Time pressure filling system and liquid medicine filling equipment

Abstract

The utility model discloses a time pressure filling system and liquid medicine filling equipment, and relates to the technical field of liquid filling, in particular to the time pressure filling system and the liquid medicine filling equipment, which comprise a first filter, a buffer tank and a filling valve plate which are sequentially connected in series, the time pressure filling system comprises at least two groups of buffer tanks which are arranged in parallel, first stop valves which can be independently controlled are respectively arranged at liquid inlets and liquid outlets of the buffer tanks, ventilation holes are formed in the tops of the buffer tanks, and the ventilation holes are simultaneously communicated with an external vacuum pump and a high-pressure air source. A plurality of groups of buffer tanks are arranged, at least one group is a liquid supplementing buffer tank, the other groups are filling buffer tanks, liquid supplementing, pressure balancing and liquid standing are performed in the liquid supplementing buffer tanks to separate out bubbles, the filling buffer tanks are used for filling, and the filling buffer tanks and the liquid supplementing buffer tanks are alternately switched, so that uninterrupted filling is realized, pressure fluctuation in the buffer tanks is reduced, and the filling efficiency is improved. Therefore, the filling precision is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid filling, and more specifically, to a time-pressure filling system. In addition, the utility model also relates to a liquid medicine filling device including the above time-pressure filling system. Background Art

[0002] The time-pressure filling method is a filling method that controls the filling volume by controlling the filling time under a constant filling pressure. It has the advantages of compact structure, convenient adjustment of filling volume, high control precision, and easy implementation of CIP / SIP (Cleaning in Place / Sterilization in Place), and is widely used in various filling devices;

[0003] The time-pressure filling method is widely used in plastic bottle blow-fill-seal integrated machine equipment. The existing problems are as follows: 1. The time-pressure method has high requirements for the stability of the filling pressure. The fluctuation of the filling pressure greatly affects the filling precision. Each liquid replenishment will cause pressure fluctuations in the buffer tank, thereby affecting the filling precision; 2. During the pipeline transportation of the liquid, there are many bubbles inside, and these bubbles are also calculated in the filling volume, resulting in the actual liquid filling volume not meeting the standard, that is, affecting the filling precision.

[0004] To solve the above problems, in the current prior art, the volume of the buffer tank is increased, and the liquid replenishment frequency in the buffer tank is increased to reduce the proportion of the single liquid replenishment volume to the overall volume, so as to reduce the pressure fluctuation in the system;

[0005] However, increasing the volume of the buffer tank will cause the scouring water flow in the buffer tank to be insufficient to clean its inner wall, that is, it increases the difficulty of implementing CIP / SIP; while increasing the liquid replenishment frequency and reducing the single liquid replenishment volume will cause frequent opening of various valves, resulting in valve wear and reduced sealing performance, and frequent liquid replenishment will cause liquid level fluctuations in the buffer tank, which is not conducive to the precipitation of bubbles in the liquid and also affects the filling precision.

[0006] In summary, how to provide a time-pressure filling system that can reduce the pressure fluctuation in the buffer tank without increasing the volume of the buffer tank and without increasing the liquid replenishment frequency, and thus reduce the impact on the filling precision is an urgent problem to be solved by those skilled in the art at present. Content of the Utility Model

[0007] In view of this, the purpose of the utility model is to provide a time-pressure filling system. By setting multiple groups of buffer tanks, at least one of which is a liquid replenishment buffer tank and the others are filling buffer tanks, liquid replenishment, pressure balance, and liquid static precipitation of bubbles are carried out in the liquid replenishment buffer tank, while the filling buffer tank is used for filling. Through the alternating switching of the filling buffer tank and the liquid replenishment buffer tank, continuous filling is realized, and the pressure fluctuation in the buffer tank is reduced, thereby ensuring the filling precision.

[0008] Another object of the present utility model is to provide a liquid medicine filling device including the above-mentioned time-pressure filling system, which has the same technical features and can achieve the same purpose.

