer retaining edge; 43. Inner retaining edge; 44. Second sealing groove; 45. Second sealing ring; 46. Support seat; 461. Support rod; 5. Electric push rod; 6. Filter membrane assembly; 61. Support plate; 62. Filter plate; 63. Filter membrane. Detailed implementation manners

[0030] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0031] This embodiment provides a super-high pressure liposome dispersion device, which realizes the automatic connection between the discharge pipe of the high-pressure homogenizer and the filter assembly, and reduces the risk of the filter membrane assembly in the filter pipe being polluted by external dust.

[0032] As Figure 1 shown, it includes an extruder housing 1, and a plurality of filter assemblies 2 are arranged on the extruder housing 1 along the circumferential direction and evenly distributed. Specifically, a constant-temperature water source is provided in the extruder housing 1, and the filter assemblies 2 are immersed in the constant-temperature water to provide a stable temperature environment for the filtration of liposomes. Different types of filter membrane assemblies 6 are provided in each filter assembly 2 to realize the processing of liposomes with different particle sizes.

[0033] A homogenizer discharge pipe 3 is provided directly above the extruder housing 1. Among them, the homogenizer discharge pipe 3 is aligned with one of the filter assemblies 2. A sealing sleeve 4 is sleeved on the homogenizer discharge pipe 3. An electric push rod 5 for driving the sealing sleeve 4 to lift is further included. Among them, a driving mechanism for driving the extruder housing 1 to rotate is further included, and the driving mechanism is used to switch the positions of the filter assemblies 2 to realize the alignment of different filter assemblies 2 with the homogenizer discharge pipe 3.

[0034] Since the driving mechanism for driving the extruder housing 1 is a conventional structure, the extruder housing 1 can be directly driven by a motor to rotate to realize the switching of the positions of the filter assemblies 2. Here, the driving mechanism will not be described in detail.

[0035] When preparing liposomes, as Figure 1 shown, at this time, the electric push rod 5 pushes the sealing sleeve 4 downward, so that the sealing sleeve 4 is connected to the top of the filtration component 2, and the liposomes in the outlet pipe 3 of the homogenizer are transferred into the filtration component 2. Among them, a valve is installed at the front end of the outlet pipe 3 of the homogenizer, which can be used to block the liposomes processed by the homogenizer from flowing downward from the end of the outlet pipe 3 of the homogenizer. When it is necessary to change the particle size of the liposomes, at this time, the valve is closed, and the electric push rod 5 drives the sealing sleeve 4 to move upward, so that the horizontal plane where the lowest point of the sealing sleeve 4 is located is higher than the filtration component 2. Then, the driving mechanism is used to drive the extruder housing 1 to rotate, so as to align the corresponding filtration component 2 with the outlet pipe 3 of the homogenizer. Then, the electric push rod 5 is used to push the sealing sleeve 4 downward again, so that the sealing sleeve 4 is reconnected to the filtration component 2. Then, the valve on the outlet pipe 3 of the homogenizer is opened, and thus the preparation of liposomes with different particle sizes can be realized.

[0036] In order to realize the filtration of liposomes, in this embodiment, as Figure 3 and Figure 4 shown, the filtration component 2 includes a lower housing 21 and an upper housing 22 threadedly connected to the lower housing 21. Among them, the filter membrane assembly 6 is installed between the upper housing 22 and the lower housing 21, and the upper housing 22 is connected to the outlet pipe 3 of the homogenizer through the sealing sleeve 4.

[0037] Specifically, as Figure 4 shown, a circumferentially arranged supporting seat 211 is provided on the inner wall of the lower housing 21, and a filtration outlet pipe 212 communicating with the inner cavity of the lower housing 21 is provided at the bottom of the lower housing 21. The filter membrane assembly 6 is installed above the supporting seat 211.

[0038] In order to fix the filter membrane assembly 6, in this embodiment, as Figure 4 , Figure 7 and Figure 8 shown, the filter membrane assembly 6 includes a support plate 61, a filter plate 62, and a filter membrane 63 arranged in sequence from bottom to top. Among them, the bottom wall of the support plate 61 abuts against the top wall of the supporting seat 211. The upper housing 22 is threadedly connected to the lower housing 21, and a pressing ring seat 226 extending downward is provided on the upper housing 22. When the upper housing 22 is installed on the lower housing 21, at this time, the pressing ring seat 226 presses on the upper side of the filter membrane 63 to fix the filter membrane 63 and prevent the position of the filter membrane 63 from moving during the filtration process.

[0039] When the liposomes in the outlet pipe 3 of the homogenizer are filtered by the filter membrane assembly 6, they flow into the inner cavity of the lower housing 21 and then flow out through the filtration outlet pipe 212, thus completing the treatment of the liposomes.

