Multi-channel automatic liquid separation system for sample tubes

Abstract

The utility model provides a multi-channel automatic liquid separation system for sample tubes. The multi-channel automatic liquid separation system comprises a transverse moving module, a cap screwing module, a filling module and a peristaltic pump, wherein the transverse moving module is used for moving a plurality of sample tubes; the cap screwing module is used for simultaneously screwing caps of the plurality of sample tubes; the full-automatic uncovering and liquid separating integrated device has the advantages that the full-automatic uncovering and liquid separating integrated device is compatible with multiple brands and sample tube types; automatic operation is achieved, and large-batch cell filling is easily achieved; synchronous cover opening and closing actions and synchronous liquid adding actions of six sample tubes are supported; the automatic subpackaging device is used for automatic subpackaging of cell bank construction of MCB and WCB; the device can be integrated to an automatic production line.

Description

Technical Field

[0001] The utility model relates to the field of medical devices, and particularly relates to a multi-channel automatic liquid distribution system for sample tubes. Background Art

[0002] The automatic liquid addition system for sample tubes is an automatic cell cryopreservation bench-top system device, which performs automatic and rapid opening, perfusion, and capping of a single sample tube, can reduce the time of cells exposed to cryoprotectant, and prevent the contamination risk brought by manual repetitive operation tasks. However, the existing automatic liquid addition system for sample tubes is only suitable for a single sample tube, with lower efficiency, and cannot simultaneously achieve automatic liquid addition of multiple sample tubes in multiple channels. Therefore, a multi-channel automatic liquid distribution system for sample tubes with high speed, accuracy, and reliability is needed. Summary of the Utility Model

[0003] The purpose of the utility model is to provide a multi-channel automatic liquid distribution system for sample tubes to reduce the time of cells exposed to cryoprotectant, and at the same time prevent the contamination risk brought by manual repetitive operation tasks; a fully automatic opening and liquid distribution integrated device that is compatible with multiple brands and types of sample tubes; and an automatic operation that can easily achieve large-scale cell filling.

[0004] To achieve the purpose of the utility model, the utility model provides the following technical solution: a multi-channel automatic liquid distribution system for sample tubes, which includes: a transverse movement module for moving multiple sample tubes, a capping module for simultaneously screwing the caps of multiple sample tubes, a filling module for simultaneously filling multiple sample tubes, and a peristaltic pump for providing liquid addition power to the filling module.

[0005] On the basis of the above technical solution, the following subsidiary technical solutions are further included:

[0006] Preferably, this technical solution further includes a collection module for collecting the waste liquid generated by the filling module, and a power module for providing power to the transverse movement module, the capping module, the filling module, and the peristaltic pump.

[0007] Preferably, this technical solution further includes a bottom plate, and the transverse movement module, the capping module, the filling module, the collection module, the peristaltic pump, and the power module are all arranged on the bottom plate.

[0008] Preferably, the power module is arranged adjacent to the filling module, the collection module is located between the filling module and the peristaltic pump, and the peristaltic pump is arranged adjacent to the transverse movement module.

[0009] Preferably, the capping module is arranged adjacent to the filling module.

[0010] Preferably, the extending direction of the peristaltic pump is parallel to the extending direction of the transverse movement module and perpendicular to the extending direction of the filling module.

[0011] Preferably, the transverse movement module includes a transverse movement motor, a transverse movement transmission mechanism with one end connected to the output of the transverse movement motor, a transverse movement tray connected to the other end of the transverse movement transmission mechanism and carrying a plurality of sample tubes, and a transverse movement drag chain connected to the transverse movement tray.

[0012] Preferably, the capping module includes a pair of capping side plates arranged at intervals, a capping connection plate connecting the two capping side plates, a first vertical movement motor arranged on one side of the capping connection plate, a second vertical movement motor arranged on the other side of the capping connection plate, a moving block driven by the first vertical movement motor, a capping motor located above the moving block, and a capping head connected to the output of the capping motor.

[0013] Preferably, the filling module includes a filling platform, a plurality of filling support columns for supporting the filling platform, a sliding motor horizontally arranged on the filling platform, a vertical motor vertically arranged on the filling platform, a vertical platform driven by the sliding motor and horizontally reciprocating relative to the filling platform, a filling sliding block reciprocating relative to the vertical platform, and a filling needle unit detachably fixed on the filling sliding block and having a plurality of filling needles.

