Column oven

Abstract

The utility model provides a column oven which comprises a first cavity defined by an inner container, a refrigerating and heating device and a door body and a second cavity defined by the inner container, the refrigerating and heating device and an oven body, and a second fan and a second cooling fin are arranged in the second cavity. A cold load generated on one side of the second cavity can be discharged out of the second cavity through the second fan and the second cooling fins, so that the cold load is prevented from being transmitted into the first cavity, and the temperature in the first cavity is kept stable; when the refrigerating and heating device refrigerates at one side of the first cavity, heat generated at one side of the second cavity can be discharged out of the second cavity through the second fan and the second cooling fins to prevent the heat from being transferred into the first cavity, so that the temperature in the first cavity is kept stable, and the separation accuracy of the chromatographic column is improved.

Description

Technical Field

[0001] The present application relates to the technical field of analytical instruments and equipment, and in particular to a column oven. Background Art

[0002] The temperature of the liquid chromatography column has a great influence on the adsorption and analysis results of the components therein. The temperature change and the temperature difference in the column oven will affect the accuracy of the separation results of the chromatographic column.

[0003] In traditional column ovens, due to unstable air circulation inside the oven, the heat or cold load inside the oven will be transferred to the chromatographic column reaction chamber, resulting in unstable temperature inside the chromatographic column reaction chamber, which in turn causes low accuracy of the chromatographic column separation results. Utility Model Content

[0004] In order to solve the above technical problems, the present application provides a column oven, comprising a box body and a door body, wherein the box body and the door body enclose a cavity;

[0005] An inner container and a cooling and heating device are provided in the cavity, the inner container is fixedly provided on the box body, and the cooling and heating device is fixedly provided on a side of the inner container away from the door body;

[0006] The inner tank, the cooling and heating device and the door body form a closed first cavity; the inner tank, the box body and the cooling and heating device form a second cavity; the chromatographic column is arranged in the first cavity; the second cavity is provided with a second fan and a second heat sink to drive air to move in the second cavity.

[0007] In some embodiments of the present application, a first fan and a first heat sink are provided in the first cavity to drive air to move in the first cavity.

[0008] In some embodiments of the present application, the inner tank includes an air guide shell, a fixed chromatographic column shell and an adapter; the adapter is fixed on the box body, the fixed chromatographic column shell is fixedly connected to the side of the adapter away from the door body, and the air guide shell is fixedly connected to the side of the fixed chromatographic column shell away from the door body; the air guide shell includes an inclined air guide surface, which can guide the air movement in the main cavity and accelerate the circulation of air in the main cavity.

[0009] In some embodiments of the present application, a first groove and a second groove that are interconnected are provided on the side of the adapter close to the door body, and the first groove and the second groove together form a convex groove facing the side of the fixed chromatography column housing. A plurality of mounting holes for realizing a threaded connection with the fixed chromatography column housing are spaced apart in the first groove.

[0010] In some embodiments of the present application, a sealing member is provided in the convex groove.

[0011] In some embodiments of the present application, the exterior of the inner liner is covered with a thermal insulation board to prevent heat or cold load in the second cavity from being transferred to the first cavity.

[0012] In some embodiments of the present application, an upