Detection consumable and detection equipment

By designing the connecting structure between the sample tube and the reaction tube, and using the combination of the piston structure and the sealing membrane, the pollution problem during the sample processing is solved, transfer-free treatment is achieved, the risk of sample contamination is reduced and the treatment efficiency is improved.

CN223159288UActive Publication Date: 2025-07-29SANSURE BIOTECH INC
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Patent Information

Application Number
CN202422371985.0
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-09-27
Publication Date
2025-07-29
Estimated Expiration
2034-09-27

AI Technical Summary

Technical Problem

During the sample processing process, the prior art requires processing and transport in different containers, which can easily cause sample contamination and affect the detection results.

Method used

Design a detection consumable, including a sample tube and a reaction tube, through the coordination of the piston structure and the sealing membrane, the sample tube and the reaction tube are connected. The treatment liquid flows into the reaction tube when the piston structure moves and reacts with the detection material, simplifying the processing steps and reducing the risk of contamination.

Benefits of technology

During the detection process, there is no need to transfer the mixed solution, which reduces the probability of sample contamination, simplifies processing steps, and improves processing efficiency.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model provides a detection consumable and detection equipment, and relates to in vitro diagnosis technology, the detection consumable comprises a sample tube provided with a cavity used for accommodating treatment fluid; the reaction tube is communicated with the bottom of the sample tube and is provided with a reaction cavity and a sealing film for sealing the reaction cavity; the piston structure is arranged in the cavity and sequentially moves from a first position to a second position and a third position relative to the sealing film, when the piston structure is located at the first position, the piston structure and the sealing film are arranged in a spaced mode, when the piston structure is located at the second position, the piston structure abuts against the sealing film, and when the piston structure is located at the third position, the piston structure abuts against the sealing film. The piston structure penetrates through the sealing film, and when the piston structure moves from the second position to the third position, the treatment liquid flows into the reaction cavity; according to the detection consumable, pretreatment and detection both occur in the detection consumable, a mixed solution does not need to be transferred in the detection process, and the probability that a sample is polluted is reduced.
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Description

Technical Field

[0001] The utility model relates to in vitro diagnostic technology, in particular to a detection consumable and a detection device. Background Art

[0002] During the processing of samples (such as sputum, urine, blood), it is necessary to add a processing solution to the sample in a test tube for pretreatment, and use a pipette to transfer the pretreated mixed solution to another container to realize subsequent detection processes such as nucleic acid extraction or PCR amplification. During the pretreatment and transfer processes, contamination is likely to occur, affecting the detection results.

[0003] Therefore, the present application provides a detection consumable and a detection device, using the consumable as a container for pretreatment and subsequent detection, simplifying the sample processing flow and steps, and reducing the probability of sample contamination. Summary of the Utility Model

[0004] The utility model provides a detection consumable and a detection device, aiming to solve the problem that in the existing sample processing, it is necessary to process and transfer in different containers, which is likely to cause sample contamination.

[0005] To achieve the above object, an embodiment of the utility model provides a detection consumable, including:

[0006] A sample tube provided with a cavity for accommodating a processing solution;

[0007] A reaction tube connected to the bottom of the sample tube, the reaction tube having a reaction cavity and a sealing film sealing the reaction cavity;

[0008] A piston structure disposed in the cavity;

[0009] A cover removably disposed on the top of the sample tube, the cover being provided with a pressing portion that slides axially along the sample tube, and the pressing portion pushes the piston structure to move to pierce the sealing film.

[0010] Preferably, the piston structure moves from a first position to a second position and then to a third position relative to the sealing film. When the piston structure is in the first position, the piston structure is spaced from the sealing film. When the piston structure is in the second position, the piston structure abuts against the sealing film and does not penetrate the sealing film. When the piston structure is in the third position, the piston structure penetrates the sealing film. When the piston structure moves from the second position to the third position, the processing solution flows into the reaction cavity.

[0011] Preferably, the piston structure includes a piston rod and a partition disposed on the circumferential direction of the piston rod, and the partition is provided with a notch for placing a sampling member into the cavity;

[0012] The cap includes a cover body detachably connected to the sample tube, and a relief cavity for the specimen tube to extend into the cover body is provided on the cover body. An abutting portion for pushing the sampling member into the cavity is provided in the relief cavity. The pressing portion is movably arranged on the cover body, and the piston rod is located on the moving path of the pressing portion.

