Freeze-drying device for antibody production
By introducing a plastic wrap box and cutter structure into the antibody lyophilization device, the problem of moisture after lyophilization of the antibody is solved, and the stable preservation of the antibody product is achieved.
Patent Information
- Application Number
- CN202421460502.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-25
- Publication Date
- 2025-07-01
- Estimated Expiration
- 2034-06-25
AI Technical Summary
After the existing antibody lyophilization device is completed, the antibody product is easily dampened and affects its stability.
A freeze-drying device including a freeze-drying mechanism, a support plate, a material rack, a material tray, a vacuum cover and a vacuum pump is designed. It adopts a plastic wrap box and a cutting knife structure. After the freeze-drying is completed, the material tray is placed at the notch and the plastic wrap is cut with a cutting knife to wrap the antibody product to prevent moisture.
It effectively prevents the antibody product from getting damp after lyophilization, and maintains the stability of the antibody product.
Smart Images
Figure CN223050316U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of antibody preservation, in particular to a freeze-drying device for antibody production. Background Art
[0002] An antibody freeze-drying device, also known as an antibody freeze dryer or lyophilizer, is a device specifically used to convert an antibody solution into solid powder or crystals through freeze-drying technology.
[0003] In the existing antibody freeze-drying device, during use, the antibody product is placed in the material disk, and the material disk is placed in an ultra-low temperature refrigerator for freezing treatment. After starting the switch, the temperature in the freezing chamber reaches about -50°C. Then, the vacuum cover is opened, the material disk is placed on the material rack, the vacuum cover is covered, and the antibody product is subjected to freeze-drying treatment. After the freeze-drying treatment of the antibody product is completed, the vacuum cover is inflated. After the air pressure in the vacuum cover is balanced with the air pressure in the air, the vacuum cover is removed, and then the antibody product is taken out. The opening of the material rack disk is relatively large, and the antibody product is easily affected with moisture after being taken out and contacting with the air, which affects the stability of the antibody product.
[0004] The inventor of the present invention has at least found the following problems during the implementation of this embodiment:
[0005] In the existing antibody freeze-drying device, the antibody product is easily affected with moisture after freeze-drying is completed. Summary of the Utility Model
[0006] The purpose of the utility model is to provide a freeze-drying device for antibody production, which solves the technical problem that in the existing antibody freeze-drying device, the antibody product is easily affected with moisture after freeze-drying is completed.
[0007] Utility Model Solution:
[0008] The utility model provides a freeze-drying device for antibody production, which includes a freeze-drying mechanism, a support plate, a material rack, a material disk, a vacuum cover and a vacuum pump; the freeze-drying mechanism is provided with a cooling chamber and a rubber pad; the rubber pad is located at the opening of the cooling chamber and is fixedly connected with the freeze-drying mechanism; the support plate is detachably connected with the freeze-drying mechanism and is located above the cooling chamber, and the support plate is provided with a plurality of air holes; the material rack includes a bottom plate, support columns and a top plate; one end of the support column is fixedly connected with the bottom plate, and the other end is fixedly connected with the top plate; the support column is provided with a plurality of mounting blocks, and the material disk is detachably mounted on the material rack and abuts against the mounting blocks; the freeze-drying mechanism is fixedly connected with a fresh-keeping film box, and the fresh-keeping film box is provided with a fixed shaft, a notch, a cutter and a box cover; the fixed shaft is fixedly arranged inside the fresh-keeping film box, the notch is arranged on one side of the fresh-keeping film box, the cutter is located above the notch, and the box cover is detachably arranged at one end of the fresh-keeping film box.
[0009] Furthermore, the material tray is provided with a groove, and an abutting ring is detachably installed in the groove.
[0010] Furthermore, a material cover is detachably installed in the groove.
[0011] Furthermore, a plurality of limiting columns are fixedly connected to the support plate, and a limiting cylinder is fixedly connected to the bottom plate, and the limiting cylinder is adapted to the limiting columns.
