Double-emulsification high-flux micro-fluidic chip

By designing a microfluidic chip with a step-by-step structure of flow focus and interface tension, the problem of difficult droplet size and low production efficiency in the prior art is solved, and efficient and accurate double emulsified droplet generation is achieved, which is suitable for drug delivery and biological research.

CN223082803UActive Publication Date: 2025-07-11BEIJING UNIV OF CHEM TECH
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Patent Information

Application Number
CN202422344609.2
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-09-25
Publication Date
2025-07-11
Estimated Expiration
2034-09-25

AI Technical Summary

Technical Problem

The existing double emulsification technology is difficult to accurately control the size and distribution of droplets, has low production efficiency, and high-strength mechanical action may destroy sensitive substances.

Method used

A double emulsification high-throughput microfluidic chip is designed, using flow focus technology and interfacial tension step-by-step structure to generate stable double emulsification droplets through the microflower of the intermediate layer. Using PDMS materials and precise processing technology, the manufacturing process is simplified and the chip consistency and reliability are improved.

Benefits of technology

It realizes precise control and efficient production of droplet generation, reduces experimental errors, improves production efficiency, and is suitable for various applications such as drug delivery and biological research.

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Abstract

The utility model provides a double-emulsification high-flux micro-fluidic chip. The double-emulsification high-flux micro-fluidic chip comprises a substrate, a middle layer and a cover plate, according to the utility model, the substrate is not processed, the main micro-channels are processed on the two sides of the middle layer, and the cover plate is punched, so that fluid can be conveniently introduced. A plurality of liquid drop generation units based on the flow focusing technology are designed on one side of the middle layer so as to generate liquid drops for the first time, and a stepped liquid drop generation structure based on interfacial tension is designed on the other side of the middle layer so as to generate liquid drops for the second time. The structures on the two sides of the chip are connected through the through holes. The preparation method comprises the following steps: carrying out photoetching to form a mold, preparing the middle layer by using the mold, forming the required micro-channels on the two sides of the middle layer, punching on the cover plate, and finally bonding the substrate, the middle layer and the cover plate. Through the design of the flow channel and the structure, a large number of double-emulsion droplets can be rapidly prepared, the production efficiency is improved, and the double-emulsion droplet preparation device is suitable for various applications such as drug delivery and biological research.
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