Kit for judging occurrence and development of esophageal squamous carcinoma based on detection of SASS6 protein

Abstract

The utility model discloses a kit for judging the occurrence and development of esophageal squamous carcinoma based on the detection of SASS6 protein, which is applied to the technical field of medical instruments and comprises a protective shell, the two sides of the interior of the protective shell are connected with kits in a sliding manner, and the center of the interior of the protective shell is connected with a rotating rod in a penetrating and sliding manner. And the two kits are respectively driven to slide on the two sides of the protective shell by rotating the rotating rod. Two different reagent tubes of KLF-4 and CD44 can be respectively stored in the kits on the two sides, and are stored in a differentiated manner to prevent confusion. Meanwhile, rapid storage is also facilitated, the sliding stability of the kit is improved, and the development of esophageal squamous carcinoma is conveniently detected and judged. The extrusion block is driven by the elastic force of the telescopic rod to clamp and limit the reagent tube according to the diameter of the reagent tube. Therefore, various reagent tubes with different sizes can be clamped and fixed in the storage groove, the practicability of the kit is improved, and KLF-4 or CD44 reagent tubes are convenient to store.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical devices, and particularly relates to a kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein. Background Art

[0002] The nuclear transcription factor KLF-4 mainly plays a direct inhibitory or activating role in the transcription of downstream genes, while the CD44 protein is encoded and synthesized by the CD44 gene, and the tumor stage, differentiation, and typing can be predicted through CD44. The expressions of KLF-4 and CD44 in esophageal squamous cell carcinoma were detected by immunohistochemistry, and the combined detection has guiding significance for predicting the malignancy and prognosis of esophageal squamous cell carcinoma.

[0003] Currently, the Chinese utility model with the publication number of CN215285682U discloses a cancer detection kit convenient for sealed storage. A storage and sealing component is installed on the side of the kit. One end of the side of the kit is hinged with a sealing plate. A sealing ring is bonded inside the magnetic ring. A silica gel ring is bonded to the front edge of the storage box. Sliding grooves are respectively opened at the top and bottom positions of the front of the storage box. A ball is movably embedded at the bottom end of the support bar. A placement component is installed inside the storage box. A sponge ring is bonded to the inner edge of the storage hole. A protection and positioning component is installed outside the kit. Suction cups are evenly installed on the bottom surface of the rubber plate. The reagent of this utility model is stored inside the storage box. When in use, pull the storage box at one end, and through the connection structure of the sliding groove and the sliding rod, the storage box is pulled out and unfolded, which is convenient for identification and use. And it is sealed by the silica gel ring at the connection of the storage box, and then sealed again by the sealing ring of the sealing plate, with better sealing effect, and the reagent is not easy to contact with the outside air and deteriorate.

[0004] Generally, multiple test tube placement slots are opened inside the existing kit for storing multiple reagent tubes. However, the reagent tubes are easily confused when stored together and can only rely on the labels on the reagent tubes. In actual use, for two different reagent tubes of KLF-4 and CD44, the staff needs to take the labels on different test tubes in turn to observe in order to avoid taking the wrong test tubes by mistake, which is rather troublesome and cannot store the two different reagent tubes of KLF-4 and CD44 separately. At the same time, since the sizes of the placement slots opened inside the existing kit are fixed, only reagent tubes of fixed sizes can be placed. Although placement slots with different diameters are opened, the inner diameters of the slot openings of the placement slots are fixed. When placing test tubes with inconsistent models, it is difficult to place them in or there is a large gap and they are easy to shake, so the practicability is relatively low. Summary of the Utility Model

[0005] The purpose of the present utility model is to provide a kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein. Its advantages are the functions of separately storing the KLF-4 and CD44 reagent tubes to prevent confusion and facilitating the storage of various reagent tubes with different models and sizes.

[0006] The above technical purpose of the present utility model is achieved through the following technical solutions: A kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein, including a protective outer shell. Both sides inside the protective outer shell are slidably connected with reagent boxes. A rotating rod is slidably connected through the center inside the protective outer shell. A first bevel gear is bolted to the bottom of the rotating rod. On both sides of the first bevel gear, threaded rods rotatably connected to the protective outer shell are provided. One end of each of the two threaded rods close to each other is bolted with a second bevel gear meshing with the first bevel gear. Threaded sleeves respectively welded to the bottoms of the two reagent boxes are threadedly sleeved on the surfaces of the two threaded rods.

