Reaction kettle suitable for raw material medicine synthesis
By designing a transmission mechanism, mesh barrel and discharge mechanism in the raw material synthesis reactor, the problem of low mixing efficiency of liquid raw material and powder in the traditional reactor is solved, and more efficient mixing and better mixing quality is achieved. At the same time, the uniformity of the drug liquid is improved through aeration treatment.
Patent Information
- Application Number
- CN202421763236.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-24
- Publication Date
- 2025-06-24
- Estimated Expiration
- 2034-07-24
AI Technical Summary
During the mixing and stirring of liquid raw materials and powders, the mixing efficiency of traditional raw materials synthesis reactors is low, resulting in poor mixing quality.
A reactor including a transmission mechanism, a mesh barrel and a discharge mechanism is designed. The drug liquid in the mesh barrel is driven to rotate and stir, and the drug liquid is uniformly mixed and discharged through the discharge mechanism.
The mixing efficiency of liquid raw materials and powder is improved, the mixing quality is improved, and the uniformity of the liquid in the reaction kettle is improved through aeration.
Smart Images
Figure CN223010560U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of reaction kettles, and particularly relates to a reaction kettle applicable to the synthesis of bulk drugs. Background Art
[0002] A reaction kettle refers to a container for physical or chemical reactions. Through the structural design and parameter configuration of the container, functions such as heating, evaporation, cooling, and mixing at low and high speeds required by the process are realized. The reaction kettle is a commonly used device in the production and manufacturing of bulk drugs. In the pharmaceutical process, various medicaments and drugs often require a catalyst for catalysis during synthesis, and the dropping speed, dosage, uniformity, and temperature of the catalyst will all affect the quality of the synthesized medicaments and drugs. However, there are still many deficiencies in traditional reaction kettles for the synthesis of bulk drugs. When the liquid bulk drug is mixed and stirred, as the stirring shaft rotates, the liquid and powder mixture will rotate together with the rotation, resulting in a decrease in the mixing efficiency of the liquid and powder. Content of the Utility Model
[0003] According to the problem of low mixing efficiency of the liquid bulk drug in the traditional reaction kettle for bulk drugs mentioned in the above background art, the utility model provides a reaction kettle applicable to the synthesis of bulk drugs, which can better mix the liquid bulk drug and powder, with high mixing efficiency and good mixing quality.
[0004] Technical Solution: To solve the above technical problems, the technical solution adopted by the utility model is as follows:
[0005] A reaction kettle applicable to the synthesis of bulk drugs includes a reaction kettle body, in which a transmission mechanism, a mesh cylinder, and a discharging mechanism are provided; the mesh cylinder is placed at the upper end of the discharging mechanism through a support rod, and a first rotating mechanism and a second rotating mechanism are connected to the transmission mechanism; the transmission mechanism drives the first rotating mechanism to stir and spray the liquid medicine in the mesh cylinder upward in a rotating manner, the transmission mechanism drives the second rotating mechanism to stir the liquid medicine in the reaction kettle body downward in a rotating manner, and the discharging mechanism discharges the stirred liquid medicine.
[0006] Preferably, the transmission mechanism includes a second gear, a rotating shaft, a large gear, a small gear, a second motor, and a third gear; the second motor is connected to the third gear, the large gear is arranged through the rotating shaft, one end of the rotating shaft is connected to the inner wall of the reaction kettle body, and the other end is connected to the small gear; the third gear, the second gear, and the large gear are meshed with each other.
[0007] Preferably, an annular slide rail is fixedly arranged on the inner side of the reaction kettle body, a rotating plate is arranged on the annular slide rail, and the rotating plate is connected to the annular slide rail through a slider; a second meshing ring is arranged on the rotating plate, and the second meshing ring is in contact with the small gear.
[0008] Preferably, a funnel-shaped partition group is provided inside the mesh cylinder, and a plurality of holes are provided on the surface of the mesh cylinder.
[0009] Preferably, the funnel-shaped partition assembly is composed of funnel-shaped partitions with the inner hole diameters increasing sequentially from top to bottom.
