Incubator for cell culture

Abstract

The utility model belongs to the technical field of cell culture, and particularly relates to an incubator for cell culture, which is characterized in that the interior of an incubator body is divided into an upper culture bin and a lower culture bin through a partition plate; the supporting mechanism comprises a vibration assembly and a supporting assembly, the vibration assembly comprises a vibration plate, a mounting groove is formed in the vibration plate, a micro vibrator is arranged in the mounting groove, and a vibration disc is arranged above the micro vibrator; the supporting assembly comprises a supporting plate, a supporting groove is formed in the supporting plate, and a temperature regulator is arranged in the supporting groove; according to the utility model, the cell vessels are respectively placed in the vibration disc and the supporting groove, and the vibration disc is controlled, so that the influence of different vibration amplitudes on the growth, differentiation and metabolism of cells can be known. By adjusting the temperature, the influence of different temperature settings on the physiological activity of the cells can be known. And further collecting data of cell growth, morphological change and metabolic activity. By dismounting the supporting mechanism, it is ensured that the interior of the box body can be effectively cleaned and maintained, and the service life of the incubator is prolonged.

Description

Technical Field

[0001] The utility model belongs to the technical field of cell culture, and particularly relates to an incubator for cell culture. Background Art

[0002] Cell culture refers to a method of simulating the in vivo environment (sterility, suitable temperature, pH and certain nutritional conditions, etc.) in vitro to enable cells to survive, grow, reproduce and maintain their main structures and functions. During the culture process, cells need to be placed in an incubator, which regulates the temperature inside the incubator to allow the cells to reproduce.

[0003] In modern biomedicine, cell culture technology has become an indispensable part of basic scientific research and biopharmaceutical engineering. Whether conducting cell biology research, establishing disease models, or drug screening and development, efficient and precise control of the cell growth environment is crucial.

[0004] Existing cell culture incubators cannot adjust vibration amplitude and temperature combinations to simulate different in vivo environments or experimental conditions. This requires multiple tests, resulting in low test efficiency and data bias. Furthermore, the incubator's support mechanism cannot be quickly disassembled after cell culture is complete, making post-culture cleaning and maintenance difficult. Utility Model Content

[0005] The purpose of this utility model is to provide a cell culture incubator that can precisely control the vibration amplitude of the vibrating plate and the culture temperature within the support plate to simulate different in vivo environments or experimental conditions, thereby collecting data on cell growth, morphological changes, metabolic activity, etc. Furthermore, the support mechanism can be quickly disassembled and installed, ensuring effective cleaning and maintenance of the interior of the incubator, thereby extending the service life of the incubator.

[0006] The technical solutions adopted by this utility model are as follows:

[0007] A cell culture incubator, comprising a box body, wherein the interior of the box body is divided into an upper culture chamber and a lower culture chamber by a partition, and slide rails are fixedly provided in the upper culture chamber and the lower culture chamber;

[0008] A support mechanism, the support mechanism comprising a vibration assembly slidably disposed within the upper culture chamber, and a support assembly slidably disposed within the lower culture chamber, the vibration assembly comprising a vibration plate having a plurality of mounting slots defined therein, each of the mounting slots being provided with a micro vibrator, and a vibration disk being provided above the micro vibrator;

[0009] The support assembly includes a support plate, a plurality of support grooves are formed on the support plate, and a temperature regulator is provided in each of the support grooves;

[0010] Among them, by placing the cell vessels in the vibration assembly and the support assembly respectively, and by controlling the vibration disk in the vibration assembly respectively, the effects of different vibration amplitudes on cell culture under the same conditions can be observed. At the same time, by controlling the temperature regulator in the support assembly, the effects of different temperatures on the same cells can be observed.

[0011] Furthermore, connectors are fixedly provided in the upper culture chamber and the lower culture chamber, and connecting heads are fixedly provided on the connectors.

[0012] Furthermore, the bottom of the vibration plate and the bottom of the support plate are both provided with rotating rollers, and the rotating rollers are respectively provided at the bottom of the vibration plate and the bottom of the support plate through rotating shafts and are rotatably connected.

[0013] Furthermore, the vibration plate and the bottom of the support plate are fixedly connected with sliding blocks, the positions of the sliding blocks are respectively arranged to correspond to the sliding rails, and the sliding rails are slidably connected inside the sliding blocks.

[0014] Furthermore, the vibration plate and the support plate are both provided with connection holes on one side close to the inside of the box, and the positions of the connection holes correspond to the connection head;

[0015] Wherein, after the connecting hole is connected to the connecting head, the vibration plate and the support plate can be controlled through the connector.

