CHO (Chinese hamster ovary) cell culture shaking table device

Abstract

The utility model discloses a CHO cell culture shaking table device which comprises a device shell, an oscillating mechanism arranged in the shell and a base arranged on the oscillating mechanism, the base is provided with a tray structure used for arranging culture flasks in a stepped mode, and the bottom of the tray structure is provided with a rapid installation mechanism used for being located with the base. The rapid installation mechanism comprises a bottom plate, a first fixing buckle and a second fixing buckle are arranged on the bottom plate, a first clamping opening and a second clamping opening are formed in the two sides of the base respectively, one end of the first fixing buckle is clamped in the first clamping opening, and one end of the second fixing buckle is clamped in the second clamping opening. And a driving structure is also arranged on the bottom plate. According to the utility model, the tray structure and the base can be quickly positioned, the tray structure is quickly and conveniently fixed, and meanwhile, the culture bottles are arranged in a step shape, so that the culture bottles can be conveniently observed or taken and placed.

Description

Technical Field

[0001] The utility model belongs to the technical field of cell cultivation, and in particular relates to a CHO cell culture shaking table device. Background Art

[0002] CHO cells are a cell line derived from the ovary of the Chinese hamster and are widely used in the production of recombinant proteins in biopharmaceuticals. CHO cells are typically cultured using a bioshaker. Existing bioshakers include an oscillating mechanism that drives the base to oscillate, thereby oscillating the culture flasks on the tray.

[0003] During installation, existing trays cannot quickly align the tray with the base and install the tray quickly, making installation inconvenient. Furthermore, this type of tray cannot position culture bottles of different sizes, which limits its use. Furthermore, the culture bottles are laid flat, making it difficult to place, retrieve, or observe them. Utility Model Content

[0004] The present invention aims to provide a CHO cell culture shaker device to address the aforementioned issues, such as the inability to quickly position the tray and base, the inconvenience of quick tray installation, and the inconvenience of installation. Furthermore, the tray structure is unable to position culture bottles of different sizes, resulting in limitations in its use. Furthermore, the culture bottles are arranged flat, making it difficult to place, retrieve, or observe the bottles.

[0005] To achieve the above objectives, the present invention provides the following technical solutions:

[0006] A CHO cell culture shaker device comprises a housing, an oscillating mechanism disposed within the housing, and a base disposed on the oscillating mechanism. The base is provided with a tray structure for arranging culture bottles in a stepped manner. The bottom of the tray structure is provided with a quick installation mechanism for positioning with the base.

[0007] The quick installation mechanism includes a base plate, on which a first fixing buckle and a second fixing buckle are respectively provided, and a first bayonet and a second bayonet are respectively provided on both sides of the base, one end of the first fixing buckle is clamped in the first bayonet, and one end of the second fixing buckle is clamped in the second bayonet; a driving structure is also provided on the base plate.

[0008] In one embodiment, the driving structure includes a bidirectional ball screw, which is rotatably arranged in the installation groove. The installation groove is arranged at the bottom of the bottom plate. A first nut and a second nut are respectively arranged on both sides of the bidirectional ball screw. The first nut is connected to the first fixing buckle, and the second nut is connected to the second fixing buckle. Through the transmission of the bidirectional ball screw, the first fixing buckle and the second fixing buckle move towards each other synchronously.

[0009] In one embodiment, a first guiding block is arranged on the first nut, and a second guiding block is also arranged on the second nut. Both the first guiding block and the second guiding block are movably arranged in the guiding groove. The guiding groove is arranged on one side of the installation groove, which improves the stability of the movement of the first nut and the second nut.

[0010] In one embodiment, positioning rods are further arranged at the bottom corners of the bottom plate. One end of each positioning rod is clamped in the positioning groove. The positioning groove is arranged at the corner of the base. Through the cooperation of the positioning rod and the positioning groove, the bottom plate and the base can be quickly positioned.

[0011] In one embodiment, the bottom of the tray structure is a stepped carrier plate, which is arranged on the bottom plate. A positioning stepped carrier plate is arranged above the bottom stepped carrier plate. Multiple groups of bottle positioning ports are arranged on the positioning stepped carrier plate, and the positioning stepped carrier plate is connected to the bottom stepped carrier plate through a longitudinal adjustment component, so that the culture bottles can be placed in a stepped manner.

[0012] In one embodiment, the longitudinal adjustment component includes a positioning sleeve, which is arranged on the bottom stepped carrier plate. An adjustment rod is movably arranged in the positioning sleeve. One end of the adjustment rod is connected to the positioning stepped carrier plate, and the height of the positioning stepped carrier plate can be adjusted.

