Continuous photochemical synthesis equipment capable of independently controlling temperature of light source and reaction
By adopting coil heat exchange barrel and heat exchange shell structure in continuous photochemical synthesis equipment and combining LED light strips, separate temperature control of light sources and reactions is achieved, solving the problems of poor heat dissipation performance and inaccurate temperature control in existing equipment, and improving reaction efficiency and product quality.
Patent Information
- Application Number
- CN202422214588.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-10
- Publication Date
- 2025-06-20
- Estimated Expiration
- 2034-09-10
AI Technical Summary
The existing continuous photochemical synthesis equipment has poor heat dissipation performance of light sources, which leads to an increase in temperature, affecting reaction efficiency and light source life; lacks an effective temperature control mechanism, making it difficult to accurately control reaction temperature, affecting reaction selectivity and product quality; the equipment design and manufacturing levels are different, resulting in large differences in performance, which increases the difficulty of user selection and use.
A continuous photochemical synthesis device with light source and reaction can be designed with a separate temperature control, adopting a coil heat exchange barrel and heat exchange shell structure, combined with LED light strips, to achieve accurate and stable temperature control and uniform and efficient light. The equipment keeps the reactor temperature stable through the circulating flow of the cooling medium and efficient heat conduction, and accurately monitors and controls the reaction conditions through the PLC and panel control system.
It effectively solves the problems of poor heat dissipation performance of light sources and inaccurate temperature control, improves reaction efficiency and product quality, reduces equipment performance differences, and simplifies user selection and use process.
Smart Images
Figure CN222998769U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of chemical engineering, and particularly relates to a continuous photochemical synthesis device with a light source and a reaction that can be independently temperature-controlled. Background Art
[0002] In recent years, photochemical synthesis has been widely used in the pharmaceutical field due to its advantages of being green, environmentally friendly, and renewable. Compared with traditional mercury lamps and xenon lamps, LED lamps stand out with their characteristics of less heat emission and good monochromaticity, and have become the preferred light source for photochemical synthesis equipment. LED lamps can not only accurately select a single-wavelength light source to avoid side reactions caused by clutter light sources, but also, due to their low heat generation, reduce the impact on the reaction and the service life of the light source, thereby improving the stability and reliability of the overall experiment. In addition, continuous flow technology has gradually become an important tool in the field of pharmaceutical synthesis in recent years due to its advantages of high reaction efficiency, high conversion rate, and safety and environmental protection. The combination of these technologies provides a more efficient, reliable, and sustainable solution for pharmaceutical synthesis, and promotes the innovation and development of the industry.
[0003] At present, the quality of continuous photochemical synthesis equipment on the market is uneven, and there are some significant technical defects, which limit the effect and popularity of this technology in practical applications. First of all, the heat dissipation performance of the light sources of many devices is poor, resulting in an increase in the temperature of the light source, which not only affects the reaction efficiency and stability, but may also shorten the service life of the light source. Secondly, the equipment generally lacks an effective temperature control mechanism, making it difficult to accurately control the reaction temperature, which will directly affect the selectivity of the photochemical reaction and the quality of the product. In addition, due to the uneven design and manufacturing levels of the equipment, the performance differences of different equipment in actual use are relatively large, further increasing the difficulty for users to select and use. Content of the Utility Model
[0004] (I) Technical problems to be solved: Aiming at the deficiencies of the prior art, the utility model provides a continuous photochemical synthesis device with a light source and a reaction that can be independently temperature-controlled. The continuous photochemical synthesis device with an integral structure that can be independently temperature-controlled has the advantages of precise and stable temperature control, uniform and efficient illumination, high-temperature-resistant stable materials, and high-efficiency heat conduction, and solves the problems that the light source of the existing continuous photochemical synthesis equipment has poor heat dissipation performance, resulting in an increase in temperature, affecting the reaction efficiency and the service life of the light source; lacking an effective temperature control mechanism, it is difficult to accurately control the reaction temperature, affecting the reaction selectivity and the quality of the product; the design and manufacturing levels are uneven, and the performance differences are large, increasing the difficulty for users to select and use.