[0013] Preferably, a central hole is axially provided in the cover body, the pressing portion passes through the central hole, a limiting convex ring is formed at the bottom end of the pressing portion, and the limiting convex ring limits the upper limit position of the pressing portion relative to the cover body.

[0014] Preferably, the cavity includes a first region and a second region. The first region is for accommodating the sampling member, the second region is for the piston rod to slide, and the first region and the second region are communicated through a mixing hole.

[0015] Preferably, a spike portion is provided at one end of the piston rod close to the sealing film.

[0016] Preferably, the reaction tube includes a mounting portion for detachably connecting to the bottom of the sample tube and a reaction portion formed at the lower end of the mounting portion. The sealing film is provided at the top end of the mounting portion, and the reaction cavity is provided in the mounting portion and the reaction portion.

[0017] Preferably, a mounting groove is formed at the bottom of the reaction tube, and the mounting portion is snap-fitted into the mounting groove.

[0018] Preferably, a bottom sealing ring is provided between the mounting groove and the mounting portion.

[0019] Based on the same inventive concept, the present application also provides a detection device, including the aforementioned detection consumables.

[0020] The above solution of the present utility model has the following beneficial effects:

[0021] In the present application, by connecting the reaction tube and the sample tube and using a sealing film to block at the connection, when the pressing portion pushes the piston structure to move, the piston structure pierces the sealing film, so that the reaction tube and the sample tube are connected, and the treatment liquid in the sample tube flows into the reaction tube and reacts with the detection material in the reaction tube.

[0022] In the present application, both the pretreatment and the detection occur in the detection consumables. During the detection process, there is no need to transfer the mixed solution, reducing the probability of sample contamination; at the same time, the present application can also simplify the treatment steps, enabling the mixed solution to directly flow into the reaction tube, improving the treatment efficiency.

[0023] Other features and advantages of the present utility model will be described in detail in the subsequent specific implementation part. Description of the Drawings

[0024] Figure 1 is the schematic external view of this application;

[0025] Figure 2 is the cross-sectional view of this application;

[0026] Figure 3 is Figure 2 the enlarged view of part A in

[0027] Figure 4 is the cross-sectional view of the sample tube;

[0028] Figure 5 is the cross-sectional view of the reaction tube;

[0029] Figure 6 is the three-dimensional view of the piston structure;

[0030] Figure 7 is the three-dimensional view of the cap;

[0031] Figure 8 is the schematic view of the spike part and the sealing film when the piston structure is in the first position;

[0032] Figure 9 is the schematic view of the spike part and the sealing film when the piston structure is in the second position;

[0033] Figure 10 is the schematic view of the spike part and the sealing film when the piston structure is in the third position.

[0034]

Description of the Reference Numerals

[0035] 100 - sample tube, 110 - cavity, 111 - first region, 112 - second region, 120 - mounting groove, 130 - bottom sealing ring, 140 - bottom hole, 150 - piston surrounding tube, 151 - mixing hole,

[0036] 200 - reaction tube, 210 - reaction chamber, 220 - sealing film, 230 - mounting part, 240 - reaction part,

[0037] 300 - piston structure, 310 - piston rod, 320 - partition plate, 321 - notch, 330 - spike part, 340 - piston

[0038] 400 - cap, 410 - pressing part, 411 - limiting convex ring, 420 - cover body, 430 - avoiding cavity, 440 - abutting part, 450 - top sealing ring,

[0039] 500 - sampling part. Detailed Description of the Invention

[0040] To make the technical problems, technical solutions, and advantages to be solved by the present utility model clearer, the following will be described in detail with reference to the accompanying drawings and specific embodiments.

