Liquid chromatograph-mass spectrometer mobile phase blending device

Abstract

The utility model relates to the technical field of liquid chromatography-mass spectrometry, in particular to a mobile phase blending device of a liquid chromatography-mass spectrometer, which comprises a tank body, a pretreatment cylinder is arranged in the tank body, ultrasonic blending devices are symmetrically arranged outside the pretreatment cylinder, a stirring shaft is arranged in the pretreatment cylinder, a plurality of stirring rods are arranged on the stirring shaft, and the ultrasonic blending devices are symmetrically arranged on the ultrasonic blending devices. A motor is arranged at one end of the stirring shaft, a first electromagnetic valve is arranged outside the pretreatment barrel, a rotating shaft is arranged inside the pretreatment barrel, a plurality of partition plates are arranged on the rotating shaft, and a driving motor, the electromagnetic valve, the partition plates, a slitting barrel, a slitting net, a mixing barrel and a mixing rod structure are arranged at one end of the rotating shaft. The problems that multiple components such as a collision assembly and a slitting net in the device are difficult to clean and maintain, and meanwhile the stirring efficiency can be improved are solved.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography - mass spectrometry, in particular to a mobile phase mixing device for a liquid chromatography - mass spectrometry instrument. Background Technique

[0002] Liquid chromatography - mass spectrometry, also known as LC - MS, uses liquid chromatography as the separation system and mass spectrometry as the detection system. The sample is separated from the mobile phase in the mass spectrometry part, ionized, and then the ion fragments are separated by the mass analyzer of the mass spectrometry according to the mass number. The mass spectrometry diagram is obtained through the detector. Liquid chromatography - mass spectrometry embodies the complementary advantages of chromatography and mass spectrometry, combining the high separation ability of chromatography for complex samples with the advantages of high selectivity, high sensitivity of MS, and the ability to provide relative molecular mass and structural information, and has been widely used in many fields such as drug analysis, food analysis, and environmental analysis.

[0003] Moreover, in the application document with the publication number CN220932882U, a mixing device for a liquid chromatography - mass spectrometry instrument is mentioned. When in use, the medium first passes through a pipeline mixer for mixing, and then enters the mixing tank through the liquid inlet pipeline for further homogenization. During the entry process, pressure is applied through a pressure component arranged on the liquid inlet pipeline to avoid insufficient pressure and inability to achieve good collision. After the medium is discharged through the liquid inlet pipeline, it first passes through a collision component for collision. The collided medium is collected through a current - collecting component, and the collected medium is transported through a medium transport pipeline communicated with the current - collecting component to a Venturi tube and ejected from the Venturi tube. At this time, the medium ejected from the Venturi tube is further homogenized in the uniform mixing area in the mixing tank, but there are still certain defects that need to be optimized. The specific defects are as follows: Multiple components in the device, such as the collision component and the slitting net, are difficult to clean and maintain, and at the same time, the stirring efficiency can be improved.

[0004] Therefore, it is particularly important to design a mobile phase mixing device for a liquid chromatography - mass spectrometry instrument to change the above - mentioned technical defects and improve the overall practicality. Content of the Utility Model

[0005] The purpose of the utility model is to provide a mobile phase mixing device for a liquid chromatography - mass spectrometry instrument to solve the problems raised in the above - mentioned background technique.

[0006] To achieve the above - mentioned purpose, the utility model provides the following technical solutions:

[0007] A mobile phase mixing device for a liquid chromatography - mass spectrometry instrument, comprising a tank body. Inside the tank body, there is a pretreatment cylinder. Symmetrically arranged outside the pretreatment cylinder are ultrasonic mixers. Inside the pretreatment cylinder, there is a stirring shaft. A number of stirring rods are arranged on the stirring shaft. One end of the stirring shaft is provided with a motor. Outside the pretreatment cylinder, there is a first solenoid valve. Inside the pretreatment cylinder, there is a rotating shaft. A number of partition plates are arranged on the rotating shaft. One end of the rotating shaft is provided with a driving motor;

[0008] The pretreatment cylinder is connected to a slitting cylinder. Inside the slitting cylinder, there is a slitting mesh. The slitting cylinder is connected to a mixing cylinder. Inside the mixing cylinder, there are mixing rods. The mixing rods are connected to a rotating motor. At the bottom end outside the tank body, there is an outlet pipe. Outside the outlet pipe, there is a second solenoid valve.

