Micro ultra-high performance liquid chromatography mixer

Abstract

The utility model relates to the technical field of liquid chromatography mixers, in particular to a micro ultra-high performance liquid chromatography mixer. Comprising a main body, mixer pressing caps, external connection assemblies and mixing units, one end of the main body is provided with a liquid inlet, the other end of the main body is provided with a liquid outlet, the liquid inlet and the liquid outlet are each provided with one mixer pressing cap, each mixer pressing cap is provided with one external connection assembly, a main cavity is formed in the main body, and the mixing units are arranged in the main cavity. The two ends of the mixing unit are communicated with the liquid outlet and the liquid inlet respectively, first sieve plates are arranged at the liquid inlet and the liquid outlet, and the two ends of the mixing unit are attached to the two first sieve plates respectively; the mixing unit comprises a mixing module, an outlet and an inlet are formed in the two ends of the mixing module respectively, and a plurality of flow paths are arranged in the mixing module; the mixing efficiency of unit volume is improved, the space value of the mixer is fully exerted, and the effect of fully mixing the mobile phase is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography mixers, in particular to a micro-ultra-high performance liquid chromatography mixer. Background Art

[0002] With the rapid development of chemical synthesis technology, emerging materials are increasing day by day, and the proportion of many products such as organic synthesis, physiological biochemistry, and pharmaceutical chemistry in people's daily life is gradually increasing. Therefore, analytical instruments, as an important scientific means of detection and verification of facts, occupy an important position in chemical synthesis and research on new materials. Among them, the widely used high-performance liquid chromatography occupies an important position in material analysis due to its good separation effect, rapid separation and analysis capabilities, and convenient separation methods. With the development of technology, trace and semi-trace applications in liquid chromatography are becoming more and more extensive, so the flow rate of the pump gradually decreases during use, the time of the entire analysis method gradually shortens, the peak time of the substance gradually moves forward, the entire analysis experiment time is greatly shortened, and the efficiency of scientific research work is greatly improved, so the delay volume of the entire liquid chromatography system is required to be as small as possible.

[0003] The mixer in liquid chromatography is a necessary part of the whole system, which is mainly used to promote the mixing effect of two or more mobile phases. The ideal mixer has a small mixing volume and uniform density of the mobile phase after mixing, but the two are contradictory, because for the same structure of the mixer, the larger the volume, the better the mixing effect.

[0004] Chinese patent CN212068375U discloses a high-pressure static reagent mixer, including an inner core, a liquid channel and an outer shell, wherein the liquid channel includes a first-level shunt channel group and a first-level confluence trough. The first-level shunt channel group is formed by a plurality of shunt channels drawn in parallel from the same liquid inlet pipeline joint, and a plurality of first-level shunt channel groups correspond one-to-one to a plurality of liquid inlet pipeline joints, and a plurality of first-level shunt channel groups intersect with each other; the first-level confluence trough is arranged on the surface of the inner core and is connected to the ends of all the first-level shunt channel groups, and the first-level confluence trough is also connected to the liquid outlet pipeline joint. The total length of the liquid channel required to achieve the same mixing effect is short, and the liquid volume in the high-pressure static reagent mixer is small.

[0005] However, in the above mixer, the shunt grooves and confluence grooves are multi-level crossed to form a net-like flow path. The mixing is solely based on the random distribution of the liquid in the grooves. Since the mixer inlet is divided into multiple inlets, there is a large amount of unused space at the front end of the mixing, that is, there is a space section where multiple mobile phases cannot ensure contact, and it cannot be guaranteed at which position the multiple inlet mobile phases achieve sufficient contact. Therefore, there is a large amount of space waste in this design. At the same time, due to the design that multiple mobile phase inlets are located on different sides of the mixer, the liquid at the middle position between the two mobile phases is not easily discharged, which will cause a large amount of residue and have a great impact on the next use when changing the mobile phase.

