Chromatographic column front end adsorption device

Abstract

The utility model discloses an adsorption device at the front end of a chromatographic column, which relates to the technical field of installation equipment and comprises a chromatographic column main body. Through the dismounting mechanism arranged on one side of the heating pipe, when the heating device is used, a sliding ring is pulled backwards to extrude a supporting spring on one side, at the moment, a positioning ball arranged in a positioning groove is not limited by the sliding ring, and then an inserting pipe is inserted into a connecting pipe; after the positioning groove formed in the surface of the inserting pipe is matched with the positioning ball on the surface of the connecting pipe, the sliding ring on the surface of the connecting pipe is loosened, the sliding ring limits the positioning ball again, at the moment, the positioning ball firmly fixes the inserting pipe in the connecting pipe, and on the contrary, the sliding ring and the positioning ball are pulled again to limit the inserting pipe, and the inserting pipe can be pulled out from the interior of the connecting pipe; and the pretreatment pipe can be replaced regularly, so that the main chromatographic column can be protected continuously and effectively.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatographic columns, in particular to an adsorption device at the front end of a chromatographic column. Background Technique

[0002] The adsorption device at the front end of a chromatographic column is a key auxiliary device in chromatographic analysis, aiming to improve the purification degree of samples, protect the main chromatographic column, optimize the analysis conditions and enhance the stability and accuracy of analysis results. Chromatographic analysis is a separation technique based on the difference in the distribution of chemical substances between a stationary phase and a mobile phase, and is used to separate and determine the components in a mixture. It is mainly applied in fields such as chemistry, biology, pharmacy, and environmental science. The front-end adsorption device is widely used in chromatographic techniques such as high-performance liquid chromatography (HPLC) and gas chromatography (GC), and has become a key technology to improve analysis efficiency and result reliability. With the development of automation and high-throughput analysis technologies, the design of the front-end adsorption device tends to be of higher integration and intelligence to meet the needs of complex sample analysis and efficient analysis.

[0003] However, most of the existing adsorption devices at the front end of chromatographic columns are fixedly connected by threads and do not have a structure for quick disassembly. When replacing the front-end adsorption device, it is time-consuming and laborious, and the operation is rather inconvenient. Therefore, an adsorption device at the front end of a chromatographic column is proposed. Content of the Utility Model

[0004] The utility model provides an adsorption device at the front end of a chromatographic column to solve the problem of the existing one not having quick disassembly.

[0005] The utility model provides the following technical solution: An adsorption device at the front end of a chromatographic column includes a chromatographic column main body and a liquid inlet fixed on one side of the chromatographic column main body, and further includes: a heating tube arranged inside the liquid inlet, a heating mechanism fixedly connected to the surface of the heating tube, and the heating mechanism includes a heating mesh, a temperature controller and a storage battery; a disassembly mechanism arranged on one side of the heating tube, and the disassembly mechanism includes a connecting pipe, a support spring, a sliding ring, an inserting pipe and a positioning ball; an extension head arranged on one side of the inserting pipe, a pretreatment tube fixedly connected to the inside of the extension head, and a filtering mechanism fixedly connected to the inside of the pretreatment tube, and the filtering mechanism includes a filter mesh, aluminum hydroxide and polyvinyl alcohol.

[0006] As a preferred technical solution of the utility model, the heating mesh is fixedly connected to the surface of the heating tube, one side of the heating mesh is electrically connected to a temperature controller through a power line, and one side of the temperature controller is electrically connected to a storage battery through a power line.

[0007] As a preferred technical solution of the present utility model, the connecting pipe is fixedly connected to one side of the heating pipe. A support spring is sleeved on the surface of the connecting pipe. One side of the support spring is fixedly connected to a sliding ring. An insertion pipe is inserted into the interior of the connecting pipe. Positioning grooves are formed on the surfaces of both the insertion pipe and the connecting pipe. A positioning ball is installed inside one set of the positioning grooves.

[0008] As a preferred technical solution of the present utility model, the filter screen is fixedly connected to the interior of the pretreatment pipe. Aluminum hydroxide is fixedly connected to one side of the filter screen. Polyvinyl alcohol is fixedly connected to one side of the aluminum hydroxide.