[0016] Furthermore, a protective door is hinged on the outside of the box body, an observation slot is provided on the protective door, and transparent glass is provided in the observation slot.

[0017] The technical effects achieved by this utility model are:

[0018] The utility model discloses a cell culture incubator. The support mechanism allows for rapid adjustment and replacement of the vibration and support components, ensuring accurate and efficient cell culture. Furthermore, the support mechanism allows for rapid disassembly within the incubator, ensuring that the incubator and support mechanism can be cleaned and maintained after experiments, effectively extending the service life of the incubator.

[0019] The utility model is a cell culture incubator, which places cell vessels in a vibration plate and a support groove respectively, and adjusts different vibration amplitudes by precisely controlling the vibration plate. By changing the vibration amplitude, researchers can observe the effects of different vibration intensities on cell culture under the same conditions, thereby gaining a deeper understanding of the mechanism of action of vibration stimulation on cell growth, differentiation, and metabolism. The cell culture vessels can be divided into a control group and an experimental group to further improve the accuracy and reliability of the experiment. At the same time, the temperature in the support groove can be precisely controlled by the temperature regulator in the support assembly to adjust different temperature conditions, thereby understanding the effect of temperature on the physiological activities of cells. Data on aspects such as cell growth, morphological changes, and metabolic activity can be collected. By analyzing the data, one can gain an in-depth understanding of the specific effects of vibration and temperature on cell culture, providing strong support for further research and application. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a schematic diagram of the structure of the utility model as a whole;

[0021] Figure 2 It is a partial cross-sectional view of the overall structure of the utility model;

[0022] Figure 3 This is a partial explosion diagram of the internal structure of the utility model;

[0023] Figure 4 It is a sectional view of the local structure of this utility model.

[0024] In the accompanying drawings, the components represented by the reference numerals are as follows:

[0025] 10. Box; 101. Upper culture chamber; 102. Lower culture chamber; 11. Partition; 12. Slide rail; 13. Connector; 131. Connector; 14. Protective door; 141. Observation slot;

[0026] 30. Support mechanism; 31. Vibration assembly; 311. Vibration plate; 312. Mounting slot; 313. Micro vibrator; 314. Vibration disk; 32. Support assembly; 321. Support plate; 322. Support slot; 323. Temperature regulator; 33. Rotating roller; 331. Rotating shaft; 34. Sliding block; 35. Connecting hole. DETAILED DESCRIPTION

[0027] In order to make the purpose and advantages of the present invention more clearly understood, the present invention is described in detail below with reference to the following embodiments. It should be understood that the following text is only used to describe one or several specific implementation methods of the present invention and does not strictly limit the scope of protection specifically claimed by the present invention.

[0028] like Figure 1-4As shown, a cell culture incubator includes a box body 10. The interior of the box body 10 is divided into an upper culture chamber 101 and a lower culture chamber 102 by a partition 11. Slide rails 12 are fixed in the upper culture chamber 101 and the lower culture chamber 102.

[0029] The support mechanism 30 includes a vibration assembly 31 slidably disposed within the upper culture chamber 101 and a support assembly 32 slidably disposed within the lower culture chamber 102. The vibration assembly 31 includes a vibration plate 311 having a plurality of mounting slots 312 defined therein. Each mounting slot 312 is provided with a micro vibrator 313. A vibration disk 314 is provided above the micro vibrator 313.

[0030] The support assembly 32 includes a support plate 321 , a plurality of support grooves 322 are formed on the support plate 321 , and a temperature regulator 323 is provided in each of the support grooves 322 ;

[0031] Among them, by placing the cell vessels in the vibration assembly 31 and the support assembly 32 respectively, and by controlling the vibration disk 314 in the vibration assembly 31 respectively, the effects of different vibration amplitudes on cell culture under the same conditions can be observed. At the same time, by controlling the temperature regulator 323 in the support assembly 32, the effects of different temperatures on the same cell culture can be observed.

[0032] It should be noted that, by installing a sensor inside the housing 10, the temperature inside the housing 10 can be monitored in real time, maintaining it within a set range. This ensures temperature stability during the cell culture process and prevents abnormal cell growth or death due to temperature fluctuations. Based on the above, the device is equipped with a controller that can effectively control the humidity and pH within the housing 10. The controller of the incubator is conventional in the art and will not be described in detail here.

