Solid-phase extraction column and solid-phase extraction device

Abstract

The utility model relates to a solid phase extraction column and a solid phase extraction device, the solid phase extraction column comprises a column tube and a sieve plate installed in the column tube, a solid adsorbent is placed on the sieve plate, the solid adsorbent is located in the column tube, an air bag is installed in the column tube, the air bag is buried in the solid adsorbent, and the air bag is communicated with an inflation assembly. The utility model relates to a solid-phase extraction column and a solid-phase extraction device, and aims to provide the solid-phase extraction column and the solid-phase extraction device so as to solve the problems that in the prior art, target compounds in different liquid samples are different in size, and gaps of a solid adsorbent in the solid-phase extraction column are not easy to adjust, so that the adsorption effect of the solid adsorbent on the target compounds is poor.

Description

Technical Field

[0001] The utility model relates to the technical field of sample pretreatment, and particularly relates to a solid-phase extraction column and a solid-phase extraction device. Background Art

[0002] The solid-phase extraction column is a sample pretreatment device developed from a chromatography column for extraction, separation, and concentration. The inside of the solid-phase extraction column is filled with a solid adsorbent, and these solid adsorbents are selected according to the properties of the target analyte and the required separation effect. The solid adsorbent in the solid-phase extraction column is usually a chromatographic adsorbent, which can be a silica gel matrix, a polymer matrix, or an inorganic material, etc. They process the sample by selective adsorption and elution to achieve the purpose of rapid separation, purification, and concentration.

[0003] The solid-phase extraction device is an instrument used in the fields of environmental science and technology, resource science and technology, etc. The principle of the solid-phase extraction device is based on the liquid-solid chromatography theory, and the sample is enriched, separated, and purified by selective adsorption and selective elution. This process can be approximately regarded as a simple chromatographic process, and its core lies in using the selective adsorption ability of the solid-phase material for the target separation to achieve the purification and concentration of the sample.

[0004] In the solid-phase extraction process, the liquid sample passes through the solid-phase extraction column filled with a specific solid adsorbent, the target compound is adsorbed on the surface of the solid adsorbent, and other components flow through the solid-phase extraction column with the sample mother liquor. Since the target compounds in different liquid samples are of different sizes and the gaps of the solid adsorbent in the solid-phase extraction column are not easy to adjust, the adsorption effect of the solid adsorbent on the target compound is poor. Summary of the Utility Model

[0005] In view of this, the purpose of the utility model is to provide a solid-phase extraction column and a solid-phase extraction device to solve the problem in the prior art that the target compounds in different liquid samples are of different sizes and the gaps of the solid adsorbent in the solid-phase extraction column are not easy to adjust, resulting in poor adsorption effect of the solid adsorbent on the target compound.

[0006] The utility model is realized through the following technical solutions:

[0007] A solid-phase extraction column includes a column tube and a sieve plate installed in the column tube. A solid adsorbent is placed on the sieve plate, the solid adsorbent is located inside the column tube, an airbag is installed inside the column tube, the airbag is buried in the solid adsorbent, and the airbag is communicated with an inflation assembly.

[0008] Further, the inflation assembly includes a connecting pipe communicated with the internal cavity of the airbag, and one end of the connecting pipe away from the airbag is communicated with a syringe.

[0009] Further, a filter plate is slidably connected inside the column tube. A connecting rod is fixedly connected to the filter plate. A locking assembly is installed between the connecting rod and the column tube. Through holes adapted to the connecting tubes are formed in the filter plate. The connecting tubes pass through the through holes. The airbag is located between the filter plate and the sieve plate.

[0010] Further, the locking assembly includes a limiting rod hinged to the top of the connecting rod. An elastic assembly is installed between the connecting rod and the limiting rod. When the elastic assembly is in a natural stretched state, the connecting rod and the limiting rod are respectively in contact with the inner side wall and the outer side wall of the column tube.

[0011] Further, the elastic assembly includes a spring. The two ends of the spring are respectively fixedly connected to the side walls of the connecting rod and the limiting rod. When the spring is in a natural stretched state, the connecting rod and the limiting rod are respectively in contact with the inner side wall and the outer side wall of the column tube.

