Magnetic bead cleaning device

Abstract

The utility model relates to the field of biomedical technical equipment, in particular to a magnetic bead cleaning device. The magnetic bead cleaning device comprises a base, a plurality of supporting legs are fixedly installed in the middle of the base, a cleaning cylinder is fixedly installed at the top ends of the supporting legs, a spraying pipe is fixedly installed at the top end of the cleaning cylinder through a support, supporting arms are symmetrically installed at the two ends of the base, and hydraulic rods are embedded in the two supporting arms. The placing mechanism used for mixing the primary cleaning magnetic beads is embedded in the cleaning cylinder, the placing mechanism comprises a supporting shaft, a servo motor, a supporting plate, a containing box and a pressing cover plate, the supporting shaft is rotationally installed in the cleaning cylinder, and the servo motor used for driving the supporting shaft to rotate is fixedly installed on the base; a pushing assembly used for pushing out the magnetic beads in the containing box is installed on the pressing cover plate. And the flushing frame used for single flushing of the magnetic beads is installed at the telescopic end of the hydraulic rod. The magnetic bead cleaning device has the advantages of being good in cleaning effect and convenient to count and count.

Description

Technical Field

[0001] The utility model relates to the field of biomedical technology equipment, in particular to a magnetic bead cleaning device. Background Art

[0002] Immunomagnetic beads (ImpetiCbead, abbreviated as IMB), a new immunological technology developed in recent years, combine the unique advantages of solidified reagents with the high specificity of immunological reactions. Based on immunology, it penetrates into various fields such as pathology, physiology, pharmacology, microbiology, biochemistry, and molecular genetics, and has been increasingly widely used in immunological detection, cell separation, purification of biological macromolecules, and molecular biology.

[0003] Therefore, when performing detection experiments with magnetic beads, the cleanliness of the magnetic beads themselves has a direct impact on the detection results. Traditional mixed cleaning of magnetic beads requires a large amount of cleaning solution, repeated rinsing, and the cleaning effect is generally average, which is both time-consuming and wasteful of water resources.

[0004] Therefore, it is necessary to provide a new magnetic bead cleaning device to solve the above technical problems. Content of the Utility Model

[0005] To solve the above technical problems, the utility model provides a magnetic bead cleaning device with good cleaning effect and convenient counting and statistics.

[0006] The magnetic bead cleaning device provided by the utility model includes: a base, a plurality of support legs are fixedly installed in the middle of the base, the top ends of the plurality of support legs are fixedly installed with a cleaning cylinder, the top end of the cleaning cylinder is fixedly installed with a spray pipe through a bracket, support arms are symmetrically installed at both ends of the base, and hydraulic rods are embedded on the two support arms;

[0007] A placing mechanism for initially washing magnetic beads is embedded in the cleaning cylinder, and the placing mechanism includes a support shaft, a servo motor, a support plate, a receiving box, and a pressing cover plate. The support shaft is rotatably installed in the cleaning cylinder, and the servo motor for driving the support shaft to rotate is fixedly installed on the base. The support plate is fixedly installed on the support shaft, and a plurality of receiving boxes for holding magnetic beads are evenly installed on the support plate. A pressing cover plate is fixedly installed on the top ends of the plurality of receiving boxes, and a pushing component for pushing out the magnetic beads in the receiving box is installed on the pressing cover plate;

[0008] A rinsing rack for single - rinsing magnetic beads is installed at the telescopic end of the hydraulic rod.

[0009] Preferably, a ball outlet is provided at the top of the outer wall of the containing box, an obliquely cut baffle is installed at the top of the containing box above the ball outlet, and a through hole is provided at the bottom of the containing box just below the baffle, and the diameter of the through hole is smaller than the diameter of the magnetic bead.

[0010] Preferably, the pushing assembly includes a support frame, a screw, a driving motor, a threaded sleeve, a pushing piece, an electric telescopic rod, a base plate and a push rod. The support frame is fixedly mounted on the pressure cover plate, and a screw and a driving motor for driving the screw to rotate are rotatably mounted on the support frame. A threaded sleeve is rotatably mounted on the screw, and a pushing piece for pushing the magnetic beads in the accommodating box is mounted on the threaded sleeve. Several of the electric telescopic rods are fixedly mounted on the edge of the pressure cover plate, and the telescopic ends of several of the electric telescopic rods are fixedly mounted downward through the pressure cover plate, and push rods are installed on the base plate just below the through holes opened at the bottom ends of several of the accommodating boxes, and the top ends of the push rods are inserted into the through holes opened in the accommodating boxes.

