Desalting device and chromatographic detection combination instrument

Abstract

The utility model relates to a desalting device and a chromatographic detection combination instrument, the desalting device comprises a desalting assembly, a first conductivity detection piece and a second conductivity detection piece, and the desalting assembly is used for desalting a separation flow obtained by separation of a chromatographic device. In the flow direction of the separated flow, the second conductivity detection piece and the first conductivity detection piece are respectively arranged at the upstream and downstream of the desalting assembly and are respectively used for detecting the conductivity of the separated flow before and after desalting. According to the desalting device, the conductivity of the separated flow can be detected through the first conductivity detection piece, the desalting degree of the separated flow is further reflected through the conductivity, whether the desalted separated flow meets the detection requirement or not is helped to be judged as a sample introduction condition, and the probability that the separated flow pollutes the detector is helped to be reduced. Besides, the desalting device can also be combined with the conductivity detected by the first conductivity detection piece and the second conductivity detection piece to obtain the difference value of the conductivity before and after the separation flow is desalted, so that the desalting effect of the desalting assembly can be known more accurately, and the desalting efficiency can be improved.

Description

Technical Field

[0001] The present application relates to the technical field of analytical detection, and particularly relates to a desalting device and a chromatographic detection combined instrument. Background Art

[0002] Chromatography is a high-performance physical separation technology. A chromatograph can use chromatography to separate a complex mixture sample to obtain a separated stream, and the separated stream can be injected into a detector such as a mass spectrometer for qualitative and quantitative analysis of the separated stream.

[0003] In related technologies, it often occurs that the chromatography uses a salt-containing mobile phase such as phosphate, etc., and some detectors such as mass spectrometers and charged aerosol detectors are incompatible with non-volatile salts. This requires the removal of salts in the separated stream, that is, desalting. However, desalting requires a process, and it is not possible to effectively remove salts immediately after starting desalting. If the separated stream obtained is connected to the detector before the salt content has reached the standard, it will inevitably contaminate the detector and affect its normal operation. Summary of the Utility Model

[0004] Based on this, it is necessary to provide a desalting device and a chromatographic detection combined instrument that can reduce the probability of contamination of the detector by the separated stream for the above problems.

[0005] A desalting device includes:

[0006] A desalting component for desalting the separated stream separated by a chromatographic device; and

[0007] A first conductivity detection component. In the flow direction of the separated stream, the first conductivity detection component is disposed downstream of the desalting component and is used to detect the conductivity of the separated stream after desalting by the desalting component.

[0008] In one embodiment, the desalting device further includes a control valve. In the flow direction of the separated stream, the control valve is disposed downstream of the first conductivity detection component and has a detected liquid outlet, and the control valve is configured to be able to close the detected liquid outlet.

[0009] In one embodiment, the control valve is a first switching valve and further has a first liquid inlet and a waste liquid outlet. The separated stream can flow into the first switching valve from the first liquid inlet, and the detected liquid outlet and the waste liquid outlet are configured to be able to selectively communicate with the first liquid inlet.

[0010] In one embodiment, the desalting device further includes a second conductivity detection component. In the flow direction of the separated stream, the second conductivity detection component is disposed upstream of the desalting component and is used to detect the conductivity of the separated stream before desalting by the desalting component.

[0011] In one embodiment, the desalting component includes an anion suppressor and a cation suppressor. The anion suppressor and the cation suppressor are connected in series, and the separation flow passes through both of them in sequence.

[0012] In one embodiment, the desalting device further includes a second switching valve and a bypass pipeline. The second switching valve is arranged between the second conductivity detector and the desalting component, and has a second liquid inlet, a first liquid outlet, and a second liquid outlet. The second liquid inlet is communicated with the second conductivity detector, the first liquid outlet is communicated with the desalting component, the second liquid outlet is communicated with one end of the bypass pipeline, the other end of the bypass pipeline is communicated with the first conductivity detector, and the first liquid outlet and the second liquid outlet can alternatively be communicated with the second liquid inlet.

[0013] In one embodiment, the desalting device further includes a third switching valve. The third switching valve is arranged between the cation suppressor and the anion suppressor, and has a first interface, a second interface, and a third interface. The first interface is communicated with the cation suppressor, the second interface is communicated with the anion suppressor, the third interface is communicated between the two ends of the bypass pipeline, and the third switching valve is configured to selectively communicate two of the first interface, the second interface, and the third interface.

