Fixing device suitable for multi-size mouse light aging model

Abstract

The utility model relates to a fixing device suitable for multi-size mouse light aging models, which comprises a front base, a rear base, a hole plate and a fixing seat, the front base is connected with the rear base through a telescopic component, the hole plate is arranged at the upper end of the front base, and the fixing seat is arranged at the upper end of the rear base; the neck and the tail of the mouse are fixed, the mouse does not need to be narcotized, the mouse is suitable for mice of different sizes, the mouse is not prone to bending down and struggling off, the back of the mouse can be completely exposed to ultraviolet light and evenly illuminated, experiment interference factors are reduced, meanwhile, life safety of the mouse in the whole experiment process can be guaranteed, and the mouse is convenient to use. And the experiment result is more accurate.

Description

Technical Field

[0001] The utility model relates to the field of medical experimental equipment, in particular to a fixing device suitable for multi-size mouse photoaging models. Background Art

[0002] Skin photoaging caused by long-term ultraviolet exposure is currently a hot topic in the research of skin beauty science. Since experiments directly on human skin are restricted by ethics and experimental cycles, animal models are basic tools for studying the molecular mechanism of skin photoaging and evaluating the functionality of anti-wrinkle products. There are several requirements for establishing animal models: First, the establishment of a chronic radiation model requires a certain dose of ultraviolet radiation every day for several consecutive days. In addition, to ensure successful modeling, it is necessary to ensure that the amount of radiation received by the back of the mouse each time meets certain requirements. Therefore, the movement of the mouse should be minimized during the irradiation process, and the mice should be prevented from standing and contacting each other. In addition, long-term high-dose ultraviolet radiation can cause serious damage to the vision of mice or even blindness, seriously affecting the normal physiological activities of mice and affecting the experimental results. The Chinese patent with publication number CN113616372A discloses a fixator for constructing a mouse photoaging model, which can fix the mouse's chest to avoid the influence of the mouse's free movement, standing, etc. on the radiation dose received. However, it has the following defects: (1) Since mice have strong backward force and their bodies are relatively soft, fixing the mouse's chest can easily cause the mouse to break free. If the fixation is too tight, the mouse's sternum will be suppressed, which may cause the risk of suffocation. (2) Different mice have different body lengths, and the distance between the structure for fixing the mouse's chest and the structure for accommodating the mouse's head is fixed, which cannot be applied to mice of any size. If the mouse is too long or too short, it cannot ensure that the mouse's head is not exposed while being fixed to the mouse's chest. It is easy to cause the mouse to arch its body, resulting in uneven irradiation of the mouse's back, affecting the experimental results. (3) When fixing the mouse's chest, part of the mouse's back will be covered. The mouse's back area is small, and the covered part cannot be illuminated, which will also affect the experimental results. Utility Model Content

[0003] In view of the problems existing in the prior art, the utility model proposes a fixing device suitable for a photoaging model of mice of multiple sizes. The neck and tail of the mouse are fixed without anesthesia of the mouse. The device is suitable for mice of different sizes. The mouse is not easy to bend over or break free. The back can be fully exposed to ultraviolet light and receive light evenly. While reducing experimental interference factors, the life safety of the mouse in the entire experimental process can be guaranteed, making the experimental results more accurate.

[0004] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0005] The present utility model provides a fixing device applicable to multi-size mouse photoaging models, which includes a front base, a rear base, a hole plate and a fixing seat. The front base and the rear base are connected by a telescopic component. The hole plate is arranged at the upper end of the front base, and the fixing seat is arranged at the upper end of the rear base.

[0006] Preferably, the telescopic component includes a first connecting piece and a second connecting piece matching with it. The first connecting piece is fixedly connected with the front base, the second connecting piece is fixedly connected with the rear base, and the first connecting piece and the second connecting piece are slidably inserted.

[0007] Preferably, the first connecting piece is a chute. The chute opening is fixedly connected with the lower end of the front base. The second connecting piece is a sliding rod. One end of the sliding rod is fixedly connected with the lower end of the rear base, and the other end is inserted into the chute. A fastening screw is arranged on the side wall of the chute near the rear base, and the end of the fastening screw away from the nut abuts against the sliding rod.

[0008] Preferably, the first connecting piece is a sleeve, and the second connecting piece is a sliding rod. The sleeve is fixedly connected with the lower end of the front base. One end of the sliding rod is fixedly connected with the lower end of the rear base, and the other end is inserted into the sleeve. A fastening screw is arranged on the side wall of the sleeve near the rear base, and the end of the fastening screw away from the nut abuts against the sliding rod.

[0009] Preferably, the fixing seat includes a first fixing piece and a second fixing piece. The first fixing piece is arranged at the upper end of the rear base, the second fixing piece is arranged at the upper end of the first fixing piece, and both ends of the first fixing piece and the second fixing piece are fixedly connected with the rear base through bolts.

[0010] Preferably, both the first fixing piece and the second fixing piece are rubber sheets.

[0011] Preferably, the fixing device further includes a neck ring, and the neck ring is embedded in the hole of the hole plate.

