Simulated moving bed online elution equipment

Abstract

The utility model relates to online elution equipment for a simulated moving bed. The online elution equipment comprises an adsorption system, a replacement system, a raw material feeding system, a mobile phase feeding system, a circulating system, a raffinate system and an extract system, the adsorption system comprises a plurality of adsorption columns, and each functional area is provided with at least one adsorption column; the replacement system comprises a replacement column and a replacement pipeline assembly, the structure of the replacement column is the same as that of the adsorption column, and the column top and the column bottom of the replacement column are connected with the column top and the column bottom of each adsorption column through the replacement pipeline assembly; the replacement column can replace the adsorption column in the isolation area so as to elute the adsorption column in the isolation area. Therefore, after the adsorption column in the isolation area is replaced by the replacement column, the replacement column can be connected into the circulation loop, so that the whole equipment can normally operate, the adsorption column in the isolation area does not need to be shut down during elution, and the stable and uninterrupted operation of the equipment is ensured.

Description

Technical Field

[0001] The present application relates to the technical field of separation equipment, and in particular to a simulated moving bed online elution equipment. Background Art

[0002] Simulated moving bed is a mass transfer device that uses the adsorption principle to perform liquid separation operations. It is a countercurrent continuous operation mode. By changing the material inlet and outlet positions of the fixed bed adsorption equipment, it produces an effect equivalent to the adsorbent moving continuously downward and the material moving continuously upward. As the main representative of continuous chromatography, simulated moving bed technology has the advantages of high production efficiency, low organic solvent consumption, large mass transfer driving force, and convenient automated continuous production. It is widely used in petrochemical, food industry, pharmaceutical and other fields.

[0003] Conventional simulated moving beds use adsorption beds for separation. Usually, the adsorption bed includes multiple adsorption columns, which form adsorption zones, purification zones, desorption zones, and isolation zones. Due to their own characteristics, the performance of some fillers in the adsorption columns drops sharply after a period of continuous use, and the columns need to be disassembled for elution, which takes two weeks. This will increase labor costs, lose some of the feed liquid, and the time spent will also affect the separation efficiency, which will invisibly increase costs and supply pressures. Utility Model Content

[0004] Based on this, it is necessary to provide a simulated moving bed online elution equipment to address the problem that the elution of the adsorption column in the current simulated moving bed requires equipment shutdown, resulting in high costs and affecting the separation efficiency. The equipment can elute the adsorption column without affecting the normal operation of the elution equipment, thereby ensuring the adsorption and separation efficiency of the equipment and reducing costs and supply pressure.

[0005] A simulated moving bed online elution device, comprising an adsorption system, a replacement system, a raw material feeding system, a mobile phase feeding system, a circulation system, a residual liquid extraction system and an extraction liquid system;

[0006] The adsorption system comprises a plurality of adsorption columns, which are divided into a plurality of functional zones, namely, an adsorption zone, a purification zone, a desorption zone and an isolation zone, and each functional zone has at least one adsorption column;

[0007] The replacement system includes a replacement column and a replacement pipeline assembly. The structure of the replacement column is the same as that of the adsorption column. The column top and column bottom of the replacement column are connected to the column top and column bottom of each adsorption column through the replacement pipeline assembly.

[0008] The circulation system includes a circulation pipeline, one-way valves and a circulation pump. Each of the adsorption columns is connected in series end to end through the circulation pipeline to form a circulation loop. The circulation pump is arranged on the circulation pipeline, and one one-way valve is arranged between adjacent adsorption columns. The raw material feeding system and the mobile phase feeding system are respectively connected to the tops of the adsorption columns, and the raffinate system and the extract system are respectively connected to the bottoms of the adsorption columns.

[0009] The replacement column can replace the adsorption column in the isolation area to elute the adsorption column in the isolation area.

[0010] In an embodiment of the present application, the replacement pipeline assembly includes a first replacement pipe and a second replacement pipe. One end of the first replacement pipe is connected to the top of the replacement column, and the other end of the first replacement pipe is respectively connected to the tops of the adsorption columns. One end of the second replacement pipe is connected to the bottom of the replacement column, and the other end of the second replacement pipe is respectively connected to the bottoms of the adsorption columns.

[0011] In an embodiment of the present application, the first replacement pipe includes a first replacement main pipe and a plurality of first replacement branch pipes, and the second replacement pipe includes a second replacement main pipe and a plurality of second replacement branch pipes;

[0012] The top of each adsorption column is connected to a first replacement branch pipe, and the bottom of each adsorption column is connected to a second replacement branch pipe. One end of the first replacement main pipe is connected to the top of the replacement column, and the other end is connected to each first replacement branch pipe. One end of each second replacement main pipe is connected to the bottom of the replacement column, and the other end is connected to each second replacement branch pipe.

[0013] In an embodiment of the present application, the replacement pipeline assembly further includes a plurality of input valves and a plurality of output valves. One input valve is arranged at the top of each adsorption column, and one output valve is arranged at the bottom of each adsorption column;

[0014] The input valve is connected to the first replacement pipe, and the output valve is connected to the second replacement pipe.

[0015] In an embodiment of the present application, both the input valve and the output valve are three-way valves;

[0016] The input valve has a first inlet, a second inlet and a third inlet. The first inlet is connected to the adsorption column, the second inlet is connected to the raw material feeding system, the mobile phase feeding system and the circulation pipeline, and the third inlet is connected to the first replacement pipe; the input valve has a first outlet, a second outlet and a third outlet. The first outlet is connected to the adsorption column, the second outlet is connected to the raffinate system, the extract system and the circulation pipeline, and the third outlet is connected to the second replacement pipe;

[0017] And / or, the input valve and the output valve are one of a ball valve, a regulating valve, a butterfly valve, a diaphragm valve, and a cock valve, and are driven pneumatically or electrically.

[0018] In an embodiment of the present application, the number of the replacement columns is equal to the number of the adsorption columns in the isolation zone; each of the replacement columns replaces one of the adsorption columns in the isolation zone.

[0019] In an embodiment of the present application, the raw material feeding system includes a raw material feeding pipe, a plurality of raw material feeding valves, and a first back pressure valve. A raw material feeding valve is arranged at the top of each adsorption column. The raw material feeding pipe connects the raw material barrel and each raw material feeding valve, and the first back pressure valve is arranged on the raw material feeding pipe;

[0020] And / or, the mobile phase feeding system includes a mobile phase feeding pipe, a plurality of mobile phase feeding valves, and a second back pressure valve. A mobile phase feeding valve is further arranged at the top of each adsorption column. The mobile phase feeding pipe connects the mobile phase cylinder and each mobile phase feeding valve, and the second back pressure valve is arranged on the mobile phase feeding pipe.

[0021] In an embodiment of the present application, the raffinate system includes a raffinate discharge pipe, a third back pressure valve, and a plurality of raffinate discharge valves. A raffinate discharge valve is arranged at the bottom of each adsorption column. The raffinate discharge pipe connects each raffinate discharge valve, and the third back pressure valve is arranged on the raffinate discharge pipe;

[0022] And / or, the extract system includes an extract discharge pipe, a fourth back pressure valve, and a plurality of extract discharge valves. An extract discharge valve is further arranged at the bottom of each adsorption column. The extract discharge pipe connects each extract discharge valve, and the fourth back pressure valve is arranged on the extract discharge pipe.