[0009] In order to achieve the above object, the present utility model provides the following technical solutions:

[0010] A time-pressure filling system includes a first filter, a buffer tank, and a filling valve plate connected in series in sequence;

[0011] At least two groups of the buffer tanks are provided and arranged in parallel. First stop valves that can be independently controlled are respectively arranged at the liquid inlet and outlet of the buffer tank. An air exchange hole is arranged at the top of the buffer tank. The air exchange hole is simultaneously connected to an external vacuum pump and a high-pressure air source. Second stop valves that can be independently controlled are respectively arranged on the connecting branches of the air exchange hole with the vacuum pump and the high-pressure air source.

[0012] Preferably, a liquid level gauge is arranged in the buffer tank, and the detection end of the liquid level gauge extends to the bottom of the tank body of the buffer tank.

[0013] Preferably, the liquid level gauge is a guided wave radar liquid level gauge. The output end of the liquid level gauge is electrically connected to the control unit of the external vacuum pump, the output end of the liquid level gauge is electrically connected to the control unit of the high-pressure air source, or the output end of the liquid level gauge is electrically connected to the control unit of the first stop valve.

[0014] Preferably, a pressure transmitter is connected and arranged at the air exchange hole. The output end of the pressure transmitter is electrically connected to the control unit of the external vacuum pump, the output end of the pressure transmitter is electrically connected to the control unit of the high-pressure air source, or the output end of the pressure transmitter is electrically connected to the control unit of the second stop valve.

[0015] Preferably, a second filter is connected in series on the connecting branch of the air exchange hole with the vacuum pump and / or the high-pressure air source.

[0016] Preferably, a safety valve is connected and arranged at the air exchange hole.

[0017] Preferably, a pressure reducing valve is arranged in the connecting branch of the high-pressure air source at the air exchange hole, and a back pressure valve is arranged in parallel at the output end of the pressure reducing valve.

[0018] Preferably, the first stop valve and the second stop valve are diaphragm valves.

[0019] A liquid medicine filling device includes the time-pressure filling system described in any one of the above.

[0020] The time-pressure filling system provided by the present utility model has at least the following beneficial effects compared with the prior art:

[0021] 1. The design of multiple buffer tanks is adopted. At least one group serves as a liquid replenishment buffer tank, and one group serves as a filling buffer tank. The two can be alternately switched, that is, their functions are interchanged, so as to separate the liquid replenishment and filling actions, and then realize continuous filling and continuous liquid replenishment.

[0022] 2. The liquid is statically placed in the liquid replenishment buffer tank to precipitate the internal air bubbles, reduce the influence of the air bubbles in the liquid on the filling accuracy, and the liquid replenishment buffer tank is connected to an external vacuum pump to form a negative pressure in the liquid replenishment buffer tank, which is beneficial to the rapid precipitation of the air bubbles in the liquid and shortens the time required for the liquid to statically precipitate air bubbles.

[0023] The liquid medicine filling equipment provided by the present utility model includes the above-mentioned time-pressure filling system and has the same beneficial effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only the embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained according to the provided drawings without creative efforts.

[0025] Figure 1 It is a schematic diagram of the time-pressure filling system provided by the present utility model;

[0026] Figure 2 It is a schematic diagram of the pipeline connection of the specific buffer tank provided by the present utility model.

[0027] In the figure:

[0028] 1. First filter; 2. Buffer tank; 201. Group A buffer tank; 202. Group B buffer tank; 203. Vacuum pump; 204. High-pressure air source; 205. Pressure reducing valve; 206. Back pressure valve; 207. Second filter; 208. Safety valve; 209. Liquid level gauge; 210. Pressure transmitter; 3. Filling valve plate;

[0029] 2011. First stop valve; 2012. Second stop valve. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0030] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the protection scope of the present utility model.