[0012] Preferably, a cloth light-shielding cover is also sleeved on the large-mouth end of the neck ring.

[0013] Preferably, the sleeve opening of the cloth light-shielding cover is provided with elasticity.

[0014] Preferably, the connection part of the neck ring is connected by a hook-and-loop fastener cloth.

[0015] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0016] (1) During the experiment of the present utility model, the neck and tail of the mouse are fixed, so that the entire back of the mouse is exposed to light. Due to the special structure of the relatively hard tail of the mouse, the rubber fixing seat is used to fix the tail of the mouse, which will neither cause necrosis of the mouse tail nor can firmly fix the mouse. The mouse is not easy to break free or bend its body, making the experimental results more accurate.

[0017] (2) The hole plate for fixing the mouse's neck of the present utility model is arranged at the upper end of the front base, and the fixing seat for fixing the mouse's tail is arranged at the upper end of the rear base. The front base and the rear base are connected by a telescopic component. By changing the length of the telescopic component, it can be applied to the photoaging tests of mice with different lengths.

[0018] (3) The neck ring of the present utility model is embedded in the hole of the hole plate. During the experiment, the mouse's head is stuck in the neck ring, which can protect the mouse's neck from injury. The neck ring can be adjusted according to the neck circumference of different mice. A cloth light-shielding cover is put on the large-mouth end of the neck ring, which can protect the mouse's eyes from ultraviolet light damage caused by diffuse reflection (because most of the direct light has been blocked by the neck ring, and the purpose of the cloth light-shielding cover is to reduce light leakage and diffuse reflection damage). At the same time, the dark environment can promote the mouse to calm down, which is helpful for the accuracy of the experimental results. Description of the Drawings

[0019] Figure 1 is a schematic structural diagram of the present utility model;

[0020] Figure 2 is a schematic structural diagram of the present utility model during use;

[0021] Figure 3 is an unfolded schematic structural diagram of the neck ring of the present utility model;

[0022] Reference numerals: 1, front base; 2, rear base; 3, hole plate; 4, fixing seat; 401, first fixing piece; 402, second fixing piece; 5, telescopic component; 501, first connecting piece; 502, second connecting piece; 6, neck ring; 7, cloth light-shielding cover. Detailed Embodiments

[0023] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0024] Refer to Figure 1 and Figure 2 , the present utility model provides a fixing device applicable to a photoaging model of mice with multiple sizes, including a front base 1, a rear base 2, a hole plate 3 and a fixing seat 4. The front base 1 and the rear base 2 are connected by a telescopic component 5. The hole plate 3 is arranged at the upper end of the front base 1, and the fixing seat 4 is arranged at the upper end of the rear base 2.

[0025] In this embodiment, the perforated plate 3 is used to hold the neck of the mouse, and the fixing base 4 is used to fix the tail of the mouse. During the fixing process, the distance between the perforated plate 3 and the fixing base 4 is adjusted by adjusting the length of the telescopic component 5 to suit mice of different lengths, so that the entire back of the mouse is exposed to light, and the mouse is not likely to break free or bend its body, making the experimental results more accurate. When fixing the mouse, the mouse is fed into the perforated plate 3 starting from the tail until the perforated plate 3 holds the neck of the mouse, and the tail of the mouse is fixed with the fixing base 4. The length of the telescopic component 5 is adjusted until the body of the mouse is in a natural extended length. After adjustment, the telescopic component 5 is fixed so that its length will not change randomly.

[0026] Reference Figure 1 Furthermore, it is characterized in that the telescopic component 5 includes a first connecting piece 501 and a second connecting piece 502 that matches it. The first connecting piece 501 is fixedly connected to the front base 1, the second connecting piece 502 is fixedly connected to the rear base 2, and the first connecting piece 501 and the second connecting piece 502 are slidably inserted.

[0027] In this embodiment, the first connecting piece 501 and the second connecting piece 502 are slidably inserted. The overall length of the telescopic component 5 can be adjusted by pushing and pulling, and thus the distance between the perforated plate 3 and the fixing base 4 can be changed. The first connecting piece 501 can be a chute or a sleeve, and the second connecting piece 502 is a sliding rod. The first connecting piece 501 is fixedly arranged at the lower end of the front base 1. One end of the second connecting piece 502 is fixedly connected to the rear base 2, and the other end is inserted into the first connecting piece 501. A fastening screw is arranged on the side wall of the first connecting piece 501 close to the rear base 2 for fixing the relative positions of the first connecting piece 501 and the second connecting piece 502 so that they will not slide relative to each other randomly, ensuring the stability of the fixing device.

[0028] Furthermore, the fixing base 4 includes a first fixing piece 401 and a second fixing piece 402. Both the first fixing piece 401 and the second fixing piece 402 are preferably rubber pieces. The first fixing piece 401 is arranged at the upper end of the rear base 2, the second fixing piece 402 is arranged at the upper end of the first fixing piece 401, and both ends of the first fixing piece 401 and the second fixing piece 402 are fixedly connected to the rear base 2 through bolts.