[0014] In one embodiment, the desalting component further includes a liquid supply device. The liquid supply device is communicated with the anion suppressor and the cation suppressor, and is used for supplying a regeneration liquid to both of them.

[0015] A chromatographic detection combined instrument includes a chromatographic device, a detector, and the above-mentioned desalting device. The chromatographic device, the desalting device, and the detector are arranged in sequence, and the separation flow separated by the chromatographic device can reach the detector through the desalting device.

[0016] In one embodiment, the chromatographic detection combined instrument further includes a detection input pipe. One end of the detection input pipe is connected to the desalting device, and the other end is detachably connected to the detector.

[0017] The above desalination device and chromatographic detection combined instrument can detect the conductivity of the separation flow through the first conductivity detection component, and then reflect the desalination degree of the separation flow through the conductivity, helping to judge whether the separation flow meets the detection requirements after desalination, and using this as the injection condition for the separation flow output by the chromatographic device to inject into the detector, helping to reduce the probability of contaminating the detector by the separation flow. In addition, the desalination device can also combine the conductivities detected by the first conductivity detection component and the second conductivity detection component to obtain the difference in conductivity of the separation flow before and after desalination, and more accurately know the desalination effect of the desalination component to help improve the desalination efficiency. Brief Description of the Drawings

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0019] Figure 1 It is a schematic structural diagram of a chromatographic detection combined instrument with a desalination device in an embodiment of the present application.

[0020] Figure 2 It is a schematic structural diagram of a chromatographic detection combined instrument with a desalination device in another embodiment of the present application.

[0021] Figure 3 It is a schematic structural diagram of a chromatographic detection combined instrument with a desalination device in yet another embodiment of the present application.

[0022] Description of the reference numerals: 100, desalination device; 11, anion suppressor; 13, cation suppressor; 15, liquid supply device; 17, power supply device; 30, first conductivity detection component; 50, control valve; 70, second conductivity detection component; 200, chromatographic detection combined instrument; 201, chromatographic device; 203, detector; 91, second switching valve; 92, bypass pipeline; 93, third switching valve; 95, ion activity detection component. Detailed Description of the Embodiments

[0023] In order to make the above objects, features, and advantages of the present application more obvious and understandable, the following will make a detailed description of the specific embodiments of the present application with reference to the drawings. Many specific details are set forth in the following description in order to fully understand the present application. However, the present application can be implemented in many other ways different from those described herein. Those skilled in the art can make similar improvements without departing from the connotation of the present application. Therefore, the present application is not limited by the specific embodiments disclosed below.

[0024] In the description of the present application, it should be understood that if there are terms such as "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., the orientation or positional relationship indicated by these terms is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation to the present application.

[0025] In addition, if there is a term "and / or", "and / or" is only a description of the relationship between associated objects and indicates that there can be three relationships. For example, A and / or B can represent the relationship between A and B: A exists alone, A and B exist simultaneously, and B exists alone. In addition, the character " / " in this article generally indicates that the relationship between the associated objects before and after it is an "or" relationship. If there are terms such as "first" and "second", these terms are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In the description of the present application, if there is a term "plurality", the meaning of "plurality" is at least two, such as two, three, four, five, etc., unless otherwise specifically defined.

[0026] In the present application, unless otherwise clearly specified and limited, if there are terms such as "install", "connect", "join", "fix", etc., these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the connection inside two elements or the interaction relationship between two elements, unless otherwise clearly limited. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0027] In this application, unless otherwise clearly specified and defined, if there is a description such as a first feature being "on" or "under" a second feature, its meaning can be that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature can be that the first feature is directly above or obliquely above the second feature, or simply means that the horizontal height of the first feature is higher than that of the second feature. The first feature being "under", "beneath" and "underneath" the second feature can be that the first feature is directly below or obliquely below the second feature, or simply means that the horizontal height of the first feature is less than that of the second feature.

[0028] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or there can also be an intermediate element. If an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. If present, the terms "vertical", "horizontal", "up", "down", "left", "right" and similar expressions used in this application are only for the purpose of illustration and do not represent the only implementation.

[0029] Please refer to Figure 1 , a desalting device 100 provided by an embodiment of the present application includes a desalting component and a first conductivity detector 30. The desalting component is used to desalt the separated flow obtained by separating the chromatographic device 201. In the flow direction of the separated flow, the first conductivity detector 30 is disposed downstream of the desalting component and is used to detect the conductivity of the separated flow after desalting by the desalting component.

[0030] The desalting device 100 can be disposed downstream of the chromatographic device 201. Its desalting component is connected and communicated with the chromatographic device 201 to receive the separated flow obtained by separating the chromatographic device 201. The desalting scheme adopted by the desalting component can be, but is not limited to, ion chromatography, two-dimensional switching method, electrodialysis method, reverse osmosis method, etc., as long as it can effectively remove the salt ions in the separated flow sample output by the chromatographic device 201 to achieve the desalting effect, and no specific limitation is made here.

[0031] The first conductivity detector 30 is located downstream of the desalting component. The separated flow after desalting by the desalting component needs to flow to the first conductivity detector 30 and be detected by it. It is known that the relationship between the conductivity of a solution and the ion concentration is positively correlated, that is, the higher the ion concentration, the greater the conductivity. Therefore, the conductivity detected by the first conductivity detector 30 can reflect the ion concentration situation of the separated flow after desalting.

[0032] Taking the example of the desalination component using electro-deionization, the electro-deionization method is actually a dynamic equilibrium of electrodialysis. It is not the case that when the current is turned on, the conductivity of the separated flow output by the desalination component will immediately decrease. Instead, it requires a balance time of more than ten minutes. If the solution is connected to the detector 203 during this period, it will inevitably contaminate the detector 203. Therefore, adding a first conductivity detector 30 for detecting the conductivity of the detection solution downstream of the desalination component can detect the conductivity of the separated flow flowing out of the desalination component in real time, so as to observe whether the salt in the separated flow is removed completely. According to the magnitude of the conductivity, it can be judged whether the current mobile phase can be connected to detectors 203 such as the detector 203 that cannot use volatile salt solutions.

[0033] The above-mentioned desalination device 100 can detect the conductivity of the separated flow through the first conductivity detector 30, and then reflect the desalination degree of the separated flow through the conductivity, helping to judge whether the desalination of the separated flow meets the detection requirements after desalination, and using this as the injection condition for the separated flow output by the chromatographic device 201 to be injected into the detector 203, helping to reduce the probability of the separated flow contaminating the detector 203.

[0034] In some embodiments, the desalination device 100 further includes a control valve 50. In the flow direction of the separated flow, the control valve 50 is arranged downstream of the first conductivity detector 30 and has a detection liquid outlet. The control valve 50 is configured to be able to close the detection liquid outlet.

[0035] It can be understood that the detection liquid outlet of the control valve 50 is used to be connected and communicated with the injection port of the detector 203. When the control valve 50 opens the detection liquid outlet, the separated flow after desalination by the desalination component can flow through the detection liquid outlet of the control valve 50 to the detector 203. When the control valve 50 closes the detection liquid outlet, the separated flow after desalination by the desalination component is blocked by the control valve 50 and cannot enter the detector 203.

[0036] In this way, the control valve 50 can control whether the separated flow after desalination by the desalination component can enter the detector 203, so as to disconnect the desalination component from the detector 203 when necessary to protect the detector 203 from contamination.

[0037] Furthermore, the control valve 50 is a first switching valve and also has a first liquid inlet and a waste liquid outlet. The separated flow can flow into the first switching valve from the first liquid inlet. The detection liquid outlet and the waste liquid outlet are configured to be able to selectively communicate with the first liquid inlet.

[0038] Specifically, the first switching valve can be a three-way valve, and can be a two-position three-way valve, or can also be a two-position six-way valve or other valves with the same or similar functions. The first switching valve can switch the liquid outlet communicating with the first liquid inlet between the detection liquid outlet and the waste liquid outlet. The first liquid inlet is communicated with the desalting component, and the first conductivity detector 30 is located between the first switching valve and the desalting component. The detection liquid outlet can be communicated with a downstream detector 203 such as a mass spectrometer, and the waste liquid outlet is communicated with a waste liquid bucket, a sewer, etc.

