Separation and purification device for D-ribose

Abstract

The utility model relates to the technical field of D-ribose separation and purification, in particular to a D-ribose separation and purification device which comprises a stirring barrel, a purification barrel and a chromatography layer arranged in the purification barrel, an installation ring is installed on the inner wall of the purification barrel, a supporting ring is fixedly connected to the inner wall of the installation ring, the upper end of the supporting ring is connected with a filter membrane in an abutting mode, and the lower end of the supporting ring is connected with a filter screen. The lower end of the stirring barrel is connected with a lengthened valve pipe in a penetrating manner, a movable ring is arranged on the outer side of the lengthened valve pipe, and the inner wall of the movable ring is fixedly connected with a first O-shaped sealing ring extruded with the outer wall of the lengthened valve pipe through a mounting groove; when the filter membrane needs to be taken down, the two extrusion discs are rotated to the positions corresponding to the two limiting holes, then the two extrusion discs enter the two limiting holes and extrude the two pressed plates downwards, then the filter membrane can be extruded and fixed, when the filter membrane needs to be taken down, only opposite steps need to be carried out, the filter membrane is further convenient to disassemble, assemble, clean or replace, and the filter membrane is convenient to use. Therefore, the purpose of avoiding influence on the filtering effect is achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of separation and purification of D-ribose, in particular to a device for separating and purifying D-ribose. Background Art

[0002] D-ribose is a pentose monosaccharide, whose chemical structure is similar to that of glucose, but has different optical rotation properties and shows dextrorotation. As an important pharmaceutical intermediate, D-ribose is widely used in the production of various nucleic acid drugs. At the same time, it is also used in the treatment of cardiovascular diseases, neuropathy, muscle diseases, etc., showing good clinical effects and application prospects. Through the process of separating and purifying D-ribose, impurities therein can be effectively removed, thereby improving the purity of D-ribose.

[0003] A high-efficiency purification device for D-ribose with the patent number of CN 211411256 U disclosed in the Chinese patent, when the first motor is powered on and rotates, the rotating shaft rotates, thereby driving the stirring fan blades to rotate, and the fermentation broth poured in from the fermentation broth inlet and the medicinal materials poured in from the medicinal material inlet can be stirred evenly and fully reacted. After the reaction is completed, then the plug board and the first control valve are opened, and the fermentation broth enters the chromatography separation chamber. After passing through the filtration separation layer, a filtrate is obtained. The filtrate can obtain a chromatographic solution after passing through the chromatography layer. The chromatographic solution enters the crystallization chamber through the chromatographic solution transfer pipe. An appropriate amount of ethanol solution is added through the ethanol inlet. After heating and cooling, crystals are obtained. Finally, the crystals enter the centrifugal drying chamber through the material passing hole. The second motor is powered on and rotates, driving the centrifugal drying chamber to rotate, and the purified D-ribose crystals are obtained by centrifugation. The whole process is completed in one go, without going through other complex processes, and the purified D-ribose crystals can be obtained efficiently, saving a lot of time and improving work efficiency.

[0004] However, the filtration separation layer of the above device is located inside the chromatography separation chamber, which is not convenient for disassembling, cleaning or replacing the filtration separation layer. Therefore, after using for a period of time, the accumulation of impurities will affect the filtration effect. Therefore, it is necessary to propose a device for separating and purifying D-ribose to solve the above problems. Summary of the Utility Model

[0005] The purpose of the utility model is to provide a device for separating and purifying D-ribose, which has the characteristics of being convenient for disassembling, cleaning or replacing the filter membrane to avoid affecting the filtration effect.

[0006] To achieve the above object, the present utility model provides the following technical solution: A separation and purification device for D-ribose, including a stirring cylinder, a purification cylinder, and a chromatography layer disposed inside the purification cylinder. An installation ring is installed on the inner wall of the purification cylinder, a support ring is fixedly connected to the inner wall of the installation ring, a filter membrane abuts against the upper end of the support ring. The lower end of the stirring cylinder is connected through a lengthened valve pipe, an activity ring is arranged on the outer side of the lengthened valve pipe, and a first O-ring that is fixedly connected to the outer wall of the lengthened valve pipe through an installation groove is arranged on the inner wall of the activity ring. The lower end of the activity ring is fixedly connected to an extrusion cylinder, and a second O-ring that is fixedly connected to the inner wall of the installation ring through an installation groove is arranged on the outer wall of the extrusion cylinder;

[0007] Both the left and right sides of the purification cylinder are fixedly connected with support plates. Rotating rods are rotatably connected to the upper ends of the two support plates. Steering plates are fixedly connected to the upper ends of the two rotating rods. Screws penetrate and are threadedly connected to the outer walls of the two steering plates. Pressure-receiving plates are fixedly connected to both the left and right sides of the extrusion cylinder. Limiting holes are opened at the upper ends of the two pressure-receiving plates. Extrusion discs that extend into the two limiting holes are fixedly connected to the lower ends of the two screws.