[0040] Since there are multiple groups of filter components 2 provided on the extruder housing 1, and the top openings of the filter components 2 not connected to the sealing sleeve 4 are open, it is easy for dust from the outside to come into contact with the filter membrane assembly 6, which will affect the cleanliness of the liposomes. Therefore, in this embodiment, as Figure 5 and Figure 8 shown, a blocking plate 221 is fixedly provided on the inner wall of the upper housing 22. A through hole 2213 penetrating up and down is provided on the blocking plate 221. A number of uniformly distributed communication ports 2212 are provided in the circumferential direction of the through hole 2213. It further includes a blocking seat 223 that moves up and down inside the upper housing 22. As Figure 7 shown, a push rod 2232 that extends upward through the through hole 2213 is fixedly provided on the blocking seat 223. The outer wall of the push rod 2232 is slidably connected to the inner wall of the through hole 2213. A number of blocking blocks 2233 on the blocking seat 223 are aligned with the communication ports 2212. Among them, the blocking seat 223 can be switched between a first state and a second state. In the first state, the blocking block 2233 is located below the blocking plate 221 to open the communication port 2212. At this time, the top wall of the push rod 2232 is flush with the top wall of the blocking plate 221. In the second state, the blocking block 2233 is inserted into the communication port 2212 to close the communication port 2212. At this time, the top wall of the push rod 2232 is higher than the top wall of the blocking plate 221.

[0041] When the filter component 2 is not connected to the homogenizer discharge pipe 3, at this time the filter component 2 is in the second state, and the blocking seat 223 closes the communication port 2212 on the blocking plate 221, thereby being able to prevent dust from the outside from coming into contact with the filter membrane assembly 6 and reducing the risk of the filter membrane assembly 6 being contaminated.

[0042] In order to realize the switching of the blocking seat 223 between the first state and the second state, in this embodiment, as Figure 5 and Figure 8 shown, a positioning seat 222 is fixedly provided inside the upper housing 22 and below the blocking seat 223. Among them, a positioning sleeve 2221 is provided on the positioning seat 222 and extends vertically upward. The bottom wall of the blocking seat 223 is provided with a guiding sleeve 2231 that extends vertically downward. Among them, the guiding sleeve 2231 is sleeved outside the positioning sleeve 2221, and the inner wall of the guiding sleeve 2231 is slidably connected to the outer wall of the positioning sleeve 2221. Among them, a compression spring 224 is installed in the inner cavity of the positioning sleeve 2221. One end of the compression spring 224 abuts against the positioning seat 222, and the other end of the compression spring 224 abuts against the blocking seat 223.

[0043] The compression spring 224 is used to provide an upward pushing force for the plugging seat 223. The plugging seat 223 is used to close the communication port 2212. When the push rod 2232 is subjected to a downward pressure, the plugging seat 223 compresses the compression spring 224, thereby opening the communication port 2212 and transporting the liposomes in the outlet pipe 3 of the homogenizer to the position of the filter membrane assembly 6 to achieve the filtration of liposomes.

[0044] It should be noted here that the bottom edge of the guide sleeve 2231 is bent outward to form a flange, as Figure 5 described, the top wall of the plugging seat 223 is an upwardly arched surface. When the liposomes enter the inner cavity of the upper housing 22 from the communication port 2212, at this time, the liposomes will slide down along the arched surface of the plugging seat 223, preventing the falling liposomes from contacting the compression spring 224, and at the same time being able to prevent the liposomes from entering the inner cavity of the positioning sleeve 2221, solving the problem of liposomes remaining in the inner cavity of the positioning sleeve 2221.

[0045] When the sealing sleeve 4 is combined with the upper housing 22, it can apply a pressure to the push rod 2232 to open the communication port 2212. In this embodiment, as Figure 6 shown, a support seat 46 is fixedly provided in the inner cavity of the sealing sleeve 4. Among them, a support rod 461 aligned with the push rod 2232 is fixedly provided on the support seat 46. Among them, the support rod 461 extends vertically downward. When the sealing sleeve 4 is combined with the upper housing 22, at this time, the support rod 461 abuts against the push rod 2232, and then pushes the push rod 2232 downward, thereby opening the communication port 2212.

[0046] Under normal circumstances, the sealing sleeve 4 is slidably connected to the outlet pipe 3 of the homogenizer. At this time, a gap remains between the inner wall of the sealing sleeve 4 and the outer wall of the outlet pipe 3 of the homogenizer. At this time, the liposomes flowing out of the outlet pipe 3 of the homogenizer are likely to flow out from the gap between the sealing sleeve 4 and the outlet pipe 3 of the homogenizer. To solve this problem, in this embodiment, as Figure 4 and Figure 6 shown, the bottom of the outlet pipe 3 of the homogenizer is turned outward to form a bent edge 31. A first sealing groove 312 is formed between the bent edge 31 and the outer wall of the outlet pipe 3 of the homogenizer. A first sealing ring 32 is provided inside the first sealing groove 312. The sealing sleeve 4 is provided with a plugging flange 41 for abutting against the first sealing ring 32.

