Immunochromatography detection device for liquid sample

Abstract

The utility model relates to the technical field of biological detection instruments, in particular to a liquid sample immunochromatography detection device which comprises at least one detection unit used for detecting sample liquid and provided with a sample feeding end used for being in contact with the sample liquid; the foldable carrier can be folded to form at least two folds, and the detection units are arranged on the folds; when the carrier is in a folded state, the detection units are wrapped between two adjacent layers of hinges, the sample introduction ends of the detection units extend out of the carrier, and the detection units are not in contact with each other; the protection part is used for coating the sample introduction end of the detection unit, and the protection part is separably arranged on the carrier; due to the fact that the carrier is foldable, the size of the whole device is obviously reduced in a packaging state, and the device is especially suitable for a detection device for multi-item joint detection.

Description

Technical Field

[0001] The utility model relates to the technical field of biological detection instruments, in particular to a liquid sample immunochromatographic detection device. Background Art

[0002] Immunochromatographic reagent strip detection devices have been widely used in clinical disease diagnosis, food safety testing, environmental monitoring, and other fields. For example, in clinical disease diagnosis, the device can be used to quickly detect pathogens, tumor markers, and other biomarkers in the blood; in food safety testing, it can be used to detect harmful substances or pesticide residues in food.

[0003] The structure of an immunochromatographic test strip typically involves multiple components, including the test strip itself (i.e., the test unit) and a rigid outer shell (i.e., the housing), which work together to achieve accurate testing of the test strip.

[0004] The shell fixes the reagent strip inside through its internal structure to prevent it from moving or being damaged during transportation and use; at the same time, it avoids external contamination and interference, ensuring the stability and reliability of the reagent strip; however, in actual applications, this detection device is relatively large due to the presence of the shell, especially for immunoassay reagent devices that perform multiple tests; therefore, it still needs to be improved. Utility Model Content

[0005] In order to solve at least one of the technical problems mentioned in the background technology, the purpose of the present invention is to provide a liquid sample immunochromatographic detection device.

[0006] To achieve the above objectives, the present invention provides the following technical solutions:

[0007] In one aspect, the present invention provides a liquid sample immunochromatographic detection device, comprising:

[0008] At least one detection unit, used for detecting the sample liquid, the detection unit having a sampling end for contacting with the sample liquid;

[0009] A carrier capable of being folded to form at least two folds, wherein the detection unit is disposed on the folds; when the carrier is folded, the detection unit is enclosed between two adjacent folds, the sampling end of the detection unit extends out of the carrier, and the detection units do not contact each other;

[0010] The protective component is used to cover the injection end of the detection unit and is detachably arranged on the carrier.

[0011] As an optional embodiment of the present invention, the carrier includes two hinges, and the two hinges can be folded in half to cover the detection unit.

[0012] As an alternative embodiment of the present utility model, the carrier includes three consecutive folding pages;

[0013] The detection unit is disposed on the middle folding page, and the two side folding pages jointly cover the detection unit; alternatively, the two side folding pages are alternately folded on the middle folding page, and the detection unit is located between two adjacent layers of folding pages.

[0014] As an alternative embodiment of the present utility model, the carrier includes at least three continuously folded folding pages, and the folding pages are continuously folded with each other in a "Z" shape; the detection unit is located between two adjacent layers of folding pages.

[0015] As an alternative embodiment of the present utility model, the carrier includes a central folding page and top folding pages folded on both sides of the top surface of the central folding page; a continuous "Z" - shaped folding structure is formed between the top folding pages and the central folding page.

[0016] As an alternative embodiment of the present utility model, the detection unit is pasted and / or clamped on the carrier.

[0017] As an alternative embodiment of the present utility model, the folding page is provided with an adhesive bonding site for pasting the detection unit; or a card slot for the detection unit to be inserted is formed on the folding page.

[0018] As an alternative embodiment of the present utility model, at least one side wall of the two opposite side walls of the card slot is provided with a positioning protrusion for clamping the detection unit.