[0012] A solid-phase extraction device includes a bracket. A conduction channel is installed on the bracket. The top end of the conduction channel is communicated with a solid-phase extraction column. A receiving assembly for containing liquid is placed at the bottom end of the conduction channel.

[0013] Further, the receiving assembly includes a test tube. The opening end of the test tube faces the bottom end of the conduction channel.

[0014] Further, the number of the conduction channels is multiple. The numbers of the solid-phase extraction columns and the test tubes are both adapted to the number of the conduction channels.

[0015] Further, a mounting plate is installed on the bracket. A plurality of through holes are provided in the mounting plate. The diameters of the plurality of through holes are all larger than the diameter of the test tube body and smaller than the diameter of the test tube opening. The number of the through holes is equal to the number of the conduction channels, and the positions of the plurality of through holes correspond to the positions of the plurality of conduction channels one by one.

[0016] Further, a plurality of horizontally extending sliding grooves are formed in the side wall of the bracket. The plurality of sliding grooves are all adapted to the outer contour of the mounting plate.

[0017] The beneficial effects of the present utility model are as follows:

[0018] For this solid-phase extraction column, a liquid sample passes through a column tube filled with a specific solid adsorbent. The target compound is adsorbed on the surface of the solid adsorbent, while other components flow through the column tube along with the sample mother liquor. When the target compound has a large volume and the liquid sample flows slowly, the airbag is adjusted through the air-inflating component, causing the volume of the airbag to decrease and the gap between the solid adsorbents to increase, ensuring the adsorption effect of the target compound while accelerating the flow efficiency of the liquid sample. When the target compound has a small volume and the liquid sample flows quickly, the airbag is adjusted through the air-inflating component, causing the volume of the airbag to increase and the gap between the solid adsorbents to decrease under the squeezing effect of the airbag, improving the adsorption effect of the target compound. Compared with the prior art, by adjusting the gap between the solid adsorbents in the solid-phase extraction column, it is possible to adapt to target compounds of different sizes in different liquid samples and improve the adsorption effect of the solid adsorbent on the target compound.

[0019] Other advantages, objectives, and features of the present utility model will be described to some extent in the subsequent specification, and to some extent, will be obvious to those skilled in the art based on the study of the following text, or can be taught from the practice of the present utility model. The objectives and other advantages of the present utility model can be achieved and obtained through the following specification. Brief Description of the Drawings

[0020] Figure 1 is a perspective view of the solid-phase extraction column of the present utility model;

[0021] Figure 2 is a schematic structural diagram of the solid-phase extraction column of the present utility model;

[0022] Figure 3 For the present utility model Figure 2 is a partial enlarged view of part A in the present utility model;

[0023] Figure 4 is a schematic structural diagram of the filter plate of the present utility model;

[0024] Figure 5 is a schematic structural diagram of the solid-phase extraction device of the present utility model;

[0025] Figure 6 is a partial structural schematic diagram of the solid-phase extraction device of the present utility model;

[0026] Figure 7 is a schematic structural diagram of the mounting plate of the present utility model. [[ID=3a6]]

[0027] In the figure: [[ID=an]]

[0028] 1. Column tube; 2. Sieve plate; 3. Solid adsorbent; 4. Airbag; 5. Connecting tube; 6. Syringe; 7. Filter plate; 8. Connecting rod; 9. Through hole; 10. Limiting rod; 11. Spring; 12. Bracket; 13. Conducting channel; 14. Test tube; 15. Mounting plate; 16. Through hole; 17. Slide groove. Detailed implementation manners

[0029] To make the objectives, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are some but not all of the embodiments of the present utility model. Components of the embodiments of the present utility model usually described and illustrated in the accompanying drawings here can be arranged and designed in various different configurations.

[0030] Therefore, the following detailed description of the embodiments of the present utility model provided in the accompanying drawings is not intended to limit the scope of the present utility model to be protected, but merely represents the selected embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the scope of protection of the present utility model.

