Tangential flow filtering system for laboratory

Abstract

The utility model belongs to the technical field of bioengineering, and discloses a tangential flow filtering system for a laboratory. The device comprises a shell, and the shell is provided with a circulating tank assembly and a liquid supplementing tank assembly used for supplementing liquid to the circulating tank assembly; the circulating tank assembly comprises a liquid inlet used for receiving liquid supplemented by the liquid supplementing tank assembly, a liquid discharging opening used for discharging liquid and a liquid returning opening used for receiving circulating liquid. The liquid outlet is provided with a pipeline, the pipeline is provided with a liquid discharge driving part for driving the circulating tank assembly, the liquid discharge driving part is connected with a membrane package clamp through the pipeline, and the membrane package clamp divides the material liquid into a backflow flow path for circulating to the liquid return opening and a permeation flow path communicated with an external device; the circulating tank assembly is of an upper stirring type and comprises a tank body, an integrated weighing and stirring unit is arranged at the bottom end in the tank body, and the weight of feed liquid in the tank body is weighed while stirring power is provided. The method is used for application and verification of a tangential flow process section in a laboratory, and meets the requirements of rapid verification and result inspection of a sample.

Description

Technical Field

[0001] The utility model relates to the technical field of bioengineering, and particularly relates to a tangential flow filtration system for laboratories. Background Art

[0002] In the field of biopharmaceuticals, tangential flow filtration is a widely adopted filtration operation method, which is mostly applied to clarification filtration, product concentration, heat source removal, small molecule impurity removal, buffer replacement, etc.

[0003] At present, the tangential flow filtration system is large in scale, occupies a large area, and the production process is fixed, which is not conducive to the verification of small batch samples and the rapid inspection of results. Summary of the Utility Model

[0004] The purpose of the utility model is to solve the above problems, and provide a tangential flow filtration system for laboratories, which is used for the application and verification of the tangential flow process section in the laboratory, and meets the rapid verification of samples and the inspection of results.

[0005] To achieve the above purpose, the utility model provides the following technical solution: a tangential flow filtration system for laboratories, including a housing, the housing is equipped with a circulation tank assembly and a liquid supplement tank assembly for supplementing liquid to the circulation tank assembly; the circulation tank assembly includes a liquid inlet for receiving the liquid supplemented by the liquid supplement tank assembly, a liquid discharge port for discharging liquid, and a liquid return port for receiving the circulating liquid; a pipeline is arranged at the liquid discharge port, and a liquid discharge driving part for driving the circulation tank assembly is arranged on the pipeline, the liquid discharge driving part is connected with a membrane package clamp through the pipeline, and the membrane package clamp divides the feed liquid into a reflux flow path circulating to the liquid return port and a permeate flow path communicated with an external device;

[0006] The circulation tank assembly is an upper stirring type, including a tank body, and an integrated weighing and stirring unit is arranged at the bottom end inside the tank body to weigh the weight of the feed liquid inside the tank body while providing stirring power.

[0007] According to the utility model, further, the integrated weighing and stirring unit includes a stirring motor with a vertically upward output shaft, and a blade assembly with magnetism is arranged on the outer periphery of the output shaft.

[0008] According to the utility model, further, the integrated weighing and stirring unit further includes a weighing chip, and the weighing chip and the stirring motor are integrated into an integrated structure.

[0009] According to the utility model, further, the liquid discharge driving part is a power pump.

[0010] According to the utility model, further, the power pump is a peristaltic pump or a diaphragm pump.

[0011] According to the present utility model, further, the pipeline is a silica gel tube. As a disposable consumable, the pipeline is replaced every time a test is performed to avoid pipeline contamination and improve test accuracy.

[0012] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0013] 1. Better applicability. Due to its smaller volume and the miniaturization and flexibility of system control, it is more suitable for the space requirements of laboratories and the changing usage methods.

[0014] 2. More excellent process application cost. The pipeline uses a flexible tube, and the flexible tube is used as a disposable consumable to avoid the problem of cleaning residues.

[0015] 3. Flexible application. The filter outlet can be optionally equipped with a sensor to support the realization and control of accurate process flows. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic structural diagram of a tangential flow filtration system for a laboratory according to the present utility model;

[0017] Figure 2 It is a schematic structural diagram of another perspective of a tangential flow filtration system for a laboratory according to the present utility model;

[0018] Figure 3 It is a schematic structural diagram of a circulation tank assembly.

[0019] In the figure: 100 - housing, 200 - circulation tank assembly, 210 - liquid inlet, 220 - liquid discharge port, 230 - return liquid port, 240 - integrated weighing and stirring unit, 250 - blade assembly, 300 - liquid supplement tank assembly, 400 - pump, 500 - membrane package clamp, 600 - pressure sensor, 700 - flow meter, 800 - disposable conductivity meter, 900 - pH detector, 1000 - UV detector, 1100 - adjustable height display screen. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0020] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0021] Such as Figure 1 and Figure 2As shown in the figure, a tangential flow filtration system in an embodiment of the present utility model is applicable to tangential flow filtration tests in laboratories, enabling faster and more frequent exploration of test models and process parameters. It includes a housing 100 for installing a filtration component. A circulation tank component 200 and a liquid replenishment tank component 300 for replenishing the circulation tank component 200 with liquid are installed on the top surface of the housing 100, and the two are connected through pipelines. The circulation tank component 200 has a liquid inlet 210, a liquid discharge port 220, and a liquid return port 230. The position of the liquid discharge port 210 is lower than that of the liquid inlet 210. A pipeline is connected to the liquid inlet 210, and the other end of the pipeline is connected to the liquid replenishment tank component 300. The liquid discharge port 220 is connected to a pump 400 through a pipeline. The pump 400 is connected to a membrane package fixture 500 through a pipeline. After being filtered by the membrane package fixture 500, two output paths are provided. One is a reflux flow path, which circulates back into the circulation tank component 200 through the liquid return port 230, and the other is a permeate flow path, which is output to an external permeate liquid device. Preferably, the pump 400 serves as a power unit, and a peristaltic pump or a diaphragm pump can be selected. Among them, the membrane package fixture 500 is a prior art and will not be elaborated here.