[0009] As a preferred solution of the present utility model, a cover cylinder is provided at the top of the tank body. The cover cylinder is connected to the tank body by bolts. And a sealing ring is provided at the bottom of the cover cylinder. An inlet pipe is provided on the cover cylinder for adding raw materials.

[0010] As a preferred solution of the present utility model, an inspection door is provided on one side of the tank body. There is a slot on the tank body. Inside the slot, there is a limiting plate. A positioning groove is provided on the limiting plate. A positioning block adapted to the positioning groove is provided on one side of the inspection door. A sealing gasket is provided on one side of the inspection door. And the position between the inspection door and the tank body is fixed by bolts. A handle is provided on the inspection door.

[0011] As a preferred solution of the present utility model, the pretreatment cylinder is in the shape of an inverted conical cylinder. The number of the stirring rods and the partition plates are equally spaced.

[0012] As a preferred solution of the present utility model, a sealing ring is provided inside the slitting cylinder. And the slitting cylinder is connected to the pretreatment cylinder by bolts. At the top of the mixing cylinder, there is an accommodation cavity with an upward opening. A groove is provided at the top end of the accommodation cavity. The groove is adapted to the slitting cylinder.

[0013] As a preferred solution of the present utility model, the mixing rods are in the shape of blades. And the output shaft of the rotating motor is key - connected to the mixing rods.

[0014] Compared with the prior art, the beneficial effects of the present utility model are:

[0015] In the present utility model, a mobile phase mixing device for a liquid chromatography-mass spectrometry instrument is provided. By utilizing the structures of solenoid valves, partition plates, slitting cylinders, slitting meshes, mixing cylinders, and mixing rods, the raw materials are pretreated through a pretreatment cylinder, and an ultrasonic mixer is used to generate strong local disturbances and energy transfer to the raw materials. Such disturbances help to break the stratification, agglomerates, or concentration gradients in the liquid, promoting the uniform mixing of the mobile phase. Then, a preliminary mixing is carried out in cooperation with a stirring shaft. After that, the mixture is shunted and conveyed to the slitting mesh through the partition plate and the solenoid valve. The slitting mesh further breaks the large particles and can also change the flow characteristics of the raw materials, making them more smoothly and uniformly conveyed to the inside of the mixing cylinder. Finally, it is conveyed out through the liquid outlet pipe. Among them, the mixing rod prevents the raw materials from settling and accumulating. The provided inspection door and cover plate facilitate the disassembly of the internal components for later maintenance, solving the problems that multiple components in the device, such as the collision components and the slitting mesh, are difficult to clean and maintain, and at the same time, the stirring efficiency can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a planar structure diagram of the whole of the present utility model;

[0017] Figure 2 is a schematic diagram of the inspection door of the present utility model;

[0018] Figure 3 is a schematic structural diagram of the whole interior and the mixing rod assembly of the present utility model.

[0019] In the figure: 1, tank body; 101, pretreatment cylinder; 102, ultrasonic mixer; 103, stirring shaft; 104, stirring rod; 105, motor; 106, first solenoid valve; 2, rotating shaft; 201, partition plate; 202, slitting cylinder; 203, slitting mesh; 204, mixing cylinder; 205, mixing rod; 206, rotating motor; 207, liquid outlet pipe; 208, second solenoid valve; 209, driving motor. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0020] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0021] For the convenience of understanding the present utility model, the present utility model will be described more comprehensively with reference to the relevant drawings. Several embodiments of the present utility model are given. However, the present utility model can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present utility model more thorough and comprehensive.

[0022] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there may also be an intermediate element. When an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intermediate element at the same time. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field to which this utility model belongs. The terms used herein in the description of the present utility model are for the purpose of describing specific embodiments only and are not intended to limit the present utility model. The term "and / or" used herein includes any and all combinations of one or more of the related listed items.

