Production system for gamma-aminobutyric acid

Abstract

The utility model relates to the technical field of biology, in particular to a production system for gamma-aminobutyric acid, which comprises a reaction kettle, a discharge port of the reaction kettle is communicated with a filter device, a filtrate outlet of the filter device is communicated with an extraction kettle, an organic phase outlet of the extraction kettle is communicated with a pH regulating kettle, and a discharge port of the pH regulating kettle is communicated with a resin column. A liquid inlet of the resin column is communicated with a desorption agent storage tank; a desorption liquid outlet of the resin column is communicated with a first concentration device; a concentrated liquid outlet of the first concentration device is communicated with a second concentration device; a concentrated liquid outlet of the second concentration device is communicated with a first crystallization kettle; a decoloring liquid outlet of the decoloring kettle is communicated with the second crystallization kettle, a discharge port of the second crystallization kettle is communicated with the drying device, and a discharge port of the drying device is communicated with the product storage tank. The production system is reasonable in design, continuous production can be realized, and the gamma-aminobutyric acid product with high yield, high yield and high purity can be obtained.

Description

Technical Field

[0001] The utility model relates to the field of biotechnology, in particular to a production system for γ-aminobutyric acid. Background Art

[0002] γ-aminobutyric acid (also known as 4-aminobutyric acid, γ-aminobutyric acid, abbreviated as GABA) is a naturally occurring non-protein amino acid and an important inhibitory neurotransmitter in the central nervous system. It is irreversibly catalyzed by L-glutamic acid decarboxylase (GAD) to generate L-glutamic acid (L-glutamic acid, L-Glu). It has a variety of physiological functions, such as improving sleep, treating depression, enhancing immunity, lowering blood pressure, improving visual cortex function, resisting obesity, alleviating anxiety and menopausal syndrome, and treating epilepsy. However, the content of GABA produced endogenously in the human body is low, and it is often necessary to supplement it externally to maintain human health.

[0003] The preparation methods of γ-aminobutyric acid mainly include chemical synthesis method, plant enrichment method, microbial fermentation method and biotransformation method. Chemical synthesis mainly uses γ-butyrolactone, γ-halogenated butyronitrile, 2-bromopropionic acid and glutaric anhydride as substrates to synthesize GABA. Its reaction speed is fast and the yield is high, but it has the disadvantages of harsh conditions, high energy consumption, high cost, low yield and poor safety, and cannot be used in the fields of food, medicine, etc. Enriching GABA from plants by low-temperature or high-salt stress treatment is simple, safe and environmentally friendly, but it has the limitations of low enrichment yield and high cost, and cannot meet the market demand. The microbial fermentation method has a long production cycle, a relatively low production yield and difficult subsequent separation and extraction, which limits its industrial application. The biotransformation method, that is, the whole-cell catalytic transformation method, is more and more favored due to its advantages of simple operation, mild conditions, high raw material utilization rate, high conversion rate and low separation and purification cost. Therefore, it is necessary to develop a production system for γ-aminobutyric acid to solve the above problems. Summary of the Utility Model

[0004] The technical problem to be solved by the utility model is: aiming at the deficiencies of the prior art, to provide a production system for the separation, purification and preparation of γ-aminobutyric acid, and using this production system, γ-aminobutyric acid products with high yield, high purity and high output can be obtained.

[0005] To solve the above technical problems, the technical solution of the utility model is:

[0006] A production system for γ-aminobutyric acid, comprising a reaction kettle. The discharge port of the reaction kettle is connected to a filtering device, the filtrate outlet of the filtering device is connected to an extraction kettle, the organic phase outlet of the extraction kettle is connected to a pH adjustment kettle, the discharge port of the pH adjustment kettle is connected to a resin column, the liquid inlet of the resin column is connected to an analytical agent storage tank, the analytical liquid outlet of the resin column is connected to a first concentration device, the concentrated liquid outlet of the first concentration device is connected to a second concentration device, the concentrated liquid outlet of the second concentration device is connected to a first crystallization kettle, the discharge port of the first crystallization kettle is connected to a decolorization kettle, the decolorized liquid outlet of the decolorization kettle is connected to a second crystallization kettle, the discharge port of the second crystallization kettle is connected to a drying device, and the discharge port of the drying device is connected to a product storage tank.