[0023] In an embodiment of the present application, the simulated moving bed on-line elution device further includes a program control valve group and an automatic control system. All valves form the program control valve group. The automatic control system is connected to the program control valve group for control. The automatic control system can control the opening and closing states of the valves in the program control valve group in manual and automatic operation modes;

[0024] Each of the valves in the program control valve group is independently controlled, and the valves in the program control valve group except the input valve and the output valve are one of a ball valve, a needle valve, a globe valve, and a butterfly valve, and are controlled pneumatically or electrically.

[0025] In an embodiment of the present application, the number of the multiple adsorption columns is six. Among them, the adsorption zone includes two of the adsorption columns, the purification zone includes two of the adsorption columns, the desorption zone includes one of the adsorption columns, the isolation zone includes one of the adsorption columns, and the replacement system includes one replacement column;

[0026] The replacement column can replace the adsorption column in the isolation zone, so that the adsorption column in the isolation zone can be eluted.

[0027] After adopting the above technical solution, the present application has at least the following technical effects:

[0028] For the simulated moving bed online elution equipment of the present application, the multiple adsorption columns of the adsorption system are divided into multiple functional zones, each functional zone has at least one adsorption column, the replacement column of the replacement system is arranged side by side with the multiple adsorption columns, the replacement column is respectively connected to the top and bottom of each adsorption column through a replacement pipeline assembly, the circulation pipeline of the circulation system connects the adsorption columns and the replacement column in series to form a circulation loop, the circulation pump is arranged in the circulation pipeline, and the raw material feeding system and the mobile phase feeding system are respectively connected to the top of each adsorption column. The replacement column can replace the adsorption column in the isolation zone, so that the replacement column can temporarily store materials, and at the same time, the adsorption column in the isolation zone can be eluted.

[0029] For this simulated moving bed online elution equipment, the replacement pipeline assembly in the replacement system is used to connect the replacement column to the top and bottom of each adsorption column. When the adsorption column in the isolation zone needs to be eluted, the replacement column is connected to the circulation loop to replace the adsorption column in the isolation zone. At this time, the adsorption column in the isolation zone is not in the circulation loop, and the adsorption column can be eluted. In this way, after using the replacement column to replace the adsorption column in the isolation zone, the adsorption column in the isolation zone does not need to stop the machine during elution, which will not affect the normal operation of the entire equipment, so that the simulated moving bed online elution equipment can normally perform separation operations, ensure the adsorption separation efficiency, and reduce costs and supply pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic structural diagram of the simulated moving bed online elution equipment according to an embodiment of the present application.

[0031] Figure 2 is Figure 1 The replacement schematic diagram of the shown simulated moving bed online elution equipment.

[0032] Figure 3 is Figure 1 The partial schematic diagram at the first adsorption column of the shown simulated moving bed online elution equipment.

[0033] Figure 4 It is a flowchart of the simulated moving bed online elution method according to an embodiment of the present application.

[0034] Wherein: 100 is an on-line elution device for simulated moving bed; 110 is an adsorption system; 101 is an adsorption column; 111 is the first adsorption column; 112 is the second adsorption column; 113 is the third adsorption column; 114 is the fourth adsorption column; 115 is the fifth adsorption column; 116 is the sixth adsorption column; 120 is a replacement system; 121 is a replacement column; 122 is a replacement pipeline assembly; 1221 is the first replacement main pipe; 1222 is the first replacement branch pipe; 1223 is the second replacement main pipe; 1224 is the second replacement branch pipe; 123 is an input valve; 1231 is the first inlet; 1232 is the second inlet; 1233 is the third inlet; 124 is an output valve; 1241 is the first outlet; 1242 is the second outlet; 1243 is the third outlet; 130 is a raw material feeding system; 131 is a raw material feeding pipe; 132 is a raw material feeding valve; 133 is the first back pressure valve; 134 is a raw material pump; 140 is a mobile phase feeding system; 141 is a mobile phase feeding pipe; 142 is a mobile phase feeding valve; 143 is the second back pressure valve; 144 is a mobile phase pump; 150 is a circulation system; 151 is a circulation pipeline; 152 is a circulation pump; 153 is a one-way valve; 160 is a raffinate system; 161 is a raffinate discharge pipe; 162 is a raffinate discharge valve; 163 is the third back pressure valve; 170 is an extract system; 171 is an extract discharge pipe; 172 is an extract discharge valve; 173 is the fourth back pressure valve. Detailed implementation manners

[0035] To make the above objects, features, and advantages of the present application more apparent and understandable, the following will describe the detailed implementation manners of the present application with reference to the accompanying drawings. Many specific details are set forth in the following description to fully understand the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the connotation of the present application. Therefore, the present application is not limited by the specific embodiments disclosed below.

[0036] In the description of the present application, it should be understood that if there appear such terms as "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., the orientation or positional relationship indicated by these terms is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present application.

[0037] In addition, if the terms "first" and "second" appear, these terms are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In the description of this application, if the term "a plurality of" appears, "a plurality of" means at least two, such as two, three, etc., unless otherwise specifically and clearly defined.

[0038] In this application, unless otherwise clearly specified and defined, if terms such as "installed", "connected", "linked", "fixed", etc. appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components, unless otherwise clearly defined. For those of ordinary skill in the art, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0039] In this application, unless otherwise clearly specified and defined, if there is a description such as a first feature "on" or "under" a second feature, its meaning can be that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature can be that the first feature is directly above or obliquely above the second feature, or merely indicates that the first feature has a higher horizontal height than the second feature. The first feature being "under", "beneath" and "underneath" the second feature can be that the first feature is directly below or obliquely below the second feature, or merely indicates that the first feature has a lower horizontal height than the second feature.

[0040] It should be noted that if an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or there may also be an intermediate element. If an element is considered to be "connected" to another element, it can be directly connected to the other element or there may be an intermediate element at the same time. If so, the terms "vertical", "horizontal", "up", "down", "left", "right" and similar expressions used in this application are only for the purpose of illustration and do not represent the only implementation.

[0041] See Figure 1 , this application provides an on-line elution device 100 for a simulated moving bed. Figure 1The structure diagram of the simulated moving bed online elution device 100 of one embodiment of the present application is shown in FIG. The simulated moving bed online elution device 100 is a mass transfer device that uses the adsorption principle to perform liquid separation operations. It operates in a countercurrent continuous manner and simultaneously and regularly changes the material inlet and outlet positions of the fixed bed adsorption device to produce an effect equivalent to the continuous upward movement of the adsorbent and the continuous downward movement of the material, thereby achieving the purpose of adsorption separation.

[0042] It is understandable that, due to their own characteristics, the performance of certain fillers in the adsorption column of the simulated moving bed drops sharply after a period of continuous use, and the column needs to be dismantled for elution, a process that takes two weeks. This will increase labor costs and lose part of the slurry, and the time consumed will also invisibly increase costs and supply pressures. To this end, the present application provides a new type of simulated moving bed online elution equipment 100, which can elute the adsorption column 101 without affecting the normal operation of the elution equipment, thereby ensuring the adsorption and separation efficiency of the equipment and reducing costs and supply pressures. The specific structure of the simulated moving bed online elution equipment 100 of one embodiment is introduced below.

