Filtering device for synthesis of fosfomycin levo-fosfomycin dextro-fosfomycin amine salt

Abstract

The utility model provides a filtering device for fosfomycin left-phosphorus right-amine salt synthesis, and particularly relates to the technical field of pharmaceutical production, which comprises a cylindrical filtering tank, two ends of the filtering tank are provided with end sockets, the upper ends and the lower ends of the end sockets are respectively provided with an inlet and an outlet, a filtering bag is arranged in the filtering tank, and the upper edge of the filtering bag is tightly attached and connected with the edge of the filtering tank. A filter cartridge with an upper opening is arranged in the filter bag, the upper edge of the filter cartridge is tightly attached and connected with the upper edge of the filter bag, a plurality of filter plates are arranged in the filter cartridge, a detachable structure is arranged between the filter plates and the filter cartridge, and a plurality of filter holes are formed in the outer ring of the filter cartridge and the filter plates. According to the utility model, non-uniform decolorizing and filtering are improved, so that the decolorizing and filtering efficiency is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of pharmaceutical production, and particularly relates to a filtering device for the synthesis of levofloxacin fosfomycin amide salt. Background Art

[0002] In the production of levofloxacin fosfomycin amide salt, the activated carbon adsorption decolorization filtration process is generally adopted. The existing filtering device includes a filtering tank, and a filter bag is provided in the filtering tank. The activated carbon is put into the filter bag, and the raw material liquid contacts the activated carbon and then passes through the filter bag to achieve filtration. Such a device has the following disadvantages: the activated carbon will accumulate together, resulting in uneven distribution of the activated carbon, uneven decolorization filtration, and thus affecting the decolorization filtration efficiency.

[0003] In view of the above deficiencies, a filtering device for the synthesis of levofloxacin fosfomycin amide salt is now needed to improve the uneven decolorization filtration and thus improve the decolorization filtration efficiency. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a filtering device for the synthesis of levofloxacin fosfomycin amide salt, which can improve the uneven decolorization filtration and thus improve the decolorization filtration efficiency.

[0005] The utility model provides the following technical solutions:

[0006] A filtering device for the synthesis of levofloxacin fosfomycin amide salt includes a cylindrical filtering tank. Both ends of the filtering tank are provided with end caps. The upper end and the lower end of the end caps are respectively provided with an inlet and an outlet. A filter bag is arranged in the filtering tank. The upper edge of the filter bag is closely attached to and connected with the edge of the filtering tank. An upper-opening filter cylinder is arranged in the filter bag. The upper edge of the filter cylinder is closely attached to and connected with the upper edge of the filter bag. A plurality of filter plates are arranged inside the filter cylinder. The filter plates and the filter cylinder are of a detachable structure, and a plurality of filter holes are arranged on the outer ring of the filter cylinder and on the filter plates.

[0007] Preferably, a sealing weir is arranged along the circumferential direction on the inner side of the upper part of the filtering tank; the upper edge of the filter bag is arranged between two sealing gaskets, the sealing gaskets are arranged on the sealing weir, and a pressing plate is arranged on the inner side of the upper end cap. The pressing plate presses the sealing gaskets tightly.

[0008] Preferably, the upper edge of the filter cylinder extends outward and is located between the pressing plate and the sealing gasket;

[0009] Preferably, a clamping groove is arranged in the transverse cutting direction of the filter cylinder, and the depth of the clamping groove is half of the diameter of the filter cylinder. An arc-shaped fixing groove is arranged inside the filter cylinder. The filter plates are embedded inside the filter cylinder through the clamping grooves, and the ends of the filter plates are embedded inside the fixing grooves.

[0010] Preferably, one end of the filter plate is provided with a fixing ear, the fixing ear penetrates through the side wall of the filter cylinder, and a fixing hole is arranged on the fixing ear. A pin is arranged inside the fixing hole.

[0011] Preferably, a holding ear is provided at the other end of the filter plate, and the holding ear, the fixing ear and the filter plate are integrally formed structures.

[0012] Preferably, notches for the ends of the holding ear and the fixing ear to pass through are provided on both sides of the sealing weir.

[0013] Preferably, the fixing hole is integrally cross-shaped, a lug matching the fixing hole is provided at the lower part of the pin column, and a stabilizing block is provided at the upper part of the pin column.