[0039] It can be understood that, except during the switching process, at the same moment, only one of the detection liquid outlet and the waste liquid outlet can be communicated with the first liquid inlet for liquid discharge. When the first liquid inlet is communicated with the detection liquid outlet, the waste liquid outlet is closed. When the first liquid inlet is communicated with the waste liquid outlet, the detection liquid outlet is closed. In other words, the separated flow desalted by the desalting component flows into the first switching valve from the first liquid inlet. When the conductivity measured by the first conductivity detector 30 is not greater than the set value, the first liquid inlet is communicated with the detection liquid outlet, and the separated flow flows into the detector 203 from the detection liquid outlet for detection. When the conductivity measured by the first conductivity detector 30 is greater than the set value, the first liquid inlet is communicated with the waste liquid outlet, and the separated flow is discharged from the waste liquid outlet.

[0040] In this way, the first switching valve can, by changing the liquid outlet communicated with the first liquid inlet, sample the separated flow to the detector 203 as a sample as needed or discharge it as waste liquid.

[0041] In some embodiments, the desalting component includes an anion suppressor 11 and a cation suppressor 13. The anion suppressor 11 and the cation suppressor 13 are connected in series, and the separated flow flows through both of them in sequence.

[0042] In this way, the desalting component uses the method of electro-de-salting, enabling the separated flow to flow through the anion suppressor 11 and the cation suppressor 13 in sequence, and fully removing cations and anions.

[0043] Furthermore, the desalting component further includes a liquid supply device 15. The liquid supply device 15 is communicated with the anion suppressor 11 and the cation suppressor 13, and is used to provide a regeneration liquid to both of them. Specifically, the regeneration liquid is pure water.

[0044] In this way, the liquid supply device 15 can help the anion suppressor 11 and the cation suppressor 13 maintain the ability to work continuously. Using pure water as the regeneration liquid can more efficiently carry away the cations and anions separated by the anion suppressor 11 and the cation suppressor 13.

[0045] Further, the desalination device 100 further includes a controller (not shown in the figure). The desalination assembly further includes a power supply device 17. The power supply device 17 is electrically connected to the anion suppressor 11 and the cation suppressor 13, and the liquid supply device 15, the power supply device 17, and the first conductivity detector 30 are all electrically connected to the controller. In addition, the first switching valve can also be electrically connected to the controller.

[0046] Among them, the power supply device 17 is used to supply power to the anion suppressor 11 and the cation suppressor 13. Specifically, it may include a power part and an electronic control part, and the electronic control part can control the magnitude of the current and voltage supplied to the anion suppressor 11 and the cation suppressor 13.

[0047] The controller can receive and process the detection data of the first conductivity detector 30 through the electrical connection relationship, and based on this detection data, control the magnitude of the current and voltage output by the power supply device 17, as well as the on-off situation of the control valve 50.

[0048] It can be understood that the controller can be, but is not limited to, a single-chip microcomputer, a mobile terminal or a host computer such as a computer, and a control program can be preset. The electrical connection is the way for the controller to realize data transmission between it and the connection target, which can be either a wired method or a wireless method.

[0049] In this way, the controller can make the working process of the desalination device 100 proceed in a more automated manner, which helps to improve the automation degree of the device.

[0050] Please also refer to Figure 2 , in some embodiments, the desalination device 100 further includes a second conductivity detector 70. In the flow direction of the separation flow, the second conductivity detector 70 is arranged upstream of the desalination assembly and is used to detect the conductivity of the separation flow before desalination by the desalination assembly.

[0051] It can be understood that the second conductivity detector 70 is located upstream of the desalination assembly. The separation flow flowing into the desalination assembly first flows through the second conductivity detector 70 and is detected by it. Therefore, the conductivity detected by the second conductivity detector 70 can reflect the ion concentration situation of the separation flow before desalination. The second conductivity detector 70 can also be electrically connected to the controller.

[0052] In this way, the desalination device 100 can control the working intensity of the desalination assembly according to the conductivity detected by the second conductivity detector 70. At the same time, by combining the conductivity detected by the first conductivity detector 30, the difference in conductivity of the separation flow before and after desalination can be obtained, and the desalination effect of the desalination assembly can be more accurately known, and based on this, the flow rate of the regeneration liquid provided by the liquid supply device 15 and / or the magnitude of the current and voltage output by the power supply device 17 can be adjusted to help improve the desalination efficiency.