[0007] By adopting the above technical solutions, the two reagent boxes are respectively driven to slide on both sides of the protective outer shell by rotating the rotating rod. Not only can two different reagent tubes of KLF-4 and CD44 be separately stored in the reagent boxes on both sides to prevent confusion by separate storage. At the same time, it is also convenient for quick storage, improves the sliding stability of the reagent box, and is convenient for detecting and judging the development of esophageal squamous cell carcinoma. By utilizing the elastic force of the telescopic rod to drive the extrusion block to clamp and limit according to the diameter of the reagent tube. Thus, various reagent tubes with different sizes can be clamped inside the storage groove, improving the practicality of the reagent box and facilitating the storage of KLF-4 or CD44 reagent tubes.

[0008] The present utility model is further arranged as follows: A fixing block is adhesively connected inside the reagent box. A storage groove is opened inside the fixing block. A reagent tube is slidably connected inside the storage groove. A first telescopic rod is bolted inside the fixing block. One end of the first telescopic rod close to the reagent tube is welded with an extrusion block. A second telescopic rod respectively bolted to the fixing block and the extrusion block is sleeved on the surface of the first telescopic rod.

[0009] By adopting the above technical solutions, various reagent tubes with different sizes can be clamped inside the storage groove, facilitating the storage of KLF-4 or CD44 reagent tubes.

[0010] The present utility model is further arranged as follows: Buffer pads used in cooperation with the threaded sleeves are adhesively connected to both sides inside the protective outer shell.

[0011] By adopting the above technical solutions, the collision between the threaded sleeve during left and right sliding and the protective outer shell is buffered, thereby reducing the vibration intensity inside the reagent box.

[0012] The present utility model is further arranged as follows: Anti-slip pads are adhesively connected to both sides of the bottom of the protective outer shell.

[0013] Adopting the above technical solution, the friction when placing the protective shell is increased, thereby improving the stability.

[0014] The present utility model is further configured as: Handles are bolted to both sides of the top of the protective shell.

[0015] Adopting the above technical solution, it is convenient to lift the protective shell for carrying, thereby facilitating the movement of the stored reagent tubes.

[0016] The present utility model is further configured as: An anti-slip sticker is adhered to the side of the extrusion block close to the reagent tube, and an inclined groove for cooperating with the reagent tube is opened at the top of the extrusion block.

[0017] Adopting the above technical solution, it is convenient for the bottom of the reagent tube to directly push the extrusion block to one side by using the inclined groove, so as to put the reagent tube into the storage groove. At the same time, the anti-slip sticker can improve the stability of the extrusion block pressing and fixing the reagent tube.

[0018] The present utility model is further configured as: A sponge pad bonded to the reagent kit is provided at the bottom of the inner cavity of the storage groove.

[0019] Adopting the above technical solution, buffer protection is provided for the bottom of the reagent tube, thereby preventing direct collision with the bottom of the reagent kit.

[0020] In summary, the present utility model has the following beneficial effects:

[0021] 1. By rotating the rotating rod, the two reagent kits are respectively driven to slide on both sides of the protective shell. Not only can two different reagent tubes of KLF-4 and CD44 be stored in the reagent kits on both sides respectively for separate storage to prevent confusion. At the same time, it is also convenient for quick storage, improves the sliding stability of the reagent kit, and is convenient for detecting and judging the development of esophageal squamous cell carcinoma;

[0022] 2. By using the elastic force of the telescopic rod to drive the extrusion block to clamp and limit according to the diameter of the reagent tube. Thus, various reagent tubes of different sizes can be clamped and fixed inside the storage groove, improving the practicality of the reagent kit and facilitating the storage of KLF-4 or CD44 reagent tubes. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 is a schematic structural diagram of the present utility model;

[0024] Figure 2 is a structural sectional view of the present utility model;

[0025] Figure 3 is the present utility model Figure 2 Enlarged view of point A in.