[0014] Preferably, a pinching ear is provided at the upper part of the stabilizing block.

[0015] Advantages of the utility model:

[0016] In this device, the activated carbon can be placed in layers through the filter plate, thereby improving the uniformity of the activated carbon, and further improving the decolorization and filtration efficiency; and the filter plate of this device is convenient for disassembly and assembly, facilitating subsequent maintenance; Description of the drawings

[0017] The drawings are used to provide a further understanding of the utility model, and constitute a part of the specification. Together with the embodiments of the utility model, they are used to explain the utility model, and do not constitute a limitation to the utility model. In the drawings:

[0018] Figure 1 is the overall view of the utility model;

[0019] Figure 2 is the structural diagram of the filter cartridge;

[0020] Figure 3 is the cross-sectional view of the utility model;

[0021] Figure 4 is the structural diagram of the filter plate;

[0022] Figure 5 is the structural diagram of the filter bag;

[0023] The labels in the figure are: 1. Filter tank; 2. Head; 3. Inlet; 4. Outlet; 5. Filter cartridge; 6. Filter plate; 7. Holding ear; 8. Fixing ear; 9. Pin column; 10. Lug; 11. Stabilizing block; 12. Pinching ear; 13. Card slot; 14. Fixing slot; 15. Sealing weir; 16. Pressure plate; 17. Filter bag; 18. Fixing hole; 19. Filter hole; 20. Sealing gasket. Detailed implementation manners

[0024] Example 1:

[0025] As Figures 1 to 5, A filtering device for the synthesis of fosfomycin levofloxacin and dextrorotatory aminosalt, comprising a cylindrical filtering tank 1. Both ends of the filtering tank 1 are provided with end covers 2, and the end covers 2 and the filtering tank 1 are connected through traditional flange surfaces. An inlet 3 and an outlet 4 are respectively provided at the upper and lower ends of the end cover 2 for feeding and discharging. A filter bag 17 is arranged inside the filtering tank 1, and the upper edge of the filter bag 17 is tightly attached to the edge of the filtering tank 1. The above are all prior arts and will not be elaborated here. To ensure airtightness, a sealing weir 15 is welded along the circumferential direction on the inner side of the upper part of the filtering tank 1, and the upper end surface of the sealing weir 15 is slightly lower than the upper edge of the filtering tank 1. The upper edge of the filter bag 17 is arranged between two sealing gaskets 20, and the sealing gaskets 20 and the filter bag 17 are connected by hot melting. The sealing gaskets 20 are arranged on the sealing weir 15, and a pressing plate 16 is arranged inside the upper end cover 2. The pressing plate 16 is integrated with the flange surface, and the pressing plate 16 presses the sealing gasket 20 to ensure the airtightness of the connection.

[0026] A filter cylinder 5 with an upper opening is arranged inside the filter bag 1. The upper edge of the filter cylinder 5 is tightly attached to the upper edge of the filter bag 17, that is, the upper edge of the filter cylinder 5 extends outward and is located between the pressing plate 16 and the sealing gasket 20 to ensure the airtightness of the upper edge of the filter cylinder 5. Two layers of filter plates 19 are arranged inside the filter cylinder 1. The filter plates 19 are used to place activated carbon to ensure uniform distribution of the activated carbon and avoid accumulation of the activated carbon. A number of filter holes 19 are arranged on the outer circle of the filter cylinder 5 and the filter plate 6 to ensure the filtering performance. The number and aperture of the filter holes 19 are determined according to actual requirements.

[0027] Example 2:

[0028] On the basis of Example 1, the filter plate 19 and the filter cylinder 5 are of a detachable structure. A clamping groove 13 is arranged in the transverse cutting direction of the filter cylinder 5, and the depth of the clamping groove 13 is half of the diameter of the filter cylinder 5. An arc-shaped fixing groove 14 is welded inside the filter cylinder 5. The filter plate 6 is inserted into the filter cylinder 5 through the clamping groove 13, and the end of the filter plate 6 is inserted into the fixing groove 14. It can be directly pulled out for placement and removal, thereby realizing the detachment and combination of the filter plate 19.