[0041] As Figures 1-10 shown, an embodiment of the present utility model provides a detection consumable, including a sample tube 100, a reaction tube 200, a piston structure 300, and a cover 400. The sample tube 100 has a cavity 110 for accommodating a processing liquid, and the reaction tube 200 has a reaction cavity 210 for accommodating a detection material. The reaction tube 200 is disposed at the bottom of the sample tube 100, and a sealing film 220 for sealing the reaction cavity 210 is provided on the reaction tube 200. The piston structure 300 is disposed in the aforementioned cavity 110, and the piston structure 300 moves from a first position to a second position and then to a third position relative to the sealing film 220. When the piston structure 300 is located at the first position, the piston structure 300 is spaced from the sealing film 220. At this time, the sealing film 220 is intact and still plays a role in sealing the cavity. When the piston structure 300 is located at the second position, the piston structure 300 abuts against the sealing film 220, but at this time the piston structure 300 does not penetrate the sealing film 220, that is, at this time the piston structure 300 only fits with the sealing film 220 and does not damage the sealing film 220. When the piston structure 300 is located at the third position, the piston structure 300 penetrates the sealing film 220. At this time, the sealing film 220 is damaged and the sealing effect fails. During the movement of the piston structure 300 from the second position to the third position, the processing liquid in the cavity 110 flows into the processing cavity through the damaged sealing film 220 to detect the mixed solution.

[0042] The aforementioned cover 400 is detachably disposed on the top of the sample tube 100, and a pressing portion 410 is provided on the cover 400. The pressing portion 410 pushes the piston structure 300 from the first position through the second position and then to the third position.

[0043] It can be understood that the present application can be used for nucleic acid extraction and amplification. A swab is used as a sampling member 500 for sampling. After sampling, the sampling member 500 is placed into the cavity 110, and the processing liquid in the cavity 110 pre-treats the sample.

[0044] In some embodiments of the present application, the piston structure 300 includes a piston rod 310 and a partition 320. The partition 320 is disposed on the circumference of the piston rod 310, and a notch 321 is provided on the partition 320. The sampling member 500 can be put into the cavity 110 through the notch 321. Preferably, the shape of the partition 320 is the same as the shape of the cavity 110. When the cover 400 is opened, the partition 320 plays a certain isolation role to prevent large-particle contaminants from falling into the cavity 110; at the same time, the partition 320 also plays a guiding role to prevent the piston structure 300 from being skewed when assembled in the sample tube 100.

[0045] Preferably, a reinforcing rib is provided between the partition plate and the piston rod 310.

[0046] The aforementioned cover 400 includes a cover body 420, and the cover body 420 is detachably connected to the reaction tube 200. A relief cavity 430 is provided on the surface of the cover body 420 facing the reaction tube 200. When the cover body 420 is assembled on the upper end of the reaction tube 200, the upper end of the reaction tube 200 is located within the relief cavity 430. A contact portion 440 is further provided within the relief cavity 430, and the contact portion 440 is used to push the sampling member 500 into the cavity 110 through the notch 321.

[0047] Existing sampling members 500 usually have a break-off head design. Therefore, after the sampling member 500 is broken, it is easy for the collection portion of the sampling member 500 (usually the end with sterile cotton) to fail to immerse in the processing liquid. At this time, the contact portion 440 is used to further push the sampling member 500 downward to ensure that the collection portion is immersed in the processing liquid.

[0048] The aforementioned pressing portion 410 is movably provided on the cover body 420, and the piston rod 310 is located on the movement path of the pressing portion 410.

[0049] It can be understood that the contact portion 440 is a ring structure. When the ring-structured contact portion 440 contacts the sampling member 500, it can ensure the contact effect and prevent the contact portion 440 from being misaligned with the sampling member 500. The height of the contact portion 440 is greater than the height of the cover body 420 to ensure that when the cover body 420 covers the sample tube 100, the lower end of the contact portion 440 extends into the sample tube 100.

[0050] Combined with the ring-structured contact portion 440, the contact portion 440, the cover body 420, and the pressing portion 410 can be coaxially arranged, and the piston rod 310 is coaxially arranged with the pressing portion 410.

[0051] A central hole is further provided at the center of the cover body 420. The central hole penetrates the cover body 420 along the axial direction of the cover body 420. The pressing portion 410 is arranged within the central hole and can move axially within the central hole. A limiting convex ring 411 is formed at the bottom end of the pressing portion 410, and the limiting convex ring 411 limits the upper limit position of the pressing portion 410 relative to the cover body 420.