[0029] In this embodiment, both the first fixing piece 401 and the second fixing piece 402 are preferably rubber pieces. When fixing the tail of the mouse, the tail of the mouse is clamped by the first fixing piece 401 and the second fixing piece 402. Both ends of the first fixing piece 401 and the second fixing piece 402 are fixedly connected to the rear base 2 through bolts. Since the tail of the mouse is relatively hard, the tail of the mouse is clamped by two elastic rubber pieces, which will neither harm the tail of the mouse nor increase the friction force on the tail of the mouse, making it impossible for the mouse to break free.

[0030] ReferenceFigure 2 and Figure 3 Further, the fixing device further includes a neck ring 6 which is embedded in the hole of the hole plate 3. The large-mouth end of the neck ring 6 is located on the side of the hole plate 3 away from the fixing base. A cloth light-shielding cover 7 is also sleeved on the large-mouth end of the neck ring 6.

[0031] In this embodiment, the neck ring is embedded in the hole plate 3. The hole plate 3 clamps the neck of the mouse through the neck ring 6. The neck of the mouse will be clamped at the small-mouth end of the neck ring 6, and the head of the mouse is located inside the neck ring 6. The connection part of the neck ring 6 is connected by a velcro cloth, and the size of the two ports can be adjusted according to the thickness of the necks of different mice. A cloth light-shielding cover 7 is sleeved on the large-mouth end of the neck ring 6, so that the eyes of the mouse are in a dark environment and the breathing of the mouse is not affected. On the one hand, it can protect the eyes of the mouse from light damage. On the other hand, the mouse in the dark environment helps the mouse to calm down. To facilitate the putting on and taking off of the cloth light-shielding cover 7, the mouth of the cloth light-shielding cover 7 can be provided with elasticity. Before fixing the mouse, first put the neck ring 6 on the head of the mouse, so that the neck of the mouse is clamped at the small-mouth end of the neck ring 6, and then send the mouse into the hole plate 3 from the tail until the neck ring 6 is clamped by the hole plate 3, and then fix the tail of the mouse.

[0032] The foregoing has shown and described the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and the descriptions in the specification only illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and all these changes and improvements fall within the scope of the present invention claimed.

Claims

1. A fixing device suitable for a multi-size mouse photoaging model, characterized in that: The invention comprises a front base (1), a rear base (2), a hole plate (3), a fixing seat (4) and a neck ring (6); the front base (1) and the rear base (2) are connected via a telescopic assembly (5); the hole plate (3) is arranged at the upper end of the front base (1); and the fixing seat (4) is arranged at the upper end of the rear base (2); the fixing seat (4) comprises a first fixing plate (401) and a second fixing plate (402); the first fixing plate (401) is arranged at the upper end of the rear base (2); and the second fixing plate (402) is arranged at the upper end of the first fixing plate (401); and the two ends of the first fixing plate (401) and the second fixing plate (402) are respectively fixedly connected to the rear base (2) via bolts; and the neck ring (6) is embedded in the hole of the hole plate (3).

2. A fixing device suitable for a multi-size mouse photoaging model according to claim 1, characterized in that: The telescopic assembly (5) comprises a first connecting member (501) and a second connecting member (502) matched therewith, wherein the first connecting member (501) is fixedly connected to the front base (1), the second connecting member (502) is fixedly connected to the rear base (2), and the first connecting member (501) and the second connecting member (502) are slidably plugged into each other.

3. A fixing device suitable for a multi-size mouse photoaging model according to claim 2, characterized in that: The first connecting member (501) is a slide groove, and the groove opening is fixedly connected to the lower end of the front base. The second connecting member (502) is a sliding rod, and one end of the sliding rod is fixedly connected to the lower end of the rear base, and the other end is inserted into the slide groove. A fastening screw is provided on the side wall of the slide groove close to one end of the rear base, and the fastening screw is pressed against the slide rod at one end away from the nut.

4. The fixing device suitable for a multi-size mouse photoaging model according to claim 2, characterized in that: The first connecting member (501) is a sleeve, and the second connecting member (502) is a sliding rod. The sleeve is fixedly connected to the lower end of the front base, one end of the sliding rod is fixedly connected to the lower end of the rear base, and the other end is inserted into the sleeve. A fastening screw is provided on the side wall of the sleeve close to one end of the rear base, and the fastening screw is pressed against the sliding rod at one end away from the nut.

5. The fixing device suitable for a multi-size mouse photoaging model according to claim 1, characterized in that: The first fixing sheet (401) and the second fixing sheet (402) are both rubber sheets.

6. The fixing device suitable for a multi-size mouse photoaging model according to claim 1, characterized in that: The large mouth end of the neck ring (6) is also covered with a cloth light shield (7).

7. The fixing device suitable for a multi-size mouse photoaging model according to claim 6, characterized in that: The opening of the cloth light shield (7) is elastic.

8. The fixing device suitable for a multi-size mouse photoaging model according to claim 1, characterized in that: The connection of the neck ring (6) is connected by means of Velcro.

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