Kit for detecting activity of NK (Natural Killer) cells

Abstract

The utility model provides an NK cell activity detection kit, and belongs to the technical field of kits. The NK cell activity detection kit disclosed by the utility model comprises a shell, a cover plate, a supporting part, a movable limiting part, a fixed limiting part, a fixed clamping block, a movable clamping block, a spring, a placement groove and the like, the test tubes with different thicknesses can be stably placed in the movable limiting holes, meanwhile, the test tubes can be conveniently pulled out and inserted through the fixed limiting parts, and the test tubes can be directly pulled out when the test tubes are used; in addition, the fixed limiting part and the movable limiting part can realize double fixation of the test tube; in addition, the test tube rack is further provided with a supporting part, a plurality of clamping grooves are formed in the supporting part, and the clamping grooves can adapt to fixation of test tubes with different lengths in actual use.

Description

Technical Field

[0001] The utility model relates to the technical field of kits, in particular to a NK cell activity detection kit. Background Art

[0002] In the human immune system, T lymphocytes are responsible for the primary immune function. Cytotoxic T lymphocytes are a specialized type of T lymphocyte that play a crucial role in defending against tumor formation and viral infection. When cytotoxic T lymphocytes are killing, their T cell receptors must recognize antigenic peptides presented by MHC molecules on antigen-presenting cells or target cells. During this process, the T cell receptors must recognize not only the antigenic peptides but also the type of MHC molecule bound to them, a phenomenon known as MHC restriction. However, in order to evade the body's immune surveillance, most tumor cells and some virus-infected cells typically significantly downregulate or even eliminate the expression of MHC molecules on their cell surfaces (referred to as "self-loss"). Consequently, T lymphocytes are unable to function.

[0003] NK cells (natural killer cells) were discovered in the 1970s while researchers were studying the specific killing of target cells by T cells. NK cells also primarily kill tumor cells and virus-infected cells, but they mediate innate immune responses and can instantly kill tumor cells and virus-infected cells independently of antibodies and complement. NK cell activity can be used as an indicator of the body's ability to fight tumors and viral infections. Testing NK cell activity can aid in the diagnosis of certain diseases and monitor a patient's immune status.

[0004] Traditional test kits for detecting NK cell activity mainly consist of a box body and an inner liner with a hole for inserting test tubes. In order to prevent the test tubes from slipping, the diameter of the hole is usually slightly smaller than the diameter of the test tube. When inserting the test tubes, the flexibility of the inner liner is used to clamp the outer wall of the test tube. Therefore, during the process of inserting the test tubes, the user usually needs to hold the box body with his hand and then forcefully pull out the test tubes. This makes it inconvenient to insert and pull out the test tubes in the traditional test kit for detecting NK cell activity, and the stability of the test tubes in the test kit is extremely poor. At the same time, the singleness of the stabilizing device makes it unable to adapt to the storage of test tubes of different lengths and thicknesses.

[0005] Therefore, it is of great practical significance to provide a kit for detecting cell activity that can quickly and conveniently insert and withdraw test tubes and has good test tube stability. Utility Model Content

[0006] The purpose of the utility model is to provide a NK cell activity detection kit. The NK cell activity detection kit of the utility model is convenient for insertion and withdrawal and has good stability, thereby solving the technical problems of inconvenient insertion and withdrawal of test tubes and poor stability in the prior art.

[0007] In order to achieve the above-mentioned purpose of the utility model, the utility model provides the following technical solutions:

[0008] The utility model provides a NK cell activity detection kit, comprising:

[0009] The housing is a square box with an open top;

[0010] a cover plate, covering the opening of the housing;

[0011] A support portion is vertically arranged on the inner bottom surface of the shell, and a plurality of slots are evenly arranged in the vertical direction on the side wall of the support portion;

[0012] a fixed limiting portion, fixed to the upper end of the supporting portion in a horizontal direction, wherein a movable limiting hole is formed on the fixed limiting portion, and the movable limiting hole is used to clamp the test tube;

[0013] The movable limiting part is clamped in the clamping slot. A fixed limiting hole is opened on the movable limiting part. The movable limiting hole and the fixed limiting hole are arranged opposite to each other, and the two cooperate to fix the test tube.