[0008] To facilitate improving the stability of the up-and-down movement of the activity ring, as a preferred embodiment of the separation and purification device for D-ribose of the present utility model, two guiding cylinders are fixedly connected to the lower end of the stirring cylinder, and sliding rods fixedly connected to the activity ring are slidably connected inside the two guiding cylinders.

[0009] To prevent the activity ring from disengaging from the outer wall of the lengthened valve pipe, as a preferred embodiment of the separation and purification device for D-ribose of the present utility model, a retaining ring located below the activity ring is fixedly connected to the outer wall of the lengthened valve pipe.

[0010] To facilitate improving the smoothness when the second O-ring enters the inside of the installation ring, as a preferred embodiment of the separation and purification device for D-ribose of the present utility model, a fillet is provided at the corner of the upper side of the inner wall of the installation ring.

[0011] To facilitate separately rotating the two screws, as a preferred embodiment of the separation and purification device for D-ribose of the present utility model, handwheels are fixedly connected to the upper ends of the two screws.

[0012] To facilitate fixing the two support plates and the stirring cylinder, as a preferred embodiment of the separation and purification device for D-ribose of the present utility model, L-shaped connecting plates are respectively fixedly connected between the left and right sides of the two support plates and the stirring cylinder.

[0013] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0014] Place the filter membrane inside the installation ring, support the filter membrane through the support ring, then move the movable ring, the extrusion cylinder and the two pressure-receiving plates downward until the extrusion cylinder abuts against the filter membrane. Then rotate the two extrusion plates to positions corresponding to the two limiting holes, and then make the two extrusion plates enter the two limiting holes and squeeze the two pressure-receiving plates downward, thereby the filter membrane can be squeezed and fixed. When it is necessary to remove the filter membrane, just perform the steps in the reverse order, further achieving the purpose of facilitating the disassembly, cleaning or replacement of the filter membrane to avoid affecting the filtration effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 is the overall front sectional view of the present utility model;

[0016] Figure 2 of the present utility model Figure 1 is the enlarged view at A in;

[0017] Figure 3 is the connection structure diagram of the extrusion cylinder of the present utility model.

[0018] In the figure: 1, stirring cylinder; 2, support plate; 3, purification cylinder; 4, extended valve pipe; 5, installation ring; 6, support ring; 7, filter membrane; 8, movable ring; 9, first O-ring; 10, chromatography layer; 11, extrusion cylinder; 12, second O-ring; 13, rotating rod; 14, steering plate; 15, screw rod; 16, extrusion plate; 17, limiting hole; 18, guide cylinder; 19, sliding rod; 20, retaining ring; 21, pressure-receiving plate. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0019] Please refer to Figures 1 to 3 , a separation and purification device for D-ribose, comprising a stirring cylinder 1, a purification cylinder 3 and a chromatography layer 10 arranged inside the purification cylinder 3. An installation ring 5 is installed on the inner wall of the purification cylinder 3, a support ring 6 is fixedly connected to the inner wall of the installation ring 5, the upper end of the support ring 6 abuts against a filter membrane 7, the lower end of the stirring cylinder 1 is connected through an extended valve pipe 4, an activity ring 8 is arranged outside the extended valve pipe 4, a first O-ring 9 that is pressed against the outer wall of the extended valve pipe 4 is fixedly connected to the inner wall of the activity ring 8 through an installation groove, the lower end of the activity ring 8 is fixedly connected to an extrusion cylinder 11, and a second O-ring 12 that is pressed against the inner wall of the installation ring 5 is fixedly connected to the outer wall of the extrusion cylinder 11 through an installation groove;

[0020] Both the left and right sides of the purification cylinder 3 are fixedly connected with support plates 2. The upper ends of the two support plates 2 are rotatably connected with rotating rods 13. The upper ends of the two rotating rods 13 are fixedly connected with steering plates 14. The outer walls of the two steering plates 14 penetrate and are threadedly connected with screw rods 15. Both the left and right sides of the extrusion cylinder 11 are fixedly connected with pressure-receiving plates 21. The upper ends of the two pressure-receiving plates 21 are provided with limiting holes 17. The lower ends of the two screw rods 15 are fixedly connected with extrusion discs 16 extending into the two limiting holes 17.

