Modularized liquid chromatogram mobile phase mixing and enhancing device with adjustable cavity

Abstract

The utility model discloses a modularized liquid chromatogram mobile phase mixing enhancing device with an adjustable cavity, which comprises a plurality of groups of adjusting cylinders which are connected in sequence, a plurality of groups of spiral blocks are arranged outside the adjusting cylinders and are connected in sequence, a plurality of groups of spiral blocks are arranged outside the adjusting cylinders, and a plurality of groups of spiral blocks are arranged outside the adjusting cylinders and are connected in sequence. The spiral blocks extend into the adjusting cylinder, one end of each spiral block is provided with a threaded groove, and the other end of each spiral block is provided with a threaded column. According to the mobile phase mixing enhancing device for the liquid chromatography, flexible adjustment of mobile phase mixing conditions is realized, mixing uniformity and efficiency are improved, and the mobile phase mixing enhancing device for the liquid chromatography is simple in structure, easy to operate and maintain, high in expandability and customizability, suitable for various liquid chromatography analysis scenes and capable of meeting different experiment requirements.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography mobile phase mixing enhancement devices, in particular to a modular adjustable cavity liquid chromatography mobile phase mixing enhancement device. Background Technique

[0002] Liquid chromatography analysis is a chromatographic analysis method using liquid as the mobile phase. When the analyzed sample in the liquid mobile phase passes through the stationary phase in the chromatographic column, each component is effectively separated. Then, through the detection system and recording system, the measurement result and chromatogram can be obtained. The stationary phase can be a solid or a liquid coated on the surface of the solid. The former is called liquid-solid chromatography, and the latter is called liquid-liquid chromatography. High-performance liquid chromatography analysis uses a high-pressure infusion pump, a high-sensitivity detector, and a high-efficiency particulate stationary phase, and has the advantages of high separation efficiency, good selectivity, high sensitivity, and fast analysis speed. Liquid chromatography instruments are widely used in various fields such as chemical engineering, biochemistry, pharmaceutical industry, food analysis, and environmental pollution analysis.

[0003] In liquid chromatography analysis, the uniform mixing of the mobile phase is crucial for ensuring the accuracy and stability of the analysis results. However, traditional liquid chromatography instruments are often limited by the fixed mixing structure during the mobile phase mixing process and it is difficult to adjust the mixing effect according to actual needs. Therefore, it is of great practical significance to develop a tool that can flexibly adjust the mixing conditions, especially to achieve a better mixing effect by changing the mixing space. Content of the Utility Model

[0004] The purpose of the utility model is to provide a modular adjustable cavity liquid chromatography mobile phase mixing enhancement device to solve the problems proposed in the above background technique that the liquid chromatography mobile phase mixing enhancement device is not convenient for flexible adjustment of the mobile phase mixing conditions, not convenient for operation and maintenance, affecting its scalability and customizability, not conducive to meeting different experimental needs, and affecting the uniformity and efficiency of mixing.

[0005] To achieve the above purpose, the utility model provides the following technical solution: A modular adjustable cavity liquid chromatography mobile phase mixing enhancement device includes adjustment cylinders. The adjustment cylinders are in multiple groups and are connected in sequence. A spiral block is arranged outside the adjustment cylinders. The spiral blocks are in multiple groups and are connected in sequence. The spiral block extends into the adjustment cylinder. One end of each spiral block is provided with a threaded groove, and the other end of each spiral block is provided with a threaded post, and the threaded post is in threaded cooperation with the threaded groove. A convex tube is installed at one end of each adjustment cylinder, and an annular groove is arranged on the outer wall of the convex tube. A concave sleeve is installed at the other end of each adjustment cylinder.

[0006] Preferably, a threaded long rod is arranged outside the adjusting cylinder on one side of the spiral block. Eccentric convex blocks are symmetrically installed inside the concave sleeve. Pressing arms are installed at one ends of the eccentric convex blocks. A sealing ring is arranged inside the concave sleeve on one side of the eccentric convex block.

[0007] Preferably, positioning plates are installed on the outer walls of the concave sleeve on both sides of the pressing arm. Limiting pins are installed on the inner walls of the positioning plates on one side of the pressing arm.