[0043] See also Figure 1 In one embodiment, the simulated moving bed online elution device 100 includes an adsorption system 110, a replacement system 120, a raw material feeding system 130, a mobile phase feeding system 140, a circulation system 150, a residual liquid extraction system 160, and an extraction liquid system 170. The adsorption system 110 includes a plurality of adsorption columns 101, and the plurality of adsorption columns 101 are divided into a plurality of functional areas, namely, an adsorption area, a purification area, a desorption area, and an isolation area, and each functional area has at least one adsorption column 101. The replacement system 120 includes a replacement column 121 and a replacement pipeline assembly 122. The structure of the replacement column 121 is the same as that of the adsorption column 101. The column top and column bottom of the replacement column 121 are connected to the column top and column bottom of each adsorption column 101 through the replacement pipeline assembly 122. The circulation system 150 includes a circulation pipeline 151, a one-way valve 153 and a circulation pump 152. Each adsorption column 101 is connected in series through the circulation pipeline 151 to form a circulation loop. The circulation pump 152 is arranged in the circulation pipeline 151. A one-way valve 153 is arranged between adjacent adsorption columns 101. The raw material feeding system 130 and the mobile phase feeding system 140 are respectively connected to the top of each adsorption column 101. The residual liquid extraction system 160 and the extraction liquid system 170 are respectively connected to the bottom of each adsorption column 101. The replacement column 121 can replace the adsorption column 101 in the isolation zone to elute the adsorption column 101 in the isolation zone.

[0044] The adsorption system 110 is the main adsorption bed of the simulated moving bed online elution device 100. The adsorption, purification, and desorption of raw materials are achieved through the adsorption system 110. The raw material feeding system 130 is connected to the mobile phase feeding system 140 and the adsorption system 110. The raw material feeding system 130 supplies raw materials to the adsorption system 110, and the mobile phase feeding system 140 supplies the mobile phase to the adsorption system 110. The mobile phase can flow in the adsorption system 110 as a carrier for the raw materials. The mixture of the raw materials and the mobile phase is denoted as the material. The raffinate system 160 is connected to the extract system 170 and the adsorption system 110. After the adsorption system 110 completes the adsorption and separation of the raw materials to generate raffinate and extract, the raffinate is extracted through the raffinate system 160, and the extract is extracted through the extract system 170.

[0045] Specifically, the adsorption system 110 includes multiple adsorption columns 101. The adsorption and separation of raw materials are achieved through the multiple adsorption columns 101. The multiple adsorption columns 101 are arranged side by side and connected through a circulation system 150 to form a circulation loop. The circulation system 150 includes a circulation pipeline 151 and a circulation pump 152. The circulation pipeline 151 serially connects the multiple adsorption columns 101 from beginning to end to form a circulation loop. The circulation pump 152 is arranged on the circulation pipeline 151 to provide power for the flow of the material in the circulation loop. Moreover, a check valve 153 is provided in the circulation pipeline 151 between two adjacent adsorption columns 101 to ensure the unidirectional flow of the material and prevent backflow. That is to say, in this application, the circulation system 150 is used to serially connect multiple adsorption columns 101 to form a circulation loop for the material to flow, so as to perform the adsorption and separation operation on the raw materials.

[0046] Moreover, the multiple adsorption columns 101 form multiple functional zones of the adsorption system 110. The multiple functional zones are respectively an adsorption zone, a purification zone, a desorption zone, and an isolation zone. Each functional zone has at least one adsorption column 101, and the corresponding functions are realized through the adsorption column 101 in the corresponding functional zone. For example, the adsorption column 101 in the adsorption zone can perform adsorption operations, the adsorption column 101 in the purification zone can perform purification operations, the adsorption column 101 in the desorption zone can perform desorption operations, and the adsorption column 101 in the isolation zone can perform temporary storage operations. When the circulation loop operates, the positions of each functional zone will change to produce the effect of the continuous downward movement of the adsorbent and the continuous upward movement of the material. The operating principle of the adsorption system 110 is prior art and will not be elaborated here. Only the structure and principle of how the adsorption column 101 is eluted without affecting the normal operation of the equipment after running for a period of time are described here.

[0047] In order to realize the elution of the adsorption column 101 without stopping the equipment, the simulated moving bed online elution equipment 100 of the present application further includes a replacement system 120 to replace the adsorption column 101 through the replacement system 120. Specifically, the replacement system 120 includes a replacement column 121 and a replacement pipeline assembly 122. The replacement column 121 is connected to the top and bottom of each adsorption column 101 through the replacement pipeline assembly 122. The structure of the replacement column 121 is the same as that of the adsorption column 101, and the replacement column 121 can perform adsorption separation operations when replacing the adsorption column 101. When the equipment is running normally (the adsorption column 101 does not need to be eluted), the adsorption system 110 works normally, and the connection between the replacement pipeline assembly 122 and each adsorption column 101 is disconnected. When replacing the adsorption column 101, the replacement pipeline assembly 122 can communicate with the corresponding adsorption column 101 and disconnect from the other adsorption columns 101. The replacement of the adsorption column 101 in the isolation area is realized through the replacement column 121, and the adsorption separation function of the adsorption system 110 will not be affected.

[0048] After a certain adsorption column 101 has been continuously used for a period of time and its adsorption performance has decreased, when this adsorption column 101 runs to the isolation area, the top of the replacement column 121 is connected to the top of the adsorption column 101 in the isolation area through the replacement pipeline assembly 122, and the bottom of the replacement column 121 is connected to the bottom of the adsorption column 101 in the isolation area through the replacement pipeline assembly 122. At this time, the replacement column 121 is connected into the circulation loop. The previous adsorption column 101, the raw material feeding system 130, and the mobile phase feeding system 140 can be connected to the replacement column 121 through the replacement pipeline assembly 122. The bottom of the replacement column 121 can be connected to the top of the next adsorption column 101, the raffinate system 160, and the extract system 170 through the replacement pipeline assembly 122. That is, the remaining adsorption columns 101 and the replacement column 121 are connected to the circulation pipeline 151 through the replacement pipeline assembly 122 to form a circulation loop, and the separation operation can continue to ensure the stable and uninterrupted operation of the equipment.

[0049] At the same time, the adsorption column 101 in the isolation area is replaced from the circulation loop. This adsorption column 101 does not participate in the separation operation, and the column can be disassembled and eluted. Exemplarily, the packing in the adsorption column 101 (such as resin, etc.) can be replaced or the packing in the adsorption column 101 can be cleaned, etc., so that the packing in the adsorption column 101 can restore its own adsorption characteristics. After the adsorption column 101 is eluted, the adsorption column 101 is installed back in place. When this adsorption column 101 runs to the isolation area again, this adsorption column 101 is connected into the circulation loop to replace the replacement column 121 from the circulation loop. When the performance of the remaining adsorption columns 101 decreases, the remaining adsorption columns 101 can be eluted in this way.

[0050] After the adsorption column 101 in the isolation zone is replaced by the replacement column 121, the replacement column 121 can be connected to the circulation loop so that the entire device can operate normally without downtime due to the removal and elution of the adsorption column 101 in the isolation zone, ensuring the stable and uninterrupted operation of the device. The raw material and the mobile phase can flow normally in the circulation loop, and each adsorption column 101 can adsorb and separate the material to obtain raffinate and extract. In this way, the removal and elution of the column do not take time, and the separation efficiency of the entire device can be ensured to meet the usage requirements.