[0052] By forming the limiting convex ring 411 at the bottom end of the pressing portion 410, it can effectively prevent the pressing portion 410 from disengaging from the cover body 420, causing the piston rod 310 to lose the pressure to move to the second position and the third position.

[0053] In this embodiment, when the pressing part 410 is at the upper limit position, the pressing part 410 cannot be further pulled out upward. At this time, the bottom end of the pressing part 410 abuts against the upper end of the piston rod 310. The position where the piston rod 310 abuts against the pressing part 410 can be defined as the first position. When pressing the pressing part 410 downward, the piston rod 310 passes through the second position and the third position in sequence.

[0054] In some other embodiments, when the pressing part 410 is at the upper limit position, the pressing part 410 cannot be further pulled out upward. At this time, there is a gap between the bottom end of the pressing part 410 and the upper end of the piston rod 310. After the pressing part 410 moves downward a certain distance, it pushes the piston rod 310 to move downward. In this case, the position of the piston rod 310 when it is not under the pressure of the pressing part 410 can be defined as the first position. When pressing the pressing part 410 downward, the piston rod 310 passes through the second position and the third position in sequence. In this embodiment, the pressing part 410 and the piston rod 310 are arranged at intervals, which can effectively avoid the damage of the sealing film 220 caused by the accidental touch of the pressing part 410.

[0055] Preferably, a top sealing ring 450 is further arranged between the pressing part 410 and the central hole.

[0056] In the aforementioned sample tube 100, the cavity 110 includes a first region 111 and a second region 112. The first region 111 is used to accommodate the sampling part 500, and the second region 112 is used for the piston rod 310 to slide. The first region 111 and the second region 112 are communicated through the mixing hole 151.

[0057] In this embodiment, the upper end of the sample tube 100 is open, and a bottom hole 140 is provided at the bottom end. A piston surrounding tube 150 is arranged in the sample tube 100. The piston surrounding tube 150 is coaxially arranged with the sample tube 100. The region surrounded by the piston surrounding tube 150 is the second region 112, and the region between the piston surrounding tube 150 and the sample tube 100 is the first region 111. The aforementioned mixing hole 151 is arranged in the radial direction of the piston surrounding tube 150. The piston surrounding tube 150 is arranged above the bottom hole 140 and communicated with the bottom hole 140. The aforementioned sealing film 220 is located below the bottom hole 140. When the piston structure 300 moves downward, the lower end of the piston structure 300 passes through the bottom hole 140 to pierce the sealing film 220.

[0058] The aforementioned piston structure 300 further includes a piston 340 and a spike portion 330. The piston 340 is disposed axially on the piston rod 310 and is located below the partition 320. The spike portion 330 is disposed at one end of the piston rod 310 close to the sealing film 220. The spike portion 330 is closer to the sealing film 220 than the piston 340. It can be understood that the spike portion 330 and the piston rod 310 can be integrally formed or can adopt an assembly structure. The piston 340 is located within the piston surrounding tube 150, and the piston 340 and the piston surrounding tube 150 can slide relative to each other. When the piston rod 310 moves downward, the piston 340 moves downward synchronously with the piston rod 310. When at rest, the piston 340 can generate frictional force with the piston surrounding tube 150 to ensure that the piston structure 300 always remains in the first position without external intervention on the pressing portion 410, and to prevent the piston structure 300 from accidentally piercing the sealing film 220 under the action of gravity.

[0059] In some embodiments of the present application, a protective cover for preventing the pressing portion 410 from being touched may further be provided on the cover body 420.

[0060] In addition, the cooperation between the piston surrounding tube 150 and the piston 340 also plays a guiding role, preventing the piston rod 310 from tilting during movement, making it difficult to pierce the sealing film 220 or the piercing area being small, and the processing liquid flowing into the reaction chamber 210 slowly.

[0061] The aforementioned reaction tube 200 is detachably disposed at the bottom of the sample tube 100. Specifically, the reaction tube 200 includes a mounting portion 230 and a reaction portion 240. The mounting portion 230 is used for detachably disposing at the bottom of the sample tube 100. The reaction portion 240 is disposed at the lower end of the mounting portion 230. The reaction chamber 210 is disposed within the mounting portion 230 and the reaction portion 240. The sealing film 220 is disposed at the top of the mounting portion 230.