[0029] To ensure the stability of the filter plate 6, a fixing ear 8 is provided at one end of the filter plate 6. The fixing ear 8 penetrates through the side wall of the filter cartridge 5, and a fixing hole 18 is provided on the fixing ear 5. A pin 9 is provided in the fixing hole 18, and the position of the filter plate 6 is stabilized by the cooperation of the pin 9 and the fixing hole 18. To ensure the stability of the pin 9, the fixing hole 18 is integrally cross-shaped, and a lug 10 matching the fixing hole 18 is provided at the lower part of the pin 9. In this way, the lug 10 can only penetrate through the fixing hole 18 through a specific position and a specific direction, thereby preventing the pin 9 from slipping off. A stabilizing block 11 is provided at the upper part of the pin 9, and a gripping ear 12 is provided at the upper part of the stabilizing block 11, which facilitates the hand to hold the pin 9. A gripping ear 12 is provided at the other end of the filter plate 6, which facilitates the lateral pulling of the filter plate 6 through the gripping ear 12. Among them, the gripping ear 12, the fixing ear 8, and the filter plate 6 are of an integrally formed structure, which can improve the structural stability. Notches for the ends of the gripping ear 12 and the fixing ear 8 to pass through are provided on both sides of the sealing weir 15, which avoids the inconvenience caused by blocking during the placement and removal of the filter tank 1, and thus facilitates the placement and removal of the entire filter tank 1.

[0030] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A filtering device for the synthesis of levofloxacin fosfomycin salt, comprising a cylindrical filtering tank, with end heads provided at both ends of the filtering tank, an inlet and an outlet are respectively provided at the upper end and the lower end of the end head, a filter bag is arranged inside the filtering tank, and the upper edge of the filter bag is tightly attached and connected to the edge of the filtering tank, and it is characterized in that: A filter cartridge with an upper opening is arranged inside the filter bag. The upper edge of the filter cartridge is closely attached and connected to the upper edge of the filter bag. A number of filter plates are arranged inside the filter cartridge. The filter plates and the filter cartridge are of a detachable structure, and a number of filter holes are provided on the outer ring of the filter cartridge and on the filter plates.

2. The filtration device for the synthesis of levofloxacin fosfomycin salt according to claim 1, characterized in that: A sealing weir is arranged along the circumferential direction on the inner side of the upper part of the filter tank; the upper edge of the filter bag is arranged between two sealing gaskets. The sealing gaskets are arranged on the sealing weir, and a pressing plate is arranged on the inner side of the upper end head. The pressing plate presses the sealing gaskets tightly.

3. The filtering device for synthesizing levofloxacin fosfomycin salt according to claim 2, wherein: The upper edge of the filter cartridge extends outward and is located between the pressing plate and the sealing gasket.

4. A filtering device for the synthesis of levofloxacin fosfomycin trometamol according to claim 1, characterized in that: A clamping groove is arranged in the transverse cutting direction of the filter cartridge. The depth of the clamping groove is half of the diameter of the filter cartridge. An arc-shaped fixing groove is arranged inside the filter cartridge; the filter plate is embedded inside the filter cartridge through the clamping groove, and the end part of the filter plate is embedded inside the fixing groove.

5. A filtering device for the synthesis of levofloxacin fosfomycin salt according to claim 4, characterized in that: One end part of the filter plate is provided with a fixing ear. The fixing ear penetrates through the side wall of the filter cartridge, and a fixing hole is arranged on the fixing ear. A pin is arranged inside the fixing hole.

6. The filtration device for the synthesis of levofloxacin fosfomycin salt according to claim 1, wherein: The other end part of the filter plate is provided with a holding ear, and the holding ear, the fixing ear and the filter plate are of an integrally formed structure.

7. The filtration device for the synthesis of levofloxacin fosfomycin salt according to claim 6, characterized in that: Notches for the end parts of the holding ear and the fixing ear to pass through are arranged on both sides of the sealing weir.

8. A filtering device for the synthesis of levofloxacin fosfomycin salt according to claim 7, characterized in that: The fixing hole is integrally cross-shaped. A lug matching the fixing hole is arranged at the lower part of the pin, and a stabilizing block is arranged at the upper part of the pin.

9. The filtering device for the synthesis of levofloxacin fosfomycin salt according to claim 8, wherein: A pinching ear is arranged at the upper part of the stabilizing block.

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