[0014] Furthermore, the support portion includes:

[0015] a bottom plate, the lower side of which is connected to the inner bottom surface of the shell;

[0016] The support plate is fixed on the bottom plate in a vertical direction, and at least two support plates are provided. The side walls on the same side of at least two support plates are provided with the card slot.

[0017] Furthermore, the support portion further includes:

[0018] A limiting member is provided on the support plate at the open end of the slot, and the limiting member is passed through the through hole. The limiting member is used to limit the movable limiting portion.

[0019] Furthermore, the fixed limiting portion includes:

[0020] A fixed clamping block, both ends of which are connected to the upper ends of the two adjacent support plates;

[0021] The movable clamping block is slidably connected to the fixed clamping block, and arc grooves are respectively provided on two side walls of the fixed clamping block and the movable clamping block that are opposite to each other.

[0022] Furthermore, the fixing clamp block is provided with two placement grooves, and the two placement grooves are respectively located on both sides of the arc groove.

[0023] Furthermore, a spring and a drive plate are provided in the placement slot, one end of the spring is connected to the side wall of the placement slot, and the other end is connected to one side of the drive plate, and the spring is used to apply tension to the drive plate.

[0024] Furthermore, a connecting shaft is provided on the other side of the driving plate, one end of the connecting shaft is fixedly connected to the driving plate, and the other end passes through the fixed clamp block and is connected to the movable clamp block, and the spring drives the movable clamp block and the driving plate to move synchronously.

[0025] Furthermore, the movable limiting portion includes several flat plates, the middle of the flat plates is provided with the fixed limiting hole, the upper side of the flat plates is provided with a snap-in slot, and after the flat plates are snapped into the snap-in slots, the flat plates are limited by the snap-in slots.

[0026] Compared with the prior art, the present invention includes structures such as a fixed limiting part and a movable limiting part. When in use, test tubes of different thicknesses can be placed stably in the movable limiting hole. At the same time, the fixed limiting part is convenient for the insertion and extraction of the test tube, and the test tube can be directly pulled out when in use. In addition, the fixed limiting part and the movable limiting part described in the present invention can achieve dual fixation of the test tube. In addition, the present invention is also provided with a supporting part, and a plurality of card slots are opened in the supporting part, and the card slots can adapt to the fixation of test tubes of different lengths in actual use. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a top view of the NK cell activity detection kit of the utility model;

[0028] Figure 2 This is a first cross-sectional view of the NK cell activity detection kit of the utility model;

[0029] Figure 3 This is a second cross-sectional view of the NK cell activity detection kit of the present utility model;

[0030] Figure 4 This is a top view of the movable limiting plate of the NK cell activity detection kit of the present utility model;

[0031] Figure 5 for Figure 1 A magnified view of middle A;

[0032] Figure 6 for Figure 2 Enlarged view of middle B;

[0033] Among them, 100-shell, 200-cover, 300-support part, 400-fixed limiting part, 500-movable limiting part, 600-slot, 700-movable limiting hole, 800-fixed limiting hole, 301-bottom plate, 302-support plate, 303-limiting member, 304-through hole, 401-fixed clamping block, 402-movable clamping block, 403-arc groove, 404-placement groove, 405-spring, 406-drive plate, 407-connecting shaft, 501-flat plate, 502-clamping groove. DETAILED DESCRIPTION

[0034] The following embodiments are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0035] In the description of this application, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application.

[0036] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature specified as "first" or "second" may explicitly or implicitly include one or more of such features. Throughout this application, unless otherwise specified, "plurality" means two or more.