[0019] As an alternative embodiment of the present utility model, the protective component is in a closed - loop sleeve structure, the protective component and the carrier are integrally formed, and an easy - tear line surrounding the protective component is formed at the connection position between the two; or the protective component is a closed - loop protective sleeve, and the protective sleeve is sleeved on the folded carrier.

[0020] On the other hand, the present utility model further provides another liquid sample immunochromatographic detection device, including:

[0021] At least one detection unit for detecting the sample liquid, and the detection unit has a sampling end for contacting the sample liquid;

[0022] A carrier, which includes a first carrier and a second carrier both capable of being folded. The first carrier includes at least two first folding pages capable of folding with each other; the second carrier includes at least one second folding page capable of being continuously folded in a "Z" shape; both ends of the second carrier are respectively fixed on the two first folding pages;

[0023] The detection unit is disposed on the second folding page; when the carrier is in the folded state, the detection unit is wrapped between the second folding pages, and the liquid inlet end of the detection unit extends out of the second folding page and the liquid inlet end of the detection unit is wrapped between the two first folding pages.

[0024] Compared with the prior art, the advantages of adopting this solution are as follows:

[0025] In this solution, by setting a foldable carrier to install the detection unit, compared with the existing method of encapsulating the detection unit with a rigid outer shell:

[0026] First of all, since the carrier is foldable, the volume of the entire device is significantly reduced in the packaging state (which can also be understood as the folded state), especially for the detection device for multiplex joint detection. This is beneficial to reducing the transportation cost.

[0027] Secondly, in this solution, in the folded state, the entire detection unit is wrapped by the carrier and the protective component, so that the entire detection unit will not be exposed and contaminated.

[0028] At the same time, the detection units do not contact each other, so that crosstalk between the detection units during detection can be prevented, affecting the detection results.

[0029] In addition, the protective component is detachably disposed on the carrier. Therefore, when detection is required, the protective component can be separated from the carrier, so that the sampling end of the detection unit is exposed. In this way, the device can be detected by the immersion detection method during detection, that is, without the assistance of devices such as droppers, the exposed sampling end can be directly immersed in the sample solution for detection, realizing immersion detection.

[0030] After the detection is completed, the folding pages of the carrier are directly unfolded to expose the entire detection unit, so as to facilitate the operator to observe the detection results displayed on the detection unit. Brief Description of the Drawings

[0031] Figure 1 It is a schematic structural view of Embodiment 1 in the packaging state Figure 1 ;

[0032] Figure 2 It is a schematic structural view of Embodiment 1 in the packaging state Figure 2 ;

[0033] Figure 3 It is a schematic structural view of one of the folding pages of the carrier of Embodiment 1 for bonding the detection unit;

[0034] Figure 4 It is a schematic structural view of one of the folding pages of the carrier of Embodiment 1 for clamping the detection unit;

[0035] Figure 5 In the embodiment of Example 1, in which the carrier adopts an accordion fold, the structure thereof in the folded state is schematically shown. Figure 1 ;

[0036] Figure 6 In the embodiment of Example 1, in which the carrier adopts an accordion fold, the structure thereof in the folded state is schematically shown. Figure 2 ;

[0037] Figure 7 This is a schematic diagram of the structure of the carrier in Example 1, which is folded in half;

[0038] Figure 8 This is a schematic structural diagram of the carrier in Example 1 using an accordion folding method;

[0039] Figure 9 This is a schematic structural diagram of the carrier in Example 1 using a core-folding method;

[0040] Figure 10 This is a schematic structural diagram of the carrier in Example 1 using the Guanyin folding method;

[0041] Figure 11 This is a schematic structural diagram of the carrier in Example 1 using an open-door folding method;

[0042] Figure 12 This is a structural diagram of Example 2 in the unfolded state. DETAILED DESCRIPTION

[0043] The following is an explanation and description of the technical solutions of the embodiments of the present invention in conjunction with the drawings of the embodiments of the present invention, but the following embodiments are only preferred embodiments of the present invention and are not exhaustive. Based on the embodiments in the embodiments, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present invention.

[0044] In the following description, terms such as "inside", "outside", "up", "down", "left", "right", etc. that indicate directions or positional relationships are only used to facilitate the description of the embodiments and simplify the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operate in a specific direction. Therefore, they should not be understood as limiting the present invention.

