Solid-phase extraction device

Abstract

The utility model relates to the field of devices for treating liquid with solid adsorbents, in particular to a solid-phase extraction device. The solid-phase extraction device comprises a support and a solid-phase extraction column limiting plate, a liquid storage container limiting plate is arranged on the upper portion of the support, a collection container limiting plate assembly is arranged on the lower portion of the support, a containing hole is formed in the liquid storage container limiting plate, an anti-skid gasket is arranged in the containing hole, and the anti-skid gasket is used for tightly squeezing a corresponding liquid storage container. The fixing plate is fixed at any position in the vertical direction; the solid-phase extraction column limiting plate is used in cooperation with a container opening of the collection container during an experiment, a through hole is formed in the solid-phase extraction column limiting plate, the size of the through hole is smaller than that of the container opening of the liquid collection container, and when the collection container below the solid-phase extraction column limiting plate needs to be taken away or replaced in the elution process or after solid-phase extraction operation is completed, the through hole can be replaced. The liquid storage container can be upwards adjusted to any position to be fixed, and the liquid storage container at the upper part does not need to be completely taken out, so that the whole solid-phase extraction operation is more convenient.

Description

Technical Field

[0001] The utility model relates to the field of devices for treating liquids with solid adsorbents, in particular to a solid phase extraction device. Background Art

[0002] Solid phase extraction is a sample pretreatment technology widely used in chemical analysis. The main process is sample loading-solid phase extraction-eluent collection. It enriches the target components and removes impurities by passing the sample solution through an extraction column filled with solid phase extraction materials (such as silica gel, polymers, etc.) and utilizing the adsorption of specific components by the solid phase materials. This technology has important applications in environmental monitoring, food safety, biomedicine and other fields. However, the existing solid phase extraction devices have the following problems: automated solid phase extraction instruments are expensive and have poor versatility; simple solid phase extraction usually uses butterfly clamps combined with an iron stand for operation. The disadvantage is that when multiple samples are subjected to solid phase extraction operations at the same time, more experimental devices are required, and the experimental space occupied is large, causing inconvenience in operation.

[0003] For example, the Chinese utility model patent with the authorization announcement number CN202289599U discloses a simple solid phase extraction device, which includes an upper support plate, a lower support plate and a base. The upper and lower support plates are respectively provided with a plurality of through holes, and the corresponding through holes of the upper and lower support plates are kept coaxial. The through holes of the upper support plate are used to fix the liquid storage container, the through holes of the lower support plate are used to fix the solid phase extraction column, and the base is used to place the collection container. The device can perform multiple groups of solid phase extraction operations simultaneously, solving the problem that when the above-mentioned simple device performs multiple groups of solid phase extraction operations simultaneously, more experimental devices are required, the space occupied is large, and the operation is inconvenient. However, the liquid storage container on the upper support plate of the device cannot be fixed when it moves upward. When the extraction column needs to be replaced during the extraction process or when the lower extraction column needs to be removed after the extraction is completed, the upper liquid storage container can only be completely taken out before subsequent operations can be performed. The taken-out liquid storage container needs to be re-placed with a bracket or other components, which brings great inconvenience to the solid phase extraction work. Utility Model Content

[0004] The utility model aims to provide a solid phase extraction device to solve the problem that in the existing device, when replacing or removing the lower liquid container during solid phase extraction, the upper liquid container cannot be fixed after being moved upward, and the liquid container can only be completely taken out, which brings great inconvenience to the solid phase extraction work.

[0005] In order to achieve the above-mentioned purpose, the solid phase extraction device of the present utility model adopts the following technical scheme:

[0006] A solid-phase extraction device, comprising a bracket and a solid-phase extraction column limiting plate. The upper part of the bracket is provided with a liquid storage container limiting plate for carrying a liquid storage container, and the lower part is provided with a collection container limiting plate assembly for carrying a collection container. A placement hole is provided on the liquid storage container limiting plate, and an anti-slip gasket is arranged in the placement hole. The anti-slip gasket is used to tightly squeeze the corresponding liquid storage container to fix it at any position in the up and down direction. The collection container limiting plate assembly includes a collection container bearing plate. The solid-phase extraction column limiting plate is used in cooperation with the container mouth of the collection container during the experiment. A through hole is provided on the solid-phase extraction column limiting plate, and the edge of the through hole is used for stop cooperation with the upper port of the liquid collection container. Its size is smaller than the size of the container mouth of the liquid collection container, and the size of the solid-phase extraction column limiting plate is larger than the size of the container mouth of the liquid collection container.