[0026] Reference numerals: 1, protective housing; 2, reagent kit; 3, rotating rod; 4, threaded rod; 5, first bevel gear; 6, second bevel gear; 7, threaded sleeve; 8, fixing block; 9, storage groove; 10, reagent tube; 11, first telescopic rod; 12, second telescopic rod; 13, extrusion block; 14, buffer pad; 15, anti-slip gasket; 16, handle; 17, sponge pad; 18, anti-slip sticker. Detailed implementation manners

[0027] The following further elaborates on the present utility model in conjunction with the accompanying drawings.

[0028] Example 1: Refer to Figure 1 , Figure 2 , a reagent kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein, including a protective housing 1. On both sides inside the protective housing 1, there is a slidably connected reagent kit 2. In the center of the inside of the protective housing 1, there is a rotatably connected rotating rod 3 running through. At the bottom of the rotating rod 3, there is a bolted first bevel gear 5. On both sides of the first bevel gear 5, there are threaded rods 4 rotatably connected to the protective housing 1. At the mutually approaching ends of the two threaded rods 4, there are bolted second bevel gears 6 meshing with the first bevel gear 5. The surfaces of the two threaded rods 4 are threadedly sleeved with two threaded sleeves 7 respectively welded to the bottoms of the two reagent kits 2. By rotating the rotating rod 3, the two reagent kits 2 are respectively driven to slide on both sides of the protective housing 1. Not only can two different reagent tubes of KLF-4 and CD44 be separately stored in the reagent kits 2 on both sides for separate storage to prevent confusion. At the same time, it is also convenient for quick storage, improves the sliding stability of the reagent kit 2, and is convenient for detecting and judging the development of esophageal squamous cell carcinoma.

[0029] Refer to Figure 2 , on both sides inside the protective housing 1, there is a buffer pad 14 adhesively connected and used in cooperation with the threaded sleeve 7. It buffers the collision between the threaded sleeve 7 during left and right sliding and the protective housing 1, thereby reducing the vibration intensity inside the reagent kit 2.

[0030] Refer to Figure 1 , Figure 2 , on both sides of the bottom of the protective housing 1, there is an anti-slip gasket 15 adhesively connected. It increases the friction when the protective housing 1 is placed, thereby improving stability.

[0031] Refer to Figure 1 , Figure 2 , on both sides of the top of the protective housing 1, there are bolted handles 16. It is convenient to lift the protective housing 1 for carrying, thereby facilitating the movement of the stored reagent tubes 10.

[0032] Brief description of the usage process: By turning the rotating rod 3, the first bevel gear 5 is driven to rotate and threadedly engage with the second bevel gear 6, so that the two threaded rods 4 rotate simultaneously inside the protective housing 1. Since the two second bevel gears 6 are located on both sides of the first bevel gear 5, the two threaded rods 4 will rotate in opposite directions. Then, through the threaded engagement between the threaded rod 4 and the threaded sleeve 7, the two reagent kits 2 slide in opposite directions under the limitation of the protective housing 1, so that the two reagent kits 2 can slide close to each other and be stored inside the protective housing 1 or slide away from each other and slide out from both sides of the protective housing 1, and two different reagent tubes of KLF-4 and CD44 can be stored.

[0033] Example 2: Refer to Figure 1 、 Figure 2 、 Figure 3 A reagent kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein. A fixing block 8 is adhesively connected inside the reagent kit 2. A receiving groove 9 is formed inside the fixing block 8. A reagent tube 10 is slidably connected inside the receiving groove 9. A first telescopic rod 11 is bolted inside the fixing block 8. One end of the first telescopic rod 11 close to the reagent tube 10 is welded with a pressing block 13. A second telescopic rod 12 bolted to the fixing block 8 and the pressing block 13 respectively is sleeved on the surface of the first telescopic rod 11. By utilizing the elastic force of the second telescopic rod 12, the pressing block 13 is driven to clamp and limit according to the diameter of the reagent tube 10. Thus, reagent tubes 10 of various different sizes can be clamped and fixed inside the receiving groove 9, improving the practicability of the reagent kit and facilitating the storage of KLF-4 or CD44 reagent tubes.