[0013] In one embodiment, a positioning knob is further arranged on the positioning sleeve. One end of the positioning knob abuts against the adjustment rod, which can position the longitudinal position of the adjustment rod.

[0014] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0015] (1) Through the opposite movement of the first fixing buckle and the second fixing buckle, the present utility model can quickly position the tray structure and the base, and quickly fix the tray structure on the base. The fixing operation of the tray structure is fast and convenient.

[0016] (2) The present utility model can position culture bottles of different specifications, and at the same time arrange the culture bottles in a stepped shape, which is convenient for observing the culture conditions of CHO cells in the culture bottles and is also convenient for taking and placing the culture bottles. Description of the Drawings

[0017] Figure 1Structural schematic diagram of an embodiment of the present utility model.

[0018] Figure 2 Half-sectional structural schematic diagram of the quick installation mechanism in an embodiment of the present utility model.

[0019] Figure 3 For Figure 1 Enlarged structural schematic diagram of part A in

[0020] Figure 4 Structural schematic diagram of the tray structure in an embodiment of the present utility model.

[0021] Figure 5 Left view structural schematic diagram of the tray structure in an embodiment of the present utility model. Detailed implementation manners

[0022] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0023] Please refer to Figures 1 - 3 , the present utility model provides a CHO cell culture shaker device, including a device housing 4, an oscillation mechanism 5 disposed inside the housing, and a base 6 disposed on the oscillation mechanism 5. The oscillation mechanism 5 is connected to a control switch 2 to control the opening and closing of the oscillation mechanism 5. A tray structure 3 for arranging culture bottles 7 in a stepped manner is disposed on the base 6, and a quick installation mechanism 1 for positioning with the base 6 is disposed at the bottom of the tray structure 3.

[0024] The quick installation mechanism 1 includes a bottom plate 112. A first fixing buckle 105 and a second fixing buckle 108 are respectively disposed on the bottom plate 112. A driving structure is also disposed on the bottom plate 112. One end of the first fixing buckle 105 is clamped in the first bayonet 106, and one end of the second fixing buckle 108 is clamped in the second bayonet 107. The first buckle and the second bayonet 107 are respectively disposed on both sides of the base 6.

[0025] The driving structure includes a bidirectional ball screw 101. The bidirectional ball screw 101 is rotatably disposed in the installation groove, and one end of the bidirectional ball screw 101 is connected to an adjustment knob 103. The installation groove is disposed at the bottom of the bottom plate 112. First and second nuts 104 and 109 are respectively disposed on both sides of the bidirectional ball screw 101. The first nut 104 is connected to the first fixing buckle 105, and the second nut 109 is connected to the second fixing buckle 108. Through the transmission of the bidirectional ball screw 101, the first fixing buckle 105 and the second fixing buckle 108 move towards each other synchronously.

[0026] Specifically, first, the bottom plate 112 is fitted to the base 6, and then the adjustment knob 103 is rotated forward. The adjustment knob 103 drives the bidirectional ball screw 101 to rotate forward. The first nut 104 and the second nut 109 move toward the base 6 on the bidirectional ball screw 101. The first nut 104 drives the first fixing buckle 105 to move, and the second nut 109 drives the second fixing buckle 108 to move. When the first fixing buckle 105 and the second fixing buckle 108 are respectively snapped into the first bayonet 106 and the second bayonet 107, the bottom plate 112 is fixed to the base 6 through the first fixing buckle 105 and the second fixing buckle 108, and then the tray structure 3 is quickly installed.

[0027] In one embodiment, a first guiding block 102 is provided on the first nut 104, and a second guiding block 110 is further provided on the second nut 109. Both the first guiding block 102 and the second guiding block 110 are movably arranged in the guiding groove 111. The guiding groove 111 is arranged on one side of the installation groove. When the first nut 104 and the second nut 109 move, they respectively drive the first guiding block 102 and the second guiding block 110 to move in the guiding groove 111, improving the stability of the movement of the first nut 104 and the second nut 109.

[0028] A positioning rod 113 is further provided at the bottom corner of the bottom plate 112. One end of the positioning rod 113 is snapped into the positioning groove 114. The positioning groove 114 is arranged at the corner of the base 6. When installing the bottom plate 112, first, the positioning rod 113 is snapped into the positioning groove 114. Through the cooperation of the positioning rod 113 and the positioning groove 114, the bottom plate 112 and the base 6 can be quickly positioned.

