Intracranial electric signal acquisition device

Abstract

The utility model discloses an intracranial electric signal acquisition device. The intracranial electric signal acquisition device comprises an electrode sleeve; the multiple macro electrodes are arranged on the outer surface of the electrode sleeve at intervals in the axial direction of the electrode sleeve; the plurality of microelectrode units are arranged on the outer surface of the electrode sleeve at intervals along the axial direction and are insulated and spaced from the macro electrode, and each microelectrode unit comprises at least one microelectrode; and each first wire is electrically connected with one corresponding microelectrode, and the first wires are integrated in the tube wall of the electrode sleeve. According to the intracranial electric signal acquisition device, the signal-to-noise ratio of the acquired electroencephalogram signals can be conveniently improved, and the interference of irrelevant signals on the acquired signals is reduced.

Description

Technical Field

[0001] The utility model relates to the field of medical detection instruments, in particular to an intracranial electrical signal acquisition device. Background Art

[0002] Stereo-electroencephalography (SEEG) technology, as a method of implanting deep brain electrodes to record brain electrical signals, is widely used in the confirmation of lesion points of drug-resistant epilepsy. The SEEG technology performs three-dimensional modeling of the brain through three-dimensional stereotactic positioning, and captures brain electrical signals in real time to achieve the purpose of accurately positioning the lesion points. The SEEG technology needs to collect brain electrical signals through an intracranial electrical signal acquisition device (i.e., an intracranial electrode).

[0003] Currently, for the acquisition of brain electrical signals by intracranial electrical signal acquisition devices, the local field potentials at the corresponding positions are mainly collected through macroelectrodes on the surface. The signals of the field potentials are the linear sum of the electrical signals of numerous neurons in the brain. The neuron signals at different positions have different degrees of influence on the total collected signal. At the same time, non-brain electrical signals such as myoelectric signals are likely to interfere with the acquisition of brain electrical signals and generate noise signals, which requires additional time to process the collected signals for noise reduction. Summary of the Utility Model

[0004] The utility model provides an intracranial electrical signal acquisition device, which is convenient for improving the signal-to-noise ratio of the collected brain electrical signals and reducing the interference of irrelevant signals on the collected signals.

[0005] An embodiment of the utility model provides an intracranial electrical signal acquisition device, which includes: an electrode sleeve; a plurality of macroelectrodes arranged at intervals along the axial direction of the electrode sleeve on the outer surface of the electrode sleeve; a plurality of microelectrode units arranged at intervals along the axial direction on the outer surface of the electrode sleeve and insulated from the macroelectrodes at intervals. Each microelectrode unit includes at least one microelectrode; a plurality of first wires, each first wire being electrically connected to a corresponding microelectrode, and the first wires being integrated into the wall of the electrode sleeve.

[0006] According to the foregoing embodiment of the utility model, the interior of the electrode sleeve has a first inner cavity extending along the axial direction, and the intracranial electrical signal acquisition device further includes: a wire fixing column at least partially passing through the first inner cavity; a plurality of second wires, each second wire being electrically connected to a corresponding macroelectrode, and the plurality of second wires extending through the wire fixing column and being limited by the wire fixing column.

[0007] According to any of the foregoing embodiments of the present utility model, the wire fixing column is provided with a wire accommodating space extending along the axial direction, and the second wire is limited in the wire accommodating space.

[0008] According to any of the foregoing embodiments of the present utility model, the wire accommodating space is a groove located on the outer peripheral surface of the wire fixing column, and the outer peripheral surface of the wire fixing column cooperates with the inner peripheral surface of the electrode sleeve, so that the second wire is limited between the groove and the inner peripheral surface of the electrode sleeve.

[0009] According to any of the foregoing embodiments of the present utility model, the wire accommodating space is a channel extending inside the wire fixing column.

[0010] According to any of the foregoing embodiments of the present utility model, the number of the wire accommodating spaces is two or more, and two or more of the wire accommodating spaces are arranged at intervals along the circumferential direction of the wire fixing column.

[0011] According to any of the foregoing embodiments of the present utility model, the wire fixing column is a hollow structure and has a second inner cavity extending along the axial direction.

[0012] According to any of the foregoing embodiments of the present utility model, the electrode sleeve is provided with a through hole communicating the first inner cavity with the outer surface of the electrode sleeve, the macro electrode covers the through hole, and the second wire passes through the through hole and is electrically connected to the macro electrode.