[0005] (2) Technical solution: To achieve the purpose of precise and stable temperature control, uniform and efficient light irradiation, high-temperature resistant stable materials, and efficient heat conduction in the continuously controlled temperature integrated photochemical synthesis equipment, the present utility model provides the following technical solution: A continuously controlled temperature integrated photochemical synthesis equipment with a separately controllable light source and reaction, including a housing and a lamp tube. The lamp tube is coaxially fixed inside the housing. A coil heat exchange barrel is also coaxially assembled inside the lamp tube. A plurality of lamp bars are equidistantly arranged along the circumferential direction of the inner wall of the lamp tube. The inside of the coil heat exchange barrel is hollow and is provided with a cooling medium. A coil reactor is also coaxially arranged between the coil heat exchange barrel and the lamp tube. The coil reactor is spiral-shaped and wound around the coil heat exchange barrel. A heat exchange housing is also arranged between the lamp tube and the housing. The inner wall of the heat exchange housing is attached to the outer wall of the lamp tube.
[0006] Preferably, an inlet and outlet for liquid are also opened on the housing. The inlet and outlet for liquid are connected to the coil reactor by a pipeline. An inlet and outlet for coil heat exchange are also opened on the housing. The inlet and outlet for coil heat exchange are connected to the coil heat exchange barrel by a pipeline.
[0007] Preferably, the coil heat exchange barrel is made of a metal material, and the cooling medium is water or oil.
[0008] Preferably, cold oil or compressor copper tubes are arranged inside the heat exchange housing.
[0009] Preferably, a spiral concave and convex surface matching the spiral-shaped coil reactor is arranged on the surface of the coil heat exchange barrel. Part of the coil reactor is embedded in the spiral concave and convex surface.
[0010] Preferably, the coil reactor is a transparent tube made of FEP or PFA material.
[0011] Preferably, the lamp bars are LED lamps.
[0012] Preferably, a PLC and panel control are also fixedly arranged at the bottom of the housing.
[0013] (3) Beneficial effects: Compared with the prior art, the present utility model provides a continuously controlled temperature integrated photochemical synthesis equipment with a separately controllable light source and reaction, having the following beneficial effects:
[0014] 1. The continuous photochemical synthesis equipment with a light source and a reaction that can be separately temperature-controlled uses the combination of a coil heat exchange barrel structure and a heat exchange shell structure. The coil heat exchange barrel of this equipment can effectively absorb and conduct the heat in the lamp barrel. Through the connection with the heat exchange equipment, the cooling medium can circulate to take away the heat, thus maintaining the temperature stability of the coil reactor. The heat exchange shell arranged between the lamp barrel and the housing contains cold oil or compressor copper tubes, which can further take away the heat on the surface of the lamp barrel and reduce the influence of the heat generated by the lamp strip on the reaction temperature, enabling the coil reactor to maintain the optimal reaction temperature during the photochemical reaction process.
[0015] 2. The continuous photochemical synthesis equipment with a light source and a reaction that can be separately temperature-controlled uses the combination of a coil reactor structure and a lamp barrel structure. The coil reactor uses a transparent tube made of FEP or PFA material, which has good chemical inertness and high-temperature resistance, ensuring the stability of the materials during the reaction process. The spiral concave-convex surface design on the surface of the coil heat exchange barrel makes part of the coil reactor embedded in it, increasing the contact area and improving the heat conduction efficiency. At the same time, several LED lamp strips are equidistantly arranged along the circumferential direction on the inner wall of the lamp barrel during the reaction process, which can uniformly irradiate the substances in the coil reactor to ensure the uniformity and efficiency of the photochemical reaction. Description of the Drawings
[0016] Figure 1 It is a three-dimensional structure diagram of the continuous photochemical synthesis equipment with a light source and a reaction that can be separately temperature-controlled in the present utility model;
[0017] Figure 2 It is a front view of the structure of the continuous photochemical synthesis equipment with a light source and a reaction that can be separately temperature-controlled in the present utility model;
[0018] Figure 3 It is a side view of the structure of the continuous photochemical synthesis equipment with a light source and a reaction that can be separately temperature-controlled in the present utility model;
[0019] Figure 4 It is a top view of the structure of the continuous photochemical synthesis equipment with a light source and a reaction that can be separately temperature-controlled in the present utility model;
[0020] Figure 5 It is a sectional view of the structure of the continuous photochemical synthesis equipment with a light source and a reaction that can be separately temperature-controlled in the present utility model.