[0031] The core of the present utility model is to provide a time-pressure filling system. By arranging multiple buffer tanks, at least one of which is a liquid replenishment buffer tank and the rest are filling buffer tanks, liquid replenishment, pressure balance, and liquid static precipitation of bubbles are carried out in the liquid replenishment buffer tank, while the filling buffer tank is used for filling. Through the alternating switching between the filling buffer tank and the liquid replenishment buffer tank, continuous filling is achieved, and the pressure fluctuation in the buffer tank is reduced, thereby ensuring the filling accuracy.

[0032] Another core of the present utility model is to provide a liquid medicine filling device including the above time-pressure filling system, which has the same technical features and achieves the same purpose.

[0033] Please refer to Figure 1 and Figure 2 , a time-pressure filling system, which includes a first filter 1, a buffer tank 2, and a filling valve plate 3 connected in series in sequence;

[0034] There are at least two buffer tanks 2, and they are arranged in parallel. Independent controllable first stop valves 2011 are respectively arranged at the liquid inlet and outlet of the buffer tank 2. A vent hole is arranged at the top of the buffer tank 2, and the vent hole is simultaneously connected to an external vacuum pump 203 and a high-pressure gas source 204. Independent controllable second stop valves 2012 are respectively arranged on the connecting branches of the vent hole with the vacuum pump 203 and the high-pressure gas source 204;

[0035] In actual operation, the liquid passes through the first filter 1 and then enters the buffer tank 2. After being stabilized by the buffer tank 2, it enters the filling valve plate 3 for continuous filling;

[0036] With the design of multiple buffer tanks 2, at least one of the buffer tanks 2 is a filling buffer tank. In this buffer tank 2, a constant-pressure air flow is applied to the filling buffer tank through the high-pressure gas source 204. The constant-pressure high-pressure gas presses the liquid in the tank out at a constant speed and flows to the filling valve plate 3, thereby realizing constant-speed filling and ensuring the filling accuracy. When the remaining liquid level in this buffer tank 2 reaches the set lower limit value, another buffer tank 2 is replaced as the new filling buffer tank, that is, continuous filling operation is realized;

[0037] Meanwhile, among multiple groups of buffer tanks 2, at least one group of buffer tanks 2 is a liquid replenishment buffer tank. That is, while filling is carried out in the filling buffer tank, the liquid upstream enters the liquid replenishment buffer tank after being filtered by the first filter 1. When the internal liquid level reaches the set upper limit value, the liquid replenishment stops. At the same time, under the action of the vacuum pump 203, the upper cavity of the liquid replenishment buffer tank is evacuated to a vacuum state, and the liquid in the liquid replenishment buffer tank is allowed to stand still, which is conducive to the release of gas inside the liquid in the liquid replenishment buffer tank, so as to reduce the influence of the gas in the liquid on the filling accuracy. After most of the bubbles in the liquid are released, the vacuum pump 203 is closed. Under the action of the high-pressure gas source 204, the pressure reducing valve 205, and the back pressure valve 206, the liquid replenishment buffer tank is pressurized to the set pressure and the pressure is regulated and stabilized until the liquid level in the original filling buffer tank reaches the set lower limit value. Then this liquid replenishment buffer tank is changed to a filling buffer tank for filling, and the original filling buffer tank is changed to a liquid replenishment buffer tank for liquid replenishment;

[0038] The main sources of gas in the liquid are the bubbles generated by the high-speed flowing liquid scouring the inner wall when it enters the buffer tank 2, or the gas originally dissolved in the liquid.