[0024] For the embodiments, please refer to Figures 1 - 3 , the present utility model provides a technical solution:

[0025] A mobile phase mixing device for a liquid chromatography - mass spectrometry instrument, comprising a tank body 1. Inside the tank body 1, there is a pretreatment cylinder 101. Symmetrically arranged outside the pretreatment cylinder 101 are ultrasonic mixers 102. Inside the pretreatment cylinder 101, there is a stirring shaft 103. A number of stirring rods 104 are arranged on the stirring shaft 103. One end of the stirring shaft 103 is provided with a motor 105. Outside the pretreatment cylinder 101, there is a first solenoid valve 106. Inside the pretreatment cylinder 101, there is a rotating shaft 2. A number of partition plates 201 are arranged on the rotating shaft 2. One end of the rotating shaft 2 is provided with a driving motor 209. The pretreatment cylinder 101 is connected to a splitting cylinder 202. Inside the splitting cylinder 202, there is a splitting mesh 203. The splitting cylinder 202 is connected to a mixing cylinder 204. Inside the mixing cylinder 204, there is a mixing rod 205. The mixing rod 205 is connected to a rotating motor 206. At the bottom end outside the tank body 1, there is an outlet pipe 207. Outside the outlet pipe 207, there is a second solenoid valve 208. Raw materials are added into the pretreatment cylinder 101 through the feeding pipe on the cover cylinder. Then, the motor 105 is started to drive the stirring shaft 103 to rotate, driving the stirring rods 104 to perform preliminary mixing and stirring on the raw materials. At the same time, the ultrasonic mixers 102 perform ultrasonic mixing treatment on the raw materials in the pretreatment cylinder to further enhance the mixing effect. Next, the driving motor 209 drives the rotating shaft 2 to rotate, enabling the partition plates 201 to split the raw materials and enter the splitting cylinder 202. The raw materials are split through the splitting mesh 203 and then flow into the mixing cylinder 204. Inside the mixing cylinder 204, the rotating motor 206 drives the mixing rod 204 to rotate to perform final mixing and stirring on the raw materials, preventing the raw materials from settling and accumulating. Finally, the second solenoid valve 208 is opened, and the mixed raw materials flow out of the device through the outlet pipe 207. During the entire working process, the design of the inspection door and the cover cylinder facilitates the disassembly and cleaning of the internal components, ensuring the long - term stable operation of the equipment;

[0026] A cover cylinder is provided at the top of the tank body 1. The cover cylinder is connected to the tank body 1 by bolts, and a sealing ring is provided at the bottom of the cover cylinder. A feed pipe is provided on the cover cylinder for adding raw materials, which is convenient for withdrawing the entire stirring shaft and cleaning the stirring shaft assembly. An inspection door is provided on one side of the tank body 1. A slot is provided on the tank body 1, and a limiting plate is provided inside the slot. A positioning groove is provided on the limiting plate. A positioning block adapted to the positioning groove is provided on one side of the inspection door. A sealing gasket is provided on one side of the inspection door, and the inspection door is fixed in position with the tank body 1 by bolts. A handle is provided on the inspection door. The internal components can be disassembled and cleaned through the inspection door. At the same time, the inspection door and the tank body form a complete sealed space. The pretreatment cylinder 101 is in the shape of an inverted conical cylinder. A plurality of stirring rods 104 and partition plates 201 are arranged at equal intervals, which is convenient for more uniform mixing and stirring. A sealing ring is provided inside the cutting cylinder 202, and the cutting cylinder 202 is connected to the pretreatment cylinder 101 by bolts. An upward-opening receiving cavity is provided at the top of the mixing cylinder 204, and a groove is provided at the top end of the receiving cavity, which is adapted to the cutting cylinder 202, facilitating the disassembly of the cutting cylinder 202 to clean the internal cutting mesh. The mixing rod 205 is in the shape of a blade, and the output shaft of the rotating motor 206 is key-connected to the mixing rod 205, preventing the raw materials from sinking and accumulating at the bottom.