[0021] In the figure: 1. Housing; 2. Lamp barrel; 3. Coil heat exchange barrel; 4. Lamp strip; 5. Coil reactor; 6. Heat exchange shell; 7. Inlet and outlet for liquid; 8. Coil heat exchange inlet and outlet; 9. PLC; 10. Panel control. Detailed Embodiment
[0022] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the protection scope of the present utility model.
[0023] Please refer to Figure 1 、 Figure 2 、 Figure 3 、 Figure 4 、 Figure 5 A light source and a continuous photochemical synthesis device with separately controllable temperature for reactions, comprising a housing 1 and a lamp cylinder 2. The lamp cylinder 2 is coaxially fixed inside the housing 1. The lamp cylinder 2 ensures that the light source and the reaction area are at the central position inside the device, providing uniform illumination, while simplifying the structural design and thermal management. It increases the stability of the device and ensures the accuracy and consistency of the positions of the light source and the reactor. A coiled tube heat exchange barrel 3 is also coaxially assembled inside the lamp cylinder 2. The coiled tube heat exchange barrel 3 enables the heat exchange barrel to evenly absorb and disperse the heat inside the lamp cylinder 2, ensuring the stability of the temperature of the reactor. It provides effective cooling to prevent overheating, thereby maintaining the optimal reaction temperature. A number of lamp strips 4 are equidistantly arranged along the circumferential direction of the inner wall of the lamp cylinder 2. The lamp strips 4 ensure uniform distribution of the illumination, avoiding uneven reactions caused by uneven light intensity, improving the efficiency and consistency of the photochemical reaction, and providing sufficient light intensity to drive the photochemical reaction. The inside of the coiled tube heat exchange barrel 3 is hollow and provided with a cooling medium, which increases the capacity of the cooling medium while reducing the weight. Such as water or oil, which takes away heat by flowing, ensuring high heat exchange efficiency and thus stabilizing the reaction temperature. A coiled tube reactor 5 is also coaxially arranged between the coiled tube heat exchange barrel 3 and the lamp cylinder 2, which can ensure that the coiled tube reactor 5 is evenly irradiated by the light source and effectively cooled by the cooling medium. The spiral shape provides a larger surface area, improving the reaction efficiency and heat exchange efficiency. The coiled tube reactor 5 is spiral-shaped and wound around the coiled tube heat exchange barrel 3, which can increase the reaction time and contact area, making the reaction more complete. It ensures the maximum heat exchange between the reactor and the heat exchange barrel, improving the accuracy and efficiency of temperature control. A heat exchange shell 6 is also arranged between the lamp cylinder 2 and the housing 1, and the inner wall of the heat exchange shell 6 is attached to the outer wall of the lamp cylinder 2. This can further enhance the heat dissipation effect, prevent the outer wall of the lamp cylinder 2 from overheating and affecting the internal reaction, and reduce the interference of external heat on the internal reaction temperature.
