Miniature fluorescent sheet scanning machine

Abstract

The utility model discloses a miniature fluorescent sheet scanning machine which comprises a box body, an upper cover is arranged above the box body, a horizontally arranged sheet clamping table is arranged in the box body, the sheet clamping table is connected with a driving mechanism, the driving mechanism is installed on the side wall of the box body, a scanning mechanism is arranged above the sheet clamping table, and the scanning mechanism is installed in the upper cover. The scanning mechanism comprises a laser module and a sensor module, a touch display screen is installed above the upper cover, and a battery bin is arranged below the piece clamping table. The biochip detection device has the beneficial effects that the left-right movement of the clamping piece table is realized through the driving mechanism, the detection of a sample on a biochip is realized through the scanning mechanism, and the detection of whether the sample contains a detected object is realized; the fluorescent sheet scanning machine is ingenious and compact in structural design, small in size and low in production cost, and miniaturization of the sheet scanning machine is achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, and particularly relates to a micro fluorescence scanner. Background Technique

[0002] A fluorescence scanner is an analytical instrument used in the fields of basic medicine and pharmacy. It can scan and image slice samples, and through tissue images, image information of detected substances such as lesions, cells, and proteins in situ in tissues can be effectively obtained.

[0003] However, the existing fluorescence scanners have complex structures, generally large sizes, and high prices. Content of the Utility Model

[0004] The purpose of the utility model is to provide a micro fluorescence scanner to solve the problems raised in the above background technique.

[0005] To achieve the above purpose, the utility model provides the following technical solution: A micro fluorescence scanner, including a box body, an upper cover is arranged above the box body, a horizontal clamping table is arranged inside the box body, the clamping table is connected with a driving mechanism, the driving mechanism is installed on the side wall of the box body, a scanning mechanism is arranged above the clamping table, the scanning mechanism is installed inside the upper cover, the scanning mechanism includes a laser module and a sensor module, a touch display screen is installed above the upper cover, and a battery compartment is arranged below the clamping table.

[0006] Further preferably, the driving mechanism includes an installation main body, the installation main body is fixed on the side wall of the box body, a horizontal track is arranged on the installation main body, an installation substrate is arranged on each of the upper and lower sides of the track, both installation substrates are connected with driving coils, and a moving magnet is arranged on the track. Through the interaction between the magnetic fields generated between the two driving coils located on the upper and lower sides of the track and the magnetic field on the moving magnet, the horizontal movement of the moving magnet is realized, and thus the driving ability of the driving mechanism is realized. At the same time, the driving mechanism with an electromagnetic field structure can effectively reduce the overall volume of the driving mechanism, and thus achieve the reduction of the overall volume of the fluorescence scanner.

[0007] Further preferably, both the installation main body and the moving magnet are connected with wireless power transmission coils and communication coils to realize the power supply and communication for the driving coils and the moving magnet.

[0008] Further preferably, the laser module includes a laser head, a beam expander lens, a collimating lens, and a diaphragm arranged in sequence from top to bottom. The laser head is used for laser emission, the beam expander lens is used for expanding the light beam, the collimating lens is used for turning the light beam into a parallel light beam, and the diaphragm is used for restricting the size of the light beam.

[0009] Further preferably, the number of the laser heads is three, which increases the number of emitted light beams and improves the irradiation range of the laser module.

[0010] Further preferably, the sensor module includes an image sensor, a filter group is provided below the image sensor, a lens group is provided below the filter group, the filter group includes three filters arranged in sequence from top to bottom, and the lens group includes two lenses symmetrically arranged up and down. The image sensor is used to collect the excitation light emitted by the filter group, the filter group is used to filter the laser to prevent the laser from interfering with the detection result, and the lens is used to collect the excitation light generated on the sample. The sensor module is used to collect the excitation light generated by the laser module irradiating the sample, and further to detect whether there is a detection object on the sample.

[0011] Further preferably, a chip card slot is provided on the clip table for limiting and fixing the carrier of the sample, that is, for limiting and fixing the biochip.