[0009] As a preferred technical solution of the present utility model, a heat preservation layer is fixedly connected to the surface of the heating mesh. The temperature controller is fixedly connected to the surface of the heat preservation layer.

[0010] As a preferred technical solution of the present utility model, the storage battery is fixedly connected to the surface of the temperature controller. The heating pipe is threadedly connected to the interior of the liquid inlet.

[0011] As a preferred technical solution of the present utility model, the number of the positioning balls is four groups.

[0012] As a preferred technical solution of the present utility model, the sliding ring is slidably connected to the surface of the connecting pipe. The positioning ball is adapted to the positioning groove formed on the surface of the insertion pipe.

[0013] Compared with the prior art, the present utility model provides an adsorption device at the front end of a chromatographic column, and has the following beneficial effects:

[0014] 1. For this adsorption device at the front end of the chromatographic column, through the disassembly mechanism arranged on one side of the heating pipe, during use, pull the sliding ring backward, so that the sliding ring squeezes the support spring on one side. At this time, the positioning ball arranged inside the positioning groove loses the limit of the sliding ring. Then insert the insertion pipe into the interior of the connecting pipe. After the positioning groove arranged on the surface of the insertion pipe fits with the positioning ball on the surface of the connecting pipe, release the sliding ring on the surface of the connecting pipe, and the sliding ring limits the positioning ball again. At this time, the positioning ball firmly fixes the insertion pipe inside the connecting pipe. On the contrary, pull the sliding ring again, and the positioning ball limits it, and the insertion pipe can be pulled out from the interior of the connecting pipe, completing rapid assembly and disassembly. The pretreatment pipe can be replaced regularly to ensure its continuous and effective protection of the main chromatographic column.

[0015] 2. The front-end adsorption device of the chromatographic column, through the heating mechanism arranged on the surface of the heating tube and the filtering mechanism arranged inside the pretreatment tube, when preprocessing the sample liquid, a filter screen, aluminum hydroxide and polyvinyl alcohol are arranged inside the pretreatment tube, which can be used to capture and remove macromolecules, particulate matter, salts and other impurities in the sample, avoiding their attachment to the main chromatographic column, resulting in column contamination or damage, and affecting the accuracy and reproducibility of chromatographic separation. Secondly, after the power is turned on and the temperature controller controls the heating network to heat to an appropriate temperature, the sample liquid is preheated to control the temperature of the sample and improve the stability and resolution of the analysis. Brief Description of the Drawings

[0016] Figure 1 It is a schematic diagram of the overall structure of the present utility model;

[0017] Figure 2 It is a schematic diagram of the structure of the disassembly mechanism of the present utility model;

[0018] Figure 3 It is a schematic diagram of the structure of the filtering mechanism of the present utility model;

[0019] Figure 4 It is a schematic diagram of the structure of the heating mechanism of the present utility model.

[0020] In the figure: 1. Chromatographic column main body; 2. Liquid inlet; 3. Heating tube; 4. Heating mechanism; 401. Heating network; 402. Temperature controller; 403. Storage battery; 5. Disassembly mechanism; 501. Connecting pipe; 502. Support spring; 503. Sliding ring; 504. Insertion pipe; 505. Positioning ball; 6. Extension head; 7. Pretreatment tube; 8. Filtering mechanism; 801. Filter screen; 802. Aluminum hydroxide; 803. Polyvinyl alcohol; 9. Thermal insulation layer. Detailed Embodiment

[0021] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present utility model.

[0022] Please refer to Figures 1-4, the present utility model discloses an adsorption device at the front end of a chromatographic column, which includes a chromatographic column main body 1 and a liquid inlet 2 fixed on one side of the chromatographic column main body 1, and further includes: a heating tube 3 arranged inside the liquid inlet 2, a heating mechanism 4 fixedly connected to the surface of the heating tube 3, and the heating mechanism 4 includes a heating mesh 401, a temperature controller 402 and a storage battery 403; a disassembly mechanism 5 arranged on one side of the heating tube 3, and the disassembly mechanism 5 includes a connecting pipe 501, a support spring 502, a sliding ring 503, an inserting pipe 504 and a positioning ball 505; an extension head 6 arranged on one side of the inserting pipe 504, a pretreatment tube 7 fixedly connected to the inside of the extension head 6, a filtering mechanism 8 fixedly connected to the inside of the pretreatment tube 7, and the filtering mechanism 8 includes a filter mesh 801, aluminum hydroxide 802 and polyvinyl alcohol 803.

