Multistage circulation structure with through holes in inner side of chromatographic column

Abstract

The utility model relates to the technical field of chemical substance separation and purification, and discloses a chromatographic column inner side through hole multi-stage circulation structure which comprises a column tube, the top of the column tube is fixedly connected with a mounting frame, and a mounting groove is formed in the mounting frame, so that the device can utilize a cross and an I-shaped frame to form multi-stage circulation of a chromatographic column inner side through hole, and the chromatographic column inner side through hole multi-stage circulation structure is formed. And each flow path uniformly and synchronously reaches each circulating hole connected with the stationary phase and then is uniformly distributed to the stationary phase for preparing the chromatographic column, so that eluent can be uniformly distributed when flowing downwards from the central hole of the piston, and the separation effect of the device is greatly improved. And the sealing piston and the distribution disc can be quickly fixed through the mortise lock mechanism, so that the sealing piston and the distribution disc are greatly convenient to mount and dismount by an operator, and the working efficiency of the device is greatly improved.

Description

Technical Field

[0001] The utility model relates to the technical field of separation and purification of chemical substances, in particular to a multi-stage flow-through structure of inner through holes of a chromatographic column. Background Technique

[0002] Chromatography is an essential separation method in laboratories, especially applicable in natural product laboratories, chemical laboratories, biological laboratories, and some scientific research and teaching practices. Chromatography is a method for separating and determining multi-component mixtures by utilizing the different physical and chemical properties of each component, including various methods such as column chromatography, thin-layer chromatography, and high-performance liquid chromatography. Among them, column chromatography is the most commonly used one in laboratories currently.

[0003] For example, in the component structure of the preparation chromatographic column of the Chinese patent with the patent application number 201821045868.3, this patent uses the separation of the main partition board and the I-shaped partition board to form multi-stage flow-through in the inner through holes of the chromatographic column. Each flow path reaches each flow-through hole connected to the stationary phase evenly and synchronously, and then is evenly distributed to the stationary phase of the preparation chromatographic column, thus avoiding the phenomenon of uneven downward flow of liquid caused by the difference in flow velocity between the central area and the surrounding area when the piston central hole flows to the periphery, and ensuring a good separation effect.

[0004] However, when using the above patent, it is necessary to use bolts and flange plates to fixedly install the piston, resulting in a large amount of time spent on installing and disassembling the piston during actual use, thus seriously affecting the working efficiency of the chromatographic column. Content of the Utility Model

[0005] The purpose of the utility model is to provide a multi-stage flow-through structure of inner through holes of a chromatographic column, which solves the problems raised in the background technique.

[0006] The embodiment of the present application provides a multi-stage flow-through structure of inner through holes of a chromatographic column, including a column tube. The top of the column tube is fixedly connected with a mounting frame. An installation groove is opened inside the mounting frame. A sealing piston is fixedly connected inside the installation groove through a plugging and locking mechanism. The bottom of the sealing piston is fixedly connected with a distribution plate. A central hole is opened inside the sealing piston.

[0007] By adopting the above technical solution, the present device can better perform uniform separation treatment on the mixture, thus greatly improving the practicability of the present device.

[0008] Optionally, the plugging and locking mechanism includes a plurality of fixing plates arranged at the top of the inner cavity of the installation groove and a plurality of plug plates installed on the peripheral side of the sealing piston. An elastic locking rod is arranged inside the plug plate. A plug slot is opened on one side of the fixing plate. A locking hole is opened at the top of the plug slot.

[0009] By adopting the above technical solution, the device can quickly fix the sealing piston and the distribution plate through the plug lock mechanism, thus greatly facilitating the installation and disassembly of the sealing piston and the distribution plate by the operator, and further greatly improving the working efficiency of the device.

[0010] Optionally, a cross and multiple sets of I-shaped frames are arranged inside the distribution plate, and through holes are formed between the multiple sets of I-shaped frames.

[0011] By adopting the above technical solution, the device can form multi-stage flow through the cross and the I-shaped frames in the inner through hole of the chromatographic column, and each flow path can uniformly and synchronously reach each flow-through hole connected to the stationary phase, and then be uniformly distributed to the stationary phase of the preparative chromatographic column, so that the eluent can be uniformly distributed when flowing downward from the central hole of the piston, thereby greatly improving the separation effect of the device.

[0012] Optionally, the elastic locking rod includes a fixed base, a return spring is fixedly connected to the bottom of the inner cavity of the fixed base, a locking rod is fixedly connected to the top of the return spring, and the top of the locking rod extends to the outside of the fixing plate through a locking hole.