[0010] Preferably, the first rotation mechanism includes a main shaft and a second stirring blade; the main shaft is placed inside the mesh cylinder, and one end thereof penetrates through the rotating plate and is connected to the second gear, and the second stirring blade is provided on the main shaft.
[0011] Preferably, the second rotation mechanism includes a first engagement ring, a first gear, an auxiliary shaft and a first stirring blade; the auxiliary shaft is arranged on the rotating plate and is connected to the first gear, the first engagement ring is connected to the inner wall of the reaction kettle body and meshes with the first gear, and the first stirring blade is provided on the auxiliary shaft.
[0012] Preferably, the discharging mechanism includes a first mesh plate, a second mesh plate, bevel gears and a first motor; the first mesh plate is connected to the second mesh plate through a connecting shaft; an annular engagement groove is provided at the lower end of the first mesh plate, the bevel gear is meshed and connected with the annular engagement groove, and the output end of the first motor is connected to the bevel gear.
[0013] Preferably, a first discharge hole is provided on the first mesh plate, and a second discharge hole is provided on the second mesh plate; a discharge port is provided at the lower end of the reaction kettle body.
[0014] Advantageous effects: Compared with the prior art, the present utility model has the following advantages:
[0015] (1) In the present utility model, the second motor drives the third gear to rotate, the third gear acts on the second gear to drive the main shaft to rotate, thereby driving the second stirring blade on the surface to rotate upward to stir the liquid medicine. The liquid medicine is separated by the funnel-shaped partition group in the mesh cylinder and sprayed out through the holes on the surface of the mesh cylinder, disrupting the external fluid flow law and improving the stirring efficiency. The second gear drives the large gear and then drives the small gear through the rotating shaft to act on the second engagement ring at the upper end of the rotating plate, reducing the rotation speed of the rotating plate. The rotating plate slides and rotates on the surface of the annular slide rail through the slider, thereby driving the first gear at one end of the auxiliary shaft to act on the first engagement ring to rotate, driving the first stirring blade on the surface of the auxiliary shaft to rotate, stirring the liquid medicine downward, completing the stirring cycle, and improving the stirring and mixing efficiency.
[0016] (2) In the present utility model, the air pump injects air into the transfer tank, conducts it into the second mesh plate through the main shaft, and sprays it out through the air holes, thereby performing aeration treatment on the liquid medicine in the reaction kettle body to make the aeration more uniform and efficient.
[0017] (3) The utility model drives the conical gear to rotate by starting the first motor, so as to act on the annular engagement groove at the bottom of the second mesh plate, drive the annular engagement groove to rotate through the connecting shaft, align the discharge holes two and one on the surfaces of the second mesh plate and the first mesh plate, and thus discharge materials. Brief Description of the Drawings
[0018] Figure 1 is the overall three-dimensional structural schematic diagram of the present invention;
[0019] Figure 2 is the internal structural schematic diagram of the present invention;
[0020] Figure 3 is the structural schematic diagram of the transmission mechanism of the present invention;
[0021] Figure 4 is the structural schematic diagram of the rotating plate of the present invention;
[0022] Figure 5 is the structural schematic diagram of the mesh cylinder of the present invention;
[0023] Figure 6 is the sectional structural schematic diagram of the mesh cylinder of the present invention;
[0024] Figure 7 is the structural schematic diagram of the first mesh plate of the present invention;
[0025] Figure 8 is the structural schematic diagram of the second mesh plate of the present invention;
[0026] In the figure: 1, first engagement ring; 2, first gear; 3, annular slide rail; 4, main shaft; 5, mesh cylinder; 6, first stirring blade; 7, second stirring blade; 8, support rod; 9, first mesh plate; 10, second mesh plate; 11, discharge port; 12, first motor; 13, conical gear; 14, reaction kettle body; 15, auxiliary shaft; 16, slider; 17, rotating plate; 18, transmission mechanism; 19, through hole; 20, second engagement ring; 21, funnel-shaped partition group; 22, connecting shaft; 23, first discharge hole; 24, annular engagement groove; 25, air vent hole; 26, second discharge hole; 27, transfer box; 28, air pump; 29, second gear; 30, rotating shaft; 31, large gear; 32, small gear; 33, cover body; 34, second motor; 35, third gear. Detailed Embodiments
[0027] The following further clarifies the present utility model in conjunction with specific embodiments. The embodiments are implemented on the premise of the technical solution of the present utility model. It should be understood that these embodiments are only used to illustrate the present utility model and not to limit the scope of the present utility model.