[0007] As an improved technical solution, the reaction kettle includes a kettle body. A jacket is provided on the outer wall of the kettle body. A feed port and a discharge port are respectively provided at the top and bottom of the kettle body. A stirring shaft, a pH sensor and a temperature sensor are provided inside the kettle body. The pH sensor and the temperature sensor are respectively electrically connected to a controller. One end of the stirring shaft is connected to a motor, and multiple layers of stirring blades are provided on the stirring shaft.

[0008] As an improved technical solution, the filtering device is a ceramic membrane filtering device with a pore size of 50 - 200 nm.

[0009] As an improved technical solution, the extraction kettle includes a kettle body. A feed port and an extractant inlet are provided at the top of the kettle body. An organic phase outlet is provided at the bottom of the kettle body. A sight glass is provided outside the kettle body. A rotating shaft is provided inside the kettle body. One end of the rotating shaft is connected to a motor, and multiple layers of stirring plates are provided on the rotating shaft.

[0010] As an improved technical solution, the pH adjustment kettle includes a kettle body. A feed port and an acid liquid inlet are provided at the top of the kettle body. A discharge port is provided at the bottom of the kettle body. An anchor stirrer and a pH sensor are provided inside the kettle body. One end of the anchor stirrer is connected to a motor, and the pH sensor is electrically connected to the controller.

[0011] As an improved technical solution, the first concentration device is a nanofiltration membrane device with a cut-off molecular weight of 100 - 200 Da.

[0012] As an improved technical solution, the second concentration device is a concentration kettle, which includes a kettle body. A feed port and a concentrated liquid outlet are respectively provided at the top and bottom of the kettle body. A jacket is provided outside the kettle body. A stirring shaft is provided inside the kettle body. One end of the stirring shaft is connected to a motor, a stirring frame is provided on the stirring shaft, and multiple stirring plates are provided on the stirring frame.

[0013] As an improved technical solution, both the first crystallization kettle and the second crystallization kettle include a kettle body. The top and bottom of the kettle body are respectively provided with a feed inlet and a discharge outlet. A jacket is provided outside the kettle body. A crystallization mother liquor outlet is provided on one side of the lower part of the kettle body. A filter screen is provided at a position corresponding to the crystallization mother liquor outlet on the inner wall of the kettle body. An anchor agitator is provided inside the kettle body, and one end of the anchor agitator is connected to a motor.

[0014] As an improved technical solution, the decolorization kettle includes a kettle body. The top of the kettle body is provided with a feed inlet and a decolorizing agent inlet. The bottom of the kettle body is provided with a decolorizing agent outlet. A decolorized liquid outlet is provided on one side of the lower part of the kettle body. A filter screen is provided at a position corresponding to the decolorized liquid outlet on the inner wall of the kettle body. A jacket is provided outside the kettle body. A stirring shaft is provided inside the decolorization kettle. One end of the stirring shaft is connected to a motor, and multiple stirring rods are provided on the stirring shaft.

[0015] As an improved technical solution, the washing kettle includes a kettle body. The top of the kettle body is provided with a feed inlet and a washing liquid inlet. The bottom of the kettle body is provided with a discharge outlet. A washing liquid outlet is provided on one side of the lower part of the kettle body. A filter screen is provided at a position corresponding to the washing liquid outlet on the inner wall of the kettle body. An anchor agitator is provided inside the kettle body, and one end of the anchor agitator is connected to a motor.