[0053] Further, the first conductivity detection member 30 and / or the second conductivity detection member 70 is a conductivity cell.

[0054] Specifically, both between the desalting assembly and the chromatograph device 201 and between the desalting assembly and the control valve 50 are connected and communicated through liquid pipelines. The first conductivity detection member 30 is disposed on the liquid pipeline between the desalting assembly and the control valve 50, and the second conductivity detection member 70 is disposed on the liquid pipeline between the desalting assembly and the chromatograph device 201.

[0055] In this way, the conductivity cell has a small volume and a simple structure, and can be well applied to the liquid pipeline to detect the conductivity of the separation flow flowing through the liquid pipeline.

[0056] It can be understood that in some other embodiments, the first conductivity detection member 30 and / or the second conductivity detection member 70 may also be a conductivity analyzer, etc., and is connected to the liquid pipeline through a detection head, as long as it can detect the conductivity of the separation flow, and no specific limitation is made here.

[0057] Please refer to Figure 3 simultaneously. In some embodiments, the desalting device 100 further includes a second switching valve 91 and a bypass pipeline 92. The second switching valve 91 is disposed between the second conductivity detection member 70 and the desalting assembly, and has a second liquid inlet, a first liquid outlet, and a second liquid outlet. The second liquid inlet is communicated with the second conductivity detection member 70, the first liquid outlet is communicated with the desalting assembly, the second liquid outlet is communicated with one end of the bypass pipeline 92, the other end of the bypass pipeline 92 is communicated with the first conductivity detection member 30, and the first liquid outlet and the second liquid outlet can selectively communicate with the second liquid inlet.

[0058] It can be understood that the second switching valve 91 can be disposed on the liquid pipeline connecting the second conductivity detection member 70 and the desalting assembly. One end of the bypass pipeline 92 in its longitudinal direction is communicated with the second liquid outlet, and the other end is connected to the liquid pipeline connecting the desalting assembly and the first conductivity detection member 30, downstream of the desalting assembly and upstream of the first conductivity detection member 30.

[0059] After the separation flow is detected by the second conductivity detection member 70, it can flow into the second switching valve 91 from the second liquid inlet. When the first liquid outlet communicates with the second liquid inlet, the separation flow flows through the first liquid outlet to the desalting assembly, and after desalting, flows to the second conductivity detection member 70. When the second liquid outlet communicates with the second liquid inlet, the separation flow bypasses the desalting assembly through the second liquid outlet and the bypass pipeline 92 and directly flows to the second conductivity detection member 70.

[0060] In this way, if it is found that the separation flow does not need to be desalted according to the detection of the second conductivity detection member 70, it can directly bypass the desalting assembly through the bypass pipeline.

[0061] Further, the desalination device 100 further includes a third switching valve 93. The third switching valve 93 is disposed between the cation suppressor 13 and the anion suppressor 11, and has a first interface, a second interface, and a third interface. The first interface is communicated with the cation suppressor 13, the second interface is communicated with the anion suppressor 11, and the third interface is communicated between both ends of the bypass pipeline 92. The third switching valve 93 is configured to selectively communicate two of the first interface, the second interface, and the third interface.

[0062] It can be understood that the cation suppressor 13 and the anion suppressor 11 can be connected in series in a liquid pipeline manner with the cation suppressor 13 upstream and the anion suppressor 11 downstream. The third switching valve 93 can be disposed on the liquid pipeline connecting the cation suppressor 13 and the anion suppressor 11, and its third interface is connected and communicated with the bypass pipeline 92 through a liquid pipeline.

[0063] Any two of the first interface, the second interface, and the third interface of the third switching valve 93 can be communicated. When two of them are communicated, the remaining one is closed. Specifically, both the second switching valve 91 and the third switching valve 93 can be three-way valves, and can be two-position three-way valves, or can also be valves with the same or similar functions such as two-position six-way valves.

