Novel reaction equipment for purifying N-(2-aminoethyl) morpholine-4-formamide oxalate

Abstract

The utility model belongs to the technical field of reaction equipment, and in particular relates to novel reaction equipment for purifying N-(2-aminoethyl) morpholine-4-formamide oxalate, which comprises a reaction tank, the top of the reaction tank is fixedly connected with a mounting cover, and the mounting cover is fixedly connected with the bottom of the reaction tank. The top of the reaction tank is fixedly communicated with a feeding pipe used for adding an N-(2-aminoethyl) morpholine-4-formamide oxalate raw material, and the top of the feeding pipe is fixedly communicated with a feeding hopper. By means of screening after cutting smashing and grinding smashing, blocky large raw materials can be smashed, so that raw material particles entering the reaction tank are smaller and finer, full contact reaction purification in the later period is facilitated, the reaction effect and efficiency are improved, the purification effect and efficiency are further improved, through the stirring mechanism, stirring is facilitated, and the raw materials can be better purified. And meanwhile, the N-(2-aminoethyl) morpholine-4-formamide oxalate attached to the inner wall of the reaction tank is favorably scraped off, so that the discharging is more complete and thorough.

Description

Technical Field

[0001] The utility model relates to the technical field of reaction equipment, in particular to a novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate. Background Art

[0002] N-(2-aminoethyl)morpholine-4-carboxamide oxalate is a key intermediate in the synthesis of landiolol hydrochloride, an oral and topical antibiotic that effectively combats bacterial infections such as oral, pharyngeal, middle ear, and pharyngitis, as well as pathogens such as gonorrhea and urinary tract infections. It is also used for the emergency treatment of tachyarrhythmias that occur during or after surgery during dynamic circulatory monitoring, and for the treatment of tachyarrhythmias such as atrial fibrillation and atrial flutter in patients with heart failure. The production and preparation of N-(2-aminoethyl)morpholine-4-carboxamide oxalate requires the use of novel reaction equipment for its purification.

[0003] However, the reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate in the related art still has shortcomings during use. When adding the N-(2-aminoethyl)morpholine-4-carboxamide oxalate raw material, the raw material may become compacted due to moisture, or enter the reaction tank for reaction due to its own large lumps. The large raw material will greatly reduce the effect and efficiency of the reaction, thereby affecting the effect and efficiency of purification. Therefore, we have proposed a new reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate to solve the above problems. Utility Model Content

[0004] The purpose of the utility model is to solve the above-mentioned shortcomings and to propose a novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate.

[0005] In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0006] A novel reaction device for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate comprises a reaction tank, a mounting cover fixedly connected to the top of the reaction tank, a feed pipe fixedly connected to the top of the reaction tank for adding the N-(2-aminoethyl)morpholine-4-carboxamide oxalate raw material, a feed hopper fixedly connected to the top of the feed pipe, heating plates fixedly connected to both sides of the reaction tank, a stirring mechanism provided between the reaction tank and the mounting cover, and a crushing mechanism provided between the mounting cover and the feed pipe, the crushing mechanism comprising a cutting and crushing assembly and a grinding and crushing assembly.

[0007] As a preferred embodiment of the present invention, the stirring mechanism includes a servo motor fixedly connected to the top of the mounting cover, a drive shaft fixedly connected to the output shaft of the servo motor, four stirring rods fixedly connected on both sides of the drive shaft, and one end of the four stirring rods located on the same side is fixedly connected to the same scraper, and both scrapers are movably abutted against the inner wall of the reaction tank.

[0008] As a preferred embodiment of the present invention, the bottoms of the two stirring rods at the bottom are fixedly connected to connecting rods, and the two scrapers are respectively fixedly connected to the bottom ends of the corresponding connecting rods.

[0009] As a preferred embodiment of the present invention, the cutting and crushing assembly includes a driving bevel gear fixedly sleeved on the outside of the drive shaft, and a horizontal shaft rotatably connected to the inner walls on both sides of the feed pipe, and the two horizontal shafts are fixedly connected to the driven bevel gears at one end close to each other, and the two driving bevel gears are respectively engaged with the corresponding driven bevel gears, and a plurality of crushing knives are fixedly connected to the outside of the two horizontal shafts.