[0037] In the description of this application, it should be noted that, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "connected" should be understood in a broad sense. For example, they can refer to fixed connections, detachable connections, or integral connections; mechanical connections or electrical connections; direct connections or indirect connections through an intermediate medium; and internal connections between two components. Those skilled in the art will understand the specific meanings of the above terms in this application based on the specific circumstances.

[0038] The utility model provides a NK cell activity detection kit, comprising:

[0039] The housing 100 is a square box with an open top;

[0040] A cover plate 200 covering the opening of the housing 100;

[0041] The support portion 300 is vertically arranged on the inner bottom surface of the housing 100, and a plurality of slots 600 are evenly arranged in the vertical direction on the sidewall of the support portion 300;

[0042] A fixed limiting portion 400 is fixed to the upper end of the support portion 300 in the horizontal direction. A movable limiting hole 700 is formed on the fixed limiting portion 400. The movable limiting hole 700 is used to clamp the test tube;

[0043] The movable limiting portion 500 is locked in the locking slot 600. A fixed limiting hole 800 is opened on the movable limiting portion 500. The movable limiting hole 700 is arranged opposite to the fixed limiting hole 800, and the two cooperate to fix the test tube.

[0044] In the present invention, the head and tail of the test tube are doubly fixed by the fixed limiting portion 400 and the movable limiting portion 500, thereby protecting the test tube from being damaged due to shaking.

[0045] Furthermore, the support portion 300 includes:

[0046] A bottom plate 301 , the lower side of which is connected to the inner bottom surface of the housing 100 ;

[0047] The support plates 302 are fixed on the bottom plate 301 in a vertical direction, and at least two support plates 302 are provided. The slots 600 are opened on the side walls of at least two support plates 302 on the same side.

[0048] The support plates 302 of the present invention are evenly arranged in the vertical direction, which can enable the movable limiting part 500 to be clamped in the clamping groove 600, thereby fixing test tubes of different lengths. Furthermore, the movable limiting part 500 can be adjusted as needed during use.

[0049] Furthermore, the support portion 300 further includes:

[0050] The limiting member 303 is provided with a through hole 304 on the support plate 302 at the open end of the slot 600 , and the limiting member 303 is passed through the through hole 304 . The limiting member 303 is used to limit the movable limiting portion 500 .

[0051] Furthermore, the fixed limiting portion 400 includes:

[0052] A fixed clamping block 401, both ends of which are connected to the upper ends of the two adjacent support plates 302;

[0053] The movable clamping block 402 is slidably connected to the fixed clamping block 401 , and arc-shaped grooves 403 are respectively formed on the two opposite side walls of the fixed clamping block 401 and the movable clamping block 402 .

[0054] Furthermore, two placement slots 404 are provided on the fixing clamp block 401 , and the two placement slots 404 are respectively located on both sides of the arc-shaped slot 403 .

[0055] Furthermore, a spring 405 and a driving plate 406 are provided in the placement groove 404 , one end of the spring 405 is connected to the side wall of the placement groove 404 , and the other end is connected to one side of the driving plate 406 , and the spring 405 is used to apply tension to the driving plate 406 .

[0056] Furthermore, a connecting shaft 407 is provided on the other side of the driving plate 406, one end of the connecting shaft 407 is fixedly connected to the driving plate 406, and the other end passes through the fixed clamp 401 and is connected to the movable clamp 402, and the spring 405 drives the movable clamp 402 and the driving plate 406 to move synchronously.

[0057] When the diameter of the test tube is larger than the size of the cavity formed by the arc-shaped groove 403, the connecting shaft 407 drives the driving plate 406 to slide, and the driving plate 406 squeezes the spring 405 in the placement groove 404, so that the cavity space formed between the movable clamping block 402 and the fixed clamping block 401 becomes larger, thereby making it adaptable to test tubes of different sizes. The placement groove, spring 405, driving plate 406 and connecting shaft 407 cooperate to enable the fixed limiter 400 to adapt to test tubes of different thicknesses. In addition, since the arc structure of the arc-shaped groove 403 is compatible with the tube wall structure of the test tube, it can provide a certain support for the test tube, making it easier to place the test tube.