[0034] Refer to Figure 3 A non-slip sticker 18 is adhesively connected to one side of the pressing block 13 close to the reagent tube 10. An inclined groove for cooperating with the reagent tube 10 is formed at the top of the pressing block 13. It is convenient for the bottom of the reagent tube 10 to directly push the pressing block 13 to one side by using the inclined groove, so as to put the reagent tube 10 into the receiving groove 9. At the same time, the non-slip sticker 18 can improve the stability of the pressing block 13 pressing and fixing the reagent tube 10.

[0035] Refer to Figure 2 、 Figure 3 A sponge pad 17 adhesively connected to the reagent kit 2 is arranged at the bottom of the inner cavity of the receiving groove 9. It buffers and protects the bottom of the reagent tube 10, so as to prevent direct collision with the bottom of the reagent kit 2.

[0036] Brief description of the usage process: By separately moving the KLF-4 or CD44 reagent tubes to two reagent kits 2, align the reagent tube 10 with the storage groove 9 opened at the top of the fixing block 8 and place it down. Then, squeeze the extrusion block 13 to one side through the reagent tube 10, so that the extrusion block 13 drives the first telescopic rod 11 and the second telescopic rod 12 to retract. After that, the second telescopic rod 12 generates a resilience force after contraction, thereby driving the first telescopic rod 11 to push the extrusion block 13 to reset according to the diameter of the reagent tube 10, so that the extrusion block 13 pushes the reagent tube 10 close to the fixing block 8, and then the reagent tube 10 is clamped inside the storage groove 9 for limit fixation.

[0037] This specific embodiment is only an explanation of the present invention, and it is not a limitation of the present invention. After reading this specification, those skilled in the art can make modifications to this embodiment that do not contribute creatively as needed, but as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A kit for judging the occurrence and development of esophageal squamous cell carcinoma based on detecting SASS6 protein, including a protective outer shell (1), characterized in that: On both sides inside the protective housing (1), a reagent kit (2) is slidably connected. A rotating rod (3) is slidably connected through the center inside the protective housing (1). A first bevel gear (5) is bolted to the bottom of the rotating rod (3). On both sides of the first bevel gear (5), threaded rods (4) rotatably connected to the protective housing (1) are provided. At the mutually approaching ends of the two threaded rods (4), second bevel gears (6) meshing with the first bevel gear (5) are bolted. Threaded sleeves (7) welded to the bottoms of the two reagent kits (2) respectively are threadedly sleeved on the surfaces of the two threaded rods (4).

2. The kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein according to claim 1, wherein: A fixing block (8) is adhesively bonded inside the reagent kit (2). A storage groove (9) is formed inside the fixing block (8). A reagent tube (10) is slidably connected inside the storage groove (9). A first telescopic rod (11) is bolted inside the fixing block (8). An extrusion block (13) is welded to the end of the first telescopic rod (11) close to the reagent tube (10). A second telescopic rod (12) bolted to the fixing block (8) and the extrusion block (13) respectively is sleeved on the surface of the first telescopic rod (11).

3. A kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein according to claim 1, characterized in that: Buffer pads (14) used in cooperation with the threaded sleeves (7) are adhesively bonded to both sides inside the protective housing (1).

4. A kit for judging the occurrence and development of esophageal squamous cell carcinoma based on detecting SASS6 protein according to claim 1, characterized in that: Anti-slip pads (15) are adhesively bonded to both sides of the bottom of the protective housing (1).

5. A kit for judging the occurrence and development of esophageal squamous cell carcinoma based on detecting SASS6 protein according to claim 1, characterized in that: Handles (16) are bolted to both sides of the top of the protective housing (1).

6. A kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein according to claim 2, characterized in that: An anti-slip sticker (18) is adhesively bonded to the side of the extrusion block (13) close to the reagent tube (10). An inclined groove used in cooperation with the reagent tube (10) is formed at the top of the extrusion block (13).

7. A kit for judging the occurrence and development of esophageal squamous cell carcinoma based on the detection of SASS6 protein according to claim 2, characterized in that: A sponge pad (17) adhesively bonded to the reagent kit (2) is arranged at the bottom of the inner cavity of the storage groove (9).

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