Device for decolorizing and concentrating clavulanic acid

Abstract

The utility model is suitable for the technical field of decolorizing and concentrating equipment, and provides a clavulanic acid decolorizing and concentrating device which comprises a decolorizing and concentrating kettle, the kettle cover is fixed at the top of the decolorizing and concentrating kettle through a bolt; the electric push rod is fixed at the central position of the top of the kettle cover through a bolt; the stainless steel thermometer probe is fixed at the output end of the electric push rod; the infrared liquid level sensor is fixed at one side, close to the stainless steel thermometer probe, of the bottom of the kettle cover through a screw; the filling pipe is fixed at one side, close to the electric push rod, of the top of the kettle cover through a bolt; the clavulanic acid solution is guided by the guide cover, so that the clavulanic acid solution is fully refrigerated to reduce the temperature, the clavulanic acid solution is ensured to be in a low-temperature state when being decolorized and concentrated in the decolorizing and concentrating kettle, the influence of temperature rise of the clavulanic acid solution on decolorizing and concentrating is avoided, and the product quality is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of decolorization and concentration equipment, in particular to a clavulanic acid decolorization and concentration device. Background Art

[0002] Clavulanic acid and other drugs are irreversible competitive β-lactamase inhibitors. They bind firmly to the enzyme and inactivate it, so they have a strong effect. They not only act on the β-lactamase of Staphylococcus aureus, but also on the β-lactamase of Gram-negative bacteria. When used in combination with penicillins and cephalosporins, they greatly enhance the antibacterial activity and significantly reduce the minimum inhibitory concentration (MIC). The drug can increase its efficacy by several to dozens of times, restoring the sensitivity of drug-resistant strains.

[0003] In actual industrial production, the production process of clavulanic acid generally goes through the steps of fermentation, membrane filtration, organic solvent extraction, concentration, decolorization, and crystallization. Except for fermentation and membrane filtration, all other operations are carried out in an ethyl acetate solvent system. Unit operations such as extraction, concentration, and decolorization are carried out under strong acid and low temperature conditions. In particular, the falling film evaporation medium operating temperature is as high as 50°C in the concentration and recovery of ethyl acetate. Under such high temperature conditions, the decolorization and concentration of clavulanic acid will be affected, reducing product quality. It is necessary to ensure that the temperature during decolorization and concentration is kept at a constant low temperature.

[0004] Therefore, a clavulanic acid decolorization and concentration device is proposed. Utility Model Content

[0005] The utility model provides a clavulanic acid decolorization and concentration device, aiming to solve the above problems.

[0006] The utility model is realized as follows: a clavulanic acid decolorization and concentration device comprises: a decolorization and concentration kettle; a kettle cover fixed to the top of the decolorization and concentration kettle by bolts; an electric push rod fixed to the center of the top of the kettle cover by bolts; a stainless steel thermometer probe fixed to the output end of the electric push rod; an infrared liquid level sensor fixed to the bottom of the kettle cover by screws at a position close to one side of the stainless steel thermometer probe; a filling pipe fixed to the top of the kettle cover by bolts at a position close to one side of the electric push rod; a flow guide hood fixed to the center of the interior of the decolorization and concentration kettle by bolts; a through hole provided at the bottom of the decolorization and concentration kettle at a position close to the outside of the flow guide hood; a flow guide groove provided at the center of the top of the flow guide hood; and a flow guide trough provided at the bottom of the decolorization and concentration kettle. The guide hole at the center of the bottom of the guide cover; the connecting pipe welded to the bottom of the decolorization and concentration kettle near the position directly below the through hole; the return cover welded to the bottom end of the connecting pipe; the circulating pump fixed by bolts at the position between the return cover and the decolorization and concentration kettle; the cooling jacket fixedly mounted on the outer wall of the decolorization and concentration kettle; the heat conduction layer coated on the inner wall of the cooling jacket; the coolant inlet pipe and the coolant outlet pipe welded to the outer wall of the cooling jacket, the coolant inlet pipe is located on one side of the coolant outlet pipe; the coolant flow cavity opened in the cooling jacket near one end of the coolant inlet pipe and the coolant outlet pipe; the support leg fixed to the bottom of the return cover by bolts; and the drain valve fixed by bolts at the center of the bottom of the return cover.

[0007] Preferably, the cross-sections of the guide cover and the guide groove are both isosceles trapezoidal structures, and the guide groove and the guide hole are connected.

[0008] Preferably, there are eight through holes in total, and the eight through holes are symmetrically opened at the inner bottom of the decolorization and concentration kettle, and the reflux cover and the through holes are all connected to the connecting pipe.

[0009] Preferably, the reflux hood is a hollow disc structure, and the reflux hood and the decolorization and concentration kettle are both connected to a circulation pump.