[0058] Furthermore, a buffer layer made of a rubber layer or other material can be added to the inner wall of the arc groove 403. By setting the material of the buffer layer to a flexible material, when placing the test tube, the force between the test tube and the arc groove 403 is buffered, thereby providing a certain protection to the tube wall of the test tube to prevent the test tube from being pinched and broken. At the same time, the flexible material of the buffer layer can further stabilize the test tube and prevent the test tube from slipping out of the cavity formed by the arc groove 403 between the fixed clamp block 401 and the movable clamp block 402.

[0059] Furthermore, the movable limiting portion 500 includes several flat plates 501, the fixed limiting hole 800 is opened in the middle of the flat plate 501, and a snap-in groove 502 is opened on the upper side of the flat plate 501. After the flat plate 501 is snapped into the snap-in groove 600, the flat plate 501 is limited by the snap-in groove 502.

[0060] Those skilled in the art will understand that the above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art will be able to modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein with equivalents. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A NK cell activity detection kit, characterized in that: include: The housing is a square box with an open top; a cover plate, covering the opening of the housing; A support portion is vertically arranged on the inner bottom surface of the shell, and a plurality of slots are evenly arranged in the vertical direction on the side wall of the support portion; a fixed limiting portion, fixed to the upper end of the supporting portion in a horizontal direction, wherein a movable limiting hole is formed on the fixed limiting portion, and the movable limiting hole is used to clamp the test tube; The movable limiting part is clamped in the clamping slot. A fixed limiting hole is opened on the movable limiting part. The movable limiting hole and the fixed limiting hole are arranged opposite to each other, and the two cooperate to fix the test tube.

2. The NK cell activity detection kit according to claim 1, characterized in that The support portion includes: a bottom plate, the lower side of which is connected to the inner bottom surface of the shell; The support plate is fixed on the bottom plate in a vertical direction, and at least two support plates are provided. The side walls on the same side of at least two support plates are provided with the card slot.

3. The NK cell activity detection kit according to claim 2, characterized in that The support portion further comprises: A limiting member is provided on the support plate at the open end of the slot, and the limiting member is passed through the through hole. The limiting member is used to limit the movable limiting portion.

4. The NK cell activity detection kit according to claim 2, characterized in that The fixed limiting portion includes: A fixed clamping block, both ends of which are connected to the upper ends of the two adjacent support plates; The movable clamping block is slidably connected to the fixed clamping block, and arc grooves are respectively provided on two side walls of the fixed clamping block and the movable clamping block that are opposite to each other.

5. The NK cell activity detection kit according to claim 4, characterized in that The fixed clamping block is provided with two placement grooves, and the two placement grooves are respectively located on both sides of the arc groove.

6. The NK cell activity detection kit according to claim 5, characterized in that A spring and a driving plate are provided in the placement slot, one end of the spring is connected to the side wall of the placement slot, and the other end is connected to one side of the driving plate. The spring is used to apply tension to the driving plate.

7. The NK cell activity detection kit according to claim 6, characterized in that A connecting shaft is provided on the other side of the driving plate, one end of the connecting shaft is fixedly connected to the driving plate, and the other end passes through the fixed clamping block and is connected to the movable clamping block, and the spring drives the movable clamping block and the driving plate to move synchronously.

8. The NK cell activity detection kit according to any one of claims 1 to 7, characterized in that: The movable limiting portion includes a plurality of flat plates, the middle of which is provided with the fixed limiting hole, and the upper side of which is provided with a clamping groove. After the flat plate is clamped in the clamping groove, the flat plate is limited by the clamping groove.

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