[0024] Please refer to Figure 1 、 Figure 2 、 Figure 3 、 Figure 4 、 Figure 5, an inlet / outlet port 7 is also provided on the housing 1. The inlet / outlet port 7 is connected to the coil reactor 5 by a pipeline. The inlet / outlet port 7 enables the reactants to conveniently enter and exit the coil reactor 5, forming a continuous flow system, thereby realizing a continuous photochemical reaction. It ensures that the reactants can smoothly flow into and out of the coil reactor 5, providing good fluidity and controllability, and guaranteeing the continuity and high efficiency of the reaction process; an inlet / outlet port 8 for coil heat exchange is also provided on the housing 1. The inlet / outlet port 8 for coil heat exchange is connected to the coil heat exchange barrel 3 by a pipeline. The inlet / outlet port 8 for coil heat exchange allows a cooling medium such as water or oil to circulate through the heat exchange barrel, effectively taking away the heat generated during the reaction process. It ensures that the cooling medium can smoothly enter and exit the coil heat exchange barrel 3, forming an effective cooling cycle, and improving the accuracy and efficiency of temperature control. The coil heat exchange barrel 3 is made of a metal material, and the cooling medium is water or oil. Metals have good thermal conductivity and can quickly conduct the heat generated by the lamp barrel 2, ensuring the stability of the reactor temperature. Water and oil are both common and efficient cooling media, which can effectively absorb and take away heat, maintaining the temperature stability of the reaction system. A cold oil or compressor copper pipe is arranged inside the heat exchange housing 6, providing additional cooling capacity to further take away the heat on the surface of the lamp barrel 2 and prevent it from having an adverse effect on the reaction temperature. Through the cooling of the cold oil or compressor copper pipe, the outer wall temperature of the lamp barrel 2 can be effectively reduced, ensuring more efficient heat management inside the equipment, thereby maintaining the optimal reaction conditions. The surface of the coil heat exchange barrel 3 is provided with a spiral concave-convex surface matching the spiral coil reactor 5. Part of the coil reactor 5 is embedded in the spiral concave-convex surface, which increases the contact area between the coil heat exchange barrel 3 and the coil reactor 5, thereby improving the heat conduction efficiency. It ensures that the coil reactor 5 is fixed on the surface of the heat exchange barrel without moving and maintains close contact, which helps to more stably control the reaction temperature and prevent uneven reactions caused by uneven heat. The coil reactor 5 is made of a transparent tube of FEP or PFA material. These two materials have good chemical inertness and high-temperature resistance, and can withstand various chemical reagents and high-temperature environments during the photochemical reaction process, ensuring the stability and safety of the reaction process. The transparent tube can ensure that the LED light source uniformly irradiates the reactants, improving the efficiency and uniformity of the photochemical reaction. The light strip 4 uses an LED lamp. A PLC 9 and a panel control 10 are also fixedly arranged at the bottom of the housing 1. Through the PLC and panel control 10 system, the reaction conditions can be accurately controlled and monitored, ensuring the stability and consistency of the photochemical reaction process, and improving the synthesis efficiency and product quality.