[0062] An installation groove 120 is further provided at the bottom of the aforementioned reaction tube 200. The installation groove 120 is formed by recessing upward from the bottom of the reaction tube 200. The aforementioned bottom hole 140 is located within the installation groove 120, and the mounting portion 230 is snap-fitted within the installation groove 120.

[0063] In some embodiments, a circumferential card slot is provided on the inner wall of the installation groove 120, and a rib adapted to the card slot is circumferentially provided on the mounting portion 230. The mounting portion 230 is assembled within the installation groove 120 through the cooperation of the rib and the card slot.

[0064] Preferably, a bottom sealing ring 130 is further provided between the mounting portion 230 and the installation groove 120. The bottom sealing ring 130 is located above the card slot or the rib.

[0065] Based on the same inventive concept, the present application further provides a detection device including the aforementioned detection consumables.

[0066] The above are the preferred embodiments of the present utility model. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present utility model, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present utility model.

Claims

1. A detection consumable, characterized in that, Comprising: A sample tube (100) provided with a cavity (110) for accommodating a processing liquid; A reaction tube (200) connected to the bottom of the sample tube (100), the reaction tube (200) having a reaction chamber (210) and a sealing film (220) for sealing the reaction chamber (210); A piston structure (300) disposed within the cavity (110); A cap (400) removably disposed on the top of the sample tube (100), the cap (400) being provided with a pressing portion (410) that slides axially along the sample tube (100), and the pressing portion (410) pushing the piston structure (300) to move to pierce the sealing film (220).

2. The detection consumable according to claim 1, wherein: The piston structure (300) moves from a first position to a second position and then to a third position relative to the sealing film (220). When the piston structure (300) is at the first position, the piston structure (300) is spaced from the sealing film (220). When the piston structure (300) is at the second position, the piston structure (300) abuts against the sealing film (220) and does not penetrate the sealing film (220). When the piston structure (300) is at the third position, the piston structure (300) penetrates the sealing film (220). When the piston structure (300) moves from the second position to the third position, the processing liquid flows into the reaction chamber (210).

3. The detection consumable according to claim 1, characterized in that: The piston structure (300) includes a piston rod (310) and a partition (320) disposed circumferentially on the piston rod (310), and the partition (320) is provided with a notch (321) for placing a sampling member (500) into the cavity (110). The cap (400) includes a cover body (420) detachably connected to the sample tube (100), and the cover body (420) is provided with an avoidance cavity (430) for a specimen tube to extend into the cover body (420). An abutting portion (440) for pushing the sampling member (500) into the cavity (110) is disposed within the avoidance cavity (430). The pressing portion (410) is movably disposed on the cover body (420), and the piston rod (310) is located on the movement path of the pressing portion (410).

4. The detection consumable according to claim 3, wherein: A central hole is axially provided in the cover body (420), the pressing portion (410) passes through the central hole, and a limiting convex ring (411) is formed at the bottom end of the pressing portion (410), and the limiting convex ring (411) limits the upper limit position of the pressing portion (410) relative to the cover body (420).

5. The detection consumable according to claim 3, wherein: The cavity (110) includes a first region (111) and a second region (112). The first region (111) is for accommodating the sampling member (500), the second region (112) is for the piston rod (310) to slide, and the first region (111) and the second region (112) are communicated through a mixing hole (151).

6. The detection consumable according to claim 3, wherein: A spike portion (330) is provided at one end of the piston rod (310) close to the sealing film (220).

7. The detection consumable according to claim 1, characterized in that: The reaction tube (200) includes a mounting portion (230) for detachably connecting to the bottom of the sample tube (100) and a reaction portion (240) formed at the lower end of the mounting portion (230). The sealing film (220) is disposed at the top of the mounting portion (230), and the reaction chamber (210) is disposed within the mounting portion (230) and the reaction portion (240).

8. The detection consumable according to claim 7, characterized in that: An installation groove (120) is formed at the bottom of the reaction tube (200), and the mounting portion (230) is snap-fitted into the installation groove (120).

9. The detection consumable according to claim 8, characterized in that: A bottom sealing ring (130) is disposed between the installation groove (120) and the mounting portion (230).

10. A detection device, characterized in that: It includes the detection consumables according to any one of claims 1-9.