[0064] In summary, the desalination device 100 includes four states: State 1, the second liquid outlet is communicated with the second liquid inlet and the first interface is communicated with the second interface, and the separated flow bypasses the desalination component through the second liquid outlet and the bypass pipeline 92 and directly flows to the second conductivity detector 70; State 2, the first liquid outlet is communicated with the second liquid inlet and the first interface is communicated with the second interface, and the separated flow flows through the cation suppressor 13 for desalination and then flows to the anion suppressor 11 through the third switching valve 93; State 3, the first liquid outlet is communicated with the second liquid inlet and the first interface is communicated with the third interface, and the separated flow flows through the cation suppressor 13 for desalination and then flows to the bypass pipeline 92 through the third switching valve 93 and flows to the second conductivity detector 70 through the bypass pipeline 92; State 4, the second liquid outlet is communicated with the second liquid inlet and the second interface is communicated with the third interface, and the separated flow sequentially flows through the bypass pipeline 92 and the third switching valve 93 to the anion suppressor 11, and flows to the second conductivity detector 70 after being desalinated by the anion suppressor 11. It can be understood that the desalination device 100 may further include a cut-off valve. The cut-off valve is disposed on the bypass pipeline 92 and is located downstream of the connection between the third interface and the bypass pipeline 92, and is in a closed state when the desalination device 100 is in State 4, cutting off the connection between the bypass pipeline 92 and the second conductivity detector 70.

[0065] In this way, the desalting device 100 can select a suitable state as needed. When desalting is not required, state one is selected; when both cation removal and anion removal are needed, state two is selected; when only cation removal is needed, state three is selected; and when only anion removal is needed, state four is selected.

[0066] In some embodiments, the desalting device 100 further includes an ion activity detection component 95. In the flow direction of the separation flow, the ion activity detection component 95 is disposed upstream of the second switching valve 91.

[0067] The ion activity detection component 95 includes a pH meter, a potassium ion electrode, a sodium ion electrode, etc., and can detect the conditions of a specific one or several ions in the separation flow.

[0068] In this way, the desalting device 100 can select a suitable state according to the detection results of the ion activity detection component 95, and perform desalting work or not perform desalting in a targeted manner.

[0069] The above-mentioned desalting device 100 can measure the conductivity of the separation flow after desalting through the first conductivity detection component 30, and use this to determine whether the separation flow can be transported to the detector 203 for detection. If the conductivity of the separation flow after desalting is not greater than the set value, the first switching valve, which serves as a control valve 50, can connect its liquid inlet to the detection liquid outlet, so that the separation flow can flow through the first switching valve to the detector 203. If the conductivity of the separation flow after desalting is greater than the set value, the first switching valve connects its liquid inlet to the waste liquid outlet, so that the separation flow directly passes through the waste liquid outlet and is discharged as waste liquid, avoiding its contamination of the detector 203. In addition, by combining the conductivity of the separation flow before desalting detected by the second conductivity detection component 70, the difference in conductivity of the separation flow before and after desalting can be obtained, more accurately knowing the desalting effect of the desalting component, and based on this, controlling the flow rate of the regeneration liquid provided by the liquid supply device 15 and / or adjusting the magnitude of the current and voltage output by the power supply device 17 to improve the desalting efficiency. At the same time, the desalting device 100 can also control the connection conditions of the second switching valve 91 and the third switching valve 93 according to the detection results of the ion activity detection component 95, so that it is in a suitable state, and perform desalting work or not perform desalting in a targeted manner. In addition, the controller can judge whether the desalting balance reaches the ideal state by reading the conductivity value, so as to judge whether the entire system has the sample injection condition, greatly improving the automation degree of the equipment and the production efficiency.

[0070] The present application also provides a chromatographic detection combined instrument 200, including a chromatographic device 201, a detector 203, and the above-mentioned desalting device 100. The chromatographic device 201, the desalting device 100, and the detector 203 are arranged in sequence, and the separation flow separated by the chromatographic device 201 can reach the detector 203 through the desalting device 100.

[0071] Among them, the detector 203 can be, but is not limited to, a mass spectrometer. When the detector 203 is a mass spectrometer, the chromatographic detection combined instrument 200 is a gas chromatography-mass spectrometry (GC-MS) instrument.