[0031] It should be noted that: Similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0032] In the above description of the present utility model, it should be noted that the orientation or positional relationship indicated by terms such as "one side", "the other side", etc. is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship when the product of the present utility model is usually placed. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present utility model. In addition, terms such as "first", "second", etc. are only used for distinguishing descriptions and cannot be understood as indicating or implying relative importance.

[0033] In addition, terms such as "the same" do not mean that the components are required to be absolutely the same, but there may be slight differences. The term "perpendicular" only means that the positional relationship between components is more perpendicular relative to "parallel", and does not mean that the structure must be completely perpendicular, but can be slightly inclined.

[0034] Please refer to Figure 1-4, the present utility model provides a technical solution: a solid-phase extraction column, including a column tube 1 and a sieve plate 2 installed in the column tube 1. A solid adsorbent 3 is placed on the sieve plate 2, and the solid adsorbent 3 is located inside the column tube 1. An airbag 4 is installed in the column tube 1, and the airbag 4 is buried in the solid adsorbent 3. The airbag 4 is connected to an inflation assembly.

[0035] In this solution: The sieve plate 2 is used to fix the solid adsorbent 3 and filter the solution to prevent the solid adsorbent 3 from flowing out with the solution. The liquid sample passes through the column tube 1 filled with a specific solid adsorbent 3, and the target compound is adsorbed on the surface of the solid adsorbent 3, while other components flow through the column tube 1 with the sample mother liquor. When the volume of the target compound is large and the liquid sample flows slowly, the airbag 4 is adjusted through the inflation assembly to make the volume of the airbag 4 smaller and the gap between the solid adsorbents 3 larger, which not only ensures the adsorption effect of the target compound but also speeds up the flow efficiency of the liquid sample. When the volume of the target compound is small and the liquid sample flows fast, the airbag 4 is adjusted through the inflation assembly to make the volume of the airbag 4 larger, and the gap between the solid adsorbents 3 becomes smaller under the extrusion of the airbag 4, improving the adsorption effect of the target compound. Compared with the prior art, by adjusting the gap of the solid adsorbent 3 in the solid-phase extraction column, it can adapt to target compounds of different sizes in different liquid samples and improve the adsorption effect of the solid adsorbent 3 on the target compound.

[0036] In this embodiment: The inflation assembly includes a connecting pipe 5 communicated with the internal cavity of the airbag 4, and one end of the connecting pipe 5 away from the airbag 4 is communicated with a syringe 6.

[0037] In this solution: The internal cavity of the airbag 4 and the syringe 6 are communicated through the connecting pipe 5. In the initial state of the syringe 6, the piston rod of the syringe 6 is located in the middle area of the syringe 6. When pulling the piston rod of the syringe 6 away from the airbag 4, part of the gas in the internal cavity of the airbag 4 is extracted, making the volume of the airbag 4 smaller. When pushing the piston rod of the syringe 6 towards the airbag 4, part of the gas in the internal cavity of the syringe 6 is pushed into the internal cavity of the airbag 4, making the volume of the airbag 4 larger.

[0038] In this embodiment: A filter plate 7 is slidably connected in the column tube 1. A connecting rod 8 is fixedly connected to the filter plate 7. A locking assembly is installed between the connecting rod 8 and the column tube 1. A through hole 9 adapted to the connecting pipe 5 is opened on the filter plate 7, and the connecting pipe 5 passes through the through hole 9. The airbag 4 is located between the filter plate 7 and the sieve plate 2.

[0039] In this solution: A filter plate 7 is slidably connected inside a column tube 1. A connecting rod 8 is fixedly installed on the filter plate 7. A locking assembly is installed between the connecting rod 8 and the column tube 1. A through hole 9 adapted to the connecting tube 5 is formed on the filter plate 7. The connecting tube 5 passes through the through hole 9. The airbag 4 is located between the filter plate 7 and the sieve plate 2. When the filter plate 7 is installed near the airbag 4 through the locking assembly, when the volume of the airbag 4 increases, the gap between the solid adsorbents 3 becomes smaller, further adjusting the gap between the solid adsorbents 3. When the filter plate 7 is installed away from the airbag 4 through the locking assembly, the gap between the solid adsorbents 3 changes with the change in the volume of the airbag 4.