[0039] As Figure 1 shown, it is the design of two groups of buffer tanks 2. One of them is a liquid replenishment buffer tank, such as the A-group buffer tank 201, and the other is a filling buffer tank, such as the B-group buffer tank 202. The functions of the two groups of buffer tanks 2 are alternately switched, separating the liquid replenishment and filling without affecting each other, eliminating the influence of the liquid replenishment of the buffer tank 2 on the filling pressure, that is, reducing the influence on the filling accuracy;

[0040] Meanwhile, after the liquid replenishment and filling are separated, after the liquid replenishment is completed, before the liquid replenishment buffer tank is switched to a filling buffer tank, the liquid can be allowed to stand still, which is conducive to the release of internal gas and reduces the influence of the gas in the liquid on the filling accuracy;

[0041] Moreover, without changing the volume of the buffer tank 2, the time for a single group of buffer tanks 2 to be used as a filling buffer tank is 0.5 times that of the prior art. That is, the liquid replenishment times of this group of buffer tanks 2 are reduced, the liquid replenishment frequency is lowered, the opening times of the corresponding valves are reduced, thereby reducing the wear of the corresponding valves and increasing the overall service life of the equipment;

[0042] At the same time, without increasing the volume of the buffer tank 2, the inside of the buffer tank 2 can be cleaned by the online fluid, and there will be no problem of insufficient scouring water flow and scouring dead angles caused by increasing the volume of the buffer tank 2, thus ensuring the safety of the entire filling process.

[0043] For the design with N groups of buffer tanks 2 and only one group being used as a filling buffer tank, the time for a single group of buffer tanks 2 to be used as a filling buffer tank is only 1 / N times that of the prior art. Its liquid replenishment times are fewer, the liquid replenishment frequency is lower, that is, the wear of the corresponding valves is less, and the overall service life is longer;

[0044] Meanwhile, for the design of setting N groups of buffer tanks 2, multiple groups of buffer tanks 2 can also be used synchronously as filling buffer tanks to increase the filling speed. Moreover, when switching between the filling buffer tank and the liquid replenishing buffer tank, by means of asynchronous switching of multiple groups, the sense of jerk of the buffer tank 2 during the switching between the filling buffer tank and the liquid replenishing buffer tank can be further reduced, and the smoothness of filling can be further ensured.

[0045] The switching method between the filling buffer tank and the liquid replenishing buffer tank is as follows:

[0046] Open the first stop valve 2011 at the liquid inlet of one group of buffer tanks 2 and close the first stop valve 2011 at the liquid outlet of this group of buffer tanks 2. At this time, this buffer tank 2 is the liquid replenishing buffer tank;

[0047] When it is necessary to switch from the liquid replenishing buffer tank to the filling buffer tank, only flip the state of the first stop valve 2011 connected to the liquid inlet and the liquid outlet of this group of buffer tanks 2.

[0048] In the liquid replenishing buffer tank, the second stop valves 2012 connected to the vacuum pump 203 and the high-pressure gas source 204 are all in the closed state. When the internal liquid level reaches the set upper limit value, close the first stop valve 2011 at the liquid inlet, and at the same time open the second stop valve 2012 connected to the vacuum pump 203, that is, evacuate the upper cavity of the buffer tank 2 to a negative pressure to facilitate gas precipitation. After reaching the predetermined time, close all the second stop valves 2012 and open the second stop valve 2012 connected to the high-pressure gas source 204. The high-pressure gas in the high-pressure gas source 204 enters the upper part of the buffer tank 2. Under the action of the high-pressure gas source 204, the pressure reducing valve 205, and the back pressure valve 206, the liquid replenishing buffer tank is pressurized to the set pressure and the pressure is stably regulated;

[0049] In the filling buffer tank, open the second stop valve 2012 connected to the high-pressure gas source 204. The high-pressure gas in the high-pressure gas source 204 enters the upper part of the buffer tank 2, and the internal liquid is discharged from the liquid outlet at the bottom of the buffer tank 2 until the set lower limit value of the liquid level is reached, and then close all the second stop valves 2012.