[0006] In summary, the existing ultra-high efficiency mixers for liquid chromatography mainly achieve uniform mixing of fluids through various mechanisms such as turbulent mixing, shear force mixing, diffusion mixing, centrifugal force mixing, and time mixing. Therefore, in the structural design of the mixer, factors such as its flow path changes, volume deformation, and flow direction changes need to be considered to trigger the above mixing principles to achieve the mixing of more than two mobile phases. At the same time, when applied to ultra-high performance liquid chromatography, the size of its volume also needs to be considered. This requires that the mixer involved has a high mixing efficiency per unit volume. During use, factors such as the environment also need to be considered, and functions such as temperature control need to be added to improve the mixing efficiency.

[0007] Therefore, there is an urgent need to provide a micro ultra-high performance liquid chromatography mixer, which, compared with the existing technology, improves the mixing efficiency per unit volume, gives full play to the spatial value of the mixer, and improves the effect of sufficient mixing of the mobile phase. Summary of the Utility Model

[0008] The utility model solves the technical problems existing in the prior art, and provides a micro ultra-high performance liquid chromatography mixer.

[0009] To achieve the above object, the technical solution adopted by the utility model is as follows:

[0010] A micro ultra-high performance liquid chromatography mixer includes a main body, a mixer compression cap, an external connection component, and a mixing unit. One end of the main body is provided with a liquid inlet, and the other end of the main body is provided with a liquid outlet. A mixer compression cap is installed at both the liquid inlet and the liquid outlet, and an external connection component is installed on each mixer compression cap. A main cavity is provided inside the main body, and the mixing unit is arranged inside the main cavity. Both ends of the mixing unit are communicated with the liquid outlet and the liquid inlet respectively. First sieve plates are provided at both the liquid inlet and the liquid outlet, and both ends of the mixing unit are respectively attached to the two first sieve plates; the mixing unit includes a mixing module, an outlet and an inlet are respectively provided at both ends of the mixing module, and multiple flow paths are provided inside the mixing module.

[0011] Furthermore, a plurality of the mixing units are provided, and a second sieve plate is installed between two adjacent mixing units.

[0012] Still further, the pore density of the second sieve plate is less than the pore density of the first sieve plate.

[0013] Still further, the mixing module includes a first stack, a second stack, a third stack, a fourth stack, a fifth stack, a fourth stack, a third stack, a second stack, and a first stack that are connected in sequence.

[0014] Still further, the first stack is provided with a first through hole and a plurality of first grooves, and the plurality of first grooves communicate with the first through hole; the second stack is provided with a plurality of second through holes and a plurality of second grooves, each second through hole communicates with one second groove, and each second through hole also communicates with one first groove; the third stack is provided with a plurality of third through holes and a plurality of third grooves, each third through hole communicates with one third groove, and each third through hole also communicates with one second groove; the fourth stack is provided with a plurality of fourth through holes and a plurality of fourth grooves, each fourth through hole communicates with one fourth groove, and each fourth through hole also communicates with one third groove; the fifth stack is provided with a plurality of fifth through holes, one end of each fifth through hole communicates with one fourth groove on the fourth stack disposed on one side, and the other end of each fifth through hole communicates with one fourth groove on the fourth stack disposed on the other side.

[0015] Still further, the first through hole, the second through hole, the third through hole, the fourth through hole, and the fifth through hole are all polygons and have the same number of sides.

[0016] Still further, the number of the first grooves, the second through holes, the second grooves, the third through holes, the third grooves, the fourth through holes, the fourth grooves, and the fifth through holes is the same.

[0017] Still further, the number of sides of the first through hole is the same as the number of the first grooves.

[0018] Still further, a plurality of mixing modules are provided inside the mixing unit, and two adjacent mixing modules are disposed in contact with each other.

[0019] Furthermore, a heating component is further included. A heating cavity is provided inside the main body, the heating cavity is disposed outside the main cavity, and the heating component is disposed inside the heating cavity.