[0013] By adopting the above technical solution, the locking effect of the device is better by using the elastic action of the return spring.

[0014] Optionally, a sealing gasket is arranged at the connection between the sealing piston and the installation groove.

[0015] By adopting the above technical solution, the sealing performance of the device can be greatly enhanced by using the sealing gasket.

[0016] Optionally, four sets of fixing plates and inserting plates are provided, and the four sets of fixing plates and inserting plates are distributed in an annular array.

[0017] By adopting the above technical solution, the fixing effect of the device is better by using the coordinated cooperation of multiple sets of fixing plates and inserting plates.

[0018] Compared with the prior art, the beneficial effects of the technical solution of the present application are as follows:

[0019] 1. By setting the sealing piston, the distribution plate, the cross and the I-shaped frames in the technical solution of the present application, the device can form multi-stage flow through the cross and the I-shaped frames in the inner through hole of the chromatographic column, and each flow path can uniformly and synchronously reach each flow-through hole connected to the stationary phase, and then be uniformly distributed to the stationary phase of the preparative chromatographic column, so that the eluent can be uniformly distributed when flowing downward from the central hole of the piston, thereby greatly improving the separation effect of the device.

[0020] 2. The technical solution of this application enables the device to quickly fix the sealing piston and the distribution plate through the plug-locking mechanism by setting up the mounting bracket, mounting groove, sealing piston, fixing plate, plug plate, elastic locking rod, slot and locking hole. This greatly facilitates the installation and disassembly of the sealing piston and the distribution plate by the operator, and thus significantly improves the working efficiency of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Other features, objects and advantages of the present utility model will become more apparent by reading the following detailed description of non-limiting embodiments with reference to the accompanying drawings:

[0022] Figure 1 It is a three-dimensional structural schematic diagram of the overall multi-stage flow-through structure of the inner through-hole of the chromatographic column of the present utility model;

[0023] Figure 2 It is a three-dimensional structural schematic diagram of the connection part of the mounting bracket and the sealing piston in the multi-stage flow-through structure of the inner through-hole of the chromatographic column of the present utility model;

[0024] Figure 3 It is an internal structural schematic diagram of the distribution plate in the multi-stage flow-through structure of the inner through-hole of the chromatographic column of the present utility model;

[0025] Figure 4 It is a cross-sectional view of the elastic locking rod in the multi-stage flow-through structure of the inner through-hole of the chromatographic column of the present utility model.

[0026] In the figure: 1, column tube; 2, mounting bracket; 3, sealing piston; 4, distribution plate; 5, central hole; 6, fixing plate; 7, plug plate; 8, elastic locking rod; 801, fixed base; 802, return spring; 803, locking rod; 9, slot; 10, locking hole; 11, cross; 12, I-shaped frame; 13, mounting groove. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0027] Please refer to Figures 1-4 , the present utility model provides a technical solution: a multi-stage flow-through structure for the inner through-hole of a chromatographic column, including a column tube 1, a mounting bracket 2 fixedly connected to the top of the column tube 1, a mounting groove 13 opened inside the mounting bracket 2, a sealing piston 3 fixedly connected inside the mounting groove 13 through a plug-locking mechanism, a distribution plate 4 fixedly connected to the bottom of the sealing piston 3, and a central hole 5 opened inside the sealing piston 3.

[0028] By adopting the above technical solution, the device can better perform uniform separation treatment on the mixture, thus significantly improving the practicality of the device.

[0029] In the embodiment of this application, as Figures 1-2As shown in the figure, the plug lock mechanism includes a plurality of fixed plates 6 arranged at the top of the inner cavity of the installation groove 13 and a plurality of plug plates 7 installed on the peripheral side of the sealing piston 3. An elastic locking rod 8 is arranged inside the plug plate 7, a slot 9 is opened on one side of the fixed plate 6, and a locking hole 10 is opened at the top of the slot 9.

[0030] By adopting the above technical solution, the device can quickly fix the sealing piston 3 and the distribution plate 4 through the plug lock mechanism, thus greatly facilitating the installation and disassembly of the sealing piston 3 and the distribution plate 4 by the operator, and further greatly improving the working efficiency of the device.

[0031] In the embodiment of the present application, as Figure 3 shown, a cross 11 and a plurality of sets of I-shaped frames 12 are arranged inside the distribution plate 4, and through holes are formed between the plurality of sets of I-shaped frames 12.

[0032] By adopting the above technical solution, the device can form multi-stage flow through the cross 11 and the I-shaped frames 12 in the inner through hole of the chromatographic column, and make each flow path uniformly reach each flow-through hole connected to the stationary phase synchronously, and then evenly distribute it to the stationary phase of the preparative chromatographic column, so that when the eluent flows downward from the central hole 5 of the piston, it can be evenly distributed, and further greatly improves the separation effect of the device.