[0007] Further, the collection container limiting plate assembly further includes a collection container limiting plate located above the collection container bearing plate. The collection container limiting plate is provided with a limiting hole for radially limiting the collection container. The limiting hole corresponds to the placement hole one by one and is coaxially arranged up and down.

[0008] Further, the liquid storage container limiting plate, the collection container bearing plate and the collection container limiting plate are all circular plates and are coaxially arranged with each other.

[0009] Further, the placement holes on the liquid storage container limiting plate and the limiting holes on the collection container limiting plate are evenly arranged circumferentially on the corresponding circular plate surfaces.

[0010] Further, the bracket includes a support rod and a circular base. The liquid storage container limiting plate, the collection container bearing plate and the collection container limiting plate are sequentially arranged at intervals with the support rod as the central axis.

[0011] Further, a collection container positioning groove for positioning the bottom of the collection container is provided on the collection container bearing plate.

[0012] Further, the anti-slip gasket is a silicone gasket or a rubber gasket.

[0013] Further, the outer diameter of the anti-slip gasket is 20mm, 30mm, 40mm or 50mm.

[0014] Beneficial effects: The solid-phase extraction device of the present utility model is a pioneering invention. Specifically, the solid-phase extraction device of the present utility model includes a bracket and a solid-phase extraction column limiting plate. The upper part of the bracket is provided with a liquid storage container limiting plate for carrying a liquid storage container, and the lower part is provided with a collection container limiting plate assembly for carrying a collection container. The collection container limiting plate assembly includes a collection container bearing plate. A placement hole is provided on the liquid storage container limiting plate, and an anti-slip gasket is arranged in the placement hole. The anti-slip gasket is used to tightly squeeze the corresponding liquid storage container to fix it at any position in the up and down directions. During the experiment, the solid-phase extraction column is clamped in the through hole of the solid-phase extraction column limiting plate, and then the solid-phase extraction column limiting plate with the solid-phase extraction column clamped is placed at the container mouth of the collection container. The solid-phase extraction column extends into the interior of the collection container. The liquid storage container is adjusted to a suitable position for solid-phase extraction operation. When it is necessary to remove or replace the collection container below it during the elution process or after the solid-phase extraction operation is completed, the liquid storage container can be adjusted upward to any position for fixation without completely removing the upper liquid storage container. This makes the entire solid-phase extraction operation more convenient. Description of the Drawings

[0015] Figure 1 is a schematic structural diagram of the solid-phase extraction device of the present utility model;

[0016] Figure 2 is a schematic structural diagram of an embodiment of the solid-phase extraction device of the present utility model;

[0017] Figure 3 is Figure 2 a schematic structural diagram of the waste liquid container and the collection container described in the embodiment.

[0018] In the figure: 1, anti-slip gasket; 11, placement hole; 2, liquid storage container limiting plate; 3, bracket; 4, solid-phase extraction column limiting plate; 5, collection container limiting plate assembly; 51, collection container limiting plate; 52, collection container bearing plate; 53, limiting hole; 54, positioning groove; 6, liquid storage container; 7, solid-phase extraction column; 8, nitrogen blowing concentration tube; 9, flow rate control valve; 10, waste liquid container; 11, collection container. Specific Embodiments

[0019] The inventive concept of the present utility model is to provide an anti-slip gasket on the through hole of the liquid container limiting plate. The anti-slip gasket is deformed under pressure, which can increase the contact area and friction force with the inserted object, thereby tightly squeezing the liquid storage container. When the liquid storage container moves upward or downward, the anti-slip gasket can fix it at any position.