[0016] After adopting the above technical solutions, the beneficial effects of the present utility model are:

[0017] The production system for γ-aminobutyric acid includes a reaction kettle. The discharge port of the reaction kettle is connected to a filtering device. The filtrate outlet of the filtering device is connected to an extraction kettle. The organic phase outlet of the extraction kettle is connected to a pH adjustment kettle. The discharge port of the pH adjustment kettle is connected to a resin column. The liquid inlet of the resin column is connected to an analytical agent storage tank. The analytical solution outlet of the resin column is connected to a first concentration device. The concentrated liquid outlet of the first concentration device is connected to a second concentration device. The concentrated liquid outlet of the second concentration device is connected to a first crystallization kettle. The discharge port of the first crystallization kettle is connected to a decolorization kettle. The decolorized liquid outlet of the decolorization kettle is connected to a second crystallization kettle. The discharge port of the second crystallization kettle is connected to a drying device. The discharge port of the drying device is connected to a product storage tank. In actual production, first, a glutamic acid solution, whole cells containing glutamic acid decarboxylase, and a calcium salt solution are put into the reaction kettle. After the reaction, the conversion liquid containing γ-aminobutyric acid enters the filtering device under the action of a delivery pump. The collected filtrate enters the extraction kettle along the pipeline under the action of the delivery pump. After extraction with an extraction agent, the collected organic phase is transported to the pH adjustment kettle. After adjusting the pH to acidic, it enters the resin column. γ-aminobutyric acid is adsorbed by the resin. The analytical agent in the analytical agent storage tank elutes the resin column. The collected analytical solution then enters the first concentration device and the second concentration device in sequence for concentration. The collected concentrated liquid then enters the first crystallization kettle for crystallization. The collected crude γ-aminobutyric acid enters the decolorization kettle. After decolorization treatment with a decolorizing agent, the collected decolorized liquid enters the second crystallization kettle. Then, the collected γ-aminobutyric acid crystals are transported to the drying device for drying, and the γ-aminobutyric acid product is stored in the product storage tank. The above production system is reasonably designed, can realize continuous production, and can obtain γ-aminobutyric acid products with high yield, high recovery rate, and high purity.

[0018] Since the reaction kettle includes a kettle body, a jacket is provided on the outer wall of the kettle body. The top and bottom of the kettle body are respectively provided with a feed port and a discharge port. A stirring shaft, a pH sensor, and a temperature sensor are provided inside the kettle body. The pH sensor and the temperature sensor are respectively electrically connected to a controller. One end of the stirring shaft is connected to a motor, and multiple layers of stirring blades are provided on the stirring shaft. The glutamic acid solution, whole cells containing glutamic acid decarboxylase, and the calcium salt solution enter the reaction kettle from the feed port. The motor starts to drive the stirring shaft and the multiple layers of stirring blades to stir and mix the materials. The pH sensor detects the pH of the materials, and the temperature sensor detects the material temperature. The conversion liquid obtained after sufficient reaction is discharged from the discharge port. The above reaction kettle is reasonably designed, facilitating the full contact and reaction of the materials and improving the conversion rate.

[0019] Since the filtering device is a ceramic membrane filtering device with a pore size of 50 - 200 nm. The effective retention of the whole cells that did not participate in the reaction is achieved by using this device.

[0020] The extraction kettle includes a kettle body, a feed port and an extractant inlet are arranged on the top of the kettle body, an organic phase outlet is arranged on the bottom of the kettle body, a sight glass is arranged on the outside of the kettle body, a rotating shaft is arranged inside the kettle body, one end of the rotating shaft is connected to a motor, and a multi-layer stirring plate is arranged on the rotating shaft. The extractant and filtrate enter the inside of the kettle body from the feed port, and the motor drives the rotating shaft and the multi-layer stirring plates to rotate after starting. The organic phase and the aqueous phase after stratification are observed through the sight glass, and then the organic phase is collected. The above-mentioned extraction kettle is reasonably designed to achieve effective extraction of γ-aminobutyric acid.