[0014] Preferably, at least part of the plurality of filling needles is inserted into the interior of the collection module.

[0015] Compared with the prior art, the utility model has the following positive effects: reducing the time of cells exposed to the cryoprotectant, and at the same time preventing the pollution risk brought by manual repetitive operation tasks; a fully automatic open cap and liquid separation integrated device, compatible with multiple brands and sample tube types; automated operation, easily realizing large-scale cell filling; good consistency, the volume precision error of sub-packaging < 5%; high efficiency and speed, 2000 tubes can be opened and separated in one hour; flexible configuration, the filling capacity range is 50 μL - 5 mL; high safety, disposable sterile filling tubes, avoiding cross-contamination; supporting synchronous open cap, close cap actions and synchronous liquid addition actions for 6 sample tubes; meeting GMP requirements, audit trail; automated sub-packaging for the establishment of cell banks for MCB and WCB; can be integrated into an automated production line. Description of the Drawings

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained according to these drawings.

[0017] Figure 1 It is a perspective view of the present utility model from the first perspective;

[0018] Figure 2This is the perspective view of the present utility model from the second perspective;

[0019] Figure 3 This is the perspective view of the present utility model from the third perspective;

[0020] Figure 4 This is the perspective view of the transverse movement module and the bottom plate in the present utility model;

[0021] Figure 5 This is the perspective view of the cap screwing module in the present utility model;

[0022] Figure 6 This is the perspective view of the filling module in the present utility model;

[0023] Figure 7 This is the perspective view of the collection module in the present utility model;

[0024] Figure 8 This is the exploded view of the present utility model. Detailed implementation manners

[0025] In the description of the present utility model, it should be noted that unless otherwise specified, the meaning of "a plurality of" is two or more; the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", "front end", "rear end", "head", "tail", etc. indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present utility model and simplifying, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation to the present utility model. In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0026] In the description of the present utility model, it should also be noted that unless otherwise clearly specified and defined, the terms "installed", "connected", "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0027] The following further elaborates on the detailed implementation manners of the present utility model with reference to the drawings.

[0028] Embodiment: As Figure 1-8As shown in the figure, the present utility model discloses a specific embodiment of a multi-channel automatic liquid dispensing system for sample tubes, which includes a transverse movement module 2000 for moving a plurality of sample tubes 8200, a capping module 3000 for simultaneously screwing the caps of a plurality of sample tubes 8200, a filling module 4000 for simultaneously filling a plurality of sample tubes 8200, a collection module 5000 for collecting the waste liquid generated by the filling module 4000, a peristaltic pump 6000 for providing liquid addition power to the filling module 4000, and a power module 7000 for providing electricity to the transverse movement module 2000, the capping module 3000, the filling module 4000, and the peristaltic pump 6000.

[0029] This embodiment further includes a bottom plate 1000, which is made of metal material or other materials. A plurality of foot pads 1020 are provided at the bottom thereof for placing on a horizontal plane, and a plurality of fixing holes 1040 are also provided on the bottom plate 1000. The transverse movement module 2000, the capping module 3000, the filling module 4000, the collection module 5000, the peristaltic pump 6000, and the power module 7000 can all be arranged on the bottom plate 1000 through the fixing holes 1040.

[0030] As Figure 4 shown in the figure, the transverse movement module 2000 includes a transverse movement motor 2200, a transverse movement transmission mechanism 2220 with one end connected to the output of the transverse movement motor 2200, a transverse movement tray 2240 connected to the other end of the transverse movement transmission mechanism 2220 and carrying a plurality of sample tubes 8200, and a transverse movement drag chain 2260 connected to the transverse movement tray 2240. The transverse movement module 2000 can achieve multi-position transfer, with high precision and fast speed.

[0031] As Figure 5 shown in the figure, the capping module 3000 includes a pair of capping side plates 3100 arranged at intervals, a capping connecting plate 3120 connecting the two capping side plates 3100, a first vertical movement motor 3200 arranged on one side of the capping connecting plate 3120, a second vertical movement motor 3300 arranged on the other side of the capping connecting plate 3120, a moving block 3400 driven by the first vertical movement motor 3200, a capping motor 3500 located above the moving block 3400, and a capping head 3540 connected to the output of the capping motor 3500. The capping module 3000 is arranged adjacent to the filling module 4000. The capping motor 350 ensures a fixed torque output in the closing cap rotation direction according to the locked-rotor current magnitude of the DC reduction motor. In the opening cap direction, the motor rotates continuously to ensure the smooth completion of opening the cap. The capping head 3540 is fixed to the inclined surface convex platform on the capping head shaft through a card slot quick insertion. The one-way slot of the capping head 3540 is circumferentially positioned with the one-way convex platform of the capping head shaft. The capping head 3540 is designed with an initial positioning inclined surface convex platform and a fine positioning inclined surface convex platform, which can be compatible with the position deviation of the sample tube and realize the smooth insertion of the capping head 3540 into the spline groove of the sample tube cap.