[0021] In this embodiment: When the filter membrane 7 needs to be installed, the filter membrane 7 needs to be cut into a shape matching the inside of the installation ring 5, and then the filter membrane 7 is placed inside the installation ring 5, and the filter membrane 7 is supported by the support ring 6. Then, the movable ring 8 and the first O-ring 9 move downward on the outer wall of the lengthened valve pipe 4, so that the extrusion cylinder 11 and the two pressure-receiving plates 21 move downward until the extrusion cylinder 11 enters the inside of the installation ring 5 and abuts against the filter membrane 7. Then, the two steering plates 14 rotate respectively along with the two rotating rods 13, thereby driving the two screw rods 15 and the two extrusion discs 16 to rotate until the positions of the two extrusion discs 16 are vertically corresponding to the two limiting holes 17. Then, the two screw rods 15 are rotated respectively, so that the two extrusion discs 16 can move downward and enter the two limiting holes 17, and then the two pressure-receiving plates 21 are squeezed downward. At the same time, the filter membrane 7 is squeezed and fixed through the extrusion cylinder 11. At this time, by setting the first O-ring 9 and the second O-ring 12 and making them squeeze against the outer wall of the lengthened valve pipe 4 and the inner wall of the installation ring 5 respectively, the fermentation liquid can be prevented from leaking during work, and the installation of the filter membrane 7 is completed. When the filter membrane 7 needs to be removed, the two extrusion discs 16 need to be disengaged from the two limiting holes 17 in the reverse steps, and then the two extrusion discs 16 are rotated 180 degrees, so that the movable ring 8 and the extrusion cylinder 11 can be pushed upward to a certain position, and the filter membrane 7 can be taken out, further achieving the purpose of facilitating the disassembly, cleaning or replacement of the filter membrane 7 to avoid affecting the filtering effect.

[0022] During work, the fermentation liquid and the medicinal materials can react fully through the stirring cylinder 1. Then, the valve of the lengthened valve pipe 4 is opened, and the fermentation liquid will flow into the inside of the extrusion cylinder 11 through the lengthened valve pipe 4, and the impurities in the fermentation liquid are filtered through the filter membrane 7 to obtain the clarified liquid, and the clarified liquid is then obtained as the chromatographic solution through the chromatographic layer 10.

[0023] As a technical optimization scheme of the present utility model, two guide cylinders 18 are fixedly connected to the lower end of the stirring cylinder 1. Slide rods 19 fixedly connected with the movable ring 8 are slidably connected inside the two guide cylinders 18.

[0024] In this embodiment: By setting the two guide cylinders 18 and the two slide rods 19, the stability of the up and down movement of the movable ring 8 is improved.

[0025] As a technical optimization solution of the present utility model, a retaining ring 20 located below the movable ring 8 is fixedly connected to the outer wall of the lengthened valve pipe 4.

[0026] In this embodiment: By providing the retaining ring 20, the movable ring 8 can be prevented from detaching from the outer wall of the lengthened valve pipe 4.

[0027] As a technical optimization solution of the present utility model, a fillet is provided at the upper corner of the inner wall of the mounting ring 5.

[0028] In this embodiment: By providing the fillet, the smoothness of the second O-ring 12 entering the interior of the mounting ring 5 can be improved.

[0029] As a technical optimization solution of the present utility model, handwheels are fixedly connected to the upper ends of the two screws 15.

[0030] In this embodiment: By providing the two handwheels, the two screws 15 can be rotated separately.

[0031] As a technical optimization solution of the present utility model, L-shaped connecting plates are fixedly connected between the left and right sides of the two support plates 2 and the mixing drum 1 respectively.

[0032] In this embodiment: By providing the two L-shaped connecting plates, the two support plates 2 and the mixing drum 1 can be fixed.