[0010] As a preferred embodiment of the present invention, the multiple crushing knives are respectively located in corresponding feed pipes.

[0011] As a preferred embodiment of the present invention, the grinding and crushing assembly includes a screen plate fixedly connected to the feed pipe, a worm fixedly sleeved on the outside of the horizontal axis, and two stabilizing plates fixedly connected to the top of the reaction tank, the front sides of the two stabilizing plates are rotatably connected to worm wheels, the two worms are respectively engaged with the corresponding worm wheels, the front sides of the two worm wheels are rotatably connected to movable rods, the ends of the two movable rods away from each other are rotatably connected to movable plates, the bottoms of the two movable plates are fixedly connected to mounting frames, the front and rear inner walls of the mounting frames are rotatably connected to grinding rollers, and the two grinding rollers are respectively rollingly connected to the tops of the corresponding screen plates.

[0012] As a preferred embodiment of the present invention, three support rods are fixedly connected to the inner walls of the front and rear sides of the feed pipe, the screen plate is fixedly connected to the top of the three support rods, the two feed pipes are fixedly connected to the sides close to each other with sealing sleeves, and the two movable plates are respectively slid into the corresponding sealing sleeves.

[0013] As a preferred embodiment of the present invention, the top of the feed hopper is detachably fixedly connected with a cover plate, the bottom of the reaction tank is fixedly connected with a discharge pipe, the top of one side of the reaction tank is fixedly connected with an air outlet pipe, and the bottom of the reaction tank is fixedly connected with four supporting legs.

[0014] In the utility model, the novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate drives the rotation of a driving shaft through a servo motor, the driving shaft drives the rotation of an active bevel gear, the active bevel gear drives the rotation of two driven bevel gears and a horizontal shaft, the two horizontal shafts drive the rotation of a crushing knife located in a feed pipe, thereby cutting and crushing large pieces of raw materials, the crushed raw materials fall onto a screen plate for screening, qualified raw material particles fall into a reaction tank for reaction, and unqualified raw material particles stay on the top of the screen plate, at this time the horizontal shaft drives the rotation of a worm, the worm drives the rotation of a worm wheel, the worm wheel drives the left and right reciprocating motion of a movable rod, a movable plate and a mounting frame, and the mounting frame drives two grinding rollers to roll back and forth on the screen plate;

[0015] In the utility model, the novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate can grind and crush unqualified raw material particles to make the raw material particles smaller, and then the raw material particles can fall into the reaction tank through the screen plate for reaction. At the same time, the driving shaft drives the rotation of the stirring rod, the connecting rod and the scraper, thereby efficiently stirring the raw material, so that it is fully contacted for reaction and purification, thereby improving the purification effect and efficiency. When discharging, the N-(2-aminoethyl)morpholine-4-carboxamide oxalate adhering to the inner wall of the reaction tank can be scraped off by the rotating scraper and discharged from the discharge pipe, making the discharge more complete and thorough.

[0016] The utility model has a reasonable structural design. By cutting, crushing and screening after grinding and crushing, larger block raw materials can be crushed, so that the raw material particles entering the reaction tank are smaller and finer, which is conducive to sufficient contact reaction and purification in the later stage, improves the effect and efficiency of the reaction, and further improves the effect and efficiency of the purification. The stirring mechanism is not only conducive to stirring and improving the reaction effect, but also conducive to scraping off the N-(2-aminoethyl)morpholine-4-carboxamide oxalate attached to the inner wall of the reaction tank and discharging it from the discharge pipe, so that the discharge is more complete and thorough. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic structural diagram of a novel reaction device for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate proposed in the present invention;

[0018] Figure 2 This is a cross-sectional view of a novel reaction device for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate proposed in the present invention;

[0019] Figure 3 for Figure 2 Schematic diagram of the structure of part A;

[0020] Figure 4 for Figure 2Schematic diagram of the structure of part B;

[0021] Figure 5 This is a stereoscopic diagram of the stirring mechanism of the novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate proposed in the present invention.