[0047] Through the above settings, when the sealing sleeve 4 is connected to the filter assembly 2, at this time, the electric push rod 5 pushes the sealing sleeve 4 downward, so that the plugging flange 41 abuts against the first sealing ring 32, thereby restricting the liposomes from flowing out from the gap between the sealing sleeve 4 and the outlet pipe 3 of the homogenizer.

[0048] Specifically, in this embodiment, as Figure 4 andFigure 6 As shown, the end of the bent edge 31 is curled to form a curled edge retaining ring 311. Among them, the curled edge retaining ring 311 abuts against the inner wall of the sealing sleeve 4 to prevent the liposome from flowing towards the first sealing groove 312. At the same time, the setting of the curled edge retaining ring 311 can improve the stability of the lifting of the sealing sleeve 4.

[0049] When the sealing sleeve 4 is connected to the upper shell 22 on the filter assembly 2, in order to strengthen the sealing of the connection, in the embodiment, as Figure 4 and Figure 6 shown, the bottom of the longitudinal section of the sealing sleeve 4 is in an inverted Y shape. Among them, the bottom of the sealing sleeve 4 is provided with an outwardly folded outer retaining edge 42 and an inwardly folded inner retaining edge 43. Among them, a second sealing groove 44 is formed between the outer retaining edge 42 and the inner retaining edge 43. A second sealing ring 45 is arranged in the second sealing groove 44. When the sealing sleeve 4 is combined with the upper shell 22, the edge of the upper shell 22 is inserted into the second sealing groove 44, and the top edge of the upper shell 22 abuts against the second sealing ring 45, thereby strengthening the sealing between the sealing sleeve 4 and the upper shell 22.

[0050] When the top wall of the upper shell 22 abuts against the second sealing ring 45, in order to strengthen the stability of the abutment, in this embodiment, as Figure 8 shown, a fitting groove 227 is provided on the top wall of the upper shell 22. After the sealing sleeve 4 is combined with the upper shell 22, the second sealing ring 45 is buckled in the fitting groove 227 to improve the stability of the second sealing ring 45.

[0051] It should be noted here that, as Figure 3 shown, the horizontal plane where the bottom wall of the inner retaining edge 43 is located is lower than the horizontal plane where the bottom wall of the outer retaining edge 42 is located. The inner retaining edge 43 is inclined and extends into the inner cavity of the upper shell 22. When the sealing sleeve 4 is connected to the upper shell 22, at this time, the inner retaining edge 43 is located above the blocking plate 221, and the bottom wall of the inner retaining edge 43 abuts against the top wall of the blocking plate 221. At this time, the liposome flowing out of the outlet pipe 3 of the homogenizer will abut against the inner retaining edge 43. Under the diversion of the inner retaining edge 43, the liposome is diverted towards the communication port 2212 and smoothly transported to the filter membrane assembly 6 for filtration.

[0052] In order to improve the sealing between the inner retaining edge 43 and the blocking plate 221, in this embodiment, as Figure 5 、 Figure 7 and Figure 8As shown, a sealing ring groove 2211 recessed downward is provided on the plugging plate 221, a sealing ring 225 is provided in the sealing ring groove 2211, the sealing ring 225 is made of rubber material. After the sealing sleeve 4 is connected to the upper shell 22, the inner retaining edge 43 abuts against the sealing ring 225 and squeezes the sealing ring 225, causing the sealing ring 225 to deform and preventing liposomes from flowing into the second sealing groove 44.

[0053] It should be noted here that a conical inclined surface is provided on the plugging plate 221, so that liposomes are guided into the communication port 2212, preventing liposomes from remaining on the plugging plate 221.

[0054] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and without departing from the spirit or basic characteristics of the present invention, the present invention can be implemented in other specific forms. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present invention.