[0033] Working principle: When installing the filter membrane 7, first cut the filter membrane 7 into a shape that matches the inside of the installation ring 5, then place the filter membrane 7 inside the installation ring 5, and support the filter membrane 7 through the support ring 6. Then, move the movable ring 8 and the first O-ring 9 downward on the outer wall of the lengthened valve tube 4, so that the extrusion cylinder 11 and the two pressure-receiving plates 21 move downward until the extrusion cylinder 11 enters the inside of the installation ring 5 and abuts against the filter membrane 7. Then, rotate the two turning plates 14 respectively along with the two rotating rods 13, thereby driving the two screw rods 15 and the two extrusion disks 16 to rotate until the positions of the two extrusion disks 16 are vertically corresponding to the two limiting holes 17. Then, rotate the two screw rods 15 respectively through the two handwheels, so that the two extrusion disks 16 can move downward and enter the inside of the two limiting holes 17, and then squeeze the two pressure-receiving plates 21 downward. At the same time, the filter membrane 7 is squeezed and fixed through the extrusion cylinder 11. At this time, by setting the first O-ring 9 and the second O-ring 12 and making them squeeze against the outer wall of the lengthened valve tube 4 and the inner wall of the installation ring 5 respectively, the fermentation broth can be prevented from leaking during work, and the installation of the filter membrane 7 is completed. When the filter membrane 7 needs to be removed, the two extrusion disks 16 need to be disengaged from the inside of the two limiting holes 17 in the reverse steps, and then the two extrusion disks 16 are rotated 180 degrees, so that the movable ring 8 and the extrusion cylinder 11 can be pushed upward to a certain position, and the filter membrane 7 can be taken out, further achieving the purpose of facilitating the disassembly, cleaning or replacement of the filter membrane 7 to avoid affecting the filtering effect;

[0034] During work, the fermentation broth and the medicinal materials can react fully through the stirring cylinder 1. Then, open the valve of the lengthened valve tube 4, and the fermentation broth will flow into the inside of the extrusion cylinder 11 through the lengthened valve tube 4, and the impurities in the fermentation broth are filtered through the filter membrane 7 to obtain the clarified liquid, and the clarified liquid is then passed through the chromatography layer 10 to obtain the chromatography solution.

[0035] In the description of the present invention, it should be noted that the processes of crystallization and centrifugal drying of the chromatography solution in this article are the same as those of the cited patents in the background art.

[0036] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An apparatus for separating and purifying D-ribose, comprising a stirring cylinder (1), a purification cylinder (3), and a chromatography layer (10) disposed inside the purification cylinder (3), characterized in that: An installation ring (5) is installed on the inner wall of the purification cylinder (3). A support ring (6) is fixedly connected to the inner wall of the installation ring (5). A filter membrane (7) abuts against the upper end of the support ring (6). A lengthened valve pipe (4) is connected through the lower end of the stirring cylinder (1). A movable ring (8) is arranged on the outer side of the lengthened valve pipe (4). A first O-ring (9) that is fixedly connected to the inner wall of the movable ring (8) through an installation groove and presses against the outer wall of the lengthened valve pipe (4) is provided. A pressing cylinder (11) is fixedly connected to the lower end of the movable ring (8). A second O-ring (12) that is fixedly connected to the outer wall of the pressing cylinder (11) through an installation groove and presses against the inner wall of the installation ring (5) is provided. Support plates (2) are fixedly connected to both the left and right sides of the purification cylinder (3). Rotating rods (13) are rotatably connected to the upper ends of the two support plates (2). Steering plates (14) are fixedly connected to the upper ends of the two rotating rods (13). Screws (15) penetrate and are threadedly connected to the outer walls of the two steering plates (14). Pressure-receiving plates (21) are fixedly connected to both the left and right sides of the pressing cylinder (11). Limit holes (17) are formed in the upper ends of the two pressure-receiving plates (21). Pressing discs (16) that extend into the two limit holes (17) are fixedly connected to the lower ends of the two screws (15).

2. The separation and purification device for D-ribose according to claim 1, wherein: Two guide cylinders (18) are fixedly connected to the lower end of the stirring cylinder (1). Slide rods (19) that are fixedly connected to the movable ring (8) are slidably connected to the interiors of the two guide cylinders (18).

3. The separation and purification device of D-ribose according to claim 1, characterized in that: A retaining ring (20) is fixedly connected to the outer wall of the lengthened valve pipe (4) and is located below the movable ring (8).

4. The separation and purification device for D-ribose according to claim 1, characterized in that: Rounded corners are provided at the upper-side corners of the inner wall of the installation ring (5).

5. The separation and purification device of D-ribose according to claim 1, characterized in that: Handwheels are fixedly connected to the upper ends of the two screws (15).

6. The separation and purification device of D-ribose according to claim 1, characterized in that: L-shaped connecting plates are fixedly connected between the two support plates (2) and the left and right sides of the stirring cylinder (1) respectively.

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