[0012] Further preferably, a guide block is provided above the battery compartment, and the clip table is slidably connected to the guide block to support and guide the clip table and ensure the smooth movement of the clip table.

[0013] Further preferably, the upper cover is hinged to the box body to realize the connection between the upper cover and the box body; magnets are provided between the upper cover and the box body to prevent gaps when the upper cover and the box body are closed.

[0014] Further preferably, a charging and data interface and a storage card slot are provided on the box body to realize charging and discharging, data transmission and storage; an antenna and a cover closing detection switch are provided inside the upper cover, and data wireless transmission and interaction are realized through the antenna, and whether the upper cover is closed is detected through the cover closing detection switch.

[0015] Beneficial effects: The micro fluorescence scanner of the present utility model realizes the left and right movement of the clip table through the driving mechanism, and realizes the detection of the sample on the biochip through the scanning mechanism, so as to detect whether the sample contains a detection object; specifically, through the magnetic field interaction between the driving coil and the moving magnet, the moving magnet is driven to move left and right, and then the clip table and the biochip and sample placed thereon are driven to move left and right; the laser module emits laser, the laser irradiates the sample to generate excitation light, and the sensor module collects the excitation light to realize optical image acquisition, and then judges whether there is a detection object on the sample to achieve the purpose of sample detection; the structure of the fluorescence scanner is ingeniously designed, compact, small in size, realizes the miniaturization of the scanner, and has low production cost. Description of the Drawings

[0016] Figure 1 It is an axonometric structure schematic diagram of the micro fluorescence scanner disclosed in the embodiment of the present utility model;

[0017] Figure 2 The front view structural schematic diagram of the micro fluorescence scanner disclosed in the embodiment of the present utility model;

[0018] Figure 3 The internal structural schematic diagram of the micro fluorescence scanner disclosed in the embodiment of the present utility model;

[0019] Figure 4 The structural schematic diagram of the driving mechanism disclosed in the embodiment of the present utility model;

[0020] Figure 5 The working principle schematic diagram of the code scanning mechanism disclosed in the embodiment of the present utility model.

[0021] Reference numerals: 1 - box body, 2 - upper cover, 3 - clip table, 4 - driving mechanism, 41 - installation main body, 42 - track, 43 - installation substrate, 44 - driving coil, 45 - mover magnet, 5 - scanning mechanism, 51 - laser module, 511 - laser head, 512 - beam expander lens, 513 - collimating lens, 514 - aperture, 52 - sensor module, 521 - image sensor, 522 - filter group, 523 - lens group, 6 - touch display screen, 7 - battery compartment, 8 - guide block. Detailed implementation manners

[0022] The following are specific embodiments of the present utility model and in combination with the attached drawings, the technical solutions of the present utility model are further described, but the present utility model is not limited to these embodiments.

[0023] Such as Figures 1-5As shown in the figure, a micro fluorescence scanner is used for detecting samples on a biochip. The structure of the micro fluorescence scanner is compact and small in size, realizing the miniaturization of the fluorescence scanner. The fluorescence scanner includes a box body 1, an upper cover 2 is arranged above the box body 1, a horizontally arranged clip table 3 is arranged inside the box body 1, the clip table 3 is connected with a driving mechanism 4, the driving mechanism 4 is installed on the side wall of the box body 1, a scanning mechanism 5 is arranged above the clip table 3, the scanning mechanism 5 is installed inside the upper cover 2, the scanning mechanism 5 includes a laser module 51 and a sensor module 52, a touch display screen 6 is installed above the upper cover 2, and a battery compartment 7 is arranged below the clip table 3. Among them, the box body 1 and the upper cover 2 form an installation structure for other components, and after being closed, they form a sealed detection cavity for the samples on the biochip; the clip table 3 is used for placing the biochip, facilitating the detection of the samples on the biochip; the driving mechanism 4 is used to drive the clip table 3 to move horizontally left and right, realizing the synchronous left and right movement of the biochip and the samples thereon, ensuring the comprehensive scanning and detection of the samples by the scanning mechanism 5; the scanning mechanism 5 is used for scanning and imaging the samples, exciting the fluorescent substances on the biochip to emit light through the laser module 51, detecting the light emission intensity of the fluorescent substances through the sensor module 52, and forming a detection image of the samples, realizing the detection of whether there are detected substances on the samples. The touch display screen 6 is used for controlling the fluorescence scanner, and the battery compartment 8 is used for placing the battery. By being powered by the battery, it can work without an external power supply, and can still continue to work for a period of time in a power-off state, ensuring the effective detection of the samples.