[0072] In some embodiments, the chromatographic detection combined instrument 200 further includes a detection input pipe (not shown in the figure). One end of the detection input pipe is connected to the desalination device 100, and the other end is detachably connected to the detector 203. In other words, the desalination device 100 can be connected and communicated with the detector 203 through the detection input pipe.

[0073] In this way, the user can plug and unplug the detection input pipe by himself according to the detection result of the first conductivity detector 30 or other requirements. For example, when the control valve 50 is not installed and used, when the conductivity of the separated flow after desalination is not greater than the set value, the user can manually plug the detection input pipe into the detector 203. When the conductivity of the separated flow after desalination is greater than the set value, the user can manually pull out the detection input pipe to prevent the separated flow from entering the detector 203 and contaminating the detector 203. This method is simple and reliable.

[0074] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope described in this specification.

[0075] The above-described embodiments only represent several implementation manners of the present application. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the patent application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present application, several modifications and improvements can still be made, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A desalination device, characterized in that: The desalination device comprises: A desalting component, used for desalting the separation flow obtained by the chromatography device (201); a first conductivity detection element (30), which is disposed downstream of the desalination component in the flow direction of the separation flow and is used to detect the conductivity of the separation flow after desalination by the desalination component; and The second conductivity detection element (70) is arranged upstream of the desalination component in the flow direction of the separation flow and is used to detect the conductivity of the separation flow before desalination by the desalination component.

2. The desalination device according to claim 1, characterized in that: The desalination device further comprises a control valve (50), which is arranged downstream of the first conductivity detection element (30) in the flow direction of the separation flow and has a detection liquid outlet. The control valve (50) is configured to be able to close the detection liquid outlet.

3. The desalination device according to claim 2, characterized in that: The control valve (50) is a first switching valve and also has a first liquid inlet and a waste liquid outlet. The separation flow can flow into the first switching valve from the first liquid inlet, and the detection liquid outlet and the waste liquid outlet are configured to be able to selectively communicate with the first liquid inlet.

4. The desalination device according to any one of claims 1 to 3, characterized in that: The desalination component comprises an anion suppressor (11) and a cation suppressor (13), wherein the anion suppressor (11) and the cation suppressor (13) are connected in series, and the separation flow flows through the two in sequence.

5. The desalination device according to claim 4, characterized in that: The desalination device further comprises a second switching valve (91) and a bypass pipeline (92). The second switching valve (91) is arranged between the second conductivity detection element (70) and the desalination component, and comprises a second liquid inlet, a first liquid outlet and a second liquid outlet. The second liquid inlet is connected to the second conductivity detection element (70), the first liquid outlet is connected to the desalination component, the second liquid outlet is connected to one end of the bypass pipeline (92), and the other end of the bypass pipeline (92) is connected to the first conductivity detection element (30). The first liquid outlet and the second liquid outlet can be selectively connected to the second liquid inlet.

6. The desalination device according to claim 5, characterized in that: The desalination device also includes a third switching valve (93), which is arranged between the cation suppressor (13) and the anion suppressor (11), and has a first interface, a second interface and a third interface, wherein the first interface is connected to the cation suppressor (13), the second interface is connected to the anion suppressor (11), and the third interface is connected between the two ends of the bypass line (92), and the third switching valve (93) is configured to selectively connect two of the first interface, the second interface and the third interface.

7. The desalination device according to claim 6, characterized in that: The desalination device further comprises an ion activity detection component (95). In the flow direction of the separation flow, the ion activity detection component (95) is arranged upstream of the second switching valve (91).

8. The desalination device according to claim 4, characterized in that: The desalination component further comprises a liquid supply device (15), wherein the liquid supply device (15) is connected to the anion suppressor (11) and the cation suppressor (13) and is used to provide regeneration liquid to both.

9. A chromatography detection combined instrument, characterized in that: It comprises a chromatographic device (201), a detector (203) and a desalination device as described in any one of claims 1 to 8, wherein the chromatographic device (201), the desalination device and the detector (203) are arranged in sequence, and the separation flow obtained by the chromatographic device (201) can reach the detector (203) through the desalination device.

10. The chromatographic detection combined instrument according to claim 9, characterized in that: The chromatography-detection combined instrument (200) further comprises a detection input tube, one end of which is connected to the desalination device, and the other end of which is pluggably connected to the detector (203).

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