Isolation feeding device

Abstract

The utility model discloses an isolated feeding device. The isolated feeding device comprises a box body, a glove box door, a protective gas inlet pipe, a filtering assembly and a vacuum connecting pipe, the box body comprises a box body, a feeding hole and a feeding hole; the glove box door is used for opening and closing the feeding hole; at least two glove holes are formed in the glove box door, and sealing gloves located on the outer edges of the glove holes are further fixedly arranged on the glove box door. An air inlet valve is arranged on the protective gas inlet pipe, one end of the protective gas inlet pipe is communicated with the interior of the box body, and the protective gas inlet pipe is used for introducing protective gas into the box body; one side of the filtering assembly is communicated with the interior of the box body; a vacuum valve is arranged on the vacuum connecting pipe, and the vacuum connecting pipe is communicated with the other side of the filtering assembly. According to the technical scheme, the box body, the glove box door, the protective gas inlet pipe, the filtering assembly and the vacuum connecting pipe are adopted, sealing gloves penetrate through glove holes to operate the interior of the box body, harm of high-toxicity medicine to feeding workers can be reduced, and the safety of ADC reaction is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical and chemical equipment, and particularly relates to an isolated feeding device. Background Art

[0002] An antibody-drug conjugate (ADC) is formed by connecting a highly toxic and highly active small molecule drug to a monoclonal antibody through a linker. The monoclonal antibody serves as a carrier to target and transport the small molecule drug to target cells. In the reaction between the highly toxic and highly active small molecule drug and the linker, as well as the reaction in which the synthesized drug linker is connected to the antibody through the linker, it is necessary to put the highly toxic drug into a reaction vessel to react with the linker or the antibody.

[0003] Currently, when putting a highly toxic drug into a reaction vessel to react with a linker or an antibody, usually, a worker directly puts the solid highly toxic drug or the highly toxic drug linker into the reaction vessel. However, by directly putting the highly toxic drug or the highly toxic drug linker into the reaction vessel by the worker, the highly toxic drug or the highly toxic drug linker is likely to endanger the life safety of the worker. Summary of the Utility Model

[0004] The main purpose of the utility model is to propose an isolated feeding device, aiming to reduce the harm of highly toxic drugs to the feeding workers and improve the safety of the ADC reaction.

[0005] To achieve the above purpose, the isolated feeding device proposed by the utility model includes:

[0006] A box body, which includes a box main body, a feed inlet, and a feeding port;

[0007] A glove box door, which is used to open and close the feed inlet. One side of the glove box door is rotatably connected to the box main body; at least two glove holes are provided on the glove box door, and a sealing glove located at the outer edge of the glove hole is fixedly arranged on the glove box door;

[0008] A protective gas inlet pipe, on which an inlet valve is provided. One end of the protective gas inlet pipe is communicated with the inside of the box body and is used to introduce protective gas into the box body;

[0009] A filtering component, one side of which is communicated with the inside of the box body; and

[0010] A vacuum connecting pipe, on which a vacuum valve is provided. The vacuum connecting pipe is communicated with the other side of the filtering component.

[0011] Optionally, a feeding pipe is fixedly arranged at the feeding port, and a feeding valve is provided on the feeding pipe.

[0012] Optionally, both the feeding port and the feeding pipe are arranged at the lower end of the box main body;

[0013] The upper end of the feeding pipe is conical, and a vibration motor is fixedly arranged on the conical surface of the feeding pipe.

[0014] Optionally, the filtering component includes: a filtering body arranged on the box body, at least one filtering plate arranged in the filtering body and used for filtering the air during vacuum pumping, a filtering maintenance cover arranged on the filtering body, and at least two detachable components detachably connecting the filtering body and the filtering maintenance cover;

[0015] One side of the filtering body is communicated with the inside of the box; the other side of the filtering component is communicated with the vacuum connecting pipe.

[0016] Optionally, the filtering component further includes at least one filtering connecting pipe, one end of the filtering connecting pipe is communicated with the inside of the box, and the other end is communicated with the filtering body;

[0017] The filtering body and the filtering maintenance cover are hermetically connected through a sealing component; the detachable component includes a first flange arranged at the upper end of the filtering body, a second flange arranged on the filtering maintenance cover, a bolt rotatably connected to the first flange, and a ring nut, and the bolt passes through the second flange and is screwed with the ring nut;

[0018] The sealing component is a sealing ring, and the sealing ring is arranged between the filtering body and the filtering maintenance cover.