[0022] In the figure: 1. Reactor; 2. Mounting cover; 3. Servo motor; 4. Feed hopper; 5. Cover plate; 6. Exhaust pipe; 7. Discharge pipe; 8. Drive shaft; 9. Stirring rod; 10. Scraper; 11. Connecting rod; 12. Heating plate; 13. Active bevel gear; 14. Driven bevel gear; 15. Stabilizing plate; 16. Worm gear; 17. Movable rod; 18. Worm; 19. Horizontal axis; 20. Moving plate; 21. Sealing sleeve; 22. Mounting frame; 23. Grinding roller; 24. Screen plate; 25. Support rod; 26. Crushing knife; 27. Feed pipe; 28. Support leg. DETAILED DESCRIPTION

[0023] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0024] Reference Figure 1-5 A novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate comprises a reaction tank 1, a mounting cover 2 being fixedly connected to the top of the reaction tank 1, a feed pipe 27 for adding the raw material of N-(2-aminoethyl)morpholine-4-carboxamide oxalate being fixedly connected to the top of the reaction tank 1, a feed hopper 4 being fixedly connected to the top of the feed pipe 27, heating plates 12 being fixedly connected to both sides of the reaction tank 1, a stirring mechanism being provided between the reaction tank 1 and the mounting cover 2, a crushing mechanism being provided between the mounting cover 2 and the feed pipe 27, and the crushing mechanism comprising a cutting and crushing assembly and a grinding and crushing assembly.

[0025] As a further feature of the present invention, the stirring mechanism includes a servo motor 3 fixedly connected to the top of the mounting cover 2, a drive shaft 8 fixedly connected to the output shaft of the servo motor 3, four stirring rods 9 fixedly connected on both sides of the drive shaft 8, one end of the four stirring rods 9 located on the same side is fixedly connected to the same scraper 10, the two scrapers 10 are movably abutted against the inner wall of the reaction tank 1, the bottoms of the two bottom stirring rods 9 are fixedly connected to a connecting rod 11, and the two scrapers 10 are respectively fixedly connected to the bottom ends of the corresponding connecting rods 11.

[0026] According to the above scheme, the servo motor 3 drives the rotation of the drive shaft 8, and the drive shaft 8 drives the rotation of the stirring rod 9, the connecting rod 11 and the scraper 10, thereby efficiently stirring the raw materials, allowing them to fully contact the reaction and purification, thereby improving the purification effect and efficiency. When discharging, the N-(2-aminoethyl)morpholine-4-carboxamide oxalate attached to the inner wall of the reaction tank 1 can be scraped off by the rotating scraper 10 and discharged from the discharge pipe 7, making the discharge more complete and smooth.

[0027] As a further improvement of the present invention, the cutting and crushing assembly includes a driving bevel gear 13 fixedly sleeved on the outside of the drive shaft 8, and a horizontal shaft 19 rotatably connected to the inner walls of both sides of the feed pipe 27. The two horizontal shafts 19 are fixedly connected to the driven bevel gear 14 at one end close to each other. The two driving bevel gears 13 are respectively meshed with the corresponding driven bevel gears 14. The outsides of the two horizontal shafts 19 are fixedly connected to a plurality of crushing knives 26. The plurality of crushing knives 26 are respectively located in the corresponding feed pipes 27. The grinding and crushing assembly includes a screen plate 24 fixedly connected to the feed pipe 27, which is fixedly sleeved on the horizontal shaft 19. The worm 18 on the outside of the shaft 19 and the two stable plates 15 fixedly connected to the top of the reaction tank 1, the front sides of the two stable plates 15 are rotatably connected to the worm gear 16, the two worms 18 are respectively engaged with the corresponding worm gear 16, the front sides of the two worm gears 16 are rotatably connected to the movable rod 17, the ends of the two movable rods 17 away from each other are rotatably connected to the movable plate 20, the bottoms of the two movable plates 20 are fixedly connected to the mounting frame 22, the front and rear inner walls of the mounting frame 22 are rotatably connected to the grinding rollers 23, and the two grinding rollers 23 are respectively rollingly connected to the tops of the corresponding screen plates 24.