[0013] According to any of the foregoing embodiments of the present utility model, the outer surface of each of the second wires has an insulating layer.

[0014] According to any of the foregoing embodiments of the present utility model, the intracranial electrical signal acquisition device further includes: a connecting sleeve sleeved on one end of the electrode sleeve; an interface member located at the end of the connecting sleeve away from the electrode sleeve, and the second wire and the first wire respectively pass through the connecting sleeve along the axial direction and are electrically connected to the interface member.

[0015] According to any of the foregoing embodiments of the present utility model, each of the microelectrode units includes two or more of the microelectrodes arranged at intervals along the circumferential direction of the electrode sleeve.

[0016] According to any of the foregoing embodiments of the present utility model, the surface area of each of the macro electrodes is less than or equal to 20 square millimeters; the surface area of each of the microelectrodes is less than or equal to 10,000 square micrometers.

[0017] An intracranial electrical signal acquisition device according to an embodiment of the present invention includes an electrode sleeve, a plurality of macroelectrodes, a plurality of microelectrode units, and a plurality of first wires. The plurality of macroelectrodes and the plurality of microelectrode units are arranged axially and spaced apart on the outer surface of the electrode sleeve, and the microelectrode units are insulated and spaced apart from the macroelectrodes. When the intracranial electrical signal acquisition device is used for intracranial electrical signal acquisition, the microelectrodes included in the microelectrode units, due to their small volume, can greatly reduce the influence of irrelevant low-frequency signals in collecting brain electrical signals, thus having a higher signal-to-noise ratio. Specifically, abnormal signals such as abnormal potential transmission at lesion sites often have the appearance of some high-frequency signals. The microelectrodes have a smaller surface area in contact with the brain tissue compared to the macroelectrodes, so they can also reduce the signal interference of irrelevant signals such as electromyographic signals to a greater extent. The microelectrodes cooperate with the macroelectrodes to be able to collect abnormal electrical signals more accurately, facilitating subsequent analysis of lesion sites or brain science research analysis. Description of the Drawings

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on the structures shown in these drawings.

[0019] Figure 1 It is a schematic structural diagram of an embodiment of the intracranial electrical signal acquisition device of the present invention;

[0020] Figures 2 to 8 It is a cross-sectional view of a wire fixing column in various alternative embodiments of the intracranial electrical signal acquisition device of the present invention;

[0021] Figure 9 It is a cross-sectional view of a microelectrode unit in an embodiment of the intracranial electrical signal acquisition device of the present invention;

[0022] Figure 10 It is a cross-sectional view of a microelectrode unit in another embodiment of the intracranial electrical signal acquisition device of the present invention.

[0023] Description of the Reference Numerals:

[0024] 110 - Electrode sleeve;

[0025] 120 - Macroelectrode;

[0026] 130 - Microelectrode unit; 131 - Microelectrode;

[0027] 140 - Wire fixing column; 141 - Groove; 142 - Channel; 143 - Second inner cavity;

[0028] 160 - First wire;

[0029] 150 - Second wire;

[0030] 170 - Connecting sleeve;

[0031] 180 - Interface part.

[0032] The realization of the purpose, functional features and advantages of the present utility model will be further described with reference to the accompanying drawings in conjunction with the embodiments. Specific embodiments

[0033] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present utility model.

[0034] It should be noted that all directional indications such as up, down, left, right, front, back... in the embodiments of the present utility model are only used to explain the relative positional relationship and movement conditions between components in a specific posture as shown in the accompanying drawings. If this specific posture changes, the directional indications will also change accordingly.

[0035] In addition, the descriptions involving "first", "second", etc. in the present utility model are only for descriptive purposes, and cannot be understood as indicating or implying their relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the ability of those of ordinary skill in the art to implement. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the protection scope required by the present utility model.

[0036] Figure 1This is a schematic structural diagram of an embodiment of the intracranial electrical signal acquisition device of the present utility model. The intracranial electrical signal acquisition device, namely the intracranial electrode, includes an electrode sleeve 110, a plurality of macroelectrodes 120, a plurality of microelectrode units 130, and a plurality of first wires 160. The plurality of macroelectrodes 120 are arranged at intervals along the axial direction of the electrode sleeve 110 on the outer surface of the electrode sleeve 110. The plurality of microelectrode units 130 are arranged at intervals along the axial direction on the outer surface of the electrode sleeve 110 and are insulated from the macroelectrodes 120 at intervals. Each microelectrode unit 130 includes at least one microelectrode 131. Each first wire 160 is electrically connected to a corresponding microelectrode 131, and the first wires 160 are integrated into the wall of the electrode sleeve 110. The electrode sleeve 110 is an insulating member, and the plurality of first wires 160 are insulated from each other.