[0019] Optionally, at least one back-mounted storage rack is further arranged on the box body;

[0020] The main body of the glove box door is made of transparent tempered glass;

[0021] An electronic balance and a balance printer are further arranged inside the box.

[0022] Optionally, it further includes: an observation operation panel fixedly arranged on the other side of the box body, at least two second glove holes are opened on the observation operation panel, and a sealing glove located on the outer edge of the second glove hole is fixedly arranged on the observation operation panel.

[0023] Optionally, it further includes: a fixing rack, and the box body is arranged on the fixing rack;

[0024] A plurality of universal wheels are arranged at the bottom of the fixing rack;

[0025] A plurality of adjusting feet are further arranged at the bottom of the fixing rack.

[0026] Optionally, the box body further includes: an elastic support component, one end of the elastic support component is fixedly connected to the box body; the other end is fixedly connected to the glove box door;

[0027] The elastic support component is a gas spring;

[0028] A sealing ring is provided between the box body and the glove box door;

[0029] The other side of the glove box door is detachably connected to the box body through an opening and closing switch.

[0030] Optionally, it further includes: a safety valve and a controller. The safety valve is arranged on the box body and communicates with the inside of the box body;

[0031] A pressure gauge is arranged on the vacuum connection pipe and between the vacuum valve and the filter assembly;

[0032] The controller is communicatively connected to the safety valve, the intake valve, the vacuum valve, the feeding valve, and the pressure gauge.

[0033] The technical solution of the present utility model adopts a box body, a glove box door, a protective gas inlet pipe, a filter assembly, and a vacuum connection pipe. The inside of the box body is operated through a sealing glove passing through a glove hole, the gas in the box is evacuated, and highly toxic drugs are put into the reactor; it can reduce the harm of highly toxic drugs to the feeding staff and improve the safety of the ADC reaction. The harm of the evacuated gas to the staff or the environment can be reduced through the filter assembly. Description of the Drawings

[0034] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on the structures shown in these drawings.

[0035] Figure 1 Structural schematic of the isolation feeding device embodiment of the present utility model Figure 1 ;

[0036] Figure 2 Structural schematic of the isolation feeding device embodiment of the present utility model Figure 2 ;

[0037] Figure 3 is Figure 2 The partial enlarged view at A in

[0038] The descriptions of the main component symbols are as follows: box body 1, box main body 11, feed inlet, charging port, back-mounted storage rack 15, elastic support assembly 16, opening and closing switch 18, glove box door 2, glove hole 21, protective gas inlet pipe 3, inlet valve 31, filter assembly 4, filter body 41, filter plate 42, filter maintenance cover 43, detachable assembly 44, first flange 441, second flange 442, bolt 443, ring nut 444, filter connecting pipe 45, sealing assembly 47, vacuum connecting pipe 5, vacuum valve 51, pressure gauge 52, feeding pipe 6, feeding valve 61, vibration motor 62, observation and operation panel 7, second glove hole 71, fixing frame 75, universal wheel 751, adjusting foot 752, safety valve 8, reactor 9, feed pipe 91.

[0039] The realization of the purpose, functional characteristics and advantages of the present utility model will be further described with reference to the embodiments and the accompanying drawings. Specific embodiments

[0040] The realization of the purpose, functional characteristics and advantages of the present utility model will be further described with reference to the embodiments and the accompanying drawings.

[0041] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present utility model.

[0042] It should be noted that if there are directional indications (such as up, down, left, right, front, back,...) involved in the embodiments of the present utility model, the directional indications are only used to explain the relative positional relationship and movement conditions between components in a specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indications will also change accordingly.

[0043] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the present utility model, the descriptions of "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the protection scope required by the present utility model.

[0044] The present utility model provides an isolation feeding device.