[0022] In this embodiment, as Figure 3 shown, the circulation tank component 200 adopts an upper stirring form, and an integrated weighing and stirring unit 240 is provided at the bottom inside the tank to provide power. The integrated weighing and stirring unit 240 is a unit that integrates a weighing chip and a stirring motor into one structure, realizing the acquisition of the weight of the liquid material while stirring. The output shaft of the stirring motor of the integrated weighing and stirring unit 240 is vertically upward and is connected to a blade assembly 250. The blade assembly includes a magnetic stirrer sleeved on the outer periphery of the output shaft of the stirring motor, and a paddle is integrally connected to the outer periphery of the magnetic stirrer. The integrated weighing and stirring unit 240 drives the blade assembly 250 to rotate, realizing the function of stirring the liquid material. Preferably, the blade assembly 250 is a suspended structure and does not contact the tank during movement, avoiding the risk of residue pollution of the liquid material caused by friction leakage of the sensing magnetic stirrer during rotation.

[0023] In this embodiment, it further includes a weighing sensor (not shown in the figure) for detecting the weight of the liquid material in the circulation tank component 200. The liquid replenishment tank component 300 has an electric valve (not shown in the figure) to control the on-off of the pipeline for replenishing the circulation tank component 200 with liquid. The weighing sensor is electrically connected to the electric valve. When the weighing sensor detects that the liquid material in the tank of the circulation tank component 200 is insufficient, a signal is sent, and the electric valve of the liquid replenishment tank component 300 is opened to replenish the circulation tank component 200 with liquid.

[0024] All the pipelines mentioned above are made of silicone hoses, which can be used as disposable consumables to avoid the problem of residual cleaning of traditional stainless steel pipelines. Moreover, the hoses have the advantages of lower material price and more flexible equipment customization configuration compared with stainless steel sensing pipelines.

[0025] In order to improve the filtering accuracy and facilitate the user to observe the data, one or more of a pressure sensor 600 for detecting the pipeline pressure, a flowmeter 700 for detecting the flow rate of the pipeline liquid, a disposable conductivity meter 800, a pH detector 900, and a UV detector 1000 can be provided on the pipeline of the circulation loop. The addition of the sensors and detectors is prior art and will not be elaborated here.

[0026] In this embodiment, an adjustable-height display screen 1100 is further provided on one side of the housing 100, fully considering the human-machine relationship in the sitting and standing postures during the operation of laboratory personnel. During the lifting process of the display screen, the display screen maintains the same inclination angle as that of the human observation, and can meet the needs of the user to observe the display data in different postures.

[0027] The laboratory tangential flow filtration system uses a single-chip microcomputer board to realize the integrated control of the system. Compared with the PLC type, it has a simple structure, a small volume, can be developed at a high level according to specific control requirements, and has an advantage in price cost. It can achieve a reduced occupied volume, rich function reservation, flexibility, and is suitable for function development.

[0028] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A laboratory tangential flow filtration system, characterized in that: The invention comprises a shell, on which a circulation tank assembly and a liquid replenishing tank assembly for replenishing liquid to the circulation tank assembly are installed; the circulation tank assembly comprises a liquid inlet for receiving liquid replenishment of the liquid replenishing tank assembly, a liquid discharge port for discharging liquid, and a liquid return port for receiving circulating liquid; the liquid discharge port is provided with a pipeline, the pipeline is provided with a liquid discharge driving part for driving the circulation tank assembly, the liquid discharge driving part is connected to a membrane package clamp through the pipeline, and the membrane package clamp divides the feed liquid into a reflux flow path circulating to the liquid return port and a permeation flow path connected to an external device; The circulation tank assembly is of top stirring type, including a tank body. An integrated weighing and stirring unit is arranged at the bottom of the tank body to provide stirring power while weighing the weight of the liquid inside the tank body.

2. A laboratory tangential flow filtration system as claimed in claim 1, characterized in that: The integrated weighing and stirring unit comprises a stirring motor with an output shaft pointing vertically upwards, and a blade assembly with magnetic properties is arranged on the outer periphery of the output shaft.

3. A laboratory tangential flow filtration system as claimed in claim 2, characterized in that: The integrated weighing and stirring unit further comprises a weighing chip, and the weighing chip and the stirring motor are integrated into an integrated structure.

4. A laboratory tangential flow filtration system as claimed in claim 1, characterized in that: The liquid discharge driving part is a power pump.

5. A laboratory tangential flow filtration system as claimed in claim 4, characterized in that: The power pump is a peristaltic pump or a diaphragm pump.

6. A laboratory tangential flow filtration system as claimed in claim 1, characterized in that: The pipeline is a silicone tube.

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