[0020] Further, the heating component includes a heating resistance wire disposed inside the heating cavity. One end of the heating resistance wire extends out of the main body and is connected to a controller.

[0021] Further, sealing gaskets are provided at both ends of the heating cavity, and the sealing gaskets are fitted with the mixer compression nut.

[0022] Further, heat insulation cotton is provided inside the heating cavity, and the heat insulation cotton is disposed near the liquid outlet.

[0023] Further, a thermocouple is inserted through the main body and extends into the heating cavity. The thermocouple is disposed near the liquid outlet, and the heat insulation cotton separates the thermocouple from the heating resistance wire.

[0024] Further, a filter pad is provided at the liquid inlet. One side of the filter pad is fitted with the first sieve plate, and the other side of the filter pad is fitted with the mixer compression nut. The filter pad is made of PEEK material.

[0025] Further, the external connection component includes a connecting screw, a cutting ring, and a connecting compression nut. The connecting compression nut extends into the mixer compression nut, and the connecting compression nut is threadedly connected to the mixer compression nut. The cutting ring is installed inside the connecting compression nut, and the connecting screw is threadedly connected to the cutting ring.

[0026] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0027] (1) The structure of the present utility model is reasonably designed and ingenious. With an integrated design concept, it has a small volume and is easy to install. The internal design of the mixing unit is in a reciprocating arrangement form of "aggregation - dispersion - aggregation", making the mixing path longer. A second sieve plate is added between each mixing unit, making the flow path of the mobile phase more complex, and the change rule of the mobile phase of "division - total - division" more diverse, which is more conducive to the mixing of the mobile phase, improves the mixing efficiency per unit volume, gives full play to the space value of the mixer, and improves the effect of the full mixing of the mobile phase.

[0028] (2) By setting the temperature of the mixer in the present utility model, the temperature of the mobile phase can be controlled before it enters the chromatographic column thermostat, ensuring that the temperature of the mobile phase flowing through the chromatographic column is closer to the set temperature of the chromatographic column thermostat, which is more conducive to the analysis and use of ultra - high performance liquid chromatography.

[0029] (3) A filter plate is added at the liquid inlet of the mixer in the present utility model. At the same time, the mixer compression nut and the main cavity body are in an embedded form, and a filter pad made of PEEK material is added in the middle to achieve high - pressure sealing.

[0030] (4) The first sieve plate at the liquid inlet of the present utility model has the function of online filtration and is detachable and replaceable, which can prevent internal pollution and blockage of the mixer, improve the mobile phase mixing of the micro ultra-high performance liquid chromatography system, and ensure the repeatability of the ultra-high performance liquid chromatography system. Description of the Drawings

[0031] Figure 1 It is a schematic diagram of the overall structure of the present utility model.

[0032] Figure 2 It is a sectional view showing the internal structure of the present utility model.

[0033] Figure 3 It is a sectional view showing the heating cavity of the present utility model.

[0034] Figure 4 It is a front view showing the mixing module of the present utility model.

[0035] Figure 5a It is a side view of the first stack of sheets of the present utility model.

[0036] Figure 5b It is a side view of the second stack of sheets of the present utility model.

[0037] Figure 5c It is a side view of the third stack of sheets of the present utility model.

[0038] Figure 5d It is a side view of the fourth stack of sheets of the present utility model.

[0039] Figure 5e It is a side view of the fifth stack of sheets of the present utility model.

[0040] Figure 6 It is a schematic diagram comparing the mixing efficiency of the mixer provided by the present utility model with that of the existing mixer.