[0037] The intracranial electrical signal acquisition device according to the embodiment of the present utility model includes an electrode sleeve 110, a plurality of macroelectrodes 120, a plurality of microelectrode units 130, and a plurality of first wires 160. The plurality of macroelectrodes 120 and the plurality of microelectrode units 130 are arranged at intervals along the axial direction on the outer surface of the electrode sleeve 110, and the microelectrode units 130 are insulated from the macroelectrodes 120 at intervals. When the intracranial electrical signal acquisition device is used for intracranial electrical signal acquisition, the microelectrodes 131 included in the microelectrode units 130, due to their tiny volume, can greatly reduce the influence of irrelevant low-frequency signals in the collection of brain electrical signals, thus having a higher signal-to-noise ratio. Specifically, abnormal signals such as abnormal potential transmission at lesion sites often have the appearance of some high-frequency signals. The microelectrodes 131 have a smaller surface area in contact with the brain tissue compared to the macroelectrodes 120, so they can also reduce the signal interference of irrelevant signals such as electromyographic signals to a greater extent. The microelectrodes cooperate with the macroelectrodes 120 to enable more accurate acquisition of abnormal electrical signals, facilitating subsequent analysis of lesion sites or brain science research analysis.

[0038] The electrode sleeve 110 has a first inner cavity extending along the axial direction. In some embodiments, the intracranial electrical signal acquisition device further includes a wire fixing column 140 and a plurality of second wires 150. The wire fixing column 140 is at least partially inserted into the first inner cavity. Each second wire 150 is electrically connected to a corresponding macroelectrode 120, and the plurality of second wires 150 extend through the wire fixing column 140 and are limited by the wire fixing column 140.

[0039] The microelectrodes 131 are connected to the first wires 160 to form a first signal channel, and the macroelectrodes 120 are connected to the second wires 150 to form a second signal channel.

[0040] In the related art, the macroelectrode 120 and the microelectrode 131 are integrated on a single insulating sleeve. Since the outer diameter of the intracranial electrical signal acquisition device is about 0.8 mm and the manufacturing requirements are of high precision, the manufacturing process is extremely complex. In the embodiments of the present application, the microelectrode unit 130 is integrated into the electrode sleeve 110, and multiple second wires 150 connected to the multiple macroelectrodes 120 extend through the wire fixing post 140 and are limited by the wire fixing post 140. During the manufacturing process of the intracranial electrical signal acquisition device, the microelectrode unit 130 and the electrode sleeve 110 are integrated into a modular structure, and the macroelectrode 120, the second wire 150, and the wire fixing post 140 are integrated into a modular structure. Then, the electrode sleeve 110 and the wire fixing post 140 are sleeved and assembled. The manufacturing process of the intracranial electrical signal acquisition device in the embodiments of the present application is transformed into modular assembly, thereby greatly improving the production efficiency. When the macroelectrode 120 or the microelectrode 131 is abnormal, only the corresponding part of the modular structure needs to be replaced to ensure its normal use. Compared with the structure in which the macroelectrode 120 and the microelectrode 131 are integrated on a single insulating sleeve, the situation where the entire intracranial electrical signal acquisition device is scrapped due to the abnormality of a single macroelectrode 120 or microelectrode 131 is avoided, thereby avoiding material waste.

[0041] In some embodiments, the surface area of each macroelectrode 120 is less than or equal to 20 square millimeters. In some embodiments, the surface area of each microelectrode 131 is less than or equal to 10,000 square micrometers.

[0042] In some embodiments, the intracranial electrical signal acquisition device further includes a connection sleeve 170 and an interface member 180. The connection sleeve 170 is sleeved on one end of the electrode sleeve 110. The interface member 180 is located at the end of the connection sleeve 170 away from the electrode sleeve 110, and the second wire 150 and the first wire 160 are respectively axially passed through the connection sleeve 170 and electrically connected to the interface member 180.

[0043] When the intracranial electrical signal acquisition device is implanted into the brain, the electroencephalogram signals generated by neurons in the brain are collected through the macroelectrode 120 and the microelectrode 131, and then the electroencephalogram signals are transmitted through the second wire 150 and the first wire 160. The electroencephalogram signals are connected to an external device through the interface member 180 to realize signal reading and storage, thereby realizing the collection of electroencephalogram signals.