[0050] In some embodiments, a liquid level gauge 209 is provided in the buffer tank 2, and the detection end of the liquid level gauge 209 extends to the bottom of the tank body of the buffer tank 2;

[0051] By adding the liquid level gauge 209 in the buffer tank 2, the liquid level in the buffer tank 2 can be monitored in real time, so as to control the switching timing between the filling buffer tank and the liquid replenishing buffer tank, and avoid the high-pressure gas in the buffer tank 2 from entering the filling valve plate 3.

[0052] Further, the liquid level gauge 209 is a guided wave radar liquid level gauge. The output end of the liquid level gauge 209 is electrically connected to the control units of the external vacuum pump 203 and the high-pressure gas source 204, or the output end of the liquid level gauge 209 is electrically connected to the control unit of the first cut-off valve 2011;

[0053] By using a guided wave radar liquid level gauge, when the liquid flushes the buffer tank 2, it is not affected by the upper layer of floating foam, ensuring the liquid level measurement accuracy. Moreover, it can send the measured liquid level data to the control units of the vacuum pump 203, the high-pressure gas source 204, and the first cut-off valve 2011 in the form of electrical signals, facilitating the realization of automatic control and the networking monitoring of production data.

[0054] In some embodiments, a weighing unit is provided in the buffer tank system, and the liquid level in the buffer tank is controlled by online weighing.

[0055] In some embodiments, a pressure transmitter 210 is connected in communication at the air vent. The output end of the pressure transmitter 210 is electrically connected to the control units of the external vacuum pump 203 and the high-pressure gas source 204, or the output end of the pressure transmitter 210 is electrically connected to the control unit of the second cut-off valve 2012;

[0056] By adding a pressure transmitter 210 at the air vent, the internal air pressure of the buffer tank 2 is monitored. At the same time, the air pressure data is transmitted to the control units of the vacuum pump 203, the high-pressure gas source 204, and the second cut-off valve 2012 in the form of electrical signals. When the buffer tank 2 is used as a liquid filling buffer tank, the pressure signal is transmitted to the vacuum pump 203 to realize the closed-loop control of negative pressure pumping; when the buffer tank 2 is used as a filling buffer tank, the pressure signal is transmitted to the control unit of the high-pressure gas source 204 to realize the closed-loop control of stable pressure application; and the data of the pressure transmitter 210 can also be transmitted to the control terminal to realize the networking monitoring of the equipment.

[0057] In some embodiments, a second filter 207 is connected in series on the connecting branch of the air vent to the vacuum pump 203 and / or the high-pressure gas source 204;

[0058] In some application scenarios, such as the filling of liquid medicine, it is necessary to sterilize and filter all the gases in contact with the liquid medicine. That is, the gases entering and leaving the buffer tank 2 are filtered through the second filter 207, thereby ensuring the filling safety of the liquid medicine.

[0059] In some embodiments, a safety valve 208 is connected in communication at the air vent;

[0060] When the buffer tank 2 is used as a filling buffer tank, the high-pressure gas source 204 applies a constant-pressure high-pressure gas to the buffer tank 2. When the pipeline is blocked, the high pressure in the buffer tank 2 will occur. When the pressure exceeds the set value of the safety valve 208, active pressure relief is carried out to ensure production safety.

[0061] In some embodiments, a pressure reducing valve 205 is provided in the communication branch of the high-pressure gas source 204 at the ventilation opening, and a back pressure valve 206 is arranged in parallel at the output end of the pressure reducing valve 205;

[0062] A pressure reducing valve 205 is provided in the communication branch of the high-pressure gas source 204 to reduce the output gas of the high-pressure gas source 204 to the required pressure. The pressure reducing valve 205 is preferably a precision pressure reducing valve to ensure that the output pressure fluctuation is small;

[0063] Moreover, a back pressure valve 206 is arranged in parallel at the output end of the pressure reducing valve 205. Even if there is a slight fluctuation in the pressure at the output end of the pressure reducing valve 205, the back pressure valve 206 can eliminate its peak pressure, that is, keep the output pressure stable and reduce the influence of the output pressure fluctuation of the high-pressure gas source 204 on the filling accuracy.