[0041] Description of the Reference Numerals:

[0042] 1. Connecting screw; 2. Blade ring; 3. Connecting compression cap; 4. Main body; 5. Main cavity; 6. Heating cavity; 7. Mixing unit; 8. First sieve plate; 9. Second sieve plate; 10. Filter pad; 11. Heating resistance wire; 12. Heat insulation cotton; 13. Thermocouple; 14. Mixer compression cap; 15. Sealing gasket; 16. Mixing module; 17. First stack of sheets; 171. First through hole; 172. First groove; 18. Second stack of sheets; 181. Second through hole; 182. Second groove; 19. Third stack of sheets; 191. Third through hole; 192. Third groove; 20. Fourth stack of sheets; 201. Fourth through hole; 202. Fourth groove; 21. Fifth stack of sheets; 211. Fifth through hole. Detailed Description of the Invention

[0043] The technical solution of the present utility model will be clearly described below in conjunction with the accompanying drawings. Obviously, the described embodiments are not all embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model. It should be noted that the orientation or positional relationship indicated by terms such as "center", "upper", "lower", "left", "right", "vertical", "horizontal", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model.

[0044] As Figure 1 , Figure 2 shown, the present utility model provides a micro ultra-high performance liquid chromatography mixer, which includes an external connection component, a mixer compression cap 14, a main body 4, a heating component and a mixing unit 7. One end of the main body 4 is provided with a liquid inlet, and the other end of the main body 4 is provided with a liquid outlet. A mixer compression cap 14 is connected to both the liquid inlet end and the liquid outlet end of the main body 4. An external connection component is connected to each mixer compression cap 14, and the external connection component is used to connect an external detection device; a heating component and a mixing unit 7 are provided inside the main body 4. The heating component is sleeved outside the buffer unit. A thermocouple 13 is provided on the side wall of the main body 4. The thermocouple 13 passes through the side wall of the main body 4 and extends into the heating component. The thermocouple 13 is arranged near the liquid outlet, and the thermocouple 13 is used to measure the temperature of the mobile phase at the liquid outlet of the mixer. The heating component is used to control the temperature of the mobile phase in the mixer.

[0045] Inside the main body 4, there is a main cavity 5. The main cavity 5 is respectively communicated with the liquid inlet and the liquid outlet. The heating component is sleeved outside the main cavity 5. The mixing unit 7 extends along the axial direction of the main cavity 5. At the liquid inlet, there is a filter pad 10 and a first sieve plate 8. One side of the first sieve plate 8 is attached to the mixing unit 7, and the other side of the first sieve plate 8 is attached to the filter pad 10. The side of the filter pad 10 away from the first sieve plate 8 is attached to the mixer compression cap 14. The filter pad 10 is provided with a plurality of filter holes. The filter pad 10 is made of PEEK material. The first sieve plate 8 is also provided with a plurality of first sieve holes. After the mixer compression cap 14 is connected to the main body 4, it acts on the filter pad 10 to play a pressing role, ensuring the sealing of the main body 4 and also used for filtering the mobile phase entering the main cavity 5; at the liquid outlet, there is a first sieve plate 8. One side of the first sieve plate 8 arranged at the liquid outlet is attached to the mixing unit 7, and the other side of the first sieve plate 8 arranged at the liquid outlet is attached to the mixer compression cap 14 arranged at the liquid outlet. The first sieve plate 8 is used for mixing and filtering the mobile phase entering the main cavity 5; there are a plurality of mixing units 7 inside the main body 4. In this embodiment, three are preferably set. A second sieve plate 9 is provided between two adjacent mixing units 7. The second sieve plate 9 is used for mixing and filtering the mobile phase passing through it. The second sieve plate 9 is provided with a plurality of second sieve holes. The three mixing units 7 extend along the axial direction of the main body 4.