[0044] In some embodiments, one end of the electrode sleeve 110, one end of the wire fixing post 140, a part of the first wire 160, and a part of the second wire 150 are wrapped by the connection sleeve 170.

[0045] In some embodiments, the outer diameter of the end of the electrode sleeve 110 close to the connection sleeve 170 is reduced to facilitate insertion into the connection sleeve 170.

[0046] The electrode sleeve 110, the wire fixing post 140, and the connecting sleeve 170 are all insulating parts. The materials of the electrode sleeve 110, the wire fixing post 140, and the connecting sleeve 170 can be one or more polymers of silicon material, thermoplastic polyurethane elastomer (TPU), polytetrafluoroethylene (PTFE), polyether block polyamide (PEBAX), polyimide (PI), nylon, rubber, polyvinyl chloride (PVC), or other non-conductive polymer materials.

[0047] The microelectrode 131, the first wire 160, and the second wire 150 can respectively include one or more materials of gold material, silver material, platinum material, iridium material, MP35N material, tantalum material, or other non-magnetic conductive metals.

[0048] In some embodiments, the connecting sleeve 170 is detachably connected to the electrode sleeve 110. In some embodiments, the connecting sleeve 170 is fixedly connected to the electrode sleeve 110. The connection forms between the connecting sleeve 170 and the electrode sleeve 110 include but are not limited to bonding, internal filling with glue or silicone or rubber or other polymer materials, hot melt connection, internal or external structural member reinforcement connection, threaded connection, etc.

[0049] Figures 2 to 8 This is a schematic cross-sectional view of the wire fixing post in various alternative embodiments of the intracranial electrical signal acquisition device of the present invention, where Figures 2 to 8 It shows the cross-section of the wire fixing post perpendicular to the axial direction in different embodiments. In some embodiments, the wire fixing post 140 is provided with a wire receiving space extending along the axial direction, and the second wire 150 is limited in the wire receiving space.

[0050] As Figures 2 to 7 , in some embodiments, the wire receiving space is a groove 141 located on the outer peripheral surface of the wire fixing post 140. The outer peripheral surface of the wire fixing post 140 cooperates with the inner peripheral surface of the electrode sleeve 110, so that the second wire 150 is limited between the groove 141 and the inner peripheral surface of the electrode sleeve 110.

[0051] As Figures 2 to 7 , when the wire receiving space is a groove 141 located on the outer peripheral surface of the wire fixing post 140, the groove 141 can be a fan-shaped groove, a square groove, a V-shaped groove, or other polygonal grooves or special-shaped grooves.

[0052] As Figure 8 , in some embodiments, the wire receiving space is a channel 142 extending inside the wire fixing post 140.

[0053] As Figure 8 , when the wire accommodation space is the channel 142 extending within the wire fixing post 140, the cross-section of the channel 142 can be circular, oval, polygonal or irregular-shaped.

[0054] As Figure 5 , in some embodiments, the number of wire accommodation spaces is more than two, and the more than two wire accommodation spaces are arranged at intervals along the circumferential direction of the wire fixing post 140. For example Figure 5 In the related embodiment, the wire accommodation space is the groove 141, and the number of grooves 141 is four. In some other embodiments, the more than two wire accommodation spaces can be more than two channels 142, and the number of wire accommodation spaces can be other numbers such as two, three, five, etc.

[0055] As Figures 5 to 7 , in some embodiments, the wire fixing post 140 is a hollow structure and has a second inner cavity 143 extending axially.

[0056] As Figure 5 , Figure 6 , in some embodiments, the wire accommodation space is spaced from the second inner cavity 143. For example, the wire accommodation space is the groove 141, and the groove 141 is spaced from the second inner cavity 143.

[0057] As Figure 7 , in some embodiments, the wire accommodation space communicates with the second inner cavity 143. For example, the wire accommodation space is the groove 141, and the groove 141 communicates with the second inner cavity 143.

[0058] In some embodiments, the electrode sleeve 110 is provided with a through hole that communicates the first inner cavity with the outer surface of the electrode sleeve 110. The macro electrode 120 covers the through hole, and the second wire 150 passes through the through hole and is electrically connected to the macro electrode 120.