[0040] In this embodiment: The locking assembly includes a limiting rod 10 hinged to the top of the connecting rod 8. An elastic component is installed between the connecting rod 8 and the limiting rod 10. When the elastic component is in a natural extended state, the connecting rod 8 and the limiting rod 10 are respectively in contact with the inner side wall and the outer side wall of the column tube 1.

[0041] In this solution: The locking assembly includes a limiting rod 10 hinged to the top of the connecting rod 8. An elastic component is installed between the connecting rod 8 and the limiting rod 10. When the elastic component is in a natural extended state, the connecting rod 8 and the limiting rod 10 are respectively in contact with the inner side wall and the outer side wall of the column tube 1. When the elastic component is in a compressed state, the connecting rod 8 and the limiting rod 10 are respectively separated from the inner side wall and the outer side wall of the column tube 1, facilitating the movement of the positions of the connecting rod 8 and the limiting rod 10.

[0042] In this embodiment: The elastic component includes a spring 11. The two ends of the spring 11 are respectively fixedly connected to the side walls of the connecting rod 8 and the limiting rod 10. When the spring 11 is in a natural extended state, the connecting rod 8 and the limiting rod 10 are respectively in contact with the inner side wall and the outer side wall of the column tube 1.

[0043] In this solution: The elastic component includes a spring 11. The two ends of the spring 11 are respectively fixedly connected to the side walls of the connecting rod 8 and the limiting rod 10. When the spring 11 is in a natural extended state, the connecting rod 8 and the limiting rod 10 are respectively in contact with the inner side wall and the outer side wall of the column tube 1. When the spring 11 is in a compressed state, the connecting rod 8 and the limiting rod 10 are respectively separated from the inner side wall and the outer side wall of the column tube 1, facilitating the movement of the positions of the connecting rod 8 and the limiting rod 10.

[0044] Please refer to Figure 1-7 , the present utility model provides a technical solution: A solid-phase extraction device, including a solid-phase extraction column and a bracket 12. A conduction channel 13 is installed on the bracket 12. The top end of the conduction channel 13 is communicated with the solid-phase extraction column; A receiving assembly for containing liquid is placed at the bottom end of the conduction channel 13.

[0045] In this solution: The bracket 12 is made of PC material or organic plastic material, which is convenient for movement. The bottom of the bracket 12 is open, reducing cross - contamination during the solid - phase extraction process. The liquid sample flows into the conduction channel 13 through the solid - phase extraction column under the action of gravity and flows out of the conduction channel 13 into the storage component, facilitating the collection of liquid during the solid - phase extraction process.

[0046] In this embodiment: The storage component includes a test tube 14, and the opening of the test tube 14 faces the bottom end of the conduction channel 13.

[0047] In this solution: The storage component includes a test tube 14, and the opening of the test tube 14 faces the bottom end of the conduction channel 13. It is convenient for collecting liquid during the solid - phase extraction process.

[0048] In this embodiment: The number of the conduction channels 13 is multiple, and the numbers of the solid - phase extraction columns and the test tubes 14 are both adapted to the number of the conduction channels 13.

[0049] In this solution: The numbers of the conduction channels 13, the solid - phase extraction columns and the test tubes 14 are all forty - five, arranged in a five - row and nine - column pattern. It can analyze multiple groups of liquid samples simultaneously, improving work efficiency.

[0050] In this embodiment: An installation plate 15 is installed on the bracket 12. Multiple through - holes 16 are provided on the installation plate 15. The diameters of the multiple through - holes 16 are all larger than the diameter of the tube body of the test tube 14 and smaller than the diameter of the tube mouth of the test tube 14; the number of the through - holes 16 is equal to the number of the conduction channels 13, and the positions of the multiple through - holes 16 correspond to the positions of the multiple conduction channels 13 one by one.

[0051] In this solution: By connecting the installation plate 15 to the bracket 12, multiple through - holes 16 are provided on the installation plate 15. The diameters of the multiple through - holes 16 are all larger than the diameter of the tube body of the test tube 14 and smaller than the diameter of the tube mouth of the test tube 14; the number of the through - holes 16 is equal to the number of the conduction channels 13, and the positions of the multiple through - holes 16 correspond to the positions of the multiple conduction channels 13 one by one. It is convenient to install the test tube 14 at the lower end of the conduction channel 13, enabling the conduit to be placed more stably under the bracket 12.