[0028] The above scheme is adopted: the servo motor 3 drives the rotation of the drive shaft 8, the drive shaft 8 drives the rotation of the active bevel gear 13, the active bevel gear 13 drives the rotation of the two driven bevel gears 14 and the horizontal shaft 19, and the two horizontal shafts 19 drive the rotation of the crushing knife 26 located in the feed pipe 27, thereby cutting and crushing large pieces of raw materials. The crushed raw materials fall onto the screen plate 24 for screening, and qualified raw material particles fall into the reaction tank 1 for reaction, while unqualified raw material particles stay on the top of the screen plate 24. At this time, the horizontal shaft 19 drives the rotation of the worm 18, and the worm 18 drives the rotation of the worm gear 16. The worm gear 16 drives the left and right reciprocating motion of the movable rod 17, the movable plate 20 and the mounting frame 22. The mounting frame 22 drives the two grinding rollers 23 to roll back and forth on the screen plate 24, thereby grinding and crushing the unqualified raw material particles, making the raw material particles smaller, and then they can fall into the reaction tank 1 through the screen plate 24 for reaction.

[0029] As a further feature of the present invention, three support rods 25 are fixedly connected to the inner walls of the front and rear sides of the feed pipe 27, the screen plate 24 is fixedly connected to the top of the three support rods 25, and the two feed pipes 27 are fixedly connected to the side close to each other with a sealing sleeve 21, and the two movable plates 20 are respectively slid into the corresponding sealing sleeves 21, which is convenient for supporting the screen plate 24, increasing the load, and preventing the grinding roller 23 from deforming during rolling. The connection between the movable plate 20 and the feed pipe 27 can be sealed through the sealing sleeve 21 to prevent leakage of material.

[0030] As a further feature of the present invention, the top of the feed hopper 4 is detachably fixedly connected to a cover plate 5, the bottom of the reaction tank 1 is fixedly connected to a discharge pipe 7, the top of one side of the reaction tank 1 is fixedly connected to an air outlet pipe 6, and the bottom of the reaction tank 1 is fixedly connected to four support legs 28.

[0031] The above solution is adopted: the feed hopper 4 can be sealed by the cover plate 5 to avoid splashing of raw materials during crushing, which is beneficial to discharging and convenient for exhaust and pressure relief. The reaction tank 1 can be stably supported by the support legs 28.

[0032] In the present invention, when in use, the N-(2-aminoethyl)morpholine-4-formamide oxalate raw material is introduced into the feed hopper 4, and the cover plate 5 is buckled to avoid the raw material from splashing out during crushing. The N-(2-aminoethyl)morpholine-4-formamide oxalate in the reaction tank 1 can be heated by the heating plate 12. The rotation of the drive shaft 8 is driven by the servo motor 3, and the drive shaft 8 drives the rotation of the active bevel gear 13. The active bevel gear 13 drives the rotation of two driven bevel gears 14 and the horizontal shaft 19. The two horizontal shafts 19 drive the rotation of the crushing knife 26 located in the feed pipe 27, thereby cutting and crushing large pieces of raw material. The crushed raw material falls onto the screen plate 24 for screening. Qualified raw material particles fall into the reaction tank 1 for reaction, while unqualified raw material particles stay on the top of the screen plate 24. At this time, the horizontal The shaft 19 drives the rotation of the worm 18, and the worm 18 drives the rotation of the worm gear 16. The worm gear 16 drives the reciprocating left and right motion of the movable rod 17, the movable plate 20 and the mounting frame 22. The mounting frame 22 drives the two grinding rollers 23 to roll back and forth on the screen plate 24, thereby grinding and crushing unqualified raw material particles to make the raw material particles smaller, and then fall into the reaction tank 1 through the screen plate 24 for reaction. At the same time, the drive shaft 8 drives the rotation of the stirring rod 9, the connecting rod 11 and the scraper 10, thereby efficiently stirring the raw materials, allowing them to fully contact the reaction and purification, thereby improving the purification effect and efficiency. When discharging, the rotating scraper 10 can scrape off the N-(2-aminoethyl)morpholine-4-carboxamide oxalate attached to the inner wall of the reaction tank 1 and discharge it from the discharge pipe 7, making the discharge more complete and smooth.