[0028] As Figure 1-8As shown in the figure, the reactor applicable to the synthesis of bulk drugs provided in this embodiment mainly includes a reactor body 14, a transmission mechanism 18, a discharging mechanism, a first rotating mechanism, a second rotating mechanism, and a mesh cylinder 5 arranged inside the reactor body 14; the first rotating mechanism and the second rotating mechanism are both arranged on the transmission mechanism 18, and the mesh cylinder 5 is placed at the upper end of the discharging mechanism through a support rod 8.
[0029] As Figure 1 , 3 shown, the upper part of the reactor body 14 is cylindrical, and the lower part is conical. A cover body 33 is provided at the upper end of the reactor body 14.
[0030] As Figure 2 , 3 shown, the transmission mechanism 18 includes a second gear 29, a rotating shaft 30, a large gear 31, a small gear 32, a third gear 35, and a cover body 33; the second gear 29, the rotating shaft 30, the large gear 31, the small gear 32, and the third gear 35 are arranged inside the reactor body 14, and a second motor 34, a transfer box 27, and an air pump 28 are provided inside the cover body 33.
[0031] The output end of the second motor 34 penetrates through the reactor body 14 and is connected to the third gear 35. The large gear 31 is arranged through the rotating shaft 30. One end of the rotating shaft 30 is connected to the inner wall of the reactor body 14, and the other end is connected to the small gear 32; the third gear 35, the second gear 29, and the large gear 31 are meshed with each other.
[0032] The transfer box 27 is fixedly arranged inside the cover body 33, and the transfer box 27 is connected to the air pump 28 through a pipeline.
[0033] As Figure 2 , 4 shown, an annular slide rail 3 is fixedly arranged inside the reactor body 14. A rotating plate 17 is arranged on the annular slide rail 3. The rotating plate 17 is movably connected to the annular slide rail 3 through a slider 16; a second meshing ring 20 is arranged on the rotating plate 17, and the second meshing ring 20 is meshed with the small gear 32. A through hole 19 is arranged at the center of the rotating plate 17.
[0034] As Figure 2 shown, the first rotating mechanism includes a main shaft 4 and a second stirring blade 7; the inside of the main shaft 4 is hollow. One end of the main shaft 4 passes through the through hole 19 and the second gear 29 and is connected to the transfer box 27, and the other end is placed inside the mesh cylinder 5. A second stirring blade 7 is arranged on the main shaft 4.
[0035] The second rotating mechanism includes a first meshing ring 1, a first gear 2, a secondary shaft 15, and a first stirring blade 6; the secondary shaft 15 is arranged on the rotating plate 17 and is connected to the first gear 2. The first meshing ring 1 is connected to the inner wall of the reactor body 14 and is meshed with the first gear 2 on one side. A first stirring blade 6 is arranged on the secondary shaft 5.
[0036] In this embodiment, the number of the first stirring blades 6, the second stirring blades 7, and the second rotating mechanism is multiple.
[0037] In this embodiment, the centers of the first engaging ring 1 and the second engaging ring 20 are the same as the center of the main shaft 4.
[0038] Start the second motor 34. The second motor 34 drives the third gear 35 to rotate. The third gear 35 acts on the second gear 29 to drive the main shaft 4 to rotate, thereby driving the second stirring blades 7 on the surface to rotate upward to stir the liquid medicine. The large gear 31 is meshed and connected with the second gear 29, and the small gear 32 is meshed with the second engaging ring 20. The second gear 29 drives the large gear 31 and then drives the small gear 32 through the rotating shaft 30 to act on the second engaging ring 20 at the upper end of the rotating plate 17, reducing the rotation speed of the rotating plate 17. The rotating plate 17 slides and rotates on the surface of the annular slide rail 3 through the slider 16, thereby driving the first gear 2 at one end of the auxiliary shaft 15 to act on the first engaging ring 1 to rotate, driving the first stirring blades 6 on the surface of the auxiliary shaft 15 to rotate, and stirring the liquid medicine downward.