[0012] Furthermore, the top plate is provided with a handle.
[0013] Furthermore, the freeze-drying mechanism is fixedly connected with a storage cylinder, and a storage cover is detachably connected to the opening of the storage cylinder.
[0014] Furthermore, one end of the cutting knife is provided with saw teeth.
[0015] Beneficial effects:
[0016] The utility model provides a freeze-drying device for antibody production. When in use, the support plate is placed above the cooling chamber, the material rack is placed on the support plate, the vacuum hood is sleeved on the material rack, the antibody product is placed in the material tray, and then it is sent into an ultra-low temperature refrigerator for freezing treatment. Then the freeze-drying mechanism is turned on. When the temperature in the cooling chamber reaches about -50 °C, the vacuum hood is opened, the material tray containing the pre-frozen antibody product is installed on the mounting block, the vacuum hood is covered, and the vacuum pump starts to work to carry out freeze-drying treatment on the antibody product. After the freeze-drying treatment is completed, the vacuum hood is removed, the material tray is taken out and placed at the notch, and the material tray is wrapped by pulling the plastic wrap, and the plastic wrap is cut off by the cutting knife. This kind of freeze-drying device for antibody production is not easy to get damp after the freeze-drying of the antibody product is completed. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] In order to more clearly illustrate the specific embodiments of the present utility model or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the specific embodiments or the prior art. Obviously, the following drawings are some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained according to these drawings.
[0018] Figure 1 It is a schematic diagram of the mechanism of the freeze-drying device for antibody production provided in this embodiment;
[0019] Figure 2 It is a schematic diagram of the structure of a part of the freeze-drying device for antibody production provided in this embodiment;
[0020] Figure 3Schematic diagram of the structure of the freeze-drying device part for antibody production provided in this embodiment.
[0021] Icon:
[0022] 100 - Freeze-drying mechanism; 110 - Cooling chamber; 120 - Rubber pad; 130 - Storage cylinder; 140 - Storage lid;
[0023] 200 - Support plate; 210 - Vent holes; 220 - Limit posts;
[0024] 300 - Material rack; 320 - Bottom plate; 330 - Limit cylinder; 331 - Mounting block; 340 - Top plate; 350 - Handle;
[0025] 400 - Material tray; 410 - Groove; 420 - Contact ring; 430 - Material lid;
[0026] 500 - Vacuum hood;
[0027] 600 - Vacuum pump;
[0028] 700 - Fresh-keeping film box; 710 - Fixed shaft; 720 - Notch; 730 - Cutter; 731 - Saw teeth; 740 - Box lid. Detailed implementation manners
[0029] To make the objectives, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Apparently, the described embodiments are some but not all of the embodiments of the present utility model. Usually, the components of the embodiments of the present utility model described and illustrated herein can be arranged and designed in various different configurations.
[0030] Therefore, the following detailed description of the embodiments of the present utility model provided in the drawings is not intended to limit the scope of the claimed present utility model, but merely represents selected embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts fall within the protection scope of the present utility model.
[0031] It should be noted that: Similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.
[0032] In the description of the present utility model, it should be noted that the orientation or positional relationship indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the utility model product is customarily placed during use. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model. In addition, terms such as "first", "second", "third", etc. are only used for distinguishing descriptions and cannot be understood as indicating or implying relative importance.
[0033] In addition, terms such as "horizontal" and "vertical" do not mean that the components are required to be absolutely horizontal or hanging vertically, but can be slightly inclined. For example, "horizontal" only means that its direction is more horizontal relative to "vertical", and does not mean that the structure must be completely horizontal, but can be slightly inclined. In the description of the present utility model, it should also be noted that unless otherwise clearly specified and limited, the terms "set", "installed", "connected", "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.
[0034] The following will describe in detail some embodiments of the present utility model with reference to the drawings. Without conflict, the following embodiments and the features in the embodiments can be combined with each other.