[0033] In the embodiment of the present application, as Figure 4 shown, the elastic locking rod 8 includes a fixed base 801, a return spring 802 is fixedly connected to the bottom of the inner cavity of the fixed base 801, a locking rod 803 is fixedly connected to the top of the return spring 802, and the top of the locking rod 803 extends to the outside of the fixed plate 6 through the locking hole 10.

[0034] By adopting the above technical solution, the locking effect of the device is better by using the elastic action of the return spring 802.

[0035] In the embodiment of the present application, as Figure 2 shown, a sealing gasket is arranged at the connection between the sealing piston 3 and the installation groove 13.

[0036] By adopting the above technical solution, the sealing performance of the device can be greatly enhanced by using the sealing gasket.

[0037] In the embodiment of the present application, as Figure 2 shown, there are four groups of fixed plates 6 and plug plates 7, and the four groups of fixed plates 6 and plug plates 7 are distributed in a circular array.

[0038] By adopting the above technical solution, the fixing effect of the device is better by using the coordinated cooperation of the multiple groups of fixed plates 6 and plug plates 7.

[0039] During use, the operator first inserts the sealing piston 3 into the inside of the installation groove 13, then presses the locking rod 803 so that it retracts into the inside of the fixed base 801 by compressing the return spring 802. After that, the sealing piston 3 is rotated so that it drives the insertion plate 7 to rotate into the slot 9 inside the fixed plate 6. When the sealing piston 3 drives the fixed base 801 to move to the position of the locking hole 10, the locking rod 803 will quickly pop out under the elastic action of the return spring 802, so that the insertion plate 7 and the fixed plate 6 can be quickly fixed, and then the sealing piston 3 and the distribution plate 4 can be quickly fixed, thus greatly facilitating the installation and disassembly of the sealing piston 3 and the distribution plate 4 by the operator, and further greatly improving the working efficiency of the device. After the installation is completed, the operator adds the eluent into the central hole 5, and uses the cross 11 and the I-shaped frame 12 inside the distribution plate 4 to form a multi-stage flow through the inner through holes of the chromatographic column, and makes each flow path uniformly reach each flow-through hole connected to the stationary phase synchronously, and then evenly distributes it to the stationary phase of the preparative chromatographic column, so that the eluent can be evenly distributed when flowing downward from the piston central hole, and further greatly improves the separation effect of the device.

Claims

1. A multi-stage flow structure with through holes inside a chromatographic column, comprising a column tube (1), characterized in that: The top of the column tube (1) is fixedly connected to a mounting frame (2), a mounting groove (13) is provided inside the mounting frame (2), a sealing piston (3) is fixedly connected inside the mounting groove (13) via a latch mechanism, a distribution plate (4) is fixedly connected to the bottom of the sealing piston (3), and a center hole (5) is provided inside the sealing piston (3).

2. The multi-stage flow structure of the inner through holes of the chromatographic column according to claim 1, characterized in that: The latch mechanism comprises a plurality of fixing plates (6) arranged at the top of the inner cavity of the mounting groove (13) and a plurality of inserting plates (7) installed on the peripheral side of the sealing piston (3), wherein an elastic locking rod (8) is arranged inside the inserting plate (7), a slot (9) is provided on one side of the fixing plate (6), and a locking hole (10) is provided at the top of the slot (9).

3. The multi-stage flow structure of the inner through holes of the chromatographic column according to claim 1, characterized in that: A cross (11) and a plurality of groups of I-shaped frames (12) are arranged inside the distribution plate (4), and through holes are formed between the plurality of groups of I-shaped frames (12).

4. The multi-stage flow structure of the inner through holes of the chromatographic column according to claim 2, characterized in that: The elastic locking rod (8) comprises a fixed base (801), the bottom of the inner cavity of the fixed base (801) is fixedly connected to a reset spring (802), the top of the reset spring (802) is fixedly connected to a locking rod (803), and the top of the locking rod (803) extends to the outside of the fixed plate (6) through a locking hole (10).

5. The multi-stage flow structure of the inner through holes of the chromatographic column according to claim 1, characterized in that: A sealing gasket is provided at the connection between the sealing piston (3) and the mounting groove (13).

6. The multi-stage flow structure of the inner through holes of the chromatographic column according to claim 2, characterized in that: The fixing plates (6) and the inserting plates (7) are each provided in four groups, and the four groups of the fixing plates (6) and the inserting plates (7) are distributed in a ring array.

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