[0024] In this application, the driving mechanism 4 includes an installation main body 41, the installation main body 41 is fixed on the side wall of the box body 1, a horizontally arranged track 42 is arranged on the installation main body 41, an installation substrate 43 is arranged on both the upper and lower sides of the track 42, both installation substrates 43 are connected with driving coils 44, and a mover magnet 45 is arranged on the track 42. Among them, the installation main body 41 is an aluminum alloy machining part structure for installing various components of the driving mechanism 4; the track 42 is used for guiding the movement of the mover magnet 45, and the two installation substrates 43 are used for installing the driving coils 44. By generating magnetic fields through the upper and lower driving coils 44, these magnetic fields interact with the magnetic field of the mover magnet 45, thereby driving the mover magnet 45 to move left and right, realizing the left and right movement of the clip table 3. Wireless power transmission coils and communication coils are connected to both the installation main body 41 and the mover magnet 45, used for transmitting electric energy and communication to the driving coils 44 and the mover magnet 45, realizing the generation of magnetic fields between the driving coils 44 and the generation of the magnetic field of the mover magnet 45, and then through the interaction between the two magnetic fields, realizing the left and right movement of the mover magnet 45 along the track 42, and further achieving the purpose of driving the clip table 3 to move left and right. This driving mechanism 4 can effectively reduce the volume of the mechanism, and thus reduce the volume of the fluorescence scanner.

[0025] In this application, the laser module 51 includes a laser head 511, a beam expander lens 512, a collimating lens 513, and a diaphragm 514, which are arranged in sequence from top to bottom. The laser head 511 emits laser light, and then the beam expander lens 512 can expand the light spot. Next, it becomes a parallel beam of parallel light through the collimating lens 513. Finally, the size of the light beam is restricted by the diaphragm 514. Among them, the number of laser heads 511 is three. The three laser heads 511 are combined together to increase the number of laser excitations, thereby expanding the irradiation area.

[0026] In this application, the sensor module 52 includes an image sensor 521. A filter group 522 is provided below the image sensor 521, and a lens group 523 is provided below the filter group 522. The filter group 522 includes three filter sheets arranged in sequence from top to bottom. The lens group 523 includes two lenses symmetrically arranged up and down. The lens group 523 can collect the excitation light generated by the fluorescent substance on the sample, and then it is collected by the image sensor 521 after passing through the filter group 522, finally realizing the imaging detection of the sample. Among them, the number of filter groups 522 is multiple, which can effectively prevent the interference of laser light. The lens group 523 is a set of two symmetrically designed lenses, which can diffuse the excitation light and convert it into parallel light, playing a magnifying effect.

[0027] In this application, the beam expander lens 512 can expand the laser light emitted by the laser head 511 into a light spot of 2 mm, and it becomes a parallel beam of parallel 2 mm through the collimating lens 513. After passing through the diaphragm 514, it becomes a light beam of 1 mm x 0.5. After the laser irradiates the sample on the biochip, excitation light will be generated. There is a reflector on the biochip. The laser can pass through the reflector and irradiate downward, while the excitation light is reflected upward under the action of the reflector. The reflected excitation light is collected by the lens group 523, and then irradiates onto the image sensor 521 after passing through the filter group 522. Finally, the image sensor 521 converts the collected optical image into an electrical signal, and finally records and interprets it into an image through the processing chip, and detects whether there is a detected substance on the sample through the image.