[0020] Based on the above concept, as a basic embodiment, the solid-phase extraction device of the present utility model includes a bracket 3 and a solid-phase extraction column limiting plate 4. The bracket 3 is used to support each component of the device. A liquid storage container limiting plate 2 is arranged on the upper part of the bracket 3, and the liquid storage container limiting plate 2 is used to carry the liquid storage container. A collection container limiting plate assembly 5 is arranged below. The liquid storage container limiting plate 2 is provided with a placement hole 11, and an anti-slip gasket 1 is arranged in the placement hole 11. The anti-slip gasket 1 is a silicone gasket or a rubber gasket. The anti-slip gasket is used to tightly squeeze the corresponding liquid storage container to fix it at any position in the up and down directions. The collection container limiting plate assembly 5 includes a collection container bearing plate 52. Preferably, in order to prevent accidental human touch from knocking down the collection container below, the collection container bearing plate 52 is provided with a positioning groove 54 for positioning the bottom of the collection container. The positioning groove 54 is coaxially arranged with the placement hole 11 on the liquid storage container limiting plate 2 in the up and down direction. A through hole is arranged on the solid-phase extraction column limiting plate 4, and the through hole is used to clamp the solid-phase extraction column 7. The solid-phase extraction column limiting plate 4 is used in cooperation with the container mouth of the collection container during the experiment. The edge of the through hole is used for stop cooperation with the upper port of the liquid collection container, and its size is smaller than the size of the container mouth of the liquid collection container. The size of the solid-phase extraction column limiting plate is larger than the size of the container mouth of the liquid collection container. In order to ensure the overall stability of the device, the weight of the bracket 3 is greater than the sum of the weights of all components.

[0021] When conducting an experiment, such as Figure 2As shown, place the collection container for collecting waste liquid, i.e., the waste liquid container 10 in the figure, into the positioning groove 54 of the collection container bearing plate 52. Insert the solid-phase extraction column 7 into the through-hole of the solid-phase extraction column limit plate 4 and place it above the upper port of the waste liquid container 10. The solid-phase extraction column extends into the liquid collection container. The size of the through-hole of the solid-phase extraction column limit plate 4 is smaller than the size of the container mouth of the waste liquid container 10, and the size of the solid-phase extraction column limit plate 4 is larger than the size of the container mouth of the waste liquid container 10. The solid-phase extraction column 7 can be of various types such as C18, NH2, SLE, cation exchange solid-phase extraction columns, etc., with specifications of 10 mL, 30 mL, or 60 mL. Fill the activation liquid into a clean liquid container. The liquid container is the sample loading tube 6, and the activation liquid is methanol or 5% hydrochloric acid aqueous solution. Set it on the anti-slip gasket 1 in the placement hole 11. The sample loading tube 6 can be freely adjusted in the up and down direction in the placement hole 11. Adjust the sample loading tube 6 to make the distance between its lower port and the solid-phase extraction column 7 appropriate. Open the flow rate control valve 9 of the sample loading tube 6 and set the flow rate. The activation solution in the sample loading tube 6 drips into the solid-phase extraction column 7 at an appropriate flow rate to activate the packing in the solid-phase extraction column 7 in sequence with the activation solution. The waste liquid after activation flows into the waste liquid container 10. Then, load the extraction solution into the sample loading tube 6. The extraction solution is 5% HCl of the mainstream cigarette smoke aromatic amines. Open the flow rate control valve 9 of the sample loading tube 6 and manually set the flow rate. The extraction solution in the sample loading tube 6 drips into the solid-phase extraction column 7 at an appropriate flow rate. At this time, the target substances in the extraction solution are adsorbed by the packing in the solid-phase extraction column 7, and the impurities flow into the waste liquid container 10 with the extraction solution. After the extraction solution in the liquid container 6 has dripped out, adjust the sample loading tube 6 upward to an appropriate position, remove the solid-phase extraction column limit plate 4 with the solid-phase extraction column 7 installed, and remove the waste liquid container 10. Then, place the collection container for collecting the target solution into the positioning groove 54 of the collection container bearing plate 52. At this time, the collection container is the collection container 11 in the figure. The size of the solid-phase extraction column limit plate 4 is larger than the size of the collection container 11, and the size of the through-hole of the solid-phase extraction column limit plate 4 is smaller than the size of the container mouth of the collection container 11. Place the solid-phase extraction column limit plate 4 with the solid-phase extraction column 7 installed at the pipe opening of the collection container 11. The solid-phase extraction column 7 extends into the collection container 8. Load the elution solution into the sample loading tube 6. The eluent can be acetonitrile, acetone, n-hexane, ammonia-methanol solution, etc. Adjust the distance between the lower opening of the sample loading tube 6 and the solid-phase extraction column 7 to an appropriate distance. Open the flow rate control valve 9 on the liquid container 6 and set an appropriate flow rate. The elution solution in the liquid container 6 elutes the target substances on the solid-phase extraction column 7 and collects them into the collection container 8.