[0046] As Figure 2 , Figure 3 shown, the heating component includes a heating resistance wire 11, a heat insulating cotton 12 and a sealing gasket 15. There is a heating cavity 6 inside the main body 4. The heating cavity 6 is sleeved outside the main cavity 5. The heating cavity 6 is not communicated with the main cavity 5. The heating resistance wire 11 is wound inside the heating cavity 6. The heating resistance wire 11 is spirally wound inside the heating cavity 6. One end of the heating resistance wire 11 passes through the main body 4 and extends out of the main body 4. The end of the heating resistance wire 11 extending out of the main body 4 is connected to a controller to form heating for the mixer. At one end of the heating cavity 6 close to the liquid outlet, there is a heat insulating cotton 12 with a certain thickness. The heat insulating cotton 12 separates the thermocouple 13 and the heating resistance wire 11. Since the heating of the heating resistance wire 11 is faster through the conduction of stainless steel than that of the mobile phase, the heat insulating cotton 12 is arranged inside the heating cavity 6 to separate the thermocouple 13 and the heating resistance wire 11, preventing the heating resistance wire 11 from heating the thermocouple 13 through the conduction of the stainless steel side wall of the main body 4, resulting in a large error in the temperature measured at the liquid outlet; sealing gaskets 15 are provided at both ends inside the heating cavity 6. The sealing gaskets 15 are made of heat-resistant materials. When the mixer compression cap 14 is connected to the main body 4, it acts on the sealing gaskets 15 to fix the heating resistance wire 11 inside the heating cavity 6 to achieve a stable effect.

[0047] The external components include connecting screws 1, a blade ring 2, and a connecting compression cap 3. The connecting compression cap 3 extends into the mixer compression cap 14 and is threadedly connected to the mixer compression cap 14. The blade ring 2 is located inside the connecting compression cap 3. The connecting screw 1 extends into the blade ring 2 and is threadedly connected to the blade ring 2. The part of the connecting screw 1 outside the blade ring 2 is connected to an external detection device.

[0048] There are differences in the sizes of the first sieve plate 8 and the second sieve plate 9. The outer shape of the first sieve plate 8 is larger than that of the second sieve plate 9, and the pore density of the first sieve plate 8 is greater than that of the second sieve plate 9. The first sieve plate 8 needs to be regularly disassembled and cleaned to prevent excessive backpressure caused by blockage in the mixer. Since the mixer is applicable to micro ultra-high performance liquid chromatography and bears a relatively large pressure, the sealing gasket 15 is regularly replaced according to the number of disassembly times. A reserved groove is provided between two adjacent mixing units 7. The second sieve plate 9 is installed inside the reserved groove to define the position of each mixing unit 7 and ensure that the mixing units 7 are coaxially arranged. At the same time, due to the smaller outer shape of the second sieve plate 9, it is more conducive to the mobile phase flowing out of the mixing unit 7 being more completely dispersed into the second sieve plate 9 for full mixing. Coupled with the smaller pore density of the second sieve plate 9, the mobile phase entering it is dispersed in a multi-directional movement, dividing the original single stream into multiple streams, changing from the original "one line" to "one surface", which better enables the solution to be mixed.

[0049] As Figure 4 shown, each mixing unit 7 includes a plurality of mixing modules 16. In this embodiment, each mixing unit 7 includes four mixing modules 16. One end of each mixing module 16 is provided with an inlet and the other end is provided with an outlet. A plurality of flow paths are provided inside each mixing module 16. Each mixing module 16 includes a first stack 17, a second stack 18, a third stack 19, a fourth stack 20, a fifth stack 21, a fourth stack 20, a third stack 19, a second stack 18, and a first stack 17 that are connected in sequence. The mobile phase in each mixing module 16 undergoes a "polymerization - dispersion - polymerization" mixing mode. A plurality of flow paths are provided inside the mixing module 16, and the mobile phase entering the mixing module 16 has to flow through a plurality of flow paths inside the mixing module 16 for full mixing. In this embodiment, eight flow paths are provided in each mixing module 16.