[0021] The pH adjustment kettle includes a kettle body, a feed port and an acid inlet are arranged on the top of the kettle body, a discharge port is arranged on the bottom of the kettle body, an anchor stirrer and a pH sensor are arranged inside the kettle body, one end of the anchor stirrer is connected to a motor, and the pH sensor is electrically connected to a controller. The organic phase and the acid solution enter the kettle body respectively, and after the motor is started, the anchor stirrer is driven to rotate, so that the acid solution and the organic phase are fully mixed, and the pH sensor transmits the pH data of the detected organic phase to the controller, and when the appropriate pH is reached, the addition of the acid solution is stopped.

[0022] Since the second concentration device is a concentration kettle, the concentration kettle includes a kettle body, the top and bottom of the kettle body are respectively provided with a feed inlet and a concentrated liquid outlet, a jacket is provided on the outside of the kettle body, a stirring shaft is provided inside the kettle body, one end of the stirring shaft is connected to the motor, a stirring frame is provided on the stirring shaft, and a plurality of stirring plates are provided on the stirring frame. The feed liquid is heated by the heat medium in the jacket, and after the motor is started, the stirring shaft, the stirring frame and the plurality of stirring plates are driven to stir and mix the feed liquid, so that the feed liquid is evenly heated, which greatly improves the concentration efficiency.

[0023] Since both the first crystallization kettle and the second crystallization kettle include a kettle body, a feed port and a discharge port are respectively arranged at the top and bottom of the kettle body, a jacket is arranged on the outside of the kettle body, a crystallization mother liquor outlet is arranged on one side of the lower part of the kettle body, a filter screen is arranged at a position of the inner wall of the kettle body corresponding to the crystallization mother liquor outlet, an anchor agitator is arranged inside the kettle body, and one end of the anchor agitator is connected to a motor. The refrigerant in the jacket is used to cool the feed liquid, and after the motor is started, the anchor agitator is driven to stir the feed liquid, so that it is evenly cooled and convenient for the formation of crystals. The crystals are discharged from the discharge port, and the crystallization mother liquor passes through the filter screen and is discharged from the crystallization mother liquor outlet under the action of the suction pump.

[0024] Since the decolorization kettle includes a kettle body, a feed inlet and a decolorizing agent inlet are provided at the top of the kettle body, a decolorizing agent outlet is provided at the bottom of the kettle body, a decolorized liquid outlet is provided on one side of the lower part of the kettle body, a filter screen is provided at a position corresponding to the decolorized liquid outlet on the inner wall of the kettle body, a jacket is provided outside the kettle body, a stirring shaft is provided inside the decolorization kettle, one end of the stirring shaft is connected to a motor, and multiple layers of stirring rods are provided on the stirring shaft. The crude γ-aminobutyric acid enters the inside of the kettle body, purified water is added, heated by the heat medium in the jacket, the motor drives the stirring shaft and the multiple layers of stirring rods to stir until dissolved, then the decolorizing agent is added and stirring continues. After decolorization treatment for a period of time, the decolorized solution passes through the filter screen and is discharged from the decolorized liquid outlet under the action of a suction filter pump, and the decolorizing agent is discharged from the decolorizing agent outlet. Description of the Drawings

[0025] Figure 1 is a schematic structural diagram of a production system for γ-aminobutyric acid of the present utility model;

[0026] Among them, 1 - reaction kettle, 2 - filtering device, 3 - extraction kettle, 4 - pH adjustment kettle, 5 - resin column, 6 - resolving agent storage tank, 7 - first concentration device, 8 - second concentration device, 9 - first crystallization kettle, 10 - decolorization kettle, 11 - second crystallization kettle, 12 - drying device, 13 - product storage tank, 14, 16 - pH sensors, 15 - temperature sensor, 17, 18 - controllers. Detailed Embodiments

[0027] In order to make the objectives, technical solutions and advantages of the present utility model clearer, the present utility model will be further described in detail below with reference to the drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present utility model and are not used to limit the present utility model.