[0008] Preferably, hinge shafts are installed on the outer walls of the pressing arms above the eccentric convex blocks. The eccentric convex blocks are movably connected to the positioning plates through the hinge shafts. Pulling rings are installed at the ends of the pressing arms far from the eccentric convex blocks.

[0009] Compared with the prior art, the beneficial effects of the present utility model are as follows: The liquid-phase chromatography mobile-phase mixing enhancement device not only realizes the flexible adjustment of the mixing conditions of the liquid-phase chromatography mobile phase by the liquid-phase chromatography mobile-phase mixing enhancement device, improves the mixing uniformity and efficiency, has a simple device structure, is easy to operate and maintain, and has high scalability and customizability, is applicable to a variety of liquid-phase chromatography analysis scenarios, and meets different experimental requirements;

[0010] By splicing multiple groups of spiral blocks together in sequence, when the spiral blocks are spliced, they are fixed by the threaded cooperation of the threaded columns and threaded grooves. One group of spiral blocks is a single modular mixing enhancement cavity unit, and multiple groups of spiral blocks can be connected or separated through standard threaded interfaces to adjust the total number and total volume of the cavities. When different numbers of spiral blocks are combined, the number of multiple groups of adjusting cylinders is adjusted in sequence. When multiple groups of adjusting cylinders are connected, the convex tube of one group of adjusting cylinders is inserted into the concave sleeve of another group of adjusting cylinders. Manually rotate the pulling ring, the pulling ring drives the pressing arm to rotate around the hinge shaft, the pressing arm drives the eccentric convex block to rotate, and the eccentric convex block is clamped into the internal annular groove to fix the convex tube and the concave sleeve, so as to facilitate the assembly and connection of multiple groups of adjusting cylinders. Multiple groups of spiral blocks are inserted into multiple groups of adjusting cylinders to conveniently form a liquid-phase chromatography mobile-phase mixing enhancement device. Users can select different numbers of modular mixing enhancement cavity units for combination according to experimental requirements to adjust the total number of mixing enhancement cavities. Inside the modular cavity unit, the mobile phase is affected by the internal mixing structure and undergoes movements such as rotation and vortex, thereby realizing mixing. According to needs, the mobile phase can sequentially pass through multiple modular mixing enhancement cavity units for multi-stage mixing, realizing the flexible adjustment of the mixing conditions of the liquid-phase chromatography mobile phase by the liquid-phase chromatography mobile-phase mixing enhancement device, improving the mixing uniformity and efficiency, having a simple device structure, being easy to operate and maintain, and having high scalability and customizability, being applicable to a variety of liquid-phase chromatography analysis scenarios, and meeting different experimental requirements. Description of the Drawings

[0011] Figure 1 is a three-dimensional structure schematic diagram of the present utility model;

[0012] Figure 2 is a front view structural schematic diagram of the present utility model;

[0013] Figure 3 is a three-dimensional structure schematic diagram of the spiral block of the present utility model;

[0014] Figure 4 is a front view sectional structural schematic diagram of the adjusting cylinder of the present utility model;

[0015] Figure 5 is a three-dimensional structure schematic diagram of the adjusting cylinder of the present utility model;

[0016] Figure 6 is a three-dimensional structure schematic diagram of the pressing arm of the present utility model;

[0017] Figure 7 is a front view sectional structural schematic diagram of the eccentric convex block of the present utility model;

[0018] Figure 8 is a three-dimensional structure schematic diagram of the thread groove of the present utility model.

[0019] In the figure: 1, threaded long rod; 2, spiral block; 3, threaded column; 4, thread groove; 5, adjusting cylinder; 6, annular groove; 7, convex tube; 8, pull ring; 9, pressing arm; 10, hinge shaft; 11, positioning plate; 12, limit pin; 13, eccentric convex block; 22, sealing ring; 23, concave sleeve. Specific embodiments

[0020] To further elaborate on the technical means and effects adopted by the present utility model to achieve the predetermined utility model purpose, the following, in conjunction with the accompanying drawings and preferred embodiments, details the specific embodiments, structures, features, and their effects of the present utility model as follows.