[0011] Preferably, the pushing member includes a sliding rod, a push plate and a transmission rod. The sliding rod is slidably installed in a through hole opened in the inner wall of the accommodating box, and the push plate is installed at one end of the sliding rod extending into the accommodating box. The sliding rod is hinged with a transmission rod, and the end of the transmission rod facing away from the sliding rod is rotatably connected to a semicircular ring welded to a threaded sleeve.

[0012] Preferably, the flushing rack includes a connecting seat, a connecting arm, a swing cylinder and a semicircular shell, the connecting seat is fixedly mounted on the telescopic end of the hydraulic rod, and the connecting arm and the swing cylinder for driving the connecting arm to rotate are rotatably mounted on the connecting seat, a semicircular shell is fixedly mounted on the front end of the connecting arm, flushing holes corresponding to multiple containing boxes are opened on the semicircular shell, and the diameter of the flushing hole is smaller than the diameter of the magnetic beads.

[0013] Preferably, the inner side wall of the semicircular shell is in contact with the outer side walls of the plurality of containing boxes, and retaining bars are welded on both sides of the flushing hole of the semicircular shell.

[0014] Preferably, a drying storage box is installed on the base on the inner sides of the two support arms.

[0015] Compared with the related art, the magnetic bead cleaning device provided by the utility model has the following beneficial effects:

[0016] 1 The utility model provides a magnetic bead cleaning device, which places a placing mechanism in a cleaning cylinder, and the placing mechanism uses the cooperation of a supporting shaft, a servo motor, a supporting plate, a containing box and a pressure cover plate to place magnetic beads in the containing box, and can be rotated and cleaned in the cleaning cylinder. After cleaning, the pushing component is used to push the magnetic beads in the containing box out, and cooperates with the flushing rack and the spray pipe to perform secondary flushing, so that the flushing is cleaner;

[0017] 2. While the pushing component pushes out and rinses the magnetic beads in the accommodating box, it can also count the magnetic beads, which is convenient for counting the number of magnetic beads. Brief Description of the Drawings

[0018] Figure 1 Schematic structural diagram of a preferred embodiment of the magnetic bead cleaning device provided by the present utility model;

[0019] Figure 2 Schematic structural diagram of another perspective of the magnetic bead cleaning device provided by the present utility model;

[0020] Figure 3 is Figure 1 Schematic structural diagram of the placement mechanism and the pushing component shown in;

[0021] Figure 4 is Figure 3 Schematic structural diagram of the accommodating box shown in;

[0022] Figure 5 is Figure 1 Schematic structural diagram of the rinsing rack shown in;

[0023] Figure 6 is Figure 1 Partial enlarged view of A shown in;

[0024] Reference numerals in the figure: 1, base; 11, support leg; 12, cleaning cylinder; 13, spray pipe; 131, nozzle; 132, adapter; 14, support arm; 15, hydraulic rod; 2, placement mechanism; 21, support shaft; 211, servo motor; 22, support plate; 23, accommodating box; 24, pressing cover plate; 231, baffle; 232, ball outlet; 3, pushing component; 31, support frame; 32, lead screw; 33, drive motor; 34, threaded sleeve; 341, semi-circular ring; 35, pushing member; 351, slide bar; 352, push plate; 353, transmission rod; 36, electric telescopic rod; 37, bottom plate; 38, push rod; 4, rinsing rack; 41, connecting seat; 42, connecting arm; 43, swing cylinder; 44, semi-circular housing; 401, rinsing hole; 441, retaining bar; 5, drying and storage box. Detailed Description of the Preferred Embodiments

[0025] In order to make the objectives, technical solutions and advantages of the present utility model more clear and understandable, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model.

[0026] The following describes the specific implementation of the present utility model in detail with reference to specific embodiments.

[0027] Please refer to Figures 1 to 6, A magnetic bead cleaning device provided by an embodiment of the present utility model, the magnetic bead cleaning device includes: a base 1, a placement mechanism 2, a pushing assembly 3, and a flushing rack 4.

[0028] A plurality of support legs 11 are fixedly installed in the middle of the base 1, the top ends of the plurality of support legs 11 are fixedly installed with a cleaning cylinder 12, the top end of the cleaning cylinder 12 is fixedly installed with a spray pipe 13 through a bracket, rear support arms 14 are symmetrically installed at both ends of the base 1, and hydraulic rods 15 are embedded on the two support arms 14;

[0029] The placement mechanism 2 for placing the initially washed magnetic beads is embedded in the cleaning cylinder 12, and the placement mechanism 2 includes a support shaft 21, a servo motor 211, a support plate 22, a receiving box 23, and a pressing cover plate 24. The support shaft 21 is rotatably installed in the cleaning cylinder 12, and the servo motor 211 for driving the support shaft 21 to rotate is fixedly installed on the base 1. The support plate 22 is fixedly installed on the support shaft 21, and a plurality of receiving boxes 23 for holding magnetic beads are evenly installed on the support plate 22. A pressing cover plate 24 is fixedly installed on the top ends of the plurality of receiving boxes 23, and a pushing assembly 3 for pushing out the magnetic beads in the receiving box 23 is installed on the pressing cover plate 24; The flushing rack 4 for single flushing of magnetic beads is installed at the telescopic end of the hydraulic rod 15.