[0050] As Figure 5a 、 Figure 5b 、 Figure 5c 、 Figure 5d 、 Figure 5eAs shown, the cross-sections of the first stack 17, the second stack 18, the third stack 19, the fourth stack 20, and the fifth stack 21 are all circular, and their outer diameters are all set to be the same; a first through-hole 171 is provided at the center of the first stack 17. The first through-hole 171 is octagonal, and a first groove 172 is connected to each of the eight inflection points of the first through-hole 171. The first through-hole 171 and the second groove 182 both penetrate through the first stack 17; eight second through-holes 181 are provided on the second stack 18. The eight second through-holes 181 have the same size. The second through-holes 181 are all octagonal. The eight second through-holes 181 are distributed along the circumferential direction of the second stack 18. Each second through-hole 181 communicates with a first groove 172, and a second groove 182 is connected to each second through-hole 181. The second through-hole 181 and the second groove 182 both penetrate through the second stack 18; eight third through-holes 191 are provided on the third stack 19. The eight third through-holes 191 have the same size. The third through-holes 191 are all octagonal. The eight third through-holes 191 are distributed along the circumferential direction of the third stack 19. Each third through-hole 191 communicates with a second groove 182, and a third groove 192 is connected to each third through-hole 191. The third through-hole 191 and the third groove 192 both penetrate through the fourth stack 20; eight fourth through-holes 201 are provided on the fourth stack 20. The eight fourth through-holes 201 have the same size. The fourth through-holes 201 are all octagonal. The eight fourth through-holes 201 are distributed along the circumferential direction of the fourth stack 20. Each fourth through-hole 201 communicates with a third groove 192, and a fourth groove 202 is connected to each fourth through-hole 201. The fourth through-hole 201 and the fourth groove 202 both penetrate through the fourth stack 20; eight fifth through-holes 211 are provided on the fifth stack 21. The eight fifth through-holes 211 are distributed along the circumferential direction of the fifth stack 21. The fifth through-holes 211 are all octagonal. One end of each fifth through-hole 211 communicates with a fourth groove 202 of the fourth stack 20 provided on one side, and the other end of each fifth through-hole 211 communicates with a fourth through-hole 201 of the fourth stack 20 provided on the other side. The fifth through-hole 211 penetrates through the fifth stack 21. The mobile phase entering each mixing module 16 flows in through the first through-hole 171 of the first stack 17 provided on one side, then is dispersed through eight flow paths, and then flows out of the mixing module 16 through the first through-hole 171 on the first stack 17 provided on the other side.

[0051] Two adjacent mixing modules 16 are arranged in a fitting manner, and the mobile phase flowing out of one mixing module 16 can smoothly enter the next adjacent mixing module 16 for mixing, realizing the transfer of the mobile phase between the two mixing modules 16. At the same time, the flow path is also changed from eight paths to one path. A plurality of mixing modules 16 are arranged in each mixing unit 7, so that the mobile phase changes in terms of linear flow rate, direction, and instantaneous cross-sectional shape, thereby improving the mixing effect of the mobile phase in the mixing module 16. Moreover, the volume, flow path, and flow direction of the flowing mobile phase change significantly, enabling the mobile phase to pass through multiple mixing units 7 in a balanced-violent-steady cycle state, which can better promote the mixing effect of the mobile phase and improve the mixing efficiency.

[0052] The working principle of a micro ultra-high performance liquid chromatography mixer provided by the present utility model: The external components at both ends of the main body 4 are connected to external detection devices, so that the mobile phase enters the interior of the main cavity 5 through the liquid inlet. The mobile phase first passes through the filter pad 10 and the first sieve plate 8 for filtration and preliminary mixing, and then flows into the interior of the mixing unit 7. Inside each mixing unit 7, the mobile phase flows through four mixing modules 16. When flowing through each mixing module 16, the mobile phase flows in a polymerization-dispersion-polymerization manner and is fully mixed through eight flow paths. When the mobile phase flows out of each mixing unit 7 and enters the next mixing unit 7, it has to flow through the second sieve plate 9. When passing through the second sieve plate 9, the mobile phase changes from one stream to multiple streams and then back to one stream for further mixing. After being fully mixed through multiple mixing units 7, finally, it passes through the first sieve plate 8 provided at the liquid outlet and then flows out of the mixer from the liquid outlet to complete the mixing of the mobile phase. When the mobile phase is mixed inside the main cavity 5, the interior of the main cavity 5 is heated by the heating resistance wire 11, and at the same time, the thermocouple 13 is used for temperature measurement to achieve the temperature control effect of the mixer, which can better promote the mixing of the mobile phase.