[0032] As Figure 6 shown, the filling module 4000 includes a filling platform 4200, a plurality of filling support columns 4220 for supporting the filling platform 4200, a sliding motor 4400 horizontally arranged on the filling platform 4200, a vertical motor 4500 vertically arranged on the filling platform 4200, a vertical platform 4600 driven by the sliding motor 4400 and horizontally reciprocating relative to the filling platform 4200, a filling sliding block 4700 reciprocating relative to the vertical platform 4600, and a filling needle unit 4800 detachably fixed on the filling sliding block 4700 and having a plurality of filling needles 4820. At least a part of the plurality of filling needles 4820 is inserted into the inside of the collection module 5000. The vertical platform 4600 is provided with a vertical slide rail 4620 extending in the vertical direction and allowing the relative movement of the filling sliding block 4700. The vertical platform 4600 is connected to a platform drag chain 4640 to ensure horizontal movement.

[0033] As Figure 7 shown, the collection module 5000 includes a collection box 5200, a collection rack 5400 for fixing the collection box 5200, and a pair of collection support columns 5600 for supporting the collection rack 5400. The collection box 5200 is detachably arranged at the top of the collection rack 5400, and the collection support columns 5600 are arranged at the bottom of the collection rack 5400.

[0034] The peristaltic pump 6000 includes a driver, a pump head, and a hose with one end connected to the pump head and the other end communicating with the filling module 4000. The extending direction of the peristaltic pump 6000 is parallel to the extending direction of the cross-movement module 2000 and perpendicular to the extending direction of the filling module 4000.

[0035] The power module 7000 is arranged adjacent to the filling module 4000, and the collection module 5000 is located between the filling module 4000 and the peristaltic pump 6000. At the same time, the peristaltic pump 6000 is arranged adjacent to the cross-movement module 2000. To further achieve electrical isolation, this embodiment further includes a power isolation plate 7200 located between the power module 7000 and the filling module 4000, and the cross-sectional shape of the power isolation plate 7200 is a 7-shaped.

[0036] This embodiment further includes a sample tube rack 8000 for accommodating a plurality of sample tubes 8200. In this embodiment, 6 sample tubes 8200 are in a group, and the sample tube rack 8000 can accommodate multiple groups of sample tubes 8200 to improve the filling efficiency.

[0037] The working steps of this embodiment are as follows:

[0038] 1. Power on and initialize; return to the origin, and the peristaltic pump 6000 starts to operate for liquid drainage and collection;

[0039] 2. After the liquid discharge is completed, the filling needle unit 4800 is transferred to the liquid addition position;

[0040] 3. Place the sample tube rack 8000 on the transverse transfer tray 2240;

[0041] 4. The transverse transfer module 2000 transfers the transverse transfer tray 2240 to the position of the first group of sample tubes 8200;

[0042] 5. The capping module 3000 performs the action of opening the cap;

[0043] 6. The transverse transfer module 2000 transfers the sample tube rack 8000 to the liquid addition position;

[0044] 7. The peristaltic pump 6000 realizes the liquid addition action;

[0045] 8. After the liquid addition is completed, the transverse transfer module 2000 is transferred to the capping position;

[0046] 9. The capping module 3000 performs the action of closing the cap;

[0047] 10. The transverse transfer module 2000 is transferred to the position of the second group of sample tubes 8200, and the action is repeated until all the sample tubes 8200 are processed;

[0048] 11. The transverse transfer module 2000 is moved out to the material taking position until the end.