[0033] In this embodiment, the housing 10 can provide an effective culture environment for cell culture, ensuring that cells can be stored and cultured in the housing 10. By arranging a partition 11 in the housing 10, the space in the housing 10 is divided into an upper culture chamber 101 and a lower culture chamber 102. Among them, a slide rail 12 is provided in both the upper culture chamber 101 and the lower culture chamber 102, and the slide rail 12 can effectively connect the vibration component 31 and the support component 32 in the support mechanism 30, thereby effectively driving the cell culture vessel into the culture environment for culture and storage. The support mechanism 30 includes a vibration component 31 that is slidably arranged in the upper culture chamber 101. By placing the vibration plate 311 in the vibration component 31 on the slide rail 12, the cell culture vessel can be driven to move flexibly inside the upper culture chamber 101. By providing a plurality of mounting slots 312 on the vibration plate 311, a plurality of cell storage vessels can be placed, which is convenient for meeting different experimental needs. A microvibrator 313 is provided inside the mounting groove 312. The microvibrator 313 can generate small and uniform vibrations, simulating the natural growth environment of cells in a living organism and promoting cell growth and differentiation. A vibration plate 314 is provided above the microvibrator 313 for supporting cell culture dishes or culture bottles. The combination of the vibration plate 314 and the microvibrator 313 ensures that the cells are subjected to uniform and appropriate vibration amplitudes during the culture process. Specifically, the support plate 321 in the support assembly 32 is slidably connected to the slide rail 12 in the lower culture chamber 102, so that the cell culture vessels in the support assembly 32 can be flexibly adjusted within the lower culture chamber 102. Multiple support grooves 322 are provided on the support plate 321, allowing multiple cell storage vessels to be placed to meet different cell culture needs. A temperature regulator 323 is provided inside the support groove 322 to provide different growth environment temperatures for the cells. At the same time, the temperature regulator 323 can directly apply the heat or cold emitted to the cell culture dish or culture bottle in the support groove 322, thereby improving the accuracy and efficiency of temperature control. Among them, the vibration component 31 and the support component 32 in the support mechanism 30 can be replaced according to the use requirements.

[0034] like Figure 2 、 Figure 4 As shown, by providing connectors 13 in the upper incubation chamber 101 and the lower incubation chamber 102, respectively, the connectors 13 can provide electrical connections for the vibration assembly 31 and the support assembly 32 in the support mechanism 30, ensuring a stable connection between the equipment in the incubator and the controller. Furthermore, by providing a connector 131 on the connector 13, the vibration plate 311 and the connection hole 35 on the support plate 321 can be quickly and securely connected, effectively reducing the risk of experimental interruption or data loss due to unstable or loose connections, and also improving experimental reliability.

[0035] like Figure 3 、 Figure 4 As shown, by providing rotating rollers 33 at the bottom of the vibration plate 311 and the support plate 321, the vibration plate 311 and the support plate 321 can be ensured to be stable during movement. At the same time, the provision of the rotating rollers 33 can also reduce friction and resistance during movement, thereby improving movement efficiency. The rotating rollers 33 are connected to the bottom of the vibration plate 311 and the support plate 321 via rotating shafts 331. The provision of the rotating shafts 331 can ensure that the rotating rollers 33 can rotate flexibly and unhindered during movement. Specifically, sliding blocks 34 are provided at the bottom of the vibration plate 311 and the support plate 321 for use with the slide rails 12. The position of the sliding blocks 34 corresponds to the slide rails 12, ensuring that the vibration plate 311 and the support plate 321 can move along a predetermined trajectory without deviation or shaking during movement. At the same time, the sliding connection between the sliding blocks 34 and the slide rails 12 can further improve the stability and accuracy of the movement of the vibration plate 311 and the support plate 321. The arrangement of the rotating roller 33 and the sliding block 34 allows for quick disassembly of the support mechanism 30 , ensuring that the incubator can be cleaned and maintained after the experiment.

[0036] like Figure 4 As shown, a connection hole 35 is provided on the side of the vibration plate 311 and the support plate 321 close to the interior of the box body 10, and the position of the connection hole 35 corresponds to the connector 131 on the connector 13, which can ensure that the vibration plate 311 and the support plate 321 can be accurately docked with the connector 13, thereby achieving electrical connection and transmission of control signals. It should be noted that when the connection hole 35 is connected to the connector 131, the user can set the required parameters (such as vibration amplitude, temperature, etc.) by operating the incubator controller, and then transmit them to the micro vibrator 313 and the temperature regulator 323 through the connector 13 to meet the needs of cell culture experiments.