[0059] In some embodiments, the outer surface of each second wire 150 has an insulating layer, thereby improving the signal anti-interference ability of the second wire 150.

[0060] Figure 9 This is a schematic cross-sectional view of the microelectrode unit in an embodiment of the intracranial electrical signal acquisition device of the present utility model, where Figure 9 The cross-section perpendicular to the axial direction of the microelectrode unit is schematically shown. In some embodiments, each microelectrode unit 130 includes a single microelectrode 131.

[0061] Figure 10 This is a schematic cross-sectional view of the microelectrode unit in another embodiment of the intracranial electrical signal acquisition device of the present utility model, where Figure 10Schematically shows a cross-section of the microelectrode unit perpendicular to the axial direction. In some embodiments, each microelectrode unit 130 includes more than two microelectrodes 131 circumferentially spaced along the electrode sleeve 110. For example, each microelectrode unit 130 includes three microelectrodes 131. In some other embodiments, each microelectrode unit 130 may include two, four, five or other numbers of microelectrodes 131.

[0062] The above are only the preferred embodiments of the present invention, and do not limit the patent scope of the present invention. Any equivalent structural transformation made by using the content of the specification and drawings of the present invention under the concept of the present invention, or direct / indirect application in other related technical fields is included in the patent protection scope of the present invention.

Claims

1. An intracranial electrical signal acquisition device, characterized in that: include: Electrode sleeve; A plurality of macro electrodes are arranged at intervals on the outer surface of the electrode sleeve along the axial direction of the electrode sleeve; A plurality of micro-electrode units are arranged at intervals along the axial direction on the outer surface of the electrode sleeve and insulated from the macro-electrode, each of the micro-electrode units comprising at least one micro-electrode; A plurality of first wires are provided, each of which is electrically connected to a corresponding microelectrode, and the first wires are integrated into the tube wall of the electrode sleeve.

2. The intracranial electrical signal acquisition device according to claim 1, characterized in that: The electrode sleeve has a first inner cavity extending axially therein, and the intracranial electrical signal acquisition device further comprises: A wire fixing column, at least partially passing through the first inner cavity; A plurality of second wires, each of which is electrically connected to a corresponding one of the macro electrodes, and the plurality of second wires extend through the wire fixing column and are limited by the wire fixing column.

3. The intracranial electrical signal acquisition device according to claim 2, characterized in that: The wire fixing column is provided with a wire accommodating space extending along the axial direction, and the second wire is confined in the wire accommodating space.

4. The intracranial electrical signal acquisition device according to claim 3, characterized in that: The wire accommodating space is a groove located on the outer circumference of the wire fixing column, and the outer circumference of the wire fixing column cooperates with the inner circumference of the electrode sleeve so that the second wire is confined between the groove and the inner circumference of the electrode sleeve.

5. The intracranial electrical signal acquisition device according to claim 3, characterized in that: The wire accommodating space is a channel extending inside the wire fixing column.

6. The intracranial electrical signal acquisition device according to claim 3, characterized in that: The number of the wire accommodating spaces is more than two, and the more than two wire accommodating spaces are arranged at intervals along the circumferential direction of the wire fixing column.

7. The intracranial electrical signal acquisition device according to claim 2, characterized in that: The wire fixing column is a hollow structure and has a second inner cavity extending along the axial direction.

8. The intracranial electrical signal acquisition device according to claim 2, characterized in that: The electrode sleeve is provided with a through hole connecting the first inner cavity with the outer surface of the electrode sleeve, the macro electrode is covered by the through hole, and the second wire passes through the through hole and is electrically connected to the macro electrode.

9. The intracranial electrical signal acquisition device according to claim 2, characterized in that: An outer surface of each of the second conductive lines has an insulating layer.

10. The intracranial electrical signal acquisition device according to claim 2, characterized in that: Also includes: A connecting sleeve, sleeved on one end of the electrode sleeve; The interface component is located at one end of the connecting sleeve away from the electrode sleeve, and the second wire and the first wire respectively pass through the connecting sleeve along the axial direction and are electrically connected to the interface component.

11. The intracranial electrical signal acquisition device according to claim 1, characterized in that: Each of the microelectrode units includes two or more microelectrodes arranged at intervals along the circumference of the electrode sleeve.

12. The intracranial electrical signal acquisition device according to claim 1, characterized in that: The surface area of ​​each macroelectrode is less than or equal to 20 square millimeters; the surface area of ​​each microelectrode is less than or equal to 10,000 square microns.

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