[0049] The advantages of the present utility model are: a fully automatic cap-opening and liquid separation integrated device, compatible with multiple brands and sample tube types; automated operation, easily realizing large-scale cell filling; good consistency, the error of the sub-packaging volume accuracy is <5%; high efficiency and speed, 2000 tubes can be cap-opened and liquid-separated in one hour; flexible configuration, the filling capacity range is 50 μL - 5 mL; high safety, a disposable sterile filling tube, avoiding cross-contamination; supporting the synchronous cap-opening, cap-closing and liquid addition actions of 6 sample tubes; the exposure time of the sample tube cap is short, and the shortest exposure time can be controlled within 5 seconds, reducing the pollution risk; meeting the GMP requirements, audit tracking, multi-level authority management; used for the automated sub-packaging of the cell bank establishment of MCB and WCB; can be integrated into an automated production line, and can be paired with a shaker for liquid separation to reduce layering and precipitation.

[0050] The above is only the preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any person skilled in the art can make several deformations and improvements without departing from the creative concept of the present utility model, and all should be covered within the protection scope of the present utility model.

Claims

1. A multi-channel automatic liquid dispensing system for sample tubes, characterized in that It includes: A transverse movement module (2000) for moving a plurality of sample tubes (8200), a capping module (3000) for simultaneously capping the plurality of sample tubes (8200), a filling module (4000) for simultaneously filling the plurality of sample tubes (8200), and a peristaltic pump (6000) for providing liquid addition power to the filling module (4000).

2. The multi-channel automatic liquid dispensing system for sample tubes according to claim 1, wherein It further includes a collection module (5000) for collecting waste liquid generated by the filling module (4000), and a power module (7000) for supplying power to the transverse movement module (2000), the capping module (3000), the filling module (4000), and the peristaltic pump (6000).

3. The multi-channel automatic liquid dispensing system for sample tubes according to claim 2, wherein It further includes a base plate (1000), wherein the transverse movement module (2000), the capping module (3000), the filling module (4000), the collection module (5000), the peristaltic pump (6000), and the power module (7000) are all arranged on the base plate (1000).

4. The multi-channel automatic liquid dispensing system for sample tubes according to claim 3, wherein: The power module (7000) is arranged adjacent to the filling module (4000), and the collection module (5000) is located between the filling module (4000) and the peristaltic pump (6000), and at the same time, the peristaltic pump (6000) is arranged adjacent to the transverse movement module (2000).

5. The multi-channel automatic liquid dispensing system for sample tubes according to claim 4, characterized in that: The capping module (3000) is arranged adjacent to the filling module (4000).

6. The multi-channel automatic liquid dispensing system for sample tubes according to claim 4 or 5, characterized in that: The extending direction of the peristaltic pump (6000) is parallel to the extending direction of the transverse movement module (2000) and perpendicular to the extending direction of the filling module (4000).

7. The multi-channel automatic liquid dispensing system for sample tubes according to claim 2 or 3 or 4 or 5, characterized in that: The transverse movement module (2000) includes a transverse movement motor (2200), a transverse movement transmission mechanism (2220) with one end connected to the output of the transverse movement motor (2200), a transverse movement tray (2240) connected to the other end of the transverse movement transmission mechanism (2220) and carrying a plurality of sample tubes (8200), and a transverse movement drag chain (2260) connected to the transverse movement tray (2240).

8. The multi-channel automatic liquid dispensing system for sample tubes according to claim 7, characterized in that: The capping module (3000) includes a pair of capping side plates (3100) arranged at intervals, a capping connecting plate (3120) connecting the two capping side plates (3100), a first vertical movement motor (3200) arranged on one side of the capping connecting plate (3120), a second vertical movement motor (3300) arranged on the other side of the capping connecting plate (3120), a moving block (3400) driven by the first vertical movement motor (3200), a capping motor (3500) located above the moving block (3400), and a capping head (3540) connected to the output of the capping motor (3500).

9. The multi-channel automatic liquid dispensing system for sample tubes according to claim 8, characterized in that: The filling module (4000) includes a filling platform (4200), a plurality of filling support columns (4220) for supporting the filling platform (4200), a sliding motor (4400) horizontally arranged on the filling platform (4200), a vertical motor (4500) vertically arranged on the filling platform (4200), a vertical platform (4600) driven by the sliding motor (4400) and horizontally reciprocating relative to the filling platform (4200), a filling sliding block (4700) reciprocating relative to the vertical platform (4600), and a filling needle unit (4800) detachably fixed on the filling sliding block (4700) and having a plurality of filling needles (4820).

10. The multi-channel automatic liquid dispensing system for sample tubes according to claim 9, characterized in that: At least a part of the plurality of filling needles (4820) is inserted into the interior of the collection module (5000).

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