[0023] Specifically, the heating mesh 401 is fixedly connected to the surface of the heating tube 3, one side of the heating mesh 401 is electrically connected to the temperature controller 402 through a power cord, and one side of the temperature controller 402 is electrically connected to the storage battery 403 through a power cord.

[0024] In this embodiment, after the power is turned on, when the temperature controller 402 controls the heating mesh 401 to heat to a suitable temperature, the sample liquid is preheated to control the temperature of the sample and improve the stability and resolution of the analysis.

[0025] Specifically, the connecting pipe 501 is fixedly connected to one side of the heating tube 3, a support spring 502 is sleeved on the surface of the connecting pipe 501, one side of the support spring 502 is fixedly connected to a sliding ring 503, an inserting pipe 504 is inserted into the inside of the connecting pipe 501, positioning grooves are formed on the surfaces of the inserting pipe 504 and the connecting pipe 501, and a positioning ball 505 is installed inside one group of the positioning grooves.

[0026] In this embodiment, the sliding ring 503 is pulled backward, so that the sliding ring 503 squeezes the support spring 502 on one side. At this time, the positioning ball 505 arranged inside the positioning groove loses the limit of the sliding ring 503. Then, the inserting pipe 504 is inserted into the inside of the connecting pipe 501. After the positioning groove arranged on the surface of the inserting pipe 504 fits with the positioning ball 505 arranged on the surface of the connecting pipe 501, the sliding ring 503 on the surface of the connecting pipe 501 is released, and the sliding ring 503 limits the positioning ball 505 again. At this time, the positioning ball 505 firmly fixes the inserting pipe 504 inside the connecting pipe 501.

[0027] Specifically, the filter mesh 801 is fixedly connected to the inside of the pretreatment tube 7, one side of the filter mesh 801 is fixedly connected to aluminum hydroxide 802, and one side of the aluminum hydroxide 802 is fixedly connected to polyvinyl alcohol 803.

[0028] In this implementation scheme, when preprocessing the sample liquid, a filter screen 801, aluminum hydroxide 802, and polyvinyl alcohol 803 are arranged inside the pretreatment tube 7, which can be used to capture and remove macromolecules, particulate matter, salts, and other impurities in the sample.

[0029] Specifically, a heat preservation layer 9 is fixedly connected to the surface of the heating mesh 401, and the temperature controller 402 is fixedly connected to the surface of the heat preservation layer 9.

[0030] Specifically, the storage battery 403 is fixedly connected to the surface of the temperature controller 402, and the heating tube 3 is threadedly connected to the inside of the liquid inlet 2.

[0031] In this implementation scheme, the heat preservation layer 9 keeps heat and avoids too fast heat dissipation.

[0032] Specifically, the number of positioning balls 505 is four groups.

[0033] Specifically, the sliding ring 503 is slidably connected to the surface of the connecting pipe 501, and the positioning ball 505 is adapted to the positioning groove formed on the surface of the inserting pipe 504.

[0034] The working principle and usage process of the present utility model: When in use, pull the sliding ring 503 backward, so that the sliding ring 503 compresses the supporting spring 502 on one side. At this time, the positioning ball 505 arranged inside the positioning groove loses the limitation of the sliding ring 503. Then insert the inserting pipe 504 into the inside of the connecting pipe 501. After the positioning groove arranged on the surface of the inserting pipe 504 fits with the positioning ball 505 on the surface of the connecting pipe 501, release the sliding ring 503 on the surface of the connecting pipe 501, and the sliding ring 503 limits the positioning ball 505 again. At this time, the positioning ball 505 firmly fixes the inserting pipe 504 inside the connecting pipe 501. On the contrary, pull the sliding ring 503 again, and the positioning ball 505 limits it, and the inserting pipe 504 can be pulled out from the inside of the connecting pipe 501 to complete rapid assembly and disassembly.