[0028] A production system for γ-aminobutyric acid, as Figure 1 shown, includes a reaction kettle 1. The discharge port of the reaction kettle 1 is connected to a filtering device 2 (a ceramic membrane filtering device with a pore size of 50 - 200 nm). The filtrate outlet of the filtering device 2 is connected to an extraction kettle 3. The organic phase outlet of the extraction kettle 3 is connected to a pH adjustment kettle 4. The discharge port of the pH adjustment kettle 4 is connected to a resin column 5 (a strong acid type gel resin column). The liquid inlet of the resin column 5 is connected to a resolving agent storage tank 6. The resolving liquid outlet of the resin column 5 is connected to a first concentration device 7 (a nanofiltration membrane device with a cut-off molecular weight of 100 - 200 Da). The concentrated liquid outlet of the first concentration device 7 is connected to a second concentration device 8. The concentrated liquid outlet of the second concentration device 8 is connected to a first crystallization kettle 9. The discharge port of the first crystallization kettle 9 is connected to a decolorization kettle 10. The decolorized liquid outlet of the decolorization kettle 10 is connected to a second crystallization kettle 11. The discharge port of the second crystallization kettle 11 is connected to a drying device 12 (a double-cone dryer). The discharge port of the drying device 12 is connected to a product storage tank 13.

[0029] In actual production, first, glutamic acid solution, whole cells containing glutamic acid decarboxylase, and calcium salt solution are put into a reaction kettle. After the reaction, the conversion solution containing γ-aminobutyric acid enters the filtration device under the action of a delivery pump. The collected filtrate enters the extraction kettle along the pipeline under the action of the delivery pump. After extraction with an extractant, the collected organic phase is transported to a pH adjustment kettle. After adjusting the pH to acidic, it enters a resin column. γ-aminobutyric acid is adsorbed by the resin. The desorbent in the desorbent storage tank elutes the resin column. The collected eluate then enters a first concentration device and a second concentration device in sequence for concentration. The collected concentrated solution then enters a first crystallization kettle for crystallization. The collected crude γ-aminobutyric acid enters a decolorization kettle and undergoes decolorization treatment with a decolorant. The collected decolorized solution then enters a second crystallization kettle. Then, the collected γ-aminobutyric acid crystals are transported to a drying device through a conveyor belt for drying, and the γ-aminobutyric acid product is stored in a product storage tank. The above production system is reasonably designed, can realize continuous production, and can obtain γ-aminobutyric acid products with high yield, high recovery rate, and high purity.

[0030] Among them, the reaction kettle 1 includes a kettle body. The outer wall of the kettle body is provided with a jacket. The top and bottom of the kettle body are respectively provided with a feed inlet and a discharge outlet. The inside of the kettle body is provided with a stirring shaft, a pH sensor 14, and a temperature sensor 15. The pH sensor 14 and the temperature sensor 15 are respectively electrically connected to a controller 17. One end of the stirring shaft is connected to a motor, and multiple layers of stirring blades are provided on the stirring shaft. Glutamic acid solution, whole cells containing glutamic acid decarboxylase, and calcium salt solution enter the reaction kettle from the feed inlet. The motor starts to drive the stirring shaft and multiple layers of stirring blades to stir and mix the materials. The pH sensor detects the pH of the materials, and the temperature sensor detects the material temperature. The conversion solution obtained after sufficient reaction is discharged from the discharge outlet. The above reaction kettle is reasonably designed, which is convenient for the materials to fully contact and react, and improves the conversion rate.