[0045] In the embodiment of the present utility model, as Figures 1 to 3 shown, the isolation feeding device includes: a box body 1, a glove box door 2, a protective gas inlet pipe 3, a filtering component 4 and a vacuum connecting pipe 5; the box body 1 includes a box main body 11, a feeding port and a feeding port; the glove box door 2 is used to open and close the feeding port, and one side of the glove box door 2 is rotatably connected to the box main body 11; at least two glove holes 21 are opened on the glove box door 2, and a sealed glove located at the outer edge of the glove hole is fixedly arranged on the glove box door 2; an intake valve 31 is arranged on the protective gas inlet pipe 3, and one end of the protective gas inlet pipe 3 is communicated with the inside of the box body 1 and is used to introduce protective gas into the box body 1; the protective gas can be nitrogen or inert gas; one side of the filtering component 4 is communicated with the inside of the box body 1; a vacuum valve 51 is arranged on the vacuum connecting pipe 5, and the vacuum connecting pipe 5 is communicated with the other side of the filtering component 4. Among them, the intake valve 31 and the vacuum valve 51 can be manual control valves or automatic control valves. The other end of the vacuum connecting pipe 5 can be communicated with a vacuum pump or a vacuum air source.

[0046] The technical solution of the present utility model adopts the box body 1, the glove box door 2, the protective gas inlet pipe 3, the filtering component 4 and the vacuum connecting pipe 5, operates on the inside of the box main body 11 through the sealed glove passing through the glove hole 21, evacuates the gas in the box and puts the highly toxic drug into the reactor 9; it can reduce the harm of the highly toxic drug to the feeding staff and improve the safety of the ADC reaction. The harm of the gas after vacuum extraction to the staff or the environment can be reduced through the filtering component 4.

[0047] Specifically, in order to more safely put the highly toxic drug into the reactor 9, a feeding pipe 6 is fixedly arranged at the feeding port, and a feeding valve 61 is arranged on the feeding pipe 6; among them, the feeding valve 61 can be a manual control valve or an automatic control valve, and the feeding pipe 6 is detachably connected to the feeding pipe 91 of the reactor 9.

[0048] Specifically, in order to more conveniently feed the reactor 9. The feeding port and the feeding pipe 6 are both arranged at the lower end of the box main body 11; that is, the feeding port and the feeding pipe 6 are both arranged at the upper end of the reactor 9.

[0049] Specifically, in order to more conveniently feed the reactor 9, the upper end of the feeding pipe 6 is tapered, and a vibration motor 62 is fixedly arranged on the tapered surface of the feeding pipe 6.

[0050] Specifically, for the convenience of replacing the filter plate 42 and maintaining the filter assembly 4, the filter assembly 4 includes: a filter body 41 disposed on the box body 11, at least one filter plate 42 disposed in the filter body 41 and used for filtering the evacuated air, a filter maintenance cover 43 disposed on the filter body 41, and at least two sets of detachable components 44 for detachably connecting the filter body 41 and the filter maintenance cover 43; Four filter plates 42 can be provided. The detachable component 44 is used to open and close the filter maintenance cover 43. Among them, the filter plate 42 can be activated carbon for adsorbing highly toxic drugs, or a filtering substance that inactivates highly toxic drugs.

[0051] Specifically, for better filtering and purifying the evacuated gas. One side of the filter body 41 communicates with the inside of the box body 1; the other side of the filter assembly 4 communicates with the vacuum connection pipe 5.

[0052] Specifically, for better pumping the gas in the box body 1 into the filter assembly 4, the filter assembly further includes at least one filter connection pipe 45. One end of the filter connection pipe 45 communicates with the inside of the box body 1, and the other end communicates with the filter body 41;

[0053] Specifically, for the convenience of installing and disassembling the filter maintenance cover 43. The filter body 41 and the filter maintenance cover 43 are hermetically connected through a sealing assembly 47; the detachable component 44 includes a first flange 441 disposed at the upper end of the filter body 41, a second flange 442 disposed on the filter maintenance cover 43, a bolt 443 rotatably connected to the first flange 441, and a ring nut 444. The bolt 443 passes through the second flange 442 and is screwed with the ring nut 444;

[0054] Specifically, for hermetically sealing the filter assembly 4; the sealing assembly 47 is a sealing ring, and the sealing ring is disposed between the filter body 41 and the filter maintenance cover 43.

[0055] Specifically, for the convenience of placing objects or medicines inside the box; at least one back-mounted shelf 15 is further provided on the box body 11;

[0056] Specifically, for the convenience of observing the internal situation of the box body 1, the main body of the glove box door 2 is made of transparent tempered glass;

[0057] Specifically, for the convenience of weighing medicines and printing medicine weighing data; an electronic balance and a balance printer are further provided inside the box body 1.