[0029] As a specific embodiment of the present application, please refer to Figures 4 - 5 , the bottom stepped carrier plate 31 of the tray structure 3 is provided on the bottom plate 112. A positioning stepped carrier plate 34 is provided on the upper side of the bottom stepped carrier plate 31. A plurality of bottle positioning openings 33 are provided on the positioning stepped carrier plate 34, and the positioning stepped carrier plate 34 is connected to the bottom stepped carrier plate 31 through a longitudinal adjustment assembly, and the culture bottles 7 can be placed in a stepped manner.

[0030] The culture bottles 7 are sequentially placed in the bottle positioning openings 33, and the bottom of the culture bottles 7 is attached to the bottom stepped carrier plate 31 to support the culture bottles 7. Through the cooperation of the positioning stepped carrier plate 34 and the bottom stepped carrier plate 31, the culture bottles 7 can be placed in a stepped manner, which is convenient for observing the culture conditions of CHO cells and at the same time convenient for taking and placing the culture bottles 7.

[0031] Specifically, the longitudinal adjustment component includes a positioning sleeve 37. The positioning sleeve 37 is arranged on the bottom stepped carrier plate 31. An adjusting rod 35 is movably arranged inside the positioning sleeve 37. One end of the adjusting rod 35 is connected to the positioning stepped carrier plate 34, and the height of the positioning stepped carrier plate 34 can be adjusted. A positioning knob 36 is also arranged on the positioning sleeve 37. One end of the positioning knob 36 abuts against the adjusting rod 35, and the longitudinal position of the adjusting rod 35 can be positioned.

[0032] Pull the positioning stepped carrier plate 34. The positioning stepped carrier plate 34 drives the adjusting rod 35 to move inside the positioning sleeve 37, thereby adjusting the height of the positioning stepped carrier plate 34. Then, by making the positioning knob 36 abut against the adjusting rod 35, the position of the adjusting rod 35 can be fixed, which can meet the use of culture bottles 7 of different specifications.

[0033] Furthermore, an auxiliary support 32 is also arranged on the bottom stepped carrier plate 31. The auxiliary support 32 is connected to the bottom plate 112, which improves the stability of the bottom stepped carrier plate 31 during installation.

[0034] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A CHO cell culture shaker device, comprising a housing, an oscillation mechanism disposed within the housing, and a base disposed on the oscillation mechanism, characterized in that, A tray structure for arranging culture bottles in a stepped manner is provided on the base, and a quick installation mechanism for positioning with the base is provided at the bottom of the tray structure; The quick installation mechanism includes a bottom plate, a first fixing buckle and a second fixing buckle are respectively arranged on the bottom plate, a first bayonet and a second bayonet are respectively arranged on both sides of the base, one end of the first fixing buckle is clamped in the first bayonet, and one end of the second fixing buckle is clamped in the second bayonet; a driving structure is also arranged on the bottom plate.

2. The CHO cell culture shaker device according to claim 1, wherein, An installation groove is arranged at the bottom of the bottom plate, the driving structure includes a bidirectional ball screw, and the bidirectional ball screw is rotatably arranged in the installation groove; a first nut and a second nut are respectively arranged on both sides of the bidirectional ball screw, the first nut is connected with the first fixing buckle, and the second nut is connected with the second fixing buckle.

3. The CHO cell culture shaker device according to claim 2, wherein, A first guide block is arranged on the first nut, a second guide block is also arranged on the second nut, a guide groove is arranged on one side in the installation groove, and both the first guide block and the second guide block are movably arranged in the guide groove.

4. The CHO cell culture shaker device according to claim 1 or 2, characterized in that, Positioning rods are also arranged at the bottom corners of the bottom plate, one end of each positioning rod is clamped in a positioning groove, and the positioning groove is arranged at the corner of the base.

5. The CHO cell culture shaker device according to claim 1, wherein The bottom of the tray structure is a stepped carrier plate, the stepped carrier plate is arranged on the bottom plate, a positioning stepped carrier plate is arranged above the stepped carrier plate, a plurality of bottle body positioning ports are arranged on the positioning stepped carrier plate, and the positioning stepped carrier plate is connected with the stepped carrier plate through a longitudinal adjustment component.

6. The CHO cell culture shaker device according to claim 5, characterized in that, The longitudinal adjustment component includes a positioning sleeve, the positioning sleeve is arranged on the stepped carrier plate, an adjustment rod is movably arranged in the positioning sleeve, and one end of the adjustment rod is connected with the positioning stepped carrier plate.

7. The CHO cell culture shaker device according to claim 6, characterized in that, A positioning knob is also arranged on the positioning sleeve, and one end of the positioning knob abuts against the adjustment rod.

Images