[0025] Working principle: When using this device, first connect the inlet and outlet 8 of the coil heat exchanger to the heat exchange device, so that the coil heat exchange barrel 3 is filled with a cooling medium, and at the same time start the lamp strip 4 on the lamp barrel 2. The substances to be reacted are introduced into the coil reactor 5 through the liquid inlet and outlet 7. The substances in the coil reactor 5 will be evenly irradiated by the lamp strip 4 and undergo a photochemical synthesis reaction. During the reaction process, the coil heat exchange barrel 3 can effectively absorb and conduct the heat in the lamp barrel 2. Through the connection with the heat exchange device, the cooling medium can circulate and take away the heat, thereby maintaining the temperature stability of the coil reactor 5, enabling the substances in the photochemical reaction to be maintained at the optimal reaction temperature. At the same time, the heat exchange shell 6 will take away the temperature on the surface of the lamp barrel 2, reducing the influence of the heat generated by the lamp strip 4 on the photochemical reaction of the substances. And several LED lamp strips 4 arranged equidistantly along the circumferential direction on the inner wall of the lamp barrel 2 can evenly irradiate the substances in the coil reactor 5, ensuring the uniformity and efficiency of the photochemical reaction. The coil heat exchange barrel 3 of this device can effectively absorb and conduct the heat in the lamp barrel 2. Through the connection with the heat exchange device, the cooling medium can circulate and take away the heat, thereby maintaining the temperature stability of the coil reactor 5; while the heat exchange shell 6 arranged between the lamp barrel 2 and the housing 1 contains cold oil or compressor copper pipes, which can further take away the heat on the surface of the lamp barrel 2, reducing the influence of the heat generated by the lamp strip 4 on the reaction temperature, so that the coil reactor 5 can be maintained at the optimal reaction temperature during the photochemical reaction process. The coil reactor 5 is made of a transparent tube of FEP or PFA material, which has good chemical inertness and high temperature resistance, ensuring the stability of the materials during the reaction process. The spiral concave and convex surface design on the surface of the coil heat exchange barrel 3 makes part of the coil reactor 5 embedded therein, increasing the contact area and improving the heat conduction efficiency. At the same time, several LED lamp strips 4 arranged equidistantly along the circumferential direction on the inner wall of the lamp barrel 2 during the reaction process can evenly irradiate the substances in the coil reactor 5, ensuring the uniformity and efficiency of the photochemical reaction.
[0026] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising a..." does not exclude the existence of additional identical elements in the process, method, article or device comprising the element.
[0027] Although embodiments of the present utility model have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present utility model. The scope of the present utility model is defined by the appended claims and their equivalents.
Claims
1. A continuous photochemical synthesis device with a light source and a reaction capable of independently controlling temperature, comprising a housing (1) and a lamp tube (2), wherein the lamp tube (2) is coaxially fixed in the housing (1), and characterized in that: A coil heat exchange barrel (3) is coaxially mounted in the lamp tube (2); a plurality of light strips (4) are equidistantly arranged on the inner wall of the lamp tube (2) along its circumferential direction; the coil heat exchange barrel (3) is hollow inside and is provided with a cooling medium; a coil reactor (5) is coaxially arranged between the coil heat exchange barrel (3) and the lamp tube (2); the coil reactor (5) is spirally shaped and is wound around the coil heat exchange barrel (3); a heat exchange shell (6) is also arranged between the lamp tube (2) and the housing (1); the inner wall of the heat exchange shell (6) is attached to the outer wall of the lamp tube (2).
2. A continuous photochemical synthesis device with independently controlled light source and reaction temperature according to claim 1, characterized in that: The shell (1) is also provided with a liquid inlet and outlet (7), and the liquid inlet and outlet (7) are connected to the coil reactor (5) by a pipeline; the shell (1) is also provided with a coil heat exchange inlet and outlet (8), and the coil heat exchange inlet and outlet (8) are connected to the coil heat exchange barrel (3) by a pipeline.
3. A continuous photochemical synthesis device with independently controlled light source and reaction temperature according to any one of claims 1 to 2, characterized in that: The coil heat exchange barrel (3) is made of metal material, and the cooling medium is water or oil.
4. A continuous photochemical synthesis device with independently controlled light source and reaction temperature according to any one of claims 1 to 2, characterized in that: The heat exchange shell (6) is provided with cooling oil or compressor copper tubes inside.
5. The continuous photochemical synthesis device with independently controlled light source and reaction temperature according to claim 1, characterized in that: The surface of the coil heat exchange barrel (3) is provided with a spiral concave-convex surface matching the spiral coil reactor (5), and the coil reactor (5) is partially embedded in the spiral concave-convex surface.
6. The continuous photochemical synthesis device with independently controlled light source and reaction temperature according to claim 1, characterized in that: The coil reactor (5) uses a transparent tube made of FEP or PFA material, and the light bar (4) uses an LED light.
7. The continuous photochemical synthesis device with independently controlled light source and reaction temperature according to claim 1, characterized in that: A PLC (9) and a control panel (10) are also fixedly arranged on the bottom of the housing (1).