[0058] Specifically, for facilitating the observation of the feeding situation of highly toxic drugs and facilitating the feeding of highly toxic drugs into the reactor 9, the isolation feeding device further includes: an observation operation panel 7 fixedly arranged on the other side of the box body 11. At least two second glove holes 71 are formed in the observation operation panel 7. A sealing glove is fixedly arranged on the outer edge of the second glove hole 71 on the observation operation panel 7. Staff can put the weighed highly toxic drugs into the inductor 9 through the feeding port via the sealing glove and the second glove hole 71.

[0059] Specifically, for facilitating the installation of the box body 1, the isolation feeding device further includes: a fixing frame 75, and the box body 1 is arranged on the fixing frame 75;

[0060] Specifically, for facilitating the movement of the box body 1, a plurality of universal wheels 751 are arranged at the bottom of the fixing frame 75;

[0061] Specifically, for fixing and lifting the box body 1, and for facilitating the adjustment and fixation of the position of the feeding port according to the position of the feed pipe 91 of the reactor 9, a plurality of adjusting feet 752 are further arranged at the bottom of the fixing frame 75.

[0062] Specifically, the box body 1 further includes: an elastic support assembly 16, one end of the elastic support assembly 16 is fixedly connected to the box body 11; the other end is fixedly connected to the glove box door 2;

[0063] The elastic support assembly 16 is a gas spring.

[0064] A sealing ring is arranged between the box body 11 and the glove box door 2;

[0065] Specifically, for better opening and closing of the glove box door 2, the other side of the glove box door 2 is detachably connected to the box body 11 through an opening and closing switch 18.

[0066] Specifically, for improving the safety of the box body 1 and improving the intelligence of the isolation feeding device. The isolation feeding device further includes: a safety valve 8 and a controller. The safety valve 8 is arranged on the box body 1 and is communicated with the inside of the box body;

[0067] A pressure gauge 52 is arranged on the vacuum connecting pipe 5 and between the vacuum valve 51 and the filtering component 4;

[0068] The controller is communicatively connected with the safety valve 8, the intake valve 31, the vacuum valve 51, the feeding valve 61, and the pressure gauge 52.

[0069] Working principle of the utility model: When it is necessary to put highly toxic drugs into the reactor 1 and the highly toxic drugs react in the reactor 1, close the safety valve 8, the intake valve 31, the vacuum valve 51, and the feeding valve 61, turn on the opening and closing switch 18, and use the opening assistance of the gas spring to open the glove box door 2. Put the sealed highly toxic drugs into the box body 1 through the feeding port, then close the glove box door 2 and turn off the opening and closing switch 18. Then open the vacuum valve 51 to evacuate the box body 1. After the pressure gauge 52 drops to a certain value, the intake valve 31 can be opened to introduce the protective gas into the box body 1 to displace the remaining air in the box body 1. When displacing the air in the box body 1, the vacuum valve is not closed. After displacing the remaining air in the box body 1 for a period of time, close the intake valve 31 and the vacuum valve 51. Then open the packaging bag of the highly toxic drugs inside the box body 11 through the sealing glove passing through the glove hole 21, weigh the highly toxic drugs, and print the weighing data of the highly toxic drugs. Then open the feeding valve 61, and the staff wears the sealing glove and passes through the second glove hole 71 to put the weighed highly toxic drugs into the reactor 9. When feeding, the vibration motor 62 can be turned on. After the feeding is completed, close the feeding valve 61.

[0070] The above are only the preferred embodiments of the utility model, and do not limit the patent scope of the utility model accordingly. Any equivalent structural transformation made by using the content of the specification and drawings of the utility model under the concept of the utility model, or direct / indirect application in other related technical fields, is included in the patent protection scope of the utility model.