[0035] When preprocessing the sample liquid, a filter screen 801, aluminum hydroxide 802, and polyvinyl alcohol 803 are arranged inside the pretreatment tube 7, which can be used to capture and remove macromolecules, particulate matter, salts, and other impurities in the sample.

[0036] Secondly, after turning on the power supply, when the temperature controller 402 controls the heating mesh 401 to heat to a suitable temperature, preheat the sample liquid to control the temperature of the sample and improve the stability and resolution of the analysis.

[0037] In summary, for the front-end adsorption device of the chromatographic column, the disassembly mechanism 5 provided on one side of the heating tube 3 can regularly replace the pretreatment tube 7 to ensure that it continuously and effectively protects the main chromatographic column. By providing the heating mechanism 4 on the surface of the heating tube 3 and the filtering mechanism 8 inside the pretreatment tube 7, it is possible to prevent substances from adhering to the main chromatographic column, resulting in column contamination or damage and affecting the accuracy and reproducibility of chromatographic separation.

[0038] It should be noted that in this text, terms such as "including", "comprising" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed, or further includes elements inherent to such process, method, article or device. Without further limitations, an element defined by the statement "including one..." does not exclude the existence of additional identical elements in the process, method, article or device including the said element.

[0039] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A chromatographic column front end adsorption device, comprising a chromatographic column body (1) and a liquid inlet (2) fixed on one side of the chromatographic column body (1), characterized in that: Also includes: A heating tube (3) is arranged inside the liquid inlet (2), the surface of the heating tube (3) being fixedly connected to a heating mechanism (4), the heating mechanism (4) comprising a heating network (401), a temperature controller (402) and a storage battery (403); A disassembly mechanism (5) arranged on one side of the heating tube (3), the disassembly mechanism (5) comprising a connecting tube (501), a supporting spring (502), a sliding ring (503), a plug-in tube (504) and a positioning ball (505); An extension head (6) is arranged on one side of the plug-in tube (504), the interior of the extension head (6) is fixedly connected to a pretreatment tube (7), the interior of the pretreatment tube (7) is fixedly connected to a filter mechanism (8), and the filter mechanism (8) comprises a filter screen (801), aluminum hydroxide (802) and polyvinyl alcohol (803).

2. The chromatographic column front end adsorption device according to claim 1, characterized in that: The heating net (401) is fixedly connected to the surface of the heating tube (3); one side of the heating net (401) is electrically connected to a temperature controller (402) via a power line; and one side of the temperature controller (402) is electrically connected to a storage battery (403) via a power line.

3. The chromatographic column front end adsorption device according to claim 1, characterized in that: The connecting tube (501) is fixedly connected to one side of the heating tube (3); a support spring (502) is sleeved on the surface of the connecting tube (501); a sliding ring (503) is fixedly connected to one side of the support spring (502); a plug-in tube (504) is inserted into the interior of the connecting tube (501); positioning grooves are provided on the surfaces of the plug-in tube (504) and the connecting tube (501); a positioning ball (505) is installed inside one group of the positioning grooves.

4. The chromatographic column front end adsorption device according to claim 1, characterized in that: The filter screen (801) is fixedly connected to the interior of the pretreatment tube (7), one side of the filter screen (801) is fixedly connected to aluminum hydroxide (802), and one side of the aluminum hydroxide (802) is fixedly connected to polyvinyl alcohol (803).

5. The chromatographic column front end adsorption device according to claim 1, characterized in that: A thermal insulation layer (9) is fixedly connected to the surface of the heating net (401), and the temperature controller (402) is fixedly connected to the surface of the thermal insulation layer (9).

6. The chromatographic column front end adsorption device according to claim 1, characterized in that: The storage battery (403) is fixedly connected to the surface of the temperature controller (402), and the heating tube (3) is threadedly connected to the inside of the liquid inlet (2).

7. The chromatographic column front end adsorption device according to claim 1, characterized in that: The number of the positioning balls (505) is four groups.

8. The chromatographic column front end adsorption device according to claim 1, characterized in that: The sliding ring (503) is slidably connected to the surface of the connecting tube (501), and the positioning ball (505) is matched with the positioning groove provided on the surface of the plug-in tube (504).

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