[0031] Among them, the extraction kettle 3 includes a kettle body. The top of the kettle body is provided with a feed inlet and an extractant inlet. The bottom of the kettle body is provided with an organic phase outlet. A sight glass is provided outside the kettle body. A rotating shaft is provided inside the kettle body. One end of the rotating shaft is connected to a motor, and multiple layers of stirring plates are provided on the rotating shaft. The extractant and the filtrate enter the inside of the kettle body from the feed inlet. After the motor starts, it drives the rotating shaft and multiple layers of stirring plates to rotate. The separated organic phase and aqueous phase are observed through the sight glass, and then the organic phase is collected. The above extraction kettle is reasonably designed, realizing the effective extraction of γ-aminobutyric acid.

[0032] The pH adjustment kettle 4 includes a kettle body, a feed port and an acid liquid inlet are arranged on the top of the kettle body, a discharge port is arranged on the bottom of the kettle body, an anchor stirrer and a pH sensor 16 are arranged inside the kettle body, one end of the anchor stirrer is connected to a motor, and the pH sensor is electrically connected to a controller 18. The organic phase and the acid liquid enter the inside of the kettle body respectively, and after the motor is started, the anchor stirrer is driven to rotate, so that the acid liquid and the organic phase are fully mixed, and the pH sensor transmits the pH data of the detected organic phase to the controller, and when the appropriate pH is reached, the addition of the acid liquid is stopped.

[0033] The second concentrating device 8 is a concentrating kettle, which includes a kettle body, a feed inlet and a concentrated liquid outlet are respectively arranged at the top and bottom of the kettle body, a jacket is arranged outside the kettle body, a stirring shaft is arranged inside the kettle body, one end of the stirring shaft is connected to the motor, a stirring frame is arranged on the stirring shaft, and a plurality of stirring plates are arranged on the stirring frame. The feed liquid is heated by the heat medium in the jacket, and after the motor is started, the stirring shaft, the stirring frame and the plurality of stirring plates are driven to stir and mix the feed liquid, so that the feed liquid is evenly heated, which greatly improves the concentration efficiency.

[0034] The first crystallization kettle 9 and the second crystallization kettle 11 both include a kettle body, the top and bottom of the kettle body are respectively provided with a feed port and a discharge port, the outside of the kettle body is provided with a jacket, a crystallization mother liquid outlet is provided on one side of the lower part of the kettle body, a filter screen is provided at a position corresponding to the crystallization mother liquid outlet on the inner wall of the kettle body, and an anchor agitator is provided inside the kettle body, and one end of the anchor agitator is connected to a motor. The refrigerant in the jacket is used to cool the feed liquid, and after the motor is started, the anchor agitator is driven to stir the feed liquid, so that it is evenly cooled and facilitates the formation of crystals. The crystals are discharged from the discharge port, and the crystallization mother liquid passes through the filter screen under the action of the suction pump and is discharged from the crystallization mother liquid outlet.

[0035] The decolorizing kettle 10 includes a kettle body, a feed port and a decolorizing agent inlet are provided at the top of the kettle body, a decolorizing agent outlet is provided at the bottom of the kettle body, a decolorizing liquid outlet is provided at one side of the lower part of the kettle body, a filter screen is provided at the position of the inner wall of the kettle body corresponding to the decolorizing liquid outlet, a jacket is provided on the outside of the kettle body, a stirring shaft is provided inside the decolorizing kettle, one end of the stirring shaft is connected to a motor, and a multi-layer stirring rod is provided on the stirring shaft. The crude γ-aminobutyric acid enters the kettle body, purified water is added, and the heat medium in the jacket is used for heating. The motor drives the stirring shaft and the multi-layer stirring rod to stir until dissolved, and then the decolorizing agent is added to continue stirring. After a period of decolorization treatment, the decolorized solution passes through the filter screen and is discharged from the decolorizing liquid outlet under the action of the suction pump, and the decolorizing agent outlet discharges the decolorizing agent.