[0053] As Figure 6 shown, the quality of the mixing of the mixer is judged according to the magnitude of the baseline pulsation. The larger the baseline pulsation, the worse the mixing. Figure 6 Among them, the existing mixer is the Shimadzu 20A SUS mixer. In comparison, it is obvious that the present utility model has advantages such as the change rule of the flow path "total - sub - total", the design of an octagonal through - hole, the addition of the first sieve plate 8 and the second sieve plate 9, and temperature controllability, etc., to achieve a higher mixing efficiency.

[0054] The structural design of the utility model is reasonable and ingenious. The biggest feature lies in the integrated design concept, with a relatively small volume and easy installation. The inside of the mixing unit 7 is designed in a reciprocating arrangement form of "aggregation - dispersion - aggregation", which makes the mixing path longer. A second sieve plate 9 is added between each mixing unit 7, making the path that the mobile phase flows through more complex, and the variation law of the mobile phase of "separation - aggregation - separation" more diverse, which is more conducive to the mixing of the mobile phase and improves the mixing efficiency. Since a filter plate is added at the liquid inlet of the mixer, and at the same time, the mixer compression cap 14 and the main cavity 5 are embedded, and a filter pad 10 made of PEEK material is added in the middle to achieve high-pressure sealing. The first sieve plate 8 at the liquid inlet has the function of online filtration and can be removed and replaced to prevent pollution and blockage inside the mixer. It improves the mixing of the mobile phase in the micro ultra-high performance liquid chromatography system and ensures the repeatability of the ultra-high performance liquid chromatography system. At the same time, by setting the temperature of the mixer, the temperature of the mobile phase can be controlled before it enters the chromatographic column thermostat, ensuring that the temperature of the mobile phase flowing through the chromatographic column is closer to the set temperature of the chromatographic column thermostat, which is more conducive to the analysis and use of ultra-high performance liquid chromatography. Therefore, the mixer provided by the utility model is suitable for popularization and application in this field, and its market prospect is very broad.

[0055] Finally, it should be noted that the above content is only used to illustrate the technical solution of the utility model, rather than a limitation on the protection scope of the utility model. Any simple modification or equivalent replacement made by those of ordinary skill in the art to the technical solution of the utility model does not depart from the essence and scope of the technical solution of the utility model.

Claims

1. A micro ultra-high performance liquid chromatography mixer, characterized in that, It includes a main body, a mixer gland, an external component, and a mixing unit. One end of the main body is provided with a liquid inlet, and the other end of the main body is provided with a liquid outlet. A mixer gland is installed at each of the liquid inlet and the liquid outlet. An external component is installed on each mixer gland. A main cavity is provided inside the main body, and the mixing unit is arranged inside the main cavity. Both ends of the mixing unit are respectively communicated with the liquid outlet and the liquid inlet. First sieve plates are provided at both the liquid inlet and the liquid outlet. Both ends of the mixing unit are respectively attached to the two first sieve plates. The mixing unit includes a mixing module. An outlet and an inlet are respectively provided at both ends of the mixing module, and multiple flow paths are provided inside the mixing module.

2. The micro ultra-high performance liquid chromatography mixer according to claim 1, wherein A plurality of mixing units are provided, and a second sieve plate is installed between two adjacent mixing units.

3. The micro ultra-high performance liquid chromatography mixer according to claim 2, characterized in that, The pore density of the second sieve plate is less than that of the first sieve plate.