[0030] Wherein, a ball outlet 232 is opened at the top end of the outer side wall of the receiving box 23, a baffle 231 arranged obliquely is installed above the ball outlet 232 at the top end of the receiving box 23, a through hole is opened at the bottom end of the receiving box 23 directly below the baffle 231, and the diameter of the through hole is smaller than the diameter of the magnetic beads.

[0031] It should be noted that: during use, the magnetic beads are equally placed in the receiving box 23, then cleaning liquid is injected into the cleaning cylinder 12, and then the servo motor 211 is started. The servo motor 211 drives the support shaft 21 to rotate, and the support shaft 21 drives the receiving box 23 to rotate in the cleaning cylinder 12, so as to agitate and clean the magnetic beads placed in the receiving box 23. After cleaning, the machine is stopped, and the pushing assembly 3 is started to push out the magnetic beads in the receiving box 23 from the ball outlet 232 one by one onto the flushing rack 4 for individual flushing by using the spray pipe 13, so as to effectively avoid repeated overall flushing.

[0032] It should also be noted that: a plurality of nozzles 131 are evenly installed on the spray pipe 13, and a conversion joint 132 for connecting to a water pump is also installed on the spray pipe 13, so that when spray flushing is required, liquid is introduced through the conversion joint 132 for spraying.

[0033] In the embodiment of the present utility model, please refer to Figure 1 and Figure 4The pushing assembly 3 includes a support frame 31, a screw rod 32, a driving motor 33, a threaded sleeve 34, a pushing piece 35, an electric telescopic rod 36, a bottom plate 37 and a push rod 38. The support frame 31 is fixedly installed on the pressure cover plate 24, and the support frame 31 is rotatably installed with a screw rod 32 and a driving motor 33 for driving the screw rod 32 to rotate. The screw rod 32 is rotatably installed with a threaded sleeve 34, and the threaded sleeve 34 is installed with a pushing piece 35 for pushing the magnetic beads in the accommodating box 23. Several electric telescopic rods 36 are fixedly installed on the edge of the pressure cover plate 24, and the telescopic ends of several electric telescopic rods 36 are fixedly installed downward through the pressure cover plate 24 with a bottom plate 37, and push rods 38 are installed on the bottom plate 37 just below the through holes opened at the bottom ends of several accommodating boxes 23, and the top ends of the push rods 38 are inserted into the through holes opened in the accommodating boxes 23

[0034] Among them, the pushing member 35 includes a sliding rod 351, a push plate 352 and a transmission rod 353. The sliding rod 351 is slidably installed in a through hole opened on the inner wall of the accommodating box 23, and the push plate 352 is installed on the end of the sliding rod 351 extending into the accommodating box 23. The sliding rod 351 is hinged with the transmission rod 353, and the end of the transmission rod 353 away from the sliding rod 351 is rotatably connected to the semicircular ring 341 welded to the threaded sleeve 34.

[0035] It should be noted that: when the pushing component 3 is in use, after the mixed cleaning is completed, the servo motor 211 stops and resets, and the driving motor 33 is started first. The driving motor 33 drives the screw rod 32 to rotate, and the screw rod 32 drives the threaded sleeve 34 to slide downward along the screw rod 32, thereby driving the semi-circular ring 341 to drive the transmission rod 353 to move downward synchronously. While the transmission rod 353 moves downward, it pushes the slide bar 351 to move into the receiving box 23, thereby pushing the push plate 352 to push the magnetic beads in the receiving box 23 to the outside of the receiving box 23, and stack them vertically one by one, and then control the electric telescopic rod 36 to drive the bottom plate 37 to intermittently rise a certain distance until the push rod 38 can push the stacked magnetic beads one by one from the ball outlet 232 and fall into the flushing rack 4, and then rinse.

[0036] It should also be noted that the inner cavity width of the containing box 23 is slightly larger than the diameter of the magnetic beads, so that when the push plate 352 pushes the magnetic beads, it cooperates with the inner wall of the containing box 23 to stack the magnetic beads one by one, and then when pushing again, the push rod 38, with the cooperation of the baffle 231, pushes the magnetic beads out of the ball outlet 232 and drops them onto the washing rack 4.