[0010] Preferably, the coolant inlet pipe and the coolant outlet pipe are both connected to the coolant flow cavity, and the cross section of the coolant flow cavity is an arc-shaped structure.

[0011] Preferably, one end of the cooling liquid inlet pipe is fixedly connected to the output end of an external refrigerator.

[0012] Compared with the prior art, the embodiments of the present application have the following beneficial effects:

[0013] The clavulanic acid solution is guided and directed by the flow guide hood, so that the clavulanic acid solution is fully refrigerated and the temperature is lowered, ensuring that the clavulanic acid solution is in a low temperature state during decolorization and concentration in the decolorization and concentration kettle, preventing the temperature rise of the clavulanic acid solution from affecting the decolorization and concentration, and improving product quality. The temperature of the middle position of the clavulanic acid solution can be detected by a stainless steel thermometer probe that adaptively rises and falls according to the change in the liquid level of the clavulanic acid solution, ensuring the accuracy of temperature detection. The temperature detection accuracy is also ensured by utilizing the clavulanic acid solution that circulates upward and downward. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a structural diagram of the utility model;

[0015] Figure 2 This is a schematic diagram of the coordination of the decolorization and concentration kettle and the flow guide cover of the utility model;

[0016] Figure 3 This is a schematic diagram of the structure of the air deflector of the utility model;

[0017] Figure 4 This is a schematic structural diagram of the kettle cover of the utility model;

[0018] Figure 5 This is a schematic diagram of the structure of the return hood of the utility model;

[0019] Figure 6 This is a schematic diagram of the cooling jacket structure of the utility model;

[0020] Figure 7 It is a cross-sectional view of the cooling jacket of the present utility model.

[0021] In the figure: 1. Decolorization and concentration kettle; 2. Kettle cover; 3. Electric push rod; 4. Stainless steel thermometer probe; 5. Infrared liquid level sensor; 6. Filling pipe; 7. Flow guide cover; 8. Through hole; 9. Flow guide groove; 10. Flow guide hole; 11. Connecting pipe; 12. Reflux cover; 13. Circulation pump; 14. Cooling jacket; 15. Heat transfer layer; 16. Coolant inlet pipe; 17. Coolant outlet pipe; 18. Coolant flow chamber; 19. Support leg; 20. Drain valve. DETAILED DESCRIPTION

[0022] Unless otherwise defined, all technical and scientific terms used herein have the same meanings as commonly understood by those skilled in the art to which this application belongs. The terms used in the specification of the application are only for the purpose of describing specific embodiments and are not intended to limit this application. The terms "including" and "having" and any variations thereof in the specification and claims of this application and the above-mentioned drawings are intended to cover non-exclusive inclusions. The terms "first", "second", etc. in the specification and claims of this application or the above-mentioned drawings are used to distinguish different objects, not to describe a specific order.

[0023] References herein to "embodiments" mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0024] The present invention provides a device for decolorizing and concentrating clavulanic acid. Figure 1-7As shown, it includes a decolorization and concentration kettle 1, the top of the decolorization and concentration kettle 1 is fixedly connected to the kettle cover 2 by bolts, the top center position of the kettle cover 2 is fixedly connected to an electric push rod 3 by bolts, the electric push rod 3 is fixedly connected to a stainless steel thermometer probe 4 through the output end on one side thereof, the bottom of the kettle cover 2 is fixedly connected to an infrared liquid level sensor 5 by screws at a side position near the stainless steel thermometer probe 4, a filling pipe 6 is welded to a side position near the top of the kettle cover 2 near the electric push rod 3, the inner bottom center position of the decolorization and concentration kettle 1 is fixedly connected to a flow guide cover 7 by bolts, and the inner bottom of the decolorization and concentration kettle 1 is provided with a through hole 8 at the outer position of the flow guide cover 7, there are eight through holes 8 in total, and the eight through holes 8 are symmetrically provided at the inner bottom of the decolorization and concentration kettle 1, and are connected to the reflux cover 12 and the through hole 8 with the connecting pipe 11, a flow guide groove 9 is provided at the top center position of the flow guide cover 7, and a flow guide hole 10 is provided at the bottom center position of the flow guide cover 7. A connecting pipe 11 is welded to the bottom of the decoloring and concentrating kettle 1 near the position just below the guide hole 10, and a return cover 12 is welded to the bottom end of the connecting pipe 11. The return cover 12 is a hollow disc structure, and the return cover 12 and the decoloring and concentrating kettle 1 are both connected to the circulating pump 13. The top of the return cover 12 and the bottom of the decoloring and concentrating kettle 1 are fixedly connected with the circulating pump 13 by bolts. A cooling jacket 14 is fixed to the outside of the decoloring and concentrating kettle 1, and the inner wall of the cooling jacket 14 is coated with a heat conductive layer 15. The cooling jacket 14 A coolant inlet pipe 16 and a coolant outlet pipe 17 are welded to the outer wall, one end of the coolant inlet pipe 16 is connected and fixed to the output end of the external refrigerator, the coolant inlet pipe 16 is located on one side of the coolant outlet pipe 17, and a coolant flow cavity 18 is opened inside the cooling jacket 14 near the coolant inlet pipe 16 and the coolant outlet pipe 17. The bottom of the return cover 12 is fixedly connected to the support leg 19 by bolts, and the drain valve 20 is fixedly connected to the center of the bottom of the return cover 12 by bolts.