4. The micro ultra-high performance liquid chromatography mixer according to claim 2, wherein The mixing module includes a first stack, a second stack, a third stack, a fourth stack, a fifth stack, a fourth stack, a third stack, a second stack, and a first stack that are sequentially communicated.

5. The micro ultra-high performance liquid chromatography mixer according to claim 4, wherein, The first stack is provided with a first through hole and a plurality of first grooves, and the plurality of first grooves are all communicated with the first through hole. The second stack is provided with a plurality of second through holes and a plurality of second grooves. Each second through hole communicates with a second groove, and each second through hole also communicates with a first groove. The third stack is provided with a plurality of third through holes and a plurality of third grooves. Each third through hole communicates with a third groove, and each third through hole also communicates with a second groove. The fourth stack is provided with a plurality of fourth through holes and a plurality of fourth grooves. Each fourth through hole communicates with a fourth groove, and each fourth through hole also communicates with a third groove. The fifth stack is provided with a plurality of fifth through holes. One end of each fifth through hole communicates with a fourth groove on the fourth stack arranged on one side, and the other end of each fifth through hole communicates with a fourth groove on the fourth stack arranged on the other side.

6. The micro ultra-high performance liquid chromatography mixer according to claim 5, characterized in that, The first through hole, the second through hole, the third through hole, the fourth through hole, and the fifth through hole are all polygons and have the same number of sides.

7. The micro ultra-high performance liquid chromatography mixer according to claim 6, characterized in that, The number of the first grooves, the second through holes, the second grooves, the third through holes, the third grooves, the fourth through holes, the fourth grooves, and the fifth through holes is the same.

8. The micro ultra-high performance liquid chromatography mixer according to claim 6, wherein The number of sides of the first through hole is the same as the number of the first grooves.

9. A micro ultra-high performance liquid chromatography mixer according to any one of claims 1-8, characterized in that, A plurality of mixing modules are provided inside the mixing unit, and two adjacent mixing modules are attached to each other.

10. The micro ultra-high performance liquid chromatography mixer according to claim 1, wherein It further includes a heating component. A heating cavity is provided inside the main body. The heating cavity is arranged outside the main cavity, and the heating component is arranged inside the heating cavity.

11. A micro ultra-high performance liquid chromatography mixer according to claim 10, characterized in that, The heating component includes a heating resistance wire. The heating resistance wire is arranged inside the heating cavity. One end of the heating resistance wire extends out of the main body, and the end of the heating resistance wire extending out of the main body is connected to a controller.

12. The micro ultra-high performance liquid chromatography mixer according to claim 11, wherein Sealing gaskets are provided at both ends of the heating cavity, and the sealing gaskets are attached to the mixer gland.

13. A micro ultra-high performance liquid chromatography mixer according to claim 11, characterized in that, The interior of the heating cavity is provided with heat insulation cotton, and the heat insulation cotton is arranged near the liquid outlet.

14. A micro ultra-high performance liquid chromatography mixer according to claim 13, characterized in that, A thermocouple is inserted through the main body, the thermocouple extends into the interior of the heating cavity, the thermocouple is arranged near the liquid outlet, and the heat insulation cotton separates the thermocouple from the heating resistance wire.

15. A micro ultra-high performance liquid chromatography mixer according to claim 1, characterized in that, A filter pad is provided at the liquid inlet, one side of the filter pad is attached to the first sieve plate, the other side of the filter pad is attached to the mixer compression cap, and the filter pad is made of PEEK material.

16. The micro ultra-high performance liquid chromatography mixer according to claim 1, characterized in that, The external component includes a connecting screw, a cutting ring and a connecting compression cap. The connecting compression cap extends into the interior of the mixer compression cap, the connecting compression cap is threadedly connected to the mixer compression cap, the cutting ring is installed inside the connecting compression cap, and the connecting screw is threadedly connected to the cutting ring.

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