Claims

1. An ultra-high pressure liposome dispersion device, comprising an extruder housing (1) and a driving mechanism for driving the extruder housing (1) to rotate, the extruder housing (1) being provided with a plurality of circumferentially distributed filter assemblies (2), the filter assemblies (2) comprising a lower housing (21), an upper housing (22) threadedly connected to the lower housing (21), and a filter membrane assembly (6) located between the upper housing (22) and the lower housing (21), a homogenizer discharge pipe (3) located above one of the filter assemblies (2) being provided above the extruder housing (1), characterized in that: The homogenizer discharge pipe (3) is sleeved with a sealing sleeve (4) and an electric push rod (5) for driving the sealing sleeve (4) to switch between a first state and a second state; a sealing plate (221) is fixedly provided on the inner wall of the upper shell (22); the sealing plate (221) is provided with a plurality of circumferentially distributed connecting ports (2212); and the sealing seat (223) is provided with a sealing block (2233) for sealing the connecting port (2212); a pushing assembly for keeping the sealing seat (223) in the first state is provided in the upper shell (22); in the first state, the sealing block (2233) is plugged into the connecting port (2212) to seal the connecting port (2212).

2. The ultra-high pressure liposome dispersion device according to claim 1, characterized in that: The push assembly includes a positioning seat (222) fixed in the inner cavity of the upper shell (22), the positioning seat (222) is provided with a positioning sleeve (2221) extending vertically upward, the bottom wall of the blocking seat (223) is provided with a guide sleeve (2231) arranged vertically downward, the guide sleeve (2231) is sleeved on the outside of the positioning sleeve (2221) and is slidably connected to the outer wall of the positioning sleeve (2221), and also includes a compression spring (224) installed in the positioning sleeve (2221), one end of the compression spring (224) is in contact with the positioning seat (222), and the other end of the compression spring (224) is in contact with the bottom wall of the blocking seat (223).

3. An ultra-high pressure liposome dispersion device according to claim 2, characterized in that: The blocking plate (221) is provided with a through hole (2213) extending upwardly therethrough, the blocking seat (223) is provided with a push rod (2232) extending upwardly through the through hole (2213), and the inner wall of the sealing sleeve (4) is fixedly provided with a support rod (461) corresponding to the push rod (2232); in a first state, the support rod (461) abuts against the push rod (2232), and the top wall of the push rod (2232) is flush with the top wall of the blocking plate (221); in a second state, the support rod (461) is out of contact with the push rod (2232), and the top wall of the push rod (2232) is higher than the top wall of the blocking plate (221).

4. An ultra-high pressure liposome dispersion device according to claim 1 or 2, characterized in that: The bottom of the homogenizer discharge pipe (3) is provided with a bent edge (31) bent outward, the bent edge (31) and the outer wall of the homogenizer discharge pipe (3) form a first sealing groove (312), a first sealing ring (32) is provided in the first sealing groove (312), and a sealing rib (41) is provided in the sealing sleeve (4), and in a first state, the sealing rib (41) abuts against the first sealing ring (32).

5. The ultra-high pressure liposome dispersion device according to claim 4, characterized in that: One end of the bent edge (31) is rolled out to form a rolled edge retaining ring (311), and the rolled edge retaining ring (311) abuts against the inner wall of the sealing sleeve (4).

6. The ultra-high pressure liposome dispersion device according to claim 2, characterized in that: The bottom longitudinal section of the sealing sleeve (4) is in an inverted Y shape. The bottom of the sealing sleeve (4) is provided with an outer rib (42) folded outward and an inner rib (43) folded inward. A second sealing groove (44) is formed between the outer rib (42) and the inner rib (43). A second sealing ring (45) is provided in the second sealing groove (44). In a first state, the second sealing ring (45) abuts against the top wall of the upper shell (22), and the outer rib (42) is inserted into the interior of the upper shell (22) and abuts against the top wall of the blocking plate (221).

7. The ultra-high pressure liposome dispersion device according to claim 6, characterized in that: The top wall of the blocking plate (221) is provided with a downwardly recessed sealing ring groove (2211), a sealing ring (225) is provided in the sealing ring groove (2211), and the top wall of the upper shell (22) is provided with a fitting groove (227). In a first state, the outer retaining edge (42) abuts against the sealing ring (225), and the second sealing ring (45) is buckled in the fitting groove (227).

8. The ultra-high pressure liposome dispersion device according to claim 1, characterized in that: The inner wall of the lower shell (21) is provided with an annular supporting seat (211), and the filter membrane assembly (6) comprises a supporting plate (61), a filter plate (62) and a filter membrane (63) which are arranged in sequence from bottom to top, and the bottom wall of the supporting plate (61) is in contact with the top wall of the supporting seat (211).

9. The ultra-high pressure liposome dispersion device according to claim 8, characterized in that: The upper shell (22) is provided with a clamping ring seat (226) arranged vertically downward. After the upper shell (22) and the lower shell (21) are installed, the bottom wall of the clamping ring seat (226) abuts against the top wall of the filter membrane (63).

10. An ultra-high pressure liposome dispersion device according to claim 1 or 9, characterized in that: The outer wall of the lower shell (21) is provided with a filtering discharge pipe (212) which is in communication with the inner cavity of the lower shell (21).

Images