[0051] For the simulated moving bed on-line elution device 100 of the above embodiment, the replacement pipeline assembly 122 in the replacement system 120 is used to connect the top and bottom of the replacement column 121 and each adsorption column 101. When the adsorption column 101 in the isolation zone needs to be eluted, the replacement column 121 is connected to the circulation loop to replace the adsorption column 101 in the isolation zone. At this time, the adsorption column 101 in the isolation zone is not in the circulation loop, and the adsorption column 101 can be eluted. In this way, after the adsorption column 101 in the isolation zone is replaced by the replacement column 121, the adsorption column 101 in the isolation zone does not need to be shut down during elution, which does not affect the normal operation of the entire device, enabling the simulated moving bed on-line elution device 100 to perform separation operations normally, ensuring the adsorption separation efficiency, and reducing costs and supply pressure.

[0052] See Figure 1 , in one embodiment, the circulation pipeline 151 includes a first circulation pipeline 151 and a second circulation pipeline 151. The bottoms and tops of adjacent adsorption columns 101 are connected in series through the second circulation pipeline 151, and the first circulation pipeline 151 connects the bottom of the last adsorption column 101 and the top of the first adsorption column 101 in series. A check valve 153 is provided in each second circulation pipeline 151, and the circulation pump 152 is provided in the first circulation pipeline 151. In this way, each adsorption column 101 is connected in series through the first circulation pipeline 151 and the second circulation pipeline 151 to form a circulation loop.

[0053] See Figure 1, in one embodiment, the raw material feeding system 130 includes a raw material feeding pipe 131, a plurality of raw material feeding valves 132, and a first back pressure valve 133. A raw material feeding valve 132 is provided at the top of each adsorption column 101. The raw material feeding pipe 131 connects the raw material tank and each raw material feeding valve 132, and the first back pressure valve 133 is provided on the raw material feeding pipe 131. The raw material feeding valve 132 is provided at the top of each adsorption column 101. The raw material feeding pipe 131 is a pipeline for transporting raw materials. One end of the raw material feeding pipe 131 is connected to the raw material tank, and the other end of the raw material feeding pipe 131 is respectively connected to each raw material feeding valve 132. When the raw material feeding valve 132 is opened, the raw material feeding pipe 131 can transport the raw materials to the corresponding adsorption column 101 through the corresponding raw material feeding valve 132. When the raw material feeding valve 132 is closed, the raw materials cannot be transported through the raw material feeding valve 132. The first back pressure valve 133 is provided on the raw material feeding pipe 131 to provide power for the transportation of the raw materials to control the flow of the raw materials in the raw material feeding pipe 131. Optionally, the raw material feeding system 130 further includes a raw material pump 134, and the raw material pump 134 is provided on the raw material feeding pipe 131.

[0054] See Figure 1 , in one embodiment, the mobile phase feeding system 140 includes a mobile phase feeding pipe 141, a plurality of mobile phase feeding valves 142, and a second back pressure valve 143. A mobile phase feeding valve 142 is further provided at the top of each adsorption column 101. The mobile phase feeding pipe 141 connects the mobile phase cylinder and each mobile phase feeding valve 142, and the second back pressure valve 143 is provided on the mobile phase feeding pipe 141. The mobile phase feeding valve 142 is provided at the top of each adsorption column 101. The mobile phase feeding pipe 141 is a pipeline for transporting the mobile phase. One end of the mobile phase feeding pipe 141 is connected to the mobile phase cylinder (solvent tank), and the other end of the mobile phase feeding pipe 141 is respectively connected to each mobile phase feeding valve 142. When the mobile phase feeding valve 142 is opened, the mobile phase feeding pipe 141 can transport the mobile phase to the corresponding adsorption column 101 through the corresponding mobile phase feeding valve 142. When the mobile phase feeding valve 142 is closed, the mobile phase cannot be transported through the mobile phase feeding valve 142. The second back pressure valve 143 is provided on the mobile phase feeding pipe 141 to provide power for the transportation of the mobile phase to control the flow of the mobile phase in the mobile phase feeding pipe 141. Optionally, the mobile phase feeding system 140 further includes a mobile phase pump 144, and the mobile phase pump 144 is provided on the mobile phase feeding pipe 141.

[0055] See Figure 1, in one embodiment, the raffinate system 160 includes a raffinate discharge pipe 161, a third back pressure valve 163, and a plurality of raffinate discharge valves 162. A raffinate discharge valve 162 is provided at the bottom of each adsorption column 101. The raffinate discharge pipe 161 is connected to each raffinate discharge valve 162, and the third back pressure valve 163 is provided on the raffinate discharge pipe 161. The raffinate discharge valves 162 are respectively provided at the bottoms of the respective adsorption columns 101. The raffinate discharge pipe 161 is a pipeline for the flow of raffinate. One end of the raffinate discharge pipe 161 is respectively connected to each raffinate discharge valve 162, and the other end of the raffinate discharge pipe 161 is connected to a corresponding storage container. When the raffinate discharge valve 162 is opened, the raffinate of the corresponding adsorption column 101 can enter the raffinate discharge pipe 161 through the raffinate discharge valve 162. The third back pressure valve 163 is provided on the raffinate discharge pipe 161 to provide power for the extraction of raffinate to control the flow of raffinate in the raffinate discharge pipe 161.

[0056] See Figure 1 , in one embodiment, the extract system 170 includes an extract discharge pipe 171, a fourth back pressure valve 173, and a plurality of extract discharge valves 172. An extract discharge valve 172 is further provided at the bottom of each adsorption column 101. The extract discharge pipe 171 is connected to each extract discharge valve 172, and the fourth back pressure valve 173 is provided on the extract discharge pipe 171. The extract discharge valves 172 are respectively provided at the bottoms of the respective adsorption columns 101. The extract discharge pipe 171 is a pipeline for the flow of extract. One end of the extract discharge pipe 171 is respectively connected to each extract discharge valve 172, and the other end of the extract discharge pipe 171 is connected to a corresponding storage container. When the extract discharge valve 172 is opened, the extract of the corresponding adsorption column 101 can enter the extract discharge pipe 171 through the extract discharge valve 172. The fourth back pressure valve 173 is provided on the extract discharge pipe 171 to provide power for the extraction of extract to control the flow of extract in the extract discharge pipe 171.

[0057] See Figure 1 , in one embodiment, the number of replacement columns 121 is equal to the number of adsorption columns 101 in the isolation zone, and each replacement column 121 replaces one adsorption column 101 in the isolation zone. It can be understood that the replacement column 121 replaces the adsorption column 101 in the isolation zone. Generally, the number of replacement columns 121 is set according to the number of adsorption columns 101 in the isolation zone. In this way, the replacement column 121 can accurately replace each adsorption column 101 in the isolation zone to elute each adsorption column 101 in the isolation zone, and at the same time ensure the stable and uninterrupted operation of the entire device.

[0058] Exemplarily, such as Figure 1As shown, the number of replacement columns 121 is one, and the number of adsorption columns 101 in the isolation zone is one. When eluting the adsorption column 101 in the isolation zone, the replacement column 121 can precisely replace one adsorption column 101 in the isolation zone. Of course, in other embodiments of the present application, the number of replacement columns 121 is at least two, and the number of replacement columns 121 is equal to the number of adsorption columns 101 in the isolation zone. When eluting each adsorption column 101 in the isolation zone, each replacement column 121 replaces the adsorption column 101 in the isolation zone one by one. It should be noted that the replacement principle of having one replacement column 121 and having at least two replacement columns 121 is essentially the same. The present application only takes the case where the number of replacement columns 121 is one as an example for illustration.