Claims

1. An isolation feeding device, characterized in that, Comprising: A box body (1), the box body (1) includes a box main body (11), a feed inlet and a charging port; A glove box door (2), the glove box door (2) is used to open and close the feed inlet, and one side of the glove box door (2) is rotatably connected to the box main body (11); at least two glove holes (21) are provided on the glove box door (2), and a sealing glove located at the outer edge of the glove hole is fixedly provided on the glove box door (2); A protective gas inlet pipe (3), an inlet valve (31) is provided on the protective gas inlet pipe (3), and one end of the protective gas inlet pipe (3) is communicated with the inside of the box body (1) and is used to introduce protective gas into the box body (1); A filtering assembly (4), one side of the filtering assembly (4) is communicated with the inside of the box body (1); and A vacuum connecting pipe (5), a vacuum valve (51) is provided on the vacuum connecting pipe (5), and the vacuum connecting pipe (5) is communicated with the other side of the filtering assembly (4).

2. The isolation feeding device according to claim 1, wherein A charging pipe (6) is fixedly provided at the charging port, and a charging valve (61) is provided on the charging pipe (6).

3. The isolation feeding device according to claim 2, wherein, Both the charging port and the charging pipe (6) are arranged at the lower end of the box main body (11); The upper end of the charging pipe (6) is tapered, and a vibration motor (62) is fixedly provided on the tapered surface of the charging pipe (6).

4. The isolation feeding device according to any one of claims 1 to 3, characterized in that, The filtering assembly (4) includes: a filtering body (41) arranged on the box main body (11), at least one filtering plate (42) arranged in the filtering body (41) and used for filtering the air during vacuum pumping, a filtering maintenance cover (43) arranged on the filtering body (41), and at least two groups of detachable components (44) for detachably connecting the filtering body (41) and the filtering maintenance cover (43); One side of the filtering body (41) is communicated with the inside of the box body (1); the other side of the filtering assembly (4) is communicated with the vacuum connecting pipe (5).

5. The isolation feeding device according to claim 4, characterized in that, The filtering assembly further includes at least one filtering connecting pipe (45), one end of the filtering connecting pipe (45) is communicated with the inside of the box body (1), and the other end is communicated with the filtering body (41); The filtering body (41) and the filtering maintenance cover (43) are hermetically connected through a sealing assembly (47); the detachable component (44) includes a first flange (441) arranged at the upper end of the filtering body (41), a second flange (442) arranged on the filtering maintenance cover (43), a bolt (443) rotatably connected to the first flange (441), and a ring nut (444), and the bolt (443) passes through the second flange (442) and is screwed with the ring nut (444); The sealing assembly (47) is a sealing ring, and the sealing ring is arranged between the filtering body (41) and the filtering maintenance cover (43).

6. The isolation feeding device according to any one of claims 1 to 3, characterized in that, At least one back-mounted storage rack (15) is further arranged on the box main body (11); The main body of the glove box door (2) is made of transparent tempered glass; An electronic balance and a balance printer are further arranged inside the box body (1).

7. The isolation feeding device according to any one of claims 1 to 3, characterized in that Also comprising: An observation operation panel (7) fixedly arranged on the other side of the box body (11), at least two second glove holes (71) are formed in the observation operation panel (7), and a sealing glove located on the outer edge of the second glove holes (71) is fixedly arranged on the observation operation panel (7).

8. The isolation feeding device according to any one of claims 1 to 3, characterized in that, It further includes: A fixing frame (75), the box body (1) is arranged on the fixing frame (75); A plurality of universal wheels (751) are arranged at the bottom of the fixing frame (75); A plurality of adjusting feet (752) are further arranged at the bottom of the fixing frame (75).

9. The isolation feeding device according to any one of claims 1 to 3, characterized in that, The box body (1) further includes: an elastic support assembly (16), one end of the elastic support assembly (16) is fixedly connected to the box body (11); the other end is fixedly connected to the glove box door (2); The elastic support assembly (16) is a gas spring; A sealing ring is arranged between the box body (11) and the glove box door (2); The other side of the glove box door (2) is detachably connected to the box body (11) through an opening and closing switch (18).

10. The isolation feeding device according to claim 2 or 3, characterized in that It further includes: A safety valve (8) and a controller, the safety valve (8) is arranged on the box body (1) and communicates with the inside of the box body; A pressure gauge (52) is arranged on the vacuum connection pipe (5) and between the vacuum valve (51) and the filter assembly (4); The controller is communicatively connected to the safety valve (8), the intake valve (31), the vacuum valve (51), the feeding valve (61), and the pressure gauge (52).

Images