[0027] The working process of the present utility model: When using this liquid chromatography-mass spectrometry mobile phase mixing device, first, raw materials are added into the pretreatment cylinder 101 through the feed pipe on the cover cylinder. Then, the motor 105 is started to drive the stirring shaft 103 to rotate, driving the stirring rods 104 to preliminarily mix and stir the raw materials. At the same time, the ultrasonic mixer 102 performs ultrasonic mixing treatment on the raw materials in the pretreatment cylinder to further enhance the mixing effect. Next, the driving motor 209 drives the rotating shaft 2 to rotate, enabling the partition plate 201 to divert the raw materials into the cutting cylinder 202, and the raw materials are cut through the cutting mesh 203 and then flow into the mixing cylinder 204. Inside the mixing cylinder 204, the rotating motor 206 drives the mixing rod 204 to rotate to perform the final mixing and stirring of the raw materials, preventing the raw materials from sinking and accumulating at the bottom. Finally, the second solenoid valve 208 is opened, and the mixed raw materials flow out of the device through the liquid outlet pipe 207. During the entire working process, the design of the inspection door and the cover cylinder facilitates the disassembly and cleaning of the internal components, ensuring the long-term stable operation of the equipment.

[0028] Although the embodiments of the present utility model have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present utility model. The scope of the present utility model is defined by the appended claims and their equivalents.

Claims

1. A mobile phase mixing device for a liquid chromatography-mass spectrometry instrument, comprising a tank body (1), characterized in that: Inside the tank body (1), a pretreatment cylinder (101) is provided. Symmetrically arranged outside the pretreatment cylinder (101) are ultrasonic mixers (102). Inside the pretreatment cylinder (101), a stirring shaft (103) is provided. A number of stirring rods (104) are arranged on the stirring shaft (103). One end of the stirring shaft (103) is provided with a motor (105). Outside the pretreatment cylinder (101), a first solenoid valve (106) is provided. Inside the pretreatment cylinder (101), a rotating shaft (2) is provided. A number of partition plates (201) are arranged on the rotating shaft (2). One end of the rotating shaft (2) is provided with a driving motor (209). The pretreatment cylinder (101) is connected to a slitting cylinder (202). Inside the slitting cylinder (202), a slitting mesh (203) is provided. The slitting cylinder (202) is connected to a mixing cylinder (204). Inside the mixing cylinder (204), a mixing rod (205) is provided. The mixing rod (205) is connected to a rotating motor (206). At the bottom end outside the tank body (1), a liquid outlet pipe (207) is provided. Outside the liquid outlet pipe (207), a second solenoid valve (208) is provided.

2. The mobile phase mixing device of a liquid chromatography-mass spectrometry instrument according to claim 1, wherein: At the top of the tank body (1), a cover cylinder is provided. The cover cylinder is connected to the tank body (1) by bolts, and a sealing ring is provided at the bottom of the cover cylinder. An inlet pipe is provided on the cover cylinder for adding raw materials.

3. The mobile phase mixing device of a liquid chromatography-mass spectrometry instrument according to claim 1, wherein: On one side of the tank body (1), a maintenance door is provided. There is a slot on the tank body (1). Inside the slot, a limiting plate is provided. On the limiting plate, a positioning groove is provided. On one side of the maintenance door, a positioning block adapted to the positioning groove is provided. On one side of the maintenance door, a sealing gasket is provided. The maintenance door and the tank body (1) are fixed in position by bolts. A handle is provided on the maintenance door.

4. A mobile phase mixing device for a liquid chromatography-mass spectrometry instrument according to claim 1, characterized in that: The pretreatment cylinder (101) is in the shape of an inverted conical cylinder. The number of stirring rods (104) and partition plates (201) are arranged at equal intervals.

5. The mobile phase mixing device of a liquid chromatography-mass spectrometry instrument according to claim 1, characterized in that: Inside the slitting cylinder (202), a sealing ring is provided. The slitting cylinder (202) and the pretreatment cylinder (101) are connected by bolts. At the top of the mixing cylinder (204), there is an accommodating cavity with an upward opening. At the top end of the accommodating cavity, there is a groove, which is adapted to the slitting cylinder (202).

6. The mobile phase mixing device of a liquid chromatography-mass spectrometry instrument according to claim 1, wherein: The mixing rod (205) is in the shape of a blade, and the output shaft of the rotating motor (206) is key-connected to the mixing rod (205).

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