[0036] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A production system for γ-aminobutyric acid, characterized in that, It includes a reaction kettle. The discharge port of the reaction kettle is connected to a filtration device. The filtrate outlet of the filtration device is connected to an extraction kettle. The organic phase outlet of the extraction kettle is connected to a pH adjustment kettle. The discharge port of the pH adjustment kettle is connected to a resin column. The liquid inlet of the resin column is connected to an analytical agent storage tank. The analytical solution outlet of the resin column is connected to a first concentration device. The concentrated liquid outlet of the first concentration device is connected to a second concentration device. The concentrated liquid outlet of the second concentration device is connected to a first crystallization kettle. The discharge port of the first crystallization kettle is connected to a decolorization kettle. The decolorized liquid outlet of the decolorization kettle is connected to a second crystallization kettle. The discharge port of the second crystallization kettle is connected to a drying device. The discharge port of the drying device is connected to a product storage tank.

2. The production system for γ-aminobutyric acid according to claim 1, characterized in that, The reaction kettle includes a kettle body. The outer wall of the kettle body is provided with a jacket. The top and bottom of the kettle body are respectively provided with a feed port and a discharge port. Inside the kettle body, there are a stirring shaft, a pH sensor, and a temperature sensor. The pH sensor and the temperature sensor are respectively electrically connected to a controller. One end of the stirring shaft is connected to a motor, and there are multiple layers of stirring blades on the stirring shaft.

3. The production system for γ-aminobutyric acid according to claim 1, wherein, The filtration device is a ceramic membrane filtration device with a pore size of 50 - 200 nm.

4. A production system for γ-aminobutyric acid according to claim 1, wherein, The extraction kettle includes a kettle body. The top of the kettle body is provided with a feed port and an extractant inlet. The bottom of the kettle body is provided with an organic phase outlet. There is a sight glass outside the kettle body. Inside the kettle body, there is a rotating shaft. One end of the rotating shaft is connected to a motor, and there are multiple layers of stirring plates on the rotating shaft.

5. A production system for γ-aminobutyric acid according to claim 1, characterized in that, The pH adjustment kettle includes a kettle body. The top of the kettle body is provided with a feed port and an acid solution inlet. The bottom of the kettle body is provided with a discharge port. Inside the kettle body, there is an anchor agitator, and one end of the anchor agitator is connected to a motor.

6. The production system for γ-aminobutyric acid according to claim 1, characterized in that, The first concentration device is a nanofiltration membrane device with a molecular weight cut-off of 100 - 200 Da.

7. A production system for γ-aminobutyric acid according to claim 1, characterized in that, The second concentration device is a concentration kettle. The concentration kettle includes a kettle body. The top and bottom of the kettle body are respectively provided with a feed port and a concentrated liquid outlet. The outer wall of the kettle body is provided with a jacket. Inside the kettle body, there is a stirring shaft, and there is a stirring frame on the stirring shaft. There are multiple stirring plates on the stirring frame.

8. A production system for γ-aminobutyric acid according to claim 1, characterized in that, Both the first crystallization kettle and the second crystallization kettle include a kettle body. The top and bottom of the kettle body are respectively provided with a feed port and a discharge port. The outer wall of the kettle body is provided with a jacket. There is a mother liquor outlet for crystallization on one side of the lower part of the kettle body. A filter screen is provided at a position corresponding to the mother liquor outlet for crystallization on the inner wall of the kettle body. There is an anchor agitator inside the kettle body.

9. The production system for γ-aminobutyric acid according to claim 1, wherein The decolorization kettle includes a kettle body. The top of the kettle body is provided with a feed port and a decolorizing agent inlet. The bottom of the kettle body is provided with a decolorizing agent outlet. There is a decolorized liquid outlet on one side of the lower part of the kettle body. A filter screen is provided at a position corresponding to the decolorized liquid outlet on the inner wall of the kettle body. There is a stirring shaft inside the decolorization kettle, and there are multiple layers of stirring rods on the stirring shaft.

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