[0035] This embodiment provides a freeze-drying device for antibody production. Please refer to Figures 1-3As shown in the figure, it includes a freeze-drying mechanism 100, a support plate 200, a material rack 300, a material tray 400, a vacuum hood 500, and a vacuum pump 600; the freeze-drying mechanism 100 is provided with a cooling chamber 110 and a rubber pad 120; the rubber pad 120 is located at the opening of the cooling chamber 110 and is fixedly connected to the freeze-drying mechanism 100; the support plate 200 is detachably connected to the freeze-drying mechanism 100 and is located above the cooling chamber 110, and the support plate 200 is provided with a number of ventilation holes 210; the material rack 300 includes a bottom plate 320, support columns, and a top plate 340; one end of the support column is fixedly connected to the bottom plate 320, and the other end is fixedly connected to the top plate 340; the support column is provided with a number of mounting blocks 331, and the material tray 400 is detachably mounted on the material rack 300 and abuts against the mounting blocks 331; the freeze-drying mechanism 100 is fixedly connected with a fresh-keeping film box 700, and the fresh-keeping film box 700 is provided with a fixed shaft 710, a notch 720, a cutter 730, and a box cover 740; the fixed shaft 710 is fixedly arranged inside the fresh-keeping film box 700, the notch 720 is arranged on one side of the fresh-keeping film box 700, the cutter 730 is located above the notch 720, and the box cover 740 is detachably arranged at one end of the fresh-keeping film box 700.
[0036] Specifically, the freeze dryer cools the cooling chamber 110 through a refrigeration compressor; the support plate 200 is used to support the material rack 300, and the ventilation holes 210 are used to ensure the heat transfer speed of the cold air in the cooling chamber 110; the rubber pad 120 is provided with an annular groove, which is convenient for the installation and positioning of the vacuum hood 500 and at the same time ensures the sealing performance of the vacuum hood 500; the material rack 300 is used to support the material tray 400, the support columns are used to connect the bottom plate 320 and the top plate 340, and a certain space is supported between the bottom plate 320 and the top plate 340 to facilitate the installation of the material tray 400. The mounting blocks 331 are used to limit the material tray 400. The fresh-keeping film box 700 is used to place the fresh-keeping film. The fresh-keeping film box 700 is provided with a box opening. The fixed shaft 710 is used to insert the fresh-keeping film shaft. The notch 720 is used to extract the fresh-keeping film. The cutter 730 is used to cut the fresh-keeping film. The box cover 740 is used to close or open the box opening. During use, the support plate 200 is placed above the cooling chamber 110, the material rack 300 is placed on the support plate 200, the vacuum hood 500 is sleeved on the material rack 300, the antibody product is placed in the material tray 400, and then it is sent into an ultra-low temperature refrigerator for freezing treatment. The freeze-drying mechanism 100 is turned on. When the temperature in the cooling chamber 110 reaches about -50 °C, the vacuum hood 500 is opened, the material tray 400 containing the pre-frozen antibody product is installed on the mounting blocks 331, the vacuum hood 500 is covered, and the vacuum pump 600 starts to work to perform freeze-drying treatment on the antibody product. After the freeze-drying treatment is completed, the vacuum hood 500 is removed, the material tray 400 is taken out and placed at the notch 720, the fresh-keeping film is pulled to wrap the material tray 400, and the fresh-keeping film is cut off by the cutter 730.
[0037] In this embodiment, the material tray 400 is provided with a groove 410, and a contact ring 420 is detachably installed in the groove 410.
[0038] Specifically, when the antibody product is freeze-dried, boiling may occur. After the antibody product is pre-frozen, a plastic wrap can be covered on the material tray 400, and the plastic wrap is pressed onto the groove 410 through the contact ring 420, and several holes are pricked in the plastic wrap.
[0039] In this embodiment, a material cover 430 is detachably installed in the groove 410.