[0037] In the embodiments of the present invention, please refer to Figure 1 and Figure 4, the rinsing rack 4 includes a connecting seat 41, a connecting arm 42, a swing cylinder 43 and a semi-circular housing 44. The connecting seat 41 is fixedly installed at the telescopic end of the hydraulic rod 15, and a connecting arm 42 is rotatably installed on the connecting seat 41, and a swing cylinder 43 for driving the connecting arm 42 to rotate. The front end of the connecting arm 42 is fixedly installed with a semi-circular housing 44. The semi-circular housing 44 is provided with rinsing holes 401 corresponding to a plurality of receiving boxes 23, and the diameter of the rinsing holes 401 is smaller than the diameter of the magnetic beads.

[0038] Wherein, a drying and storage box 5 is installed inside the base 1 between the two support arms 14.

[0039] It should be noted that when the rinsing rack 4 is in use, the hydraulic rod 15 is controlled to extend until the inner side wall of the semi-circular housing 44 is attached to the outer side wall of the receiving box 23. Then, when the push rod 38 pushes the magnetic beads out of the ball outlet 232, the rinsing holes 401 are aligned with the ball outlet 232. Thus, when the magnetic beads are pushed out of the ball outlet 232, they automatically fall into the rinsing holes 401, and then they can be rinsed by spraying with the spray pipe 13. After rinsing, the hydraulic rod 15 contracts and resets until the semi-circular housing 44 is directly above the drying and storage box 5. Then, the swing cylinder 43 is controlled to drive the connecting arm 42 to drive the semi-circular housing 44 to rotate towards the drying and storage box 5 until the magnetic beads automatically fall into the drying and storage box 5. Then, the semi-circular housing 44 is controlled to reset to be attached to the outer side wall of the receiving box 23 for the next round of rinsing.

[0040] In this embodiment: the inner side wall of the semi-circular housing 44 is attached to the outer side walls of a plurality of receiving boxes 23, and blocking strips 441 are welded on both sides of the rinsing holes 401 of the semi-circular housing 44. In this way, with the restriction of the blocking strips 441, the magnetic beads coming out of the ball outlet 232 can smoothly roll into the rinsing holes 401.

[0041] The working principle of the magnetic bead cleaning device provided by the present utility model is as follows:

[0042] In use, the magnetic beads are evenly placed in the accommodation box 23. Then, cleaning liquid is injected into the cleaning cylinder 12. Next, the servo motor 211 is started. The servo motor 211 drives the support shaft 21 to rotate, and the support shaft 21 drives the accommodation box 23 to rotate within the cleaning cylinder 12, so as to stir and clean the magnetic beads placed in the accommodation box 23. After cleaning, the machine stops. First, the drive motor 33 is started. The drive motor 33 drives the lead screw 32 to rotate, and the lead screw 32 drives the threaded sleeve 34 to slide downward along the lead screw 32, thereby driving the semi-circular ring 341 to drive the transmission rod 353 to move downward synchronously. While the transmission rod 353 moves downward, it pushes the sliding rod 351 to move into the accommodation box 23, thereby pushing the push plate 352 to push the magnetic beads in the accommodation box 23 to the outside of the accommodation box 23 and stack them vertically one by one. Then, the electric telescopic rod 36 is controlled to drive the bottom plate 37 to intermittently rise a certain distance until the push rod 38 can push the stacked magnetic beads one by one out of the ball outlet 232 and fall into the flushing holes 401 of the flushing rack 4. Then, spraying and flushing are carried out using the spray pipe 13. After flushing, the hydraulic rod 15 contracts and resets until the semi-circular shell 44 is directly above the drying and storage box 5. Then, the swing cylinder 43 is controlled to drive the connecting arm 42 to drive the semi-circular shell 44 to rotate towards the drying and storage box 5 until the magnetic beads automatically fall into the drying and storage box 5. Then, the semi-circular shell 44 is controlled to reset to fit the outer wall of the accommodation box 23 for the next round of flushing. The whole cleaning only requires one mixed cleaning and liquid removal, and then separate flushing and drying. Moreover, the semi-circular shell can be used to count the magnetic beads, and the overall cleaning effect is good.

[0043] The circuits and controls involved in the present utility model are all prior arts and will not be elaborated here.

[0044] The above are only the embodiments of the present utility model, and thus do not limit the patent scope of the present utility model. Any equivalent structural or equivalent process transformations made by using the content of the specification and drawings of the present utility model, or directly or indirectly applied in other related technical fields, shall similarly be included within the patent protection scope of the present utility model.