[0025] It should be noted that since the unit operations such as clavulanic acid concentration and decolorization are carried out under strong acid and low temperature conditions, especially the concentration and ethyl acetate recovery section, the medium operating temperature of the falling film evaporation is as high as 50°C. Under such high temperature conditions, the decolorization and concentration of clavulanic acid will be affected, reducing the product quality. It is necessary to ensure that the temperature during decolorization and concentration is at a constant low temperature state. In this embodiment, the clavulanic acid solution is guided by the flow guide 7, so that the clavulanic acid solution is fully refrigerated and the temperature is reduced, ensuring that the clavulanic acid solution is at a low temperature during decolorization and concentration inside the decolorization and concentration kettle 1, avoiding the impact of the clavulanic acid solution temperature rise on decolorization and concentration, and improving product quality. The stainless steel thermometer probe 4, which is adaptively raised and lowered according to the change in the liquid level of the clavulanic acid solution, can detect the temperature at the middle position of the clavulanic acid solution, ensuring the accuracy of temperature detection, and utilizing the clavulanic acid solution circulating up and down to ensure the accuracy of temperature detection.

[0026] Specifically, in this embodiment, this solution mainly includes a flow guide cover 7. When the clavulanic acid concentration and decolorization operation is performed, the clavulanic acid solution is injected into the interior of the decolorization and concentration kettle 1 through the filling pipe 6, and the coolant inlet pipe 16 is connected to the output end of the external refrigerator. After the coolant is cooled, it flows into the coolant flow cavity 18 through the coolant inlet pipe 16. The coolant in the coolant flow cavity 18 flows around the decolorization and concentration kettle 1. Under the conduction of the heat conduction layer 15, the cold is conducted to the interior of the decolorization and concentration kettle 1. The temperature of the clavulanic acid solution is reduced after being cooled, thereby reducing the temperature of the clavulanic acid solution during concentration and decolorization. At this time, the circulation pump 13 is powered on and the adsorption force generated by the circulation pump 13 causes the clavulanic acid solution in the decolorization and concentration kettle 1 to circulate between the decolorization and concentration kettle 1 and the reflux cover 12. Specifically, the clavulanic acid solution It is sprayed upward through the guide hole 10, and under the guidance of the guide groove 9, the clavulanic acid solution flows into the space between the decolorization and concentration kettle 1 and the guide cover 7. At this time, the clavulanic acid solution is cooled and cooled. The clavulanic acid solution passes through the through hole 8 and the connecting pipe 11 and enters the reflux cover 12. Finally, it is sprayed upward by the circulation pump 13 to form a circulation. When the temperature of the clavulanic acid solution is detected, the infrared liquid level sensor 5 detects the solution height in the decolorization and concentration kettle 1. According to the height of the detection position, the external PLC controller controls the electric push rod 3 to drive the stainless steel thermometer probe 4 downward through the output end on one side thereof, so that the stainless steel thermometer probe 4 drops to the middle of the clavulanic acid solution level. The stainless steel thermometer probe 4 is used to detect the temperature of the clavulanic acid solution, thereby controlling the flow rate of the coolant in the coolant flow cavity 18.

[0027] In a further preferred embodiment of the present invention, Figure 2-3 As shown, the cross sections of the air guide cover 7 and the air guide groove 9 are both isosceles trapezoidal structures, and the air guide groove 9 is connected to the air guide hole 10.

[0028] In this embodiment, the solvent in the decolorization and concentration kettle 1 can be inclined and guided by the outer wall of the guide cover 7 and the inner wall of the guide groove 9, so that the solvent circulates up and down, and then the solvent comes into contact with the cold energy conducted by the cooling jacket 14, thereby cooling the solvent and ensuring that the concentration and decolorization operations of the clavulanic acid in the solvent are carried out at a low temperature.

[0029] In a further preferred embodiment of the present invention, Figure 7 As shown, the coolant inlet pipe 16 and the coolant outlet pipe 17 are both connected to the coolant flow chamber 18, and the cross section of the coolant flow chamber 18 is an arc-shaped structure.