[0059] See Figures 1 to 3 , in a specific example of the present application, the number of multiple adsorption columns 101 is six. Among them, the adsorption zone includes two adsorption columns 101, the purification zone includes two adsorption columns 101, the desorption zone includes one adsorption column 101, the isolation zone includes one adsorption column 101, and the replacement system 120 includes one replacement column 121. The replacement column 121 can replace the adsorption column 101 in the isolation zone so that the adsorption column 101 in the isolation zone can be eluted. Figure 2 is Figure 1 the replacement schematic diagram of the simulated moving bed online elution device 100 shown in Figure 3 is Figure 1 the partial schematic diagram at the first adsorption column 111 in the simulated moving bed online elution device 100 shown in

[0060] In Figure 1 , the six adsorption columns 101 are arranged side by side, namely the first adsorption column 111, the second adsorption column 112, the third adsorption column 113, the fourth adsorption column 114, the fifth adsorption column 115, and the sixth adsorption column 116. The replacement column 121 is located on the side of the sixth adsorption column 116 away from the fifth adsorption column 115. A raw material feed valve 132V11, V21, V31, V41, V51, V61 is provided at the top of each adsorption column 101, and a mobile phase feed valve 142V12, V22, V32, V42, V52, V62 is provided at the column top of each adsorption column 101. One-way valves 153V13, V23, V33, V43, V53 are provided between adjacent two adsorption columns 101. A raffinate discharge valve 162V14, V24, V34, V44, V54, V64 is provided at the bottom of each adsorption column 101, and an extract discharge valve 172V15, V25, V35, V45, V55, V65 is provided at the bottom of each adsorption column 101.

[0061] The raw material feed pipe 131 in the raw material feed system 130 is connected to the raw material feed valves 132 V11, V21, V31, V41, V51, V61 of each adsorption column 101, and the mobile phase feed pipe 141 in the mobile phase feed system 140 is connected to the mobile phase feed valves 142 V12, V22, V32, V42, V52, V62 of each adsorption column 101. The raffinate discharge pipe 161 in the raffinate system 160 is connected to the raffinate discharge valves 162 V14, V24, V34, V44, V54, V64 of each adsorption column 101, and the extract discharge pipe 171 in the extract system 170 is connected to the extract discharge valves 172 V15, V25, V35, V45, V55, V65 of each adsorption column 101.

[0062] In this embodiment, when the equipment is running, two adsorption columns 101 in the adsorption zone, two adsorption columns 101 in the purification zone, one adsorption column 101 in the desorption zone, and one adsorption column 101 in the isolation zone move in sequence. When the adsorption performance of the first adsorption column 111 deteriorates and when the entire equipment runs to the point where the first adsorption column 111 is in the isolation zone, the replacement column 121 is connected to the top and bottom of the first adsorption column 111 through the replacement pipeline assembly 122 to replace the first adsorption column 111 and connect it to the circulation loop. At this time, the replacement column 121, the second adsorption column 112, the third adsorption column 113, the fourth adsorption column 114, the fifth adsorption column 115, and the sixth adsorption column 116 form a circulation loop. While the entire equipment continues to run, the first adsorption column 111 can be disassembled and eluted, as Figure 2 shown Figure 2 in which the replacement of the replacement column 121 is schematically shown in the arrow direction.

[0063] It should be noted that the principle of replacing the second adsorption column 112, the third adsorption column 113, the fourth adsorption column 114, the fifth adsorption column 115, and the sixth adsorption column 116 is essentially the same as the principle of replacing the first replacement column 121, and will not be elaborated here. Of course, in other embodiments of the present application, the number of adsorption columns 101 can also be other, and the number of adsorption columns 101 in the adsorption zone, purification zone, desorption zone, and isolation zone can be set according to the usage requirements, and its principle is essentially the same as the principle when there are six adsorption columns 101, and will not be elaborated here.

[0064] See Figure 1 and Figure 2 In an embodiment, the replacement pipeline assembly 122 includes a first replacement pipe and a second replacement pipe. One end of the first replacement pipe is connected to the top of the replacement column 121, and the other end of the first replacement pipe is respectively connected to the tops of each adsorption column 101. One end of the second replacement pipe is connected to the bottom of the replacement column 121, and the other end of the second replacement pipe is respectively connected to the bottoms of each adsorption column 101.

[0065] The first replacement pipe and the second replacement pipe are respectively connected to each adsorption column 101 at the top and bottom of the replacement column 121. The first replacement pipe is located at the top of the replacement column 121, one end of which is connected to the top of the replacement column 121, and the other end is respectively connected to the tops of each adsorption column 101. The second replacement pipe is located at the bottom of the replacement column 121, one end of which is connected to the bottom of the replacement column 121, and the other end is respectively connected to the bottoms of each adsorption column 101.

[0066] When the adsorption performance of the first adsorption column 111 deteriorates and when the entire device operates to make the first adsorption column 111 an isolation zone, the raw material feeding system 130, the mobile phase feeding system 140, and the bottom of the sixth adsorption column 116 are connected to the top of the replacement column 121 through the first replacement pipe, and the bottom of the replacement column 121 is connected to the raffinate system 160, the extract system 170, and the top of the second adsorption column 112 through the second replacement pipe. In this way, the replacement column 121 can be connected to the circulation loop to replace the first adsorption column 111.

[0067] See Figures 1 to 3 , in an embodiment, the replacement pipeline assembly 122 further includes a plurality of input valves 123 and a plurality of output valves 124. An input valve 123 is provided at the top of each adsorption column 101, and an output valve 124 is provided at the bottom of each adsorption column 101. The input valve 123 is connected to the first replacement pipe, and the output valve 124 is connected to the second replacement pipe.

[0068] An input valve 123 is provided at the top of each adsorption column 101, and an output valve 124 is provided at the bottom of each adsorption column 101. The first replacement pipe is connected to the input valve 123 and the top of the replacement column 121, and the second replacement pipe is connected to the output valve 124 and the bottom of the replacement column 121. In this embodiment, the number of input valves 123 is six, namely P11, P21, P31, P41, P51, P61, which are correspondingly arranged at the tops of the six adsorption columns 101. The number of output valves 124 is also six, namely P12, P22, P32, P42, P52, P62, which are correspondingly arranged at the bottoms of the six adsorption columns 101. The replacement column 121 is connected to the input valves 123 P11, P21, P31, P41, P51, P61 through the first replacement pipe, and is connected to the output valves 124 P12, P22, P32, P42, P52, P62 through the second replacement pipe.

[0069] When the adsorption performance of the first adsorption column 111 deteriorates and when the entire device operates to the point where the first adsorption column 111 is in the isolation zone, while the entire device continues to operate, the input valve 123P11 and the output valve 124P12 corresponding to the first adsorption column 111 are opened. At this time, the raw material feeding system 130, the mobile phase feeding system 140, and the bottom of the sixth adsorption column 116 are connected to the top of the replacement column 121 through the input valve 123P11 via the first replacement pipe. The bottom of the replacement column 121 is connected to the raffinate system 160, the extract system 170, and the top of the second adsorption column 112 through the second replacement pipe via the output valve 124P12. In this way, the replacement column 121 can be connected to the circulation loop to replace the first adsorption column 111. At this time, the first adsorption column 111 can be disassembled for elution. After the first adsorption column 111 is eluted, the first adsorption column 111 is installed in place. When the device operates again to the point where the first adsorption column 111 is in the isolation zone, the input valve 123P11 and the output valve 124P12 corresponding to the first adsorption column 111 are closed to connect the first adsorption column 111 to the circulation loop.