[0039] As Figure 2 、 5 As shown in FIGS. 6, a funnel-shaped partition assembly 21 is provided inside the mesh cylinder 5, and a plurality of holes are provided on the surface of the mesh cylinder 5. The funnel-shaped partition assembly 21 is composed of funnel-shaped partitions with the inner hole diameter increasing from top to bottom in sequence. The main shaft 4 rotates, thereby driving the second stirring blades 7 on the surface to rotate upward to stir the liquid medicine. The liquid medicine is separated by the funnel-shaped partition group 21 in the mesh cylinder 5 and sprayed out through the holes on the surface of the mesh cylinder 5, disrupting the external fluid flow law and improving the stirring efficiency.
[0040] As Figure 2 、 7 As shown in FIGS. 8, the discharging mechanism includes a first mesh plate 9, a second mesh plate 10, a bevel gear 13, and a first motor 12. The first mesh plate 9 is connected to the second mesh plate 10 through a connecting shaft 22. An annular engaging groove 24 is provided on the lower surface of the first mesh plate 9, and the bevel gear 13 is meshed and connected with the annular engaging groove 24. The output end of the first motor 12 is connected to the bevel gear 13.
[0041] A plurality of first discharging holes 23 are provided on the surface of the first mesh plate 9, and a plurality of second discharging holes 26 are provided on the surface of the second mesh plate 10. The first discharging holes 23 and the second discharging holes 26 are arranged in one-to-one correspondence, and a discharging port 11 is provided at the lower end of the reaction kettle body 14.
[0042] Start the first motor 12 to drive the bevel gear 13 to rotate, thereby acting on the annular engaging groove 24 at the bottom of the second mesh plate 10, driving the annular engaging groove 24 to rotate through the connecting shaft 22, aligning the second discharging holes 26 and the first discharging holes 23 on the surfaces of the second mesh plate 10 and the first mesh plate 9, thereby discharging materials, and the liquid medicine is discharged through the discharging port 11.
[0043] Multiple air holes 25 are fixedly arranged at the upper end of the second mesh plate 10. The air holes 25 are hollow and communicated with the inside of the main shaft 4. The air pump 28 injects air into the transfer box 27, which is introduced into the second mesh plate 10 through the main shaft 4 and ejected through the air holes 25.
[0044] The air pump conveys air into the reaction kettle body 14 through the main shaft and the air holes, aerates the medicine in the reaction kettle body 14, and is more uniform and efficient during aeration through the air pump and the air holes.
[0045] In this embodiment, the support rods 8 are arranged at the upper end of the first mesh plate 9 and are multiple in number, playing a supporting role for the mesh cylinder.
[0046] The working principle or usage process of the present utility model: First, the liquid medicine is put into the reaction kettle body 14, and then the second motor 34 is started. The second motor 34 drives the third gear 35 to rotate. The third gear 35 acts on the second gear 29 to drive the main shaft 4 to rotate, thereby driving the stirring blade II 7 on the surface to rotate upward to stir the liquid medicine; the liquid medicine is separated by the funnel-shaped partition plate group 21 in the mesh cylinder 5 and is ejected through the holes on the surface of the mesh cylinder 5, disrupting the external fluid flow law and improving the stirring efficiency; the large gear 31 is meshed and connected with the second gear 29, the small gear 32 is meshed with the second engagement ring 20. The second gear 29 drives the large gear 31 and then drives the small gear 32 through the rotating shaft 30 to act on the second engagement ring 20 at the upper end of the rotating plate 17, reducing the rotation speed of the rotating plate 17. The rotating plate 17 slides and rotates on the annular slide rail 3 through the slider 16, thereby driving the first gear 2 at one end of the auxiliary shaft 15 to rotate by acting on the first engagement ring 1, driving the stirring blade I 6 on the surface of the auxiliary shaft 15 to rotate and stir the liquid medicine downward.
[0047] After the liquid medicine in the reaction kettle body 14 is mixed and stirred, the first motor 12 is started to drive the bevel gear 13 to rotate, thereby acting on the annular engagement groove 24 at the bottom of the second mesh plate 10, driving the annular engagement groove 24 to rotate through the connecting shaft 22, aligning the second discharge holes 26 and the first discharge holes 23 on the surfaces of the second mesh plate 10 and the first mesh plate 9, so as to discharge the material, and the liquid medicine is discharged through the discharge port 11.