[0045] Example 1

[0046] See also Figures 1 - 10 As shown, this embodiment provides a liquid sample immunochromatographic detection device, including a detection unit 1, a carrier 2 and a protective component 3.

[0047] Among them, such as Figure 1As shown, the detection unit 1 is mainly used to detect the sample liquid. The detection unit 1 has a sample injection end 11, which is mainly used to contact the sample liquid to be detected.

[0048] In some embodiments, the detection unit 1 can be a test strip. The test strip that makes up the detection unit 1 mainly includes a bottom plate, absorbent paper (also known as an absorbent pad, mainly used to absorb excess sample), a nitrocellulose membrane (coated with antigens or antibodies, the place where the immune reaction occurs), a polyester fiber membrane (containing antibody or antigen markers), a glass fiber membrane, etc. The glass fiber membrane forms the sample injection end 11 of the test strip.

[0049] The bottom plate is the carrier of the immunochromatographic test strip, and other components are pasted on the bottom plate in sequence and overlap with each other to ensure the occurrence of the chromatographic reaction.

[0050] In some embodiments, multiple detection units 1 can be set up to achieve multiplex detection. For example, as Figure 1 shown, multiple detection units are arranged side by side and at intervals.

[0051] The carrier 2 is mainly used to install the detection unit 1. The carrier 2 is a foldable structure, or a foldable material, which can be folded to form at least two folds 21.

[0052] In some embodiments, in order to make the carrier 2 foldable, the carrier 2 can be made of thin plastic products (such as plastic products with a thickness of 0.2 mm - 0.5 mm). The specific material can be one or more of polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polyester resin (PET), which are not specifically limited here.

[0053] Of course, in some other alternative embodiments, the carrier 2 can also be a paper product, such as a product made of grass fiber. Grass fiber plants have a short growth cycle and are waste from other industries. Utilizing them turns waste into treasure.

[0054] Based on this foldable carrier 2, when installing the detection unit 1, the detection unit 1 is arranged on the fold 21; and when the carrier 2 is in the folded state, as Figure 5 and Figure 6 shown, the detection unit 1 is wrapped between adjacent two folds 21. The sample injection end 11 of the detection unit 1 extends out of the carrier 2, and the detection units 1 do not contact each other.

[0055] Taking the aforementioned test strip as the detection unit 1 as an example, its specific installation with the carrier 2 can be that the bottom plate of the detection unit 1 contacts and is fixed to the carrier 2; the absorbent pad is the upper end of the detection unit 1, and the glass fiber membrane (sample injection end 11) is the lower end of the detection unit 1.

[0056] When the entire detection device is packaged, it is packaged in a folded state. During actual use, it can also be used in a folded state. For example, during detection, it is in the state shown by Figure 5 and Figure 6 .

[0057] When performing detection in some scenarios, such as immersion detection, it is necessary to immerse the sampling end 11 of the detection unit 1 in the sample solution for detection. Therefore, the sampling end 11 of the detection unit 1 is designed to extend out of the carrier 2, so that the sampling end 11 can be inserted or immersed in the sample solution for detection.

[0058] In addition, since the sampling end 11 extends out of the carrier 2, that is, it is exposed, it is easily contaminated during packaging and transportation. To reduce the risk of its contamination, as shown by Figure 1 and Figure 2 , in this embodiment, a protective component 3 is provided to cover and protect the sampling end 11. In this way, it is equivalent to that the entire detection unit 1 is completely covered by the carrier 2 and the protective component 3, reducing the risk of its contamination.

[0059] As described above, during detection, the sampling end 11 needs to be exposed to contact the sample solution. Therefore, in this embodiment, the protective component is installed on the carrier 2 in a separable manner. Specifically, in the packaged state, at this time the carrier exists in a folded state, as shown by Figure 1 and Figure 2 , the protective component is connected to the carrier 2 and covers the sampling end 11; during detection, the protective component is separated from the carrier 2 to expose the sampling end 11 for subsequent detection work, which can be referred to the state shown by Figure 5 and Figure 6 .