[0070] See Figure 1 and Figure 2 , in one embodiment, the first replacement pipe includes a first replacement main pipe 1221 and a plurality of first replacement branch pipes 1222, and the second replacement pipe includes a second replacement main pipe 1223 and a plurality of second replacement branch pipes 1224. The top of each adsorption column 101 is connected to a first replacement branch pipe 1222, and the bottom of each adsorption column 101 is connected to a second replacement branch pipe 1224. One end of the first replacement main pipe 1221 is connected to the top of the replacement column 121, and the other end is connected to each first replacement branch pipe 1222. One end of each second replacement main pipe 1223 is connected to the bottom of the replacement column 121, and the other end is connected to each second replacement branch pipe 1224.

[0071] The plurality of first replacement branch pipes 1222 are arranged in parallel. One ends of the plurality of first replacement branch pipes 1222 are respectively connected to the first replacement main pipe 1221, and the other ends of the plurality of first replacement branch pipes 1222 are respectively connected to the input valves 123 at the tops of the respective adsorption columns 101. The first replacement main pipe 1221 is also connected to the top of the replacement column 121. The plurality of second replacement branch pipes 1224 are arranged in parallel. One ends of the plurality of second replacement branch pipes 1224 are respectively connected to the second replacement main pipe 1223, and the other ends of the plurality of second replacement branch pipes 1224 are respectively connected to the output valves 124 at the bottoms of the respective adsorption columns 101. The second replacement main pipe 1223 is also connected to the bottom of the adsorption column 101.

[0072] When the adsorption performance of the first adsorption column 111 decreases and when the entire device operates to the point where the first adsorption column 111 is in the isolation zone, while the entire device continues to operate, the input valve 123P11 and the output valve 124P12 corresponding to the first adsorption column 111 are opened. At this time, the raw material feeding system 130, the mobile phase feeding system 140, and the bottom of the sixth adsorption column 116 are connected to the top of the replacement column 121 through the input valve 123P11 via the first replacement branch pipe 1222 and the first replacement main pipe 1221. The bottom of the replacement column 121 is connected to the raffinate system 160, the extract system 170, and the top of the second adsorption column 112 through the second replacement main pipe 1223 and the second replacement branch pipe 1224 via the output valve 124P12. In this way, the replacement column 121 can be connected to the circulation loop to replace the first adsorption column 111.

[0073] See Figure 1 and Figure 2 , in one embodiment, both the input valve 123 and the output valve 124 are three-way valves. The three-way valve serving as the input valve 123 is provided at the top of the adsorption column 101 through a branch pipe, and the three-way valve serving as the output valve 124 is provided at the bottom of the adsorption column 101 through a branch pipe. Moreover, the input valve 123 serving as the three-way valve can also be connected to the first replacement branch pipe 1222, the raw material feeding valve 132, and the mobile phase feeding valve 142 to connect the first replacement branch pipe 1222, the raw material feeding valve 132, and the mobile phase feeding valve 142 to the top of the adsorption column 101. The output valve 124 serving as the three-way valve can also be connected to the second replacement branch pipe 1224, the raffinate discharge valve 162, and the extract discharge valve 172 to connect the second replacement branch pipe 1224, the raffinate discharge valve 162, and the extract discharge to the bottom of the adsorption column 101.

[0074] Optionally, the input valve 123 and the output valve 124 can also be valves with separate channels. In this case, the raw material feeding valve 132, the mobile phase feeding valve 142, and the input valve 123 are respectively independently provided at the top of the adsorption column 101 (such as through separate branch pipes) to independently control the opening and closing of the corresponding pipelines. The raffinate discharge valve 162, the extract discharge valve 172, and the output valve 124 are respectively independently provided at the bottom of the adsorption column 101 (such as through separate branch pipes) to independently control the opening and closing of the corresponding pipelines. Of course, in other embodiments of the present application, the input valve 123 and the output valve 124 can also be multi-way valves or a combination of valves with separate channels and multi-way valves, as long as the opening and closing control of the corresponding pipelines can be achieved.

[0075] See Figure 1 and Figure 2, in one embodiment, the input valve 123 has a first inlet 1231, a second inlet 1232, and a third inlet 1233. The first inlet 1231 is connected to the adsorption column 101, the second inlet 1232 is connected to the raw material feeding system 130, the mobile phase feeding system 140, and the circulation pipeline 151, and the third inlet 1233 is connected to the first replacement pipe; the input valve 123 has a first outlet 1241, a second outlet 1242, and a third outlet 1243. The first outlet 1241 is connected to the adsorption column 101, the second outlet 1242 is connected to the raffinate system 160, the extract system 170, and the circulation pipeline 151, and the third outlet 1243 is connected to the second replacement pipe.

[0076] At the second inlet 1232 of each input valve 123, a raw material feeding valve 132, a mobile phase feeding valve 142, and the circulation pipeline 151 connecting to the bottom of the previous adsorption column 101 are connected. At the second outlet 1242 of each output valve 124, a raffinate discharging valve 162, an extract discharging valve 172, and the circulation pipeline 151 connecting to the top of the subsequent adsorption column 101 are connected. The third inlet 1233 of each input valve 123 is connected to the first replacement branch pipe 1222, and the third outlet 1243 of each output valve 124 is connected to the second replacement branch pipe 1224. Moreover, when the equipment is operating normally, the first inlet 1231 and the second inlet 1232 of the input valve 123 are communicated and the third inlet 1233 is closed, and the first outlet 1241 and the second outlet 1242 of the output valve 124 are communicated and the third outlet 1243 is closed; when it is necessary to replace the adsorption column 101 in the isolation area, the first inlet 1231 of the corresponding input valve 123 is closed and the second inlet 1232 and the third inlet 1233 are communicated, and the first outlet 1241 of the corresponding output valve 124 is closed and the second outlet 1242 and the third outlet 1243 are communicated.

[0077] Specifically, when the equipment is operating normally, the first inlet 1231 and the second inlet 1232 of the input valve 123 are communicated and the third inlet 1233 is closed. The circulation pipeline 151 can transport materials to the adsorption column 101 through the first inlet 1231 and the second inlet 1232. If the raw material feeding valve 132 and the mobile phase feeding valve 142 are opened, raw materials and the mobile phase can be output to the adsorption column 101 through the first inlet 1231 and the second inlet 1232. The first outlet 1241 and the second outlet 1242 of the output valve 124 are communicated and the third outlet 1243 is closed. The adsorption column 101 can output materials to the circulation pipeline 151 through the first outlet 1241 and the second outlet 1242. If one of the raffinate discharging valve 162 and the extract discharging valve 172 is opened, the raffinate can be output to the raffinate discharging pipe 161 through the first outlet 1241 and the second outlet 1242, and the extract can be output to the extract discharging pipe 171 through the first outlet 1241 and the second outlet 1242.