Claims

1. A novel reaction device for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate, characterized in that: The invention comprises a reaction tank (1), wherein the top of the reaction tank (1) is fixedly connected to a mounting cover (2), the top of the reaction tank (1) is fixedly connected to a feed pipe (27) for adding N-(2-aminoethyl)morpholine-4-carboxamide oxalate raw material, the top of the feed pipe (27) is fixedly connected to a feed hopper (4), both sides of the reaction tank (1) are fixedly connected to heating plates (12), a stirring mechanism is provided between the reaction tank (1) and the mounting cover (2), a crushing mechanism is provided between the mounting cover (2) and the feed pipe (27), and the crushing mechanism comprises a cutting and crushing component and a grinding and crushing component.

2. The novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate according to claim 1, characterized in that: The stirring mechanism comprises a servo motor (3) fixedly connected to the top of the mounting cover (2); a drive shaft (8) is fixedly connected to the output shaft of the servo motor (3); four stirring rods (9) are fixedly connected to both sides of the drive shaft (8); one end of the four stirring rods (9) located on the same side is fixedly connected to the same scraper (10); and the two scrapers (10) are movably abutted against the inner wall of the reaction tank (1).

3. The novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate according to claim 2, characterized in that: The bottoms of the two stirring rods (9) at the bottom are fixedly connected to a connecting rod (11), and the two scrapers (10) are respectively fixedly connected to the bottom ends of the corresponding connecting rods (11).

4. The novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate according to claim 2, characterized in that: The cutting and crushing assembly comprises a driving bevel gear (13) fixedly sleeved on the outside of the driving shaft (8), and a transverse shaft (19) rotatably connected to the inner walls of both sides of the feed pipe (27), the two transverse shafts (19) are fixedly connected to the driven bevel gears (14) at one end close to each other, the two driving bevel gears (13) are respectively meshed with the corresponding driven bevel gears (14), and the outer sides of the two transverse shafts (19) are fixedly connected to a plurality of crushing knives (26).

5. The novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate according to claim 4, characterized in that: The plurality of crushing knives (26) are respectively located in corresponding feed pipes (27).

6. The novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate according to claim 4, characterized in that: The grinding and crushing assembly includes a screen plate (24) fixedly connected to the feed pipe (27), a worm (18) fixedly sleeved on the outside of the transverse shaft (19), and two stabilizing plates (15) fixedly connected to the top of the reaction tank (1), the front sides of the two stabilizing plates (15) are rotatably connected to the worm gear (16), the two worm gears (18) are respectively engaged with the corresponding worm gears (16), the front sides of the two worm gears (16) are rotatably connected to the movable rod (17), the ends of the two movable rods (17) away from each other are rotatably connected to the movable plate (20), the bottoms of the two movable plates (20) are fixedly connected to the mounting frame (22), the front and rear inner walls of the mounting frame (22) are rotatably connected to the grinding rollers (23), and the two grinding rollers (23) are respectively rollingly connected to the tops of the corresponding screen plates (24).

7. The novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate according to claim 6, characterized in that: Three support rods (25) are fixedly connected to the front and rear inner walls of the feed pipe (27), the screen plate (24) is fixedly connected to the top of the three support rods (25), and the two feed pipes (27) are fixedly connected to the sides close to each other with sealing sleeves (21), and the two movable plates (20) are respectively slidably provided in the corresponding sealing sleeves (21).

8. The novel reaction equipment for purifying N-(2-aminoethyl)morpholine-4-carboxamide oxalate according to claim 1, characterized in that: The top of the feed hopper (4) is detachably fixedly connected to a cover plate (5), the bottom of the reaction tank (1) is fixedly connected to a discharge pipe (7), the top of one side of the reaction tank (1) is fixedly connected to an air outlet pipe (6), and the bottom of the reaction tank (1) is fixedly connected to four support legs (28).

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