[0028] In this application, a chip card slot is provided on the clip table 3 for clamping the biochip to restrict the position of the biochip, thereby restricting the position of the sample and ensuring the detection accuracy of the sample. A biochip sensor and a code scanning module are also provided on the clip table 3. The biochip sensor is used to detect whether a biochip is placed, and the code scanning module is used to scan the QR code on the biochip to identify which detection item the sample detection on the biochip belongs to, facilitating the information collection of the sample.

[0029] In this application, a guide block 8 is provided above the battery compartment 7. The clip table 3 is slidably connected to the guide block 8 to support and guide the clip table 3, ensuring the detection accuracy of the sample. And this structural setting can make the structure of the fluorescence scanner more compact, further achieving the purpose of miniaturization. The upper cover 2 is hinged to the box body 1, and the connection method is simple; magnets are provided between the upper cover 2 and the box body 1 to ensure the sealing effect between the upper cover 2 and the box body 1 during detection and prevent gaps. The box body 1 is provided with a charging and data interface and a storage card slot to connect the power supply, charge the battery in the battery compartment 7, and store information, etc.; an antenna and a lid closing detection switch are provided in the upper cover 2, including a WIFI / Bluetooth antenna and a 4G antenna to achieve information interaction; the lid closing detection switch is used to detect whether the upper cover 2 and the box body 1 are closed.

[0030] In this application, the structure of the fluorescence scanner is designed compactly. Through the close cooperation of various mechanisms and components, the purpose of miniaturizing the equipment is achieved, effectively solving the problem of the large size of the scanner, while reducing the equipment cost and facilitating transportation.

[0031] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A micro fluorescent film scanner, comprising a housing (1), an upper cover (2) being arranged above the housing (1), characterized in that: A horizontally arranged film clamping platform (3) is provided in the box body (1), the film clamping platform (3) is connected to a driving mechanism (4), the driving mechanism (4) is installed on the side wall of the box body (1), a scanning mechanism (5) is provided above the film clamping platform (3), the scanning mechanism (5) is installed in the upper cover (2), the scanning mechanism (5) comprises a laser module (51) and a sensor module (52), a touch screen (6) is installed above the upper cover (2), and a battery compartment (7) is provided below the film clamping platform (3).

2. A micro fluorescent film scanner according to claim 1, characterized in that: The driving mechanism (4) comprises a mounting body (41), the mounting body (41) being fixed on the side wall of the box body (1), the mounting body (41) being provided with a horizontally arranged track (42), a mounting substrate (43) being provided on both upper and lower sides of the track (42), the two mounting substrates (43) being connected with a driving coil (44), and a mover magnet (45) being provided on the track (42).

3. A micro fluorescent film scanner according to claim 2, characterized in that: The installation body (41) and the mover magnet (45) are both connected to a wireless power transmission coil and a communication coil.

4. The micro fluorescent film scanner according to claim 1, characterized in that: The laser module (51) comprises a laser head (511), a beam expander lens (512), a collimator lens (513) and an aperture (514) which are arranged in sequence up and down.

5. The micro fluorescent film scanner according to claim 4, characterized in that: The number of the laser heads (511) is three.

6. The micro fluorescent film scanner according to claim 1, characterized in that: The sensor module (52) comprises an image sensor (521), a filter group (522) is arranged below the image sensor (521), a lens group (523) is arranged below the filter group (522), the filter group (522) comprises three filters arranged in sequence up and down, and the lens group (523) comprises two lenses arranged symmetrically up and down.

7. The micro fluorescent film scanner according to claim 1, characterized in that: The chip clamping platform (3) is provided with a chip card slot.

8. The micro fluorescent film scanner according to claim 1, characterized in that: A guide block (8) is provided above the battery compartment (7), and the clip platform (3) is slidably connected to the guide block (8).

9. The micro fluorescent film scanner according to claim 1, characterized in that: The upper cover (2) is hinged to the box body (1), and magnets are provided between the upper cover (2) and the box body (1).

10. The micro fluorescent film scanner according to claim 1, characterized in that: The box body (1) is provided with a charging and data interface and a storage card slot, and the upper cover (2) is provided with an antenna and a cover closing detection switch.

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