[0037] Preferably, a protective door 14 is hingedly provided on the outside of the chamber 10 to ensure that it can be easily opened and closed, providing convenient and reliable protection for cell culture experiments. An observation slot 141 is provided in the protective door 14, allowing the user to conveniently observe the cell growth and experimental progress within the incubator. It should be noted that transparent glass is provided within the observation slot 141, and the transparent glass has excellent transparency and corrosion resistance, ensuring that the user can clearly observe the conditions within the incubator while protecting the environment within the chamber 10 from external contamination.

[0038] The working principle of this utility model is as follows: the cell culture vessels are placed in the vibration disk 314 and the support groove 322 respectively, and then the vibration plate 311 and the support plate 321 are placed in the upper culture chamber 101 and the lower culture chamber 102 respectively. The sliding block 34 at the bottom is connected to the slide rail 12, and then the vibration plate 311 and the support plate 321 are driven to move along the predetermined position by the action of the rotating roller 33 and the sliding block 34. The connection hole 35 opened on the side is connected to the connector 131 provided on the connector 13 in the box 10, ensuring that the vibration assembly 31 and the support assembly 32 can be effectively controlled by the incubator. After that, the protective door 14 is closed and the parameters in the box 10 are set. The micro vibrator 313 in the vibration assembly 31 can drive the vibration disk 314 to stimulate the cell storage vessel with different vibration amplitudes, ensuring that the mechanism of the effect of different vibration amplitudes on cell growth, differentiation and metabolism can be effectively understood based on the data after the experiment. At the same time, by setting different temperatures for the temperature regulator 323 in the support assembly 32, it is ensured that after the experiment, the effects of different temperatures on cell physiological activities can be effectively understood based on the data, thereby effectively collecting data on cell growth, morphological changes, metabolic activity, etc.

[0039] The above description is only a preferred embodiment of the present invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and such improvements and modifications should also be considered within the scope of protection of the present invention. Structures, devices, and operating methods not specifically described or explained in this application shall be implemented in accordance with conventional means in the art unless otherwise specified or limited.

Claims

1. A cell culture incubator, characterized in that: The invention comprises a box body (10), wherein the interior of the box body (10) is divided into an upper culture chamber (101) and a lower culture chamber (102) by a partition (11), and a slide rail (12) is fixedly provided in each of the upper culture chamber (101) and the lower culture chamber (102); A support mechanism (30), the support mechanism (30) comprising a vibration assembly (31) slidably disposed in the upper culture chamber (101), and a support assembly (32) slidably disposed in the lower culture chamber (102), the vibration assembly (31) comprising a vibration plate (311), a plurality of mounting grooves (312) being provided in the vibration plate (311), micro vibrators (313) being provided in each of the mounting grooves (312), and a vibration disk (314) being provided above the micro vibrators (313); The support assembly (32) includes a support plate (321), a plurality of support grooves (322) are provided on the support plate (321), and a temperature regulator (323) is provided in each of the support grooves (322); By placing the cell vessels in the vibration assembly (31) and the support assembly (32) respectively, and controlling the vibration disk (314) in the vibration assembly (31) respectively, the effects of different vibration amplitudes on cell culture under the same conditions can be observed, and by controlling the temperature regulator (323) in the support assembly (32), the effects of different temperatures on the same cell culture can be observed.

2. The cell culture incubator according to claim 1, wherein: A connector (13) is fixedly provided in both the upper culture chamber (101) and the lower culture chamber (102), and a connecting head (131) is fixedly provided on the connector (13).

3. The cell culture incubator according to claim 1, wherein: The bottoms of the vibration plate (311) and the support plate (321) are both provided with rotating rollers (33), and the rotating rollers (33) are respectively provided at the bottoms of the vibration plate (311) and the support plate (321) through rotating shafts (331) and are rotatably connected.

4. The cell culture incubator according to claim 1, wherein: The bottoms of the vibration plate (311) and the support plate (321) are also fixedly connected with sliding blocks (34), the positions of the sliding blocks (34) are respectively arranged to correspond to the slide rails (12), and the slide rails (12) are respectively slidably connected inside the sliding blocks (34).

5. The cell culture incubator according to claim 2, wherein: The vibration plate (311) and the support plate (321) are both provided with a connection hole (35) on one side close to the interior of the box (10), and the position of the connection hole (35) corresponds to the connection head (131); After the connection hole (35) is connected to the connection head (131), the vibration plate (311) and the support plate (321) can be controlled through the connector (13).

6. The cell culture incubator according to claim 1, wherein: A protective door (14) is hingedly connected to the outer side of the box body (10), an observation slot (141) is provided on the protective door (14), and transparent glass is provided in the observation slot (141).

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