[0052] In this embodiment: A plurality of horizontally extending sliding grooves 17 are formed on the side wall of the bracket 12, and the plurality of sliding grooves 17 are all adapted to the outer contour of the installation plate 15.

[0053] In this solution: By forming a plurality of horizontally extending sliding grooves 17 on the side wall of the bracket 12, the plurality of sliding grooves 17 are all adapted to the outer contour of the installation plate 15. It can accommodate test tubes 14 of different heights and is convenient for adjusting the distance between the tube mouth of the test tube 14 and the lower end of the conduction channel 13.

[0054] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered within the scope of the claims of the present invention.

Claims

1. A solid-phase extraction column, comprising a column tube (1) and a sieve plate (2) installed in the column tube (1), a solid adsorbent (3) is placed on the sieve plate (2), and the solid adsorbent (3) is located in the column tube (1), characterized in that: An airbag (4) is installed inside the column tube (1), the airbag (4) is buried in the solid adsorbent (3), and the airbag (4) is communicated with an inflation assembly.

2. The solid-phase extraction column according to claim 1, wherein: The inflation assembly includes a connecting pipe (5) communicated with the internal cavity of the airbag (4), and one end of the connecting pipe (5) far away from the airbag (4) is communicated with a syringe (6).

3. The solid phase extraction column according to claim 1, wherein: A filter plate (7) is slidably connected inside the column tube (1), a connecting rod (8) is fixedly connected to the filter plate (7), a locking assembly is installed between the connecting rod (8) and the column tube (1), a through hole (9) adapted to the connecting pipe (5) is formed in the filter plate (7), the connecting pipe (5) passes through the through hole (9), and the airbag (4) is located between the filter plate (7) and the sieve plate (2).

4. The solid phase extraction column according to claim 3, wherein: The locking assembly includes a limiting rod (10) hinged to the top of the connecting rod (8), an elastic assembly is installed between the connecting rod (8) and the limiting rod (10), when the elastic assembly is in a natural stretching state, the connecting rod (8) and the limiting rod (10) are respectively attached to the inner side wall and the outer side wall of the column tube (1).

5. The solid phase extraction column according to claim 4, wherein: The elastic assembly includes a spring (11), two ends of the spring (11) are respectively fixedly connected to the side walls of the connecting rod (8) and the limiting rod (10), when the spring (11) is in a natural stretching state, the connecting rod (8) and the limiting rod (10) are respectively attached to the inner side wall and the outer side wall of the column tube (1).

6. A solid-phase extraction device, comprising the solid-phase extraction column as described in claim 1, characterized in that: It includes a bracket (12), a conduction channel (13) is installed on the bracket (12), the top end of the conduction channel (13) is communicated with the solid phase extraction column; a receiving assembly for containing liquid is placed at the bottom end of the conduction channel (13).

7. The solid-phase extraction device according to claim 6, characterized in that: The receiving assembly includes a test tube (14), and the opening end of the test tube (14) faces the bottom end of the conduction channel (13).

8. The solid-phase extraction device according to claim 7, wherein: The number of the conduction channels (13) is multiple, and the numbers of the solid phase extraction column and the test tube (14) are both adapted to the number of the conduction channels (13).

9. The solid phase extraction device according to claim 8, characterized in that: An installation plate (15) is installed on the bracket (12), a plurality of through holes (16) are formed in the installation plate (15), the diameters of the plurality of through holes (16) are all larger than the diameter of the tube body of the test tube (14) and smaller than the diameter of the tube orifice of the test tube (14); the number of the through holes (16) is equal to the number of the conduction channels (13), and the positions of the plurality of through holes (16) correspond to the positions of the plurality of conduction channels (13) one by one.

10. The solid phase extraction device according to claim 9, characterized in that: A plurality of horizontally extending sliding grooves (17) are formed in the side wall of the bracket (12), and the plurality of sliding grooves (17) are all adapted to the outer contour of the installation plate (15).

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