[0022] Based on the above embodiments, as a preferred embodiment, as Figure 1As shown, the bracket is composed of a support rod and a circular base. The collection container limit plate assembly 5 further includes a collection container limit plate 51 located above the collection container bearing plate 52. The collection container limit plate 51 is provided with limit holes 53 for radially limiting the collection container. The limit holes correspond one-to-one with the placement holes and are coaxially arranged up and down. The liquid storage container limit plate 2, the collection container bearing plate 52, and the collection container limit plate 51 are all circular plates and are coaxially arranged with each other. The placement holes on the liquid storage container limit plate 2 and the limit holes 53 on the collection container limit plate 51 are evenly arranged circumferentially on the corresponding circular plate surfaces. The liquid storage container limit plate 2, the collection container bearing plate 52, and the collection container limit plate 51 are arranged at intervals in sequence with the support rod as the central axis. In some embodiments, after the extraction is completed, the collection container 11 needs to be directly subjected to nitrogen blowing concentration operation. Therefore, the collection container 11 uses a nitrogen blowing concentration tube 8, as Figure 3 shown, the bottom tail tube of the nitrogen blowing concentration tube 8 is a slender tubular structure and cannot be placed independently. Therefore, the collection container bearing plate 52 and the collection container limit plate 51 can be used together to fix the position of the nitrogen blowing concentration tube. The size of the positioning groove 53 on the collection container bearing plate 52 should be adapted to the size of the tail tube of the nitrogen blowing concentration tube.

[0023] In the above embodiment, the bracket is composed of a single support rod and a circular base. In other embodiments, multiple support rods can also be provided to support and fix it along the circumferences of the liquid storage container limit plate 2, the collection container bearing plate 52, and the collection container limit plate 51. The liquid storage container limit plate 2, the collection container bearing plate 52, and the collection container limit plate 51 are circular or square.

[0024] The above is only a preferred embodiment of the present invention and is not intended to limit the present invention. The patent protection scope of the present invention is subject to the claims. Any equivalent structural changes made by using the description and drawings of the present invention should be included in the protection scope of the present invention by the same token.

Claims

1. A solid-phase extraction device, characterized in that, It includes a bracket and a solid-phase extraction column limiting plate. A liquid storage container limiting plate for carrying a liquid storage container is provided at the upper part of the bracket, and a collection container limiting plate assembly for carrying a collection container is provided at the lower part. A placement hole is provided on the liquid storage container limiting plate, and an anti-slip gasket is arranged in the placement hole. The anti-slip gasket is used to tightly squeeze the corresponding liquid storage container to fix it at any position in the up-and-down direction. The collection container limiting plate assembly includes a collection container bearing plate. The solid-phase extraction column limiting plate is used in cooperation with the container mouth of the collection container during the experiment. A through hole is provided on the solid-phase extraction column limiting plate, and the edge of the through hole is used for stop cooperation with the upper port of the liquid collection container. Its size is smaller than the size of the container mouth of the liquid collection container, and the size of the solid-phase extraction column limiting plate is larger than the size of the container mouth of the liquid collection container.

2. The solid phase extraction device according to claim 1, wherein The collection container limiting plate assembly further includes a collection container limiting plate located above the collection container bearing plate. A limiting hole for radially limiting the collection container is provided on the collection container limiting plate. The limiting holes are in one-to-one correspondence with and vertically coaxial with the placement holes.

3. The solid phase extraction device according to claim 2, wherein, The liquid storage container limiting plate, the collection container bearing plate, and the collection container limiting plate are all circular plates and are coaxially arranged with each other.

4. The solid-phase extraction device according to claim 3, wherein, The placement holes on the liquid storage container limiting plate and the limiting holes on the collection container limiting plate are evenly arranged circumferentially on the corresponding circular plate surfaces.

5. The solid phase extraction device according to claim 2 or 3 or 4, characterized in that, The bracket includes a support rod and a circular base. The liquid storage container limiting plate, the collection container bearing plate, and the collection container limiting plate are sequentially arranged at intervals with the support rod as the central axis.

6. The solid phase extraction device according to claim 5, wherein, A collection container positioning groove for positioning the bottom of the collection container is provided on the collection container bearing plate.

7. The solid-phase extraction device according to any one of claims 1-4, characterized in that, A collection container positioning groove for positioning the bottom of the collection container is provided on the collection container bearing plate.

8. The solid-phase extraction device according to claim 5, wherein The anti-slip gasket is a silicone gasket or a rubber gasket.

9. The solid-phase extraction device according to any one of claims 1-4, characterized in that, The anti-slip gasket is a silicone gasket or a rubber gasket.

10. The solid-phase extraction device according to any one of claims 1-4, characterized in that, The outer diameter of the anti-slip gasket is 20mm, 30mm, 40mm or 50mm.

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