[0021] Please refer to Figure 1-8 , an embodiment provided by the present utility model: A modular adjustable cavity liquid chromatography mobile phase mixing enhancement device, including an adjusting cylinder 5, there are multiple groups of adjusting cylinders 5, and multiple groups of adjusting cylinders 5 are connected in sequence. A spiral block 2 is arranged outside the adjusting cylinder 5, and there are multiple groups of spiral blocks 2, and multiple groups of spiral blocks 2 are connected in sequence. The spiral block 2 extends into the adjusting cylinder 5. Thread grooves 4 are arranged at one ends of the spiral blocks 2, and threaded columns 3 are arranged at the other ends of the spiral blocks 2, and the threaded columns 3 are in threaded cooperation with the thread grooves 4. A threaded long rod 1 is arranged outside the adjusting cylinder 5 on one side of the spiral block 2. Convex tubes 7 are installed at one ends of the adjusting cylinders 5, and annular grooves 6 are arranged on the outer walls of the convex tubes 7. Concave sleeves 23 are installed at the other ends of the adjusting cylinders 5;

[0022] Eccentric bumps 13 are symmetrically installed inside the concave sleeves 23. Pressing arms 9 are installed at one end of each of the eccentric bumps 13. A sealing ring 22 is arranged inside the concave sleeve 23 on one side of the eccentric bump 13, and the sealing ring 22 serves to seal and connect.

[0023] Positioning plates 11 are installed on the outer walls of the concave sleeves 23 on both sides of the pressing arm 9. Limit pins 12 are installed on the inner walls of the positioning plates 11 on one side of the pressing arm 9, and the limit pins 12 are slidably connected to the positioning plates 11.

[0024] Hinge shafts 10 are installed on the outer walls of the pressing arms 9 above the eccentric bumps 13, and the eccentric bumps 13 are movably connected to the positioning plates 11 through the hinge shafts 10. A pull ring 8 is installed at the end of the pressing arm 9 far from the eccentric bump 13.

[0025] Multiple groups of spiral blocks 2 are spliced together in sequence. When the spiral blocks 2 are spliced, a threaded post 3 and a threaded groove 4 are used for threaded cooperation and fixation. One group of spiral blocks 2 is a single modular hybrid enhanced cavity unit. The spiral blocks 2 have a specific hybrid structure, and multiple groups of spiral blocks 2 can be connected or separated through standard threaded interfaces to adjust the total number and total volume of the cavities. When different numbers of spiral blocks 2 are combined, the number of multiple groups of adjusting cylinders 5 is adjusted in sequence. When multiple groups of adjusting cylinders 5 are connected, the convex tube 7 of one group of adjusting cylinders 5 is inserted into the concave sleeve 23 of another group of adjusting cylinders 5. Manually rotate the pull ring 8, and the pull ring 8 drives the pressing arm 9 to rotate around the hinge shaft 10. The pressing arm 9 drives the eccentric bump 13 to rotate, and the eccentric bump 13 is clamped into the internal annular groove 6 to fix the convex tube 7 and the concave sleeve 23. Insert the limit pin 12 into the positioning plate 11, and the limit pin 12 serves to limit the pressing arm 9 to facilitate the assembly and connection of multiple groups of adjusting cylinders 5. Multiple groups of spiral blocks 2 are inserted into multiple groups of adjusting cylinders 5 to facilitate the formation of a liquid chromatography mobile phase mixing and enhancing device. Users can select different numbers of modular hybrid enhanced cavity units for combination according to experimental needs to adjust the total number of mixing and enhancing cavities. Inside the modular cavity unit, the mobile phase is affected by the internal hybrid structure and undergoes movements such as rotation and vortex, thereby achieving mixing. According to needs, the mobile phase can sequentially pass through multiple modular hybrid enhanced cavity units for multi-stage mixing, realizing the flexible adjustment of the mixing conditions of the liquid chromatography mobile phase by the liquid chromatography mobile phase mixing and enhancing device, improving the uniformity and efficiency of mixing. The device has a simple structure, is easy to operate and maintain, and has high scalability and customizability, and is applicable to a variety of liquid chromatography analysis scenarios to meet different experimental needs.