[0048] The above are only the preferred embodiments of the present utility model. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present utility model, several improvements and refinements can still be made, and these improvements and refinements should also be regarded as the protection scope of the present utility model.
Claims
1. A reactor suitable for raw material drug synthesis, comprising a reactor body (14), characterized in that: A transmission mechanism (18), a mesh cylinder (5) and a discharge mechanism are provided in the reactor body (14); the mesh cylinder (5) is placed on the upper end of the discharge mechanism via a support rod (8); the transmission mechanism (18) is connected to a first rotating mechanism and a second rotating mechanism; the transmission mechanism (18) drives the first rotating mechanism to rotate the liquid medicine in the mesh cylinder (5) upwardly for stirring and spraying; the transmission mechanism (18) drives the second rotating mechanism to rotate the liquid medicine in the reactor body (14) downwardly for stirring; and the stirred liquid medicine is discharged via the discharge mechanism.
2. The reaction kettle suitable for raw material drug synthesis according to claim 1, characterized in that: The transmission mechanism (18) comprises a second gear (29), a rotating shaft (30), a large gear (31), a small gear (32), a second motor (34) and a third gear (35); the second motor (34) is connected to the third gear (35); the large gear (31) is arranged on the rotating shaft (30); one end of the rotating shaft (30) is connected to the inner wall of the reactor body (14), and the other end is connected to the small gear (32); the third gear (35), the second gear (29) and the large gear (31) are meshed with each other.
3. The reaction kettle suitable for raw material drug synthesis according to claim 2, characterized in that: An annular slide rail (3) is fixedly provided on the inner side of the reactor body (14); a rotating plate (17) is provided on the annular slide rail (3); the rotating plate (17) is connected to the annular slide rail (3) via a slider (16); a second meshing ring (20) is provided on the rotating plate (17); and the second meshing ring (20) is in contact with a pinion (32).
4. The reaction kettle suitable for raw material drug synthesis according to claim 1, characterized in that: A funnel-shaped partition assembly (21) is provided inside the mesh tube (5), and a plurality of holes are provided on the surface of the mesh tube (5).
5. The reaction kettle suitable for raw material drug synthesis according to claim 4, characterized in that: The funnel-shaped baffle assembly (21) is composed of funnel-shaped baffles whose inner hole diameters increase successively from top to bottom.
6. The reaction kettle suitable for raw material drug synthesis according to claim 1, characterized in that: The first rotating mechanism comprises a main shaft (4) and two stirring blades (7); the main shaft (4) is placed in the mesh cylinder (5), and one end thereof passes through the rotating plate (17) and is connected to the second gear (29); the main shaft (4) is provided with two stirring blades (7).
7. The reaction kettle suitable for raw material drug synthesis according to claim 1, characterized in that: The second rotating mechanism comprises a meshing ring (1), a gear (2), an auxiliary shaft (15) and a stirring blade (6); the auxiliary shaft (15) is arranged on a rotating plate (17) and is connected to the gear (2); the meshing ring (1) is connected to the inner wall of the reactor body (14) and is meshed with the gear (2); and a stirring blade (6) is arranged on the auxiliary shaft (5).
8. The reaction kettle suitable for raw material drug synthesis according to claim 1, characterized in that: The discharge mechanism comprises a mesh plate 1 (9), a mesh plate 2 (10), a bevel gear (13) and a motor 1 (12); the mesh plate 1 (9) is connected to the mesh plate 2 (10) via a connecting shaft (22); an annular meshing groove (24) is provided at the lower end of the mesh plate 1 (9), the bevel gear (13) is meshedly connected to the annular meshing groove (24), and the output end of the motor 1 (12) is connected to the bevel gear (13).
9. The reaction kettle suitable for raw material drug synthesis according to claim 8, characterized in that: The mesh plate one (9) is provided with a discharge hole one (23), and the mesh plate two (10) is provided with a discharge hole two (26); and the lower end of the reactor body (14) is provided with a discharge port (11).