[0078] When the adsorption performance of the first adsorption column 111 deteriorates and when the entire device operates until the first adsorption column 111 becomes the isolation zone, while the entire device continues to operate, the first inlet 1231 of the input valve 123P11 corresponding to the first adsorption column 111 and the first outlet 1241 of the output valve 124P12 are closed, and the second inlet 1232, the third inlet 1233 of the input valve 123P11 corresponding to the first adsorption column 111, the second outlet 1242, and the third outlet 1243 of the output valve 124P12 are opened. At this time, the raw material feeding system 130, the mobile phase feeding system 140, and the bottom of the sixth adsorption column 116 are connected to the top of the replacement column 121 through the input valve 123P11 via the first replacement branch pipe 1222 and the first replacement main pipe 1221. The bottom of the replacement column 121 is connected to the raffinate system 160, the extract system 170, and the top of the second adsorption column 112 through the output valve 124P12 via the second replacement main pipe 1223 and the second replacement branch pipe 1224.

[0079] In this way, the replacement column 121 can be connected to the circulation loop to replace the first adsorption column 111. At this time, the first adsorption column 111 can be removed for column elution. After the first adsorption column 111 is eluted, the first adsorption column 111 is installed in place. When the device operates again until the first adsorption column 111 becomes the isolation zone, the third inlet 1233 of the input valve 123P11 corresponding to the first adsorption column 111 and the third outlet 1243 of the output valve 124P12 are closed, and the first inlet 1231, the second inlet 1232 of the input valve 123P11 corresponding to the first adsorption column 111, the first outlet 1241, and the second outlet 1242 of the output valve 124P12 are opened to connect the first adsorption column 111 to the circulation loop.

[0080] See Figure 1 and Figure 2 In one embodiment, the input valve 123 and the output valve 124 are one of a ball valve, a regulating valve, a butterfly valve, a diaphragm valve, and a cock valve, and are driven pneumatically or electrically. When the input valve 123 is a three-way valve, the input valve 123 can be any one of a ball valve, a regulating valve, a butterfly valve, a diaphragm valve, and a cock valve to achieve three-channel control. Moreover, the input valve 123 and the output valve 124 can be controlled and driven pneumatically or electrically to achieve the opening and closing control of the input valve 123 and the output valve 124.

[0081] See Figure 1 and Figure 2, in one embodiment, the simulated moving bed on-line elution device 100 further includes a programmed valve group and an automatic control system. All valves form the programmed valve group. The automatic control system is connected to the programmed valve group for control. The automatic control system can control the opening and closing states of each valve in the programmed valve group in both manual and automatic operation modes; each valve in the programmed valve group is independently controlled, and the valves in the programmed valve group except the input valve 123 and the output valve 124 are one of a ball valve, a needle valve, a globe valve, and a butterfly valve, and are controlled pneumatically or electrically.

[0082] All valves in this application form a programmed valve group, that is, the raw material feed valve 132, the mobile phase feed valve 142, the input valve 123, the check valve 153, the raffinate discharge valve 162, the extract discharge valve 172, the output valve 124, and the back pressure valve form the programmed valve group. Each valve in the programmed valve group is independently controlled and is electrically connected or communicatively connected to the automatic control system. The automatic control system can control the opening and closing states of each valve in the automatic operation mode. Moreover, each valve also has a manual operation mode, and the automatic control system can also control the opening and closing states of each valve through manual operation.

[0083] At the same time, the valves in the programmed valves except the input valve 123 and the output valve 124, that is, the raw material feed valve 132, the mobile phase feed valve 142, the check valve 153, the raffinate discharge valve 162, the extract discharge valve 172, and the back pressure valve can be any one of a ball valve, a needle valve, a globe valve, and a butterfly valve to realize the opening and closing control of a separate channel. Moreover, the valves in the programmed valves except the input valve 123 and the output valve 124, that is, the raw material feed valve 132, the mobile phase feed valve 142, the check valve 153, the raffinate discharge valve 162, the extract discharge valve 172, and the back pressure valve can be controlled and driven pneumatically or electrically to realize the opening and closing control of each valve.

[0084] For the simulated moving bed on-line elution device 100 of this application, when the adsorption performance of the adsorption column 101 decreases after running for a period of time, the replacement pipeline assembly 122 in the replacement system 120 is used to connect the replacement column 121 to the top and bottom of each adsorption column 101. When it is necessary to elute the adsorption column 101 in the isolation area, the replacement column 121 is connected to the circulation loop to replace the adsorption column 101 in the isolation area. At this time, the adsorption column 101 in the isolation area is not in the circulation loop, and the adsorption column 101 can be eluted. In this way, after using the replacement column 121 to replace the adsorption column 101 in the isolation area, the adsorption column 101 in the isolation area does not need to be shut down during elution, which will not affect the normal operation of the entire device, enabling the simulated moving bed on-line elution device 100 to perform separation operations normally, ensuring the adsorption separation efficiency, and reducing costs and supply pressure.

[0085] When the adsorption performance of the first adsorption column 111 decreases and when the entire device runs to the first adsorption column 111 as the isolation zone, while the entire device continues to operate, the input valve 123P11 and the output valve 124P12 corresponding to the first adsorption column 111 are opened. At this time, the raw material feeding system 130, the mobile phase feeding system 140, and the bottom of the sixth adsorption column 116 are connected to the top of the replacement column 121 through the input valve 123P11 by the first replacement pipe, and the bottom of the replacement column 121 is connected to the raffinate system 160, the extract system 170, and the top of the second adsorption column 112 through the second replacement pipe via the output valve 124P12. In this way, the replacement column 121 can be connected to the circulation loop to replace the first adsorption column 111. In this application, the replacement column 121 is connected to the top and bottom of each replacement column 121 through the input valve 123 and the output valve 124. By controlling the opening and closing of the corresponding input valve 123 and output valve 124, the precise replacement of the adsorption column 101 can be achieved, ensuring the stable and uninterrupted operation of the entire device.

[0086] See Figure 4 , Figure 4 is a flowchart of the simulated moving bed online elution method according to an embodiment of the present application. The present application also provides a simulated moving bed online elution method, which is applied to the simulated moving bed online elution device 100 of any of the above embodiments. The simulated moving bed online elution method at least includes the following steps;

[0087] The automatic control system controls multiple adsorption columns 101 in the adsorption system 110 to cyclically perform adsorption, purification, desorption, and isolation operations;

[0088] After a preset time, when it is necessary to elute the adsorption column 101 in the isolation zone, control the input valve 123 and the output valve 124 corresponding to the adsorption column 101 to open and connect the replacement column 121 through the replacement pipeline assembly 122;

[0089] The bottom of the previous adsorption column 101 is connected to the top of the replacement column 121 through the circulation pipeline 151, the input valve 123, and the replacement pipeline assembly 122, and the bottom of the replacement column 121 intervenes in the top of the next adsorption column 101 through the replacement pipeline assembly 122, the output valve 124, and the circulation pipeline 151;

[0090] Connect the replacement column 121 to the circulation loop, and at the same time replace the adsorption column 101 in the isolation zone for elution;

[0091] After the adsorption column 101 is eluted, the adsorption column 101 is operated as the isolation zone, the input valve 123 and the output valve 124 are closed, and the adsorption column 101 is connected to the circulation loop to replace the replacement column 121 out of the circulation loop.