[0030] In this embodiment, the provision of the cooling liquid flow cavity 18 allows the cooling liquid to flow around the outer wall of the decolorization and concentration tank 1 , thereby ensuring that the solvent in the decolorization and concentration tank 1 is fully cooled.

[0031] It should be noted that for the aforementioned embodiments, for simplicity of description, they are all expressed as a series of action combinations. However, those skilled in the art should be aware that the present invention is not limited by the order of the actions described, because according to the present invention, certain steps may be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in this specification are all preferred embodiments, and the actions and modules involved are not necessarily required by the present invention.

[0032] In the several embodiments provided in this application, it should be understood that the disclosed devices can be implemented in other ways. For example, the device embodiments described above are merely illustrative, such as the division of the above-mentioned units. In actual implementation, there may be other division methods, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the coupling or communication connection between each other shown or discussed can be through some interfaces, and the indirect coupling or communication connection between devices or units can be in the form of telecommunications or other forms.

[0033] The units described above as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed across multiple network units. Some or all of these units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0034] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the scope of protection of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, rather than all embodiments. Based on these embodiments, all other embodiments obtained by ordinary technicians in this field without making any creative work are within the scope to be protected by the present invention. Although the present invention has been described in detail with reference to the above embodiments, ordinary technicians in this field can still combine, add, delete or make other adjustments to the features in the various embodiments of the present invention according to the circumstances without conflict, without making any creative work, so as to obtain different other technical solutions that do not deviate from the concept of the present invention in essence, and these technical solutions also fall within the scope to be protected by the present invention.

Claims

1. A clavulanic acid decolorization and concentration device, characterized in that: include: Decolorization and concentration kettle (1); A kettle cover (2) fixed to the top of the decolorization and concentration kettle (1) by bolts; An electric push rod (3) fixed to the center of the top of the kettle cover (2) by bolts; A stainless steel thermometer probe (4) fixed to the output end of the electric push rod (3); An infrared liquid level sensor (5) is fixed to the bottom of the kettle cover (2) at a position close to the side of the stainless steel thermometer probe (4) by screws; A filling pipe (6) fixed to the top of the kettle cover (2) at a position close to one side of the electric push rod (3) by bolts; A flow guide cover (7) fixed to the central position of the decolorization and concentration kettle (1) by bolts; A through hole (8) is provided at the bottom of the decolorization and concentration kettle (1) near the outer side of the flow guide cover (7); A guide groove (9) is provided at the center of the top of the guide cover (7); and A diversion hole (10) is provided at the center of the bottom of the diversion cover (7); A connecting pipe (11) welded to the bottom of the decolorization and concentration kettle (1) at a position directly below the through hole (8); A reflux cover (12) welded to the bottom end of the connecting pipe (11); A circulating pump (13) fixed by bolts at a position between the reflux cover (12) and the decolorization and concentration kettle (1); A cooling jacket (14) fixedly mounted on the outer side wall of the decolorization and concentration kettle (1); a heat conducting layer (15) coated on the inner side wall of the cooling jacket (14); a coolant inlet pipe (16) and a coolant outlet pipe (17) welded to the outer wall of the cooling jacket (14), wherein the coolant inlet pipe (16) is located on one side of the coolant outlet pipe (17); A cooling liquid flow cavity (18) is provided inside the cooling jacket (14) near one end of the cooling liquid inlet pipe (16) and the cooling liquid outlet pipe (17); Support legs (19) fixed to the bottom of the return hood (12) by bolts; and A drain valve (20) is fixed at the center of the bottom of the return cover (12) by bolts.

2. A clavulanic acid decolorization and concentration device according to claim 1, characterized in that: The cross-sections of the guide cover (7) and the guide groove (9) are both isosceles trapezoidal structures, and the guide groove (9) and the guide hole (10) are connected.

3. The clavulanic acid decolorization and concentration device according to claim 1, characterized in that: There are eight through holes (8) in total, and the eight through holes (8) are symmetrically opened at the inner bottom of the decolorization and concentration kettle (1). The reflux cover (12) and the through holes (8) are both connected to the connecting pipe (11).

4. The clavulanic acid decolorization and concentration device according to claim 1, characterized in that: The reflux hood (12) is a hollow disc-shaped structure, and the reflux hood (12) and the decolorization and concentration kettle (1) are both connected to the circulation pump (13).

5. The clavulanic acid decolorization and concentration device according to claim 1, characterized in that: The coolant inlet pipe (16) and the coolant outlet pipe (17) are both connected to the coolant flow cavity (18), and the cross section of the coolant flow cavity (18) is an arc-shaped structure.

6. The clavulanic acid decolorization and concentration device according to claim 1, characterized in that: One end of the cooling liquid inlet pipe (16) is connected and fixed to the output end of the external refrigerator.

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