[0026] When the embodiment of the present application is in use: Connect to an external power supply. First, a plurality of spiral blocks 2 are spliced together in sequence. When the spiral blocks 2 are spliced, the threaded post 3 and the threaded groove 4 are used for threaded cooperation and fixation. One group of spiral blocks 2 is a single modular hybrid enhanced cavity unit. The spiral blocks 2 have a specific hybrid structure, and multiple groups of spiral blocks 2 can be connected or separated through standard threaded interfaces to adjust the total number and total volume of the cavities. When multiple groups of adjusting cylinders 5 are connected, the convex tube 7 of one group of adjusting cylinders 5 is inserted into the concave sleeve 23 of another group of adjusting cylinders 5. The pull ring 8 drives the pressure arm 9 to rotate around the hinge shaft 10. The pressure arm 9 drives the eccentric convex block 13 to rotate. The eccentric convex block 13 is clamped into the internal annular groove 6 to fix the convex tube 7 and the concave sleeve 23. The limit pin 12 is inserted into the positioning plate 11, and the limit pin 12 plays a role in limiting the pressure arm 9 to facilitate the assembly and connection of multiple groups of adjusting cylinders 5. Multiple groups of spiral blocks 2 are inserted into multiple groups of adjusting cylinders 5 to conveniently form a liquid chromatography mobile phase mixing and enhancing device. Users can select different numbers of modular hybrid enhanced cavity units for combination according to experimental requirements to adjust the total number of mixing and enhancing cavities. Inside the modular cavity unit, the mobile phase is affected by the internal hybrid structure and undergoes movements such as rotation and vortex, thereby achieving mixing and completing the use of the liquid chromatography mobile phase mixing and enhancing device.

[0027] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. Although the present invention has been disclosed above with the preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to the above-disclosed technical content to obtain equivalent embodiments with equivalent changes, but as long as the technical content of the present invention is not departed from, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A liquid chromatography mobile phase mixing enhancement device with a modular adjustable cavity, characterized in that: It includes adjusting cylinders (5). There are multiple groups of the adjusting cylinders (5), and the multiple groups of adjusting cylinders (5) are connected in sequence. A spiral block (2) is arranged outside the adjusting cylinder (5), and there are multiple groups of the spiral blocks (2), and the multiple groups of spiral blocks (2) are connected in sequence. The spiral block (2) extends into the interior of the adjusting cylinder (5). Threaded grooves (4) are arranged at one ends of the spiral blocks (2), and threaded posts (3) are arranged at the other ends of the spiral blocks (2), and the threaded posts (3) are in threaded cooperation with the threaded grooves (4). Convex tubes (7) are installed at one ends of the adjusting cylinders (5), annular grooves (6) are arranged on the outer walls of the convex tubes (7), and concave sleeves (23) are installed at the other ends of the adjusting cylinders (5).

2. The liquid chromatography mobile phase mixing enhancement device with a modular adjustable cavity according to claim 1, wherein: A threaded long rod (1) is arranged outside the adjusting cylinder (5) on one side of the spiral block (2). Eccentric convex blocks (13) are symmetrically installed inside the concave sleeves (23). Pressing arms (9) are installed at one ends of the eccentric convex blocks (13). Sealing rings (22) are arranged inside the concave sleeves (23) on one side of the eccentric convex blocks (13).

3. The liquid chromatography mobile phase mixing enhancement device with a modular adjustable cavity according to claim 2, characterized in that: Positioning plates (11) are installed on the outer walls of the concave sleeves (23) on both sides of the pressing arm (9). Limit pins (12) are installed on the inner walls of the positioning plates (11) on one side of the pressing arm (9).

4. The liquid chromatography mobile phase mixing enhancement device with a modular adjustable cavity according to claim 2, wherein: Hinge shafts (10) are installed on the outer walls of the pressing arms (9) above the eccentric convex blocks (13), and the eccentric convex blocks (13) are movably connected to the positioning plates (11) through the hinge shafts (10). Pulling rings (8) are installed at the ends of the pressing arms (9) away from the eccentric convex blocks (13).

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