[0064] In some embodiments, the first stop valve 2011 and the second stop valve 2012 are diaphragm valves; by using diaphragm valves and the special structure of diaphragm valves, the pharmaceutical liquid does not directly contact the valve stem and the valve core, reducing the possibility of the pharmaceutical liquid being contaminated, and at the same time reducing the corrosion of the valve stem and the valve core by the pharmaceutical liquid. At the same time, both the first stop valve 2011 and the second stop valve 2012 adopt electric actuators, which is convenient for realizing automatic control.

[0065] In addition to the time-pressure filling system disclosed in each of the above embodiments, the present invention also provides a pharmaceutical liquid filling device including the above time-pressure filling system. For the structures of other parts of the pharmaceutical liquid filling device, reference may be made to the prior art and will not be elaborated herein.

[0066] In this specification, each embodiment is described in a progressive manner. The key point of each embodiment is to illustrate the differences from other embodiments. The same or similar parts among the embodiments can be referred to each other.

[0067] The above has introduced in detail the time-pressure filling system and the pharmaceutical liquid filling device provided by the present invention. Specific examples are used herein to elaborate on the principle and implementation manner of the present invention. The description of the above embodiments is only used to help understand the method and its core idea of the present invention. It should be pointed out that for those of ordinary skill in the art in this technical field, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the protection scope of the claims of the present invention.

Claims

1. A time-pressure filling system, characterized in that, It includes a first filter (1), a buffer tank (2) and a filling valve plate (3) connected in series in sequence; There are at least two groups of the buffer tanks (2), which are arranged in parallel. Independent controllable first stop valves (2011) are respectively arranged at the liquid inlet and liquid outlet of the buffer tank (2). An air vent hole is arranged at the top of the buffer tank (2), and the air vent hole is simultaneously connected to an external vacuum pump (203) and a high-pressure air source (204). Independent controllable second stop valves (2012) are respectively arranged on the connecting branches of the air vent hole with the vacuum pump (203) and the high-pressure air source (204).

2. The time-pressure filling system according to claim 1, wherein A liquid level gauge (209) is arranged in the buffer tank (2), and the detection end of the liquid level gauge (209) extends to the bottom of the tank body of the buffer tank (2).

3. The time-pressure filling system according to claim 2, wherein The liquid level gauge (209) is a guided wave radar liquid level gauge. The output end of the liquid level gauge (209) is electrically connected to the control unit of the external vacuum pump (203), the output end of the liquid level gauge (209) is electrically connected to the control unit of the high-pressure air source (204), or the output end of the liquid level gauge (209) is electrically connected to the control unit of the first stop valve (2011).

4. The time-pressure filling system according to claim 1, characterized in that, A pressure transmitter (210) is connected and arranged at the air vent hole. The output end of the pressure transmitter (210) is electrically connected to the control unit of the external vacuum pump (203), the output end of the pressure transmitter (210) is electrically connected to the control unit of the high-pressure air source (204), or the output end of the pressure transmitter (210) is electrically connected to the control unit of the second stop valve (2012).

5. The time-pressure filling system according to claim 1, wherein A second filter (207) is connected in series on the connecting branch of the air vent hole with the vacuum pump (203) and / or the high-pressure air source (204).

6. The time-pressure filling system according to claim 1, wherein, A safety valve (208) is connected and arranged at the air vent hole.

7. The time-pressure filling system according to claim 1, characterized in that, A pressure reducing valve (205) is arranged in the connecting branch of the high-pressure air source (204) at the air vent hole, and a back pressure valve (206) is arranged in parallel at the output end of the pressure reducing valve (205).

8. The time pressure filling system according to claim 1, characterized in that, The first stop valve (2011) and the second stop valve (2012) are diaphragm valves.

9. A liquid medicine filling device, characterized in that, It includes the time-pressure filling system according to any one of claims 1-8.

Images