[0040] Specifically, after the antibody product is freeze-dried, a layer of plastic wrap is covered on the material cover 430 in advance, and then the material cover 430 is installed on the material tray 400 to prevent the antibody material from getting damp.
[0041] In this embodiment, a plurality of limiting posts 220 are fixedly connected to the support plate 200, and a limiting cylinder 330 is fixedly connected to the bottom plate 320. The limiting cylinder 330 is adapted to the limiting posts 220.
[0042] Specifically, the arrangement of the limiting posts 220 and the limiting cylinder 330 facilitates the positioning of the material rack 300 when it is installed on the support plate 200, and also keeps a certain distance between the support plate 200 and the bottom plate 320.
[0043] In this embodiment, the top plate 340 is provided with a handle 350.
[0044] Specifically, the handle 350 is provided for convenient taking and placing of the material rack 300.
[0045] In this embodiment, the freeze-drying mechanism 100 is fixedly connected with a storage cylinder 130, and a storage cover 140 is detachably connected to the opening of the storage cylinder 130.
[0046] Specifically, in use, two material racks 300 and multiple material trays 400 can be prepared in advance. When a batch of antibody products is freeze-dried, the storage cover 140 can be opened, the material rack 300 can be placed in the storage cylinder 130 for storage, and another batch of antibody products can be placed in the second material tray for freeze-drying, improving the freeze-drying efficiency of the antibody material.
[0047] In this embodiment, one end of the cutter 730 is provided with saw teeth 731.
[0048] Specifically, the saw teeth 731 are provided for convenient cutting of the plastic wrap that has aggregated together.
[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.
Claims
1. A freeze-drying device for antibody production, characterized in that: It comprises a freeze-drying mechanism (100), a support plate (200), a material rack (300), a material tray (400), a vacuum cover (500) and a vacuum pump (600); The freeze-drying mechanism (100) is provided with a cooling chamber (110) and a rubber pad (120); The rubber pad (120) is located at the opening of the cooling chamber (110), and is fixedly connected to the freeze-drying mechanism (100); The support plate (200) is detachably connected to the freeze-drying mechanism (100) and is located above the cooling chamber (110). The support plate (200) is provided with a plurality of air holes (210); The material rack (300) comprises a bottom plate (320), a support column and a top plate (340); One end of the support column is fixedly connected to the bottom plate (320), and the other end thereof is fixedly connected to the top plate (340); The support column is provided with a plurality of mounting blocks (331), and the material tray (400) is detachably mounted on the material rack (300), and is in abutment with the mounting blocks (331); The freeze-drying mechanism (100) is fixedly connected to a preservative film box (700), and the preservative film box (700) is provided with a fixed shaft (710), a notch (720), a cutter (730) and a box cover (740); The fixed shaft (710) is fixedly arranged inside the cling film box (700), the notch (720) is arranged on one side of the cling film box (700), the cutter (730) is located above the notch (720), and the box cover (740) is detachably arranged at one end of the cling film box (700).
2. A freeze-drying device for antibody production according to claim 1, characterized in that: The material tray (400) is provided with a groove (410), and an abutment ring (420) is detachably installed in the groove (410).
3. A freeze-drying device for antibody production according to claim 2, characterized in that: The groove (410) is detachably mounted with a material cover (430).
4. A freeze-drying device for antibody production according to claim 3, characterized in that: A plurality of limiting columns (220) are fixedly connected to the support plate (200), and a limiting cylinder (330) is fixedly connected to the bottom plate (320), wherein the limiting cylinder (330) is adapted to the limiting columns (220).
5. A freeze-drying device for antibody production according to claim 4, characterized in that: The top plate (340) is provided with a handle (350).
6. A freeze-drying device for antibody production according to claim 5, characterized in that: The freeze-drying mechanism (100) is fixedly connected to a storage cylinder (130), and a storage cover (140) is detachably connected to the opening of the storage cylinder (130).
7. A freeze-drying device for antibody production according to claim 6, characterized in that: One end of the cutter (730) is provided with saw teeth (731).