[0060] For the specific structure of the protective component, it can be one of the following two forms:

[0061] Method 1, as shown by Figure 1 , the protective component 3 and the carrier 2 are integrally formed, and the protective component 3 has a closed-loop sleeve structure. In addition, a tear line 31 surrounding the protective component 3 is formed at the connection position between the protective component 3 and the carrier 2. At this time, it is equivalent to processing the tear line 31 on a material, and the material is separated into two parts by the tear line 31. One part constitutes the carrier 2, and the other part constitutes the protective component 3. When detection is required, the protective component 3 can be torn off along the tear line 31 to expose the sampling end 11.

[0062] Method 2, as shown by Figure 2As shown, the protective component 3 is a separate component and is a closed protective sleeve, the material of which can be the same as that of the carrier 2; the protective sleeve is sleeved on the folded carrier 2 to cover the sampling end 11; thus, when detection is required subsequently, the protective sleeve can be simply removed from the carrier 2 to expose the sampling end 11.

[0063] In some embodiments, as Figure 1 shown, a plurality of detection units 1 are arranged side by side and spaced apart on the carrier 2 to ensure that the detection units 1 do not contact each other, preventing the problem of mutual crosstalk among the detection units 1 during detection.

[0064] The specific connection manner between the detection unit 1 and the carrier 2 can be one of the following two forms or a combination thereof:

[0065] Form 1, as Figure 3 shown, the detection unit 1 and the carrier 2 are fixed in a pasting manner, that is, the detection unit 1 is pasted on the carrier 2. Specifically, a plurality of glue bonding sites 210 for pasting the detection unit 1 are provided on the folding page 21 of the carrier 2 where the detection unit 1 needs to be installed. When pasting, the bottom plate of the detection unit 1 is pasted on the glue bonding sites 210.

[0066] It should be noted that only the case of one folding page 21 for bonding the detection unit is shown in Figure 3 , and the folding pages 21 of other parts of the carrier 2 are not shown.

[0067] Form 2, as Figure 4 shown, the detection unit 1 and the carrier 2 are fixed in a clamping form. Specifically, a clamping groove 211 for the detection unit 1 to be inserted is formed on the folding page 21. For example, a plurality of clamping grooves 211 arranged side by side are provided on the folding page 21, and the size of the clamping groove 211 is sufficient to accommodate the detection unit 1. During assembly, the detection unit 1 is inserted into the clamping groove 211, and the detection unit 1 is clamped by the clamping groove 211 to achieve the fixation of the detection unit 1.

[0068] It should be noted that only the case of one folding page 21 for clamping the detection unit is shown in Figure 4 , and the folding pages 21 of other parts of the carrier 2 are not shown.

[0069] In addition, in order to improve the clamping effect on the detection unit 1, in some embodiments, as Figure 4 shown, among the two side walls on the opposite sides of the clamping groove 211, at least one side wall is provided with a positioning protrusion 212 for clamping the detection unit 1. Preferably, positioning protrusions 212 are provided on both side walls, and the detection unit 1 is clamped between the positioning protrusions 212 on both sides.

[0070] It is worth noting that the connection between the detection unit 1 and the carrier 2 can be any one of the two forms mentioned above, or some detection units 1 can be installed in form one and the other part of the detection units 1 can be installed in form two. The specific selection can be made according to actual needs and is not specifically limited here.

[0071] The specific folding method of the carrier 2 can be one or more of the following forms, which are described below:

[0072] Folding method 1, such as Figure 7 As shown, the carrier 2 is folded in half. Specifically, in the folded state, the carrier 2 includes two hinges 21. The two hinges 21 can be folded in half to cover the detection unit 1. In some embodiments, the carrier 2 has a rectangular structure in the unfolded state. Among the two hinges 21, one hinge 21 is used to install the detection unit 1, and the other hinge 21 is used to cover the detection unit 1 after folding. In the folded state, the detection unit 1 is covered between the two hinges 21.