Claims

1. A magnetic bead cleaning device, comprising: A base (1), in the middle of the base (1), a plurality of support legs (11) are fixedly installed, at the top ends of the plurality of support legs (11), a cleaning cylinder (12) is fixedly installed, at the top end of the cleaning cylinder (12), a spray pipe (13) is fixedly installed through a bracket, at both ends of the base (1), support arms (14) are symmetrically installed, and hydraulic rods (15) are embedded on the two support arms (14); Characterized in that it further comprises: A placing mechanism (2), used for mixing and initially washing magnetic beads, the placing mechanism (2) is embedded in the cleaning cylinder (12), and the placing mechanism (2) includes a support shaft (21), a servo motor (211), a support plate (22), a receiving box (23) and a pressing cover plate (24), the support shaft (21) is rotatably installed in the cleaning cylinder (12), and the servo motor (211) used to drive the rotation of the support shaft (21) is fixedly installed on the base (1), the support plate (22) is fixedly installed on the support shaft (21), and a number of receiving boxes (23) for holding magnetic beads are evenly installed on the support plate (22), at the top ends of the number of receiving boxes (23), a pressing cover plate (24) is fixedly installed together, and a pushing component (3) for pushing out the magnetic beads in the receiving box (23) is installed on the pressing cover plate (24); A flushing rack (4), used for single flushing of magnetic beads, the flushing rack (4) is installed at the telescopic end of the hydraulic rod (15).

2. The magnetic bead cleaning device according to claim 1, wherein At the top end of the outer side wall of the receiving box (23), a ball outlet (232) is opened, above the ball outlet (232) at the top end of the receiving box (23), an obliquely arranged baffle (231) is installed, at the bottom end of the receiving box (23), a through hole is opened directly below the baffle (231), and the diameter of the through hole is smaller than the diameter of the magnetic beads.

3. The magnetic bead cleaning device according to claim 1, characterized in that, The pushing component (3) includes a support frame (31), a lead screw (32), a driving motor (33), a threaded sleeve (34), a pushing member (35), an electric telescopic rod (36), a bottom plate (37) and a push rod (38), the support frame (31) is fixedly installed on the pressing cover plate (24), and on the support frame (31), a lead screw (32) is rotatably installed, and a driving motor (33) used to drive the rotation of the lead screw (32), on the lead screw (32), a threaded sleeve (34) is rotatably installed, on the threaded sleeve (34), a pushing member (35) for pushing the magnetic beads in the receiving box (23) is installed, a number of electric telescopic rods (36) are fixedly installed at the edge of the pressing cover plate (24), and the telescopic ends of the number of electric telescopic rods (36) pass through the pressing cover plate (24) downward and are fixedly installed with a bottom plate (37), on the bottom plate (37), directly below the through holes opened at the bottom ends of the number of receiving boxes (23), push rods (38) are installed, and the top ends of the push rods (38) are inserted into the through holes opened in the receiving box (23).

4. The magnetic bead cleaning device according to claim 3, wherein The pushing member (35) comprises a sliding rod (351), a pushing plate (352) and a transmission rod (353); the sliding rod (351) is slidably installed in a through hole provided in the inner wall of the accommodating box (23); and the pushing plate (352) is installed at one end of the sliding rod (351) extending into the accommodating box (23); the transmission rod (353) is hingedly connected to the sliding rod (351); and the end of the transmission rod (353) facing away from the sliding rod (351) is rotatably connected to a semicircular ring (341) welded to the threaded sleeve (34).

5. The magnetic bead cleaning device according to claim 1, wherein The flushing rack (4) comprises a connecting seat (41), a connecting arm (42), a swinging cylinder (43) and a semicircular shell (44); the connecting seat (41) is fixedly mounted on the telescopic end of the hydraulic rod (15); the connecting arm (42) and the swinging cylinder (43) for driving the connecting arm (42) to rotate are rotatably mounted on the connecting seat (41); a semicircular shell (44) is fixedly mounted at the front end of the connecting arm (42); flushing holes (401) corresponding to a plurality of accommodating boxes (23) are provided on the semicircular shell (44); the diameter of the flushing hole (401) is smaller than the diameter of the magnetic beads.

6. The magnetic bead cleaning device according to claim 5, wherein The inner side wall of the semicircular shell (44) is fitted with the outer side walls of the plurality of accommodating boxes (23), and blocking bars (441) are welded on both sides of the flushing hole (401) of the semicircular shell (44).

7. The magnetic bead cleaning device according to claim 1, wherein A drying storage box (5) is installed on the base (1) on the inner side of the two support arms (14).

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