[0092] When the device is running, the automatic control system controls the two adsorption columns 101 in the adsorption area, the two adsorption columns 101 in the purification area, one adsorption column 101 in the desorption area, and one adsorption column 101 in the isolation area to move in sequence, so as to cyclically perform adsorption, purification, desorption, and isolation operations. After a period of time, when the adsorption performance of the adsorption column 101 decreases and the adsorption column 101 needs to be eluted, when the entire device runs to the adsorption column 101 as the isolation area, the automatic control system controls the input valve 123 and the output valve 124 corresponding to the adsorption column 101 to open. The bottom of the previous adsorption column 101 is connected to the top of the replacement column 121 through the circulation pipeline 151, the input valve 123, and the replacement pipeline assembly 122. The bottom of the replacement column 121 intervenes in the top of the next adsorption column 101 through the replacement pipeline assembly 122, the output valve 124, and the circulation pipeline 151.

[0093] At this time, the replacement column 121 replaces the adsorption column 101 and is connected to the circulation loop. The adsorption column 101 is replaced from the circulation loop. The remaining adsorption columns 101 and the replacement column 121 form a circulation loop. While the entire device continues to run, the adsorption column 101 can be disassembled and eluted. After the adsorption column 101 is eluted, the adsorption column 101 is installed in place. When the device runs to the adsorption column 101 as the isolation area again, the input valve 123 and the output valve 124 corresponding to the adsorption column 101 are closed to connect the adsorption column 101 to the circulation loop, and at the same time, the replacement column 121 is replaced from the circulation loop. In this way, each adsorption column 101 can be disassembled and eluted to ensure the performance of each adsorption column 101.

[0094] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of concise description, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as the scope described in this specification.

[0095] The above-described embodiments only represent several implementation manners of the present application. The description is relatively specific and detailed, but it should not be construed as a limitation to the scope of the patent application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present application, several deformations and improvements can be made, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. An on-line elution device for simulated moving bed, characterized in that It includes an adsorption system, a replacement system, a raw material feeding system, a mobile phase feeding system, a circulation system, a raffinate system, and an extract system; The adsorption system includes multiple adsorption columns, and the multiple adsorption columns are divided into multiple functional zones, namely an adsorption zone, a purification zone, a desorption zone, and an isolation zone, and each functional zone has at least one adsorption column; The replacement system includes a replacement column and a replacement pipeline assembly. The structure of the replacement column is the same as that of the adsorption column, and the top and bottom of the replacement column are connected to the top and bottom of each adsorption column through the replacement pipeline assembly; The circulation system includes a circulation pipeline, a check valve, and a circulation pump. Each adsorption column is connected in series end to end through the circulation pipeline to form a circulation loop. The circulation pump is arranged on the circulation pipeline, and a check valve is arranged between adjacent adsorption columns. The raw material feeding system and the mobile phase feeding system are respectively connected to the top of each adsorption column, and the raffinate system and the extract system are respectively connected to the bottom of each adsorption column; The replacement column can replace the adsorption column in the isolation zone to elute the adsorption column in the isolation zone.

2. The simulated moving bed online elution device according to claim 1, wherein The replacement pipeline assembly includes a first replacement pipe and a second replacement pipe. One end of the first replacement pipe is connected to the top of the replacement column, and the other end of the first replacement pipe is respectively connected to the top of each adsorption column. One end of the second replacement pipe is connected to the bottom of the replacement column, and the other end of the second replacement pipe is respectively connected to the bottom of each adsorption column.

3. The simulated moving bed on-line elution device according to claim 2, wherein The first replacement pipe includes a first replacement main pipe and multiple first replacement branch pipes, and the second replacement pipe includes a second replacement main pipe and multiple second replacement branch pipes; The top of each adsorption column is connected to a first replacement branch pipe, and the bottom of each adsorption column is connected to a second replacement branch pipe. One end of the first replacement main pipe is connected to the top of the replacement column, and the other end is connected to each first replacement branch pipe. One end of each second replacement main pipe is connected to the bottom of the replacement column, and the other end is connected to each second replacement branch pipe.

4. The simulated moving bed on-line elution device according to claim 2, characterized in that, The replacement pipeline assembly further includes multiple input valves and multiple output valves. One input valve is arranged at the top of each adsorption column, and one output valve is arranged at the bottom of each adsorption column; The input valve is connected to the first replacement pipe, and the output valve is connected to the second replacement pipe.

5. The simulated moving bed online elution device according to claim 4, characterized in that, Both the input valve and the output valve are three-way valves; The input valve has a first inlet, a second inlet, and a third inlet. The first inlet is connected to the adsorption column, the second inlet is connected to the raw material feeding system, the mobile phase feeding system, and the circulation pipeline, and the third inlet is connected to the first replacement pipe; the input valve has a first outlet, a second outlet, and a third outlet. The first outlet is connected to the adsorption column, the second outlet is connected to the raffinate system, the extract system, and the circulation pipeline, and the third outlet is connected to the second replacement pipe; And / or, the input valve and the output valve are one of a ball valve, a regulating valve, a butterfly valve, a diaphragm valve, and a cock valve, and are driven pneumatically or electrically.

6. The simulated moving bed on-line elution device according to any one of claims 1 to 5, characterized in that, The number of the replacement columns is equal to the number of the adsorption columns in the isolation zone; each of the replacement columns replaces one of the adsorption columns in the isolation zone.

7. The simulated moving bed online elution device according to any one of claims 1 to 5, characterized in that, The raw material feeding system includes a raw material feeding pipe, a plurality of raw material feeding valves, and a first back pressure valve. A raw material feeding valve is arranged at the top of each adsorption column. The raw material feeding pipe connects the raw material barrel and each raw material feeding valve, and the first back pressure valve is arranged on the raw material feeding pipe; And / or, the mobile phase feeding system includes a mobile phase feeding pipe, a plurality of mobile phase feeding valves, and a second back pressure valve. A mobile phase feeding valve is further arranged at the top of each adsorption column. The mobile phase feeding pipe connects the mobile phase cylinder and each mobile phase feeding valve, and the second back pressure valve is arranged on the mobile phase feeding pipe.

8. The simulated moving bed online elution device according to any one of claims 1 to 5, characterized in that The raffinate system includes a raffinate discharge pipe, a third back pressure valve, and a plurality of raffinate discharge valves. A raffinate discharge valve is arranged at the bottom of each adsorption column. The raffinate discharge pipe connects each raffinate discharge valve, and the third back pressure valve is arranged on the raffinate discharge pipe; And / or, the extract system includes an extract discharge pipe, a fourth back pressure valve, and a plurality of extract discharge valves. An extract discharge valve is further arranged at the bottom of each adsorption column. The extract discharge pipe connects each extract discharge valve, and the fourth back pressure valve is arranged on the extract discharge pipe.

9. The simulated moving bed online elution device according to any one of claims 1 to 5, characterized in that, The simulated moving bed on-line elution device further includes a program control valve group and an automatic control system. All the valves form the program control valve group. The automatic control system is connected to the program control valve group for control. The automatic control system can control the opening and closing states of the valves in the program control valve group in both manual and automatic operation modes; Each of the valves in the program control valve group is independently controlled, and the valves in the program control valve group except the input valve and the output valve are each one of a ball valve, a needle valve, a globe valve, and a butterfly valve, and are controlled pneumatically or electrically.

10. The simulated moving bed on-line elution device according to any one of claims 1 to 5, characterized in that, The number of the multiple adsorption columns is six. Among them, the adsorption zone includes two adsorption columns, the purification zone includes two adsorption columns, the desorption zone includes one adsorption column, the isolation zone includes one adsorption column, and the replacement system includes one replacement column; The replacement column can replace the adsorption column in the isolation zone so that the adsorption column in the isolation zone can be eluted.

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