[0073] Folding method 2, such as Figure 10 As shown, the carrier 2 is folded in the Guanyin folding manner. Specifically, in the folded state, the carrier 2 includes three continuous hinges 21. When the detection unit 1 is set, the detection unit 1 is set on the middle hinge 21, and the hinges 21 on both sides jointly cover the detection unit 1; preferably, when the carrier 2 is in the unfolded state, the whole is a rectangular structure, and the sum of the areas of the hinges 21 on both sides is equal to the area of the middle hinge 21. For example, the areas of the hinges 21 on both sides are 1 / 2 of the area of the middle hinge 21.

[0074] Folding method three, such as Figure 9 As shown, the carrier 2 is folded in a core-folding manner, and in the folded state, it includes three continuous folds 21. Specifically, the folds 21 on both sides are alternately folded on the middle fold 21, and the detection unit 1 is located between two adjacent layers of folds 21. At this time, when the carrier 2 is in the folded state, the three folds 21 form three layers of upper, middle and lower layers, and the detection unit 1 can be set between the fold 21 of the upper layer and the fold 21 of the middle layer, and / or between the fold 21 of the middle layer and the fold 21 of the lower layer.

[0075] Folding method four, such as Figure 8 As shown, the carrier 2 is folded in an accordion folding manner. Specifically, in the folded state, the carrier 2 includes at least three continuously folded hinges 21, wherein each hinge 21 is continuously folded with each other in a "Z" shape; the detection unit 1 is arranged between two adjacent layers of hinges 21.

[0076] Folding method five, such as Figure 11As shown, the carrier 2 is folded using a door-folding arrangement. Specifically, in the folded state, the carrier 2 includes a center hinge 21a and top hinges 21b folded on either side of the center hinge 21a. The top hinges 21b and center hinge 21a form a continuous Z-shaped folded structure. In this case, the detection unit 1 can be positioned between the center hinge 21a and the top hinge 21b, or alternatively, between two adjacent layers of top hinges 21b.

[0077] It is worth noting that, in the above-mentioned folding methods 1 to 5, the protective structure can adopt the protective structure provided by method 1 or method 2.

[0078] Example 2

[0079] like Figure 12 As shown, this embodiment provides another liquid sample immunochromatographic detection device, including a carrier and at least one detection unit 1.

[0080] The detection unit 1 is mainly used for detecting the sample liquid, and the detection unit 1 has a sample injection end 11 for contacting the sample liquid; it is worth noting that the detection unit 1 is specifically described in Example 1, and the description of Example 1 can be referred to, and no further details are given here.

[0081] like Figure 12 As shown, the carrier includes a first carrier 4 and a second carrier 5 both of which are foldable. In short, the first carrier 4 and the second carrier 5 are both foldable structures.

[0082] In order to achieve the foldability of the carrier, the first carrier 4 and / or the second carrier 5 can be made of thin plastic products (for example, plastic products with a thickness of 0.2 mm-0.5 mm). The specific material can be one or more of polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), and polyester resin (PET), which is not specifically limited here.

[0083] Of course, in some other optional embodiments, the first carrier 4 and / or the second carrier 5 may also be a paper product, such as a grass fiber product.

[0084] like Figure 12 As shown, the first carrier 4 includes at least two first folds 41 that can be folded into each other; the second carrier 5 includes at least one second fold 51 that can be continuously folded in a "Z" shape. The folding method of the second carrier 5 here can also be understood as the accordion folding method described in Example 1.

[0085] The first carrier 4 can be formed by folding two first hinges 41 in half, or can be folded in the accordion fold, Guanyin fold, core fold, or door fold mentioned in the first embodiment.

[0086] Taking the example that the first carrier 4 is folded in half, both ends of the second carrier 5 are respectively fixed on two first folding pages 41; the detection unit 1 is arranged on the second folding page 51. For example, as Figure 12 shown, in the second carrier 5, there is a folding page without a detection unit 1 between each detection unit 1. In this way, in the folded state, the detection units 1 can be separated by the folding pages without detection units 1 and do not contact each other, avoiding crosstalk.

[0087] In addition, when the carrier is in the folded state, the detection unit 1 is covered between the second folding pages 51, and the liquid inlet end of the detection unit 1 extends out of the second folding page 51 and the liquid inlet end of the detection unit 1 is covered between the two first folding pages 41. Among them, it is required that the lower end (i.e., the liquid inlet end 11) of the detection unit does not exceed the lower end of the first folding page 41.

[0088] At this time, equivalently, a part of the detection unit 1 is covered by the second carrier 5, and the other part (mainly the liquid inlet end) is covered by the lower part of the first carrier 4.

[0089] The carrier structure provided in this embodiment can realize standing detection. That is, when the entire carrier is unfolded, as Figure 12 shown, the two first folding pages 41 of the first carrier 4 are equivalent to two support feet to support the second carrier 5 and the detection unit 1. At this time, the liquid inlet end of the detection unit 1 is in a suspended state. In this way, with a suitable sample collector, single or multiple reagents can be detected simultaneously while standing.

[0090] It can be seen that in this embodiment, the first carrier 4 has two functions. One is that the protective structure covers the liquid inlet end of the detection unit 1, and the other is to be used as a support foot to support and erect the second carrier 5 and the detection unit 1.

[0091] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and without departing from the spirit or basic characteristics of the present invention, the present invention can be implemented in other specific forms. Therefore, in any aspect, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, it is intended to include all changes falling within the meaning and scope of the equivalent elements of the claims in the present invention.

Claims

1. A liquid sample immunochromatographic detection device, characterized in that, include: At least one detection unit, used for detecting the sample liquid, the detection unit having a sampling end for contacting with the sample liquid; A carrier capable of being folded to form at least two folds, wherein the detection unit is disposed on the folds; when the carrier is folded, the detection unit is enclosed between two adjacent folds, the sampling end of the detection unit extends out of the carrier, and the detection units do not contact each other; The protective component is used to cover the injection end of the detection unit and is detachably arranged on the carrier.

2. The immunochromatographic detection device for liquid samples according to claim 1, wherein The carrier includes two hinges, which can be folded in half to cover the detection unit.

3. The liquid sample immunochromatographic detection device according to claim 1, wherein, The carrier includes three consecutive folds; The detection unit is arranged on the middle hinge, and the hinges on both sides cover the detection unit together; or, the hinges on both sides are alternately folded on the middle hinge, and the detection unit is located between two adjacent layers of hinges.

4. The liquid sample immunochromatographic detection device according to claim 1, wherein, The carrier includes at least three continuously folded hinges, wherein the hinges are continuously folded with each other in a "Z" shape; and the detection unit is located between two adjacent layers of hinges.

5. The immunochromatographic detection device for liquid samples according to claim 1, wherein, The carrier includes a center hinge and top hinges folded on both sides of the top surface of the center hinge; a continuous Z-shaped folding structure is formed between the top hinge and the center hinge.

6. The immunochromatographic detection device for liquid samples according to claim 1, wherein The detection unit is adhered and / or clamped on the carrier.

7. The liquid sample immunochromatographic detection device according to claim 6, wherein, The hinge is provided with an adhesive site for sticking the detection unit; or the hinge is formed with a slot for the detection unit to be inserted.

8. The liquid sample immunochromatographic detection device according to claim 7, wherein, The clamping slot is located in two side walls on opposite sides, and at least one side wall is provided with a positioning protrusion for clamping the detection unit.

9. The liquid sample immunochromatographic detection device according to claim 1, wherein The protective component is a closed-loop sleeve structure, the protective component and the carrier are integrally formed, and a tear line surrounding the protective component is formed at the connection position between the two; or the protective component is a closed-loop protective sleeve, and the protective sleeve is arranged on the folded carrier.

10. A liquid sample immunochromatographic detection device, characterized in that, include: At least one detection unit, used for detecting the sample liquid, the detection unit having a sampling end for contacting with the sample liquid; A carrier comprising a first carrier and a second carrier, both of which are foldable, wherein the first carrier comprises at least two first hinges that can be folded together; the second carrier comprises at least one second hinge that can be folded continuously in a "Z" shape; and both ends of the second carrier are fixed to the two first hinges respectively; The detection unit is arranged on the second folding page; when the carrier is in the folded state, the detection unit is wrapped between the second folding pages, and the liquid inlet end of the detection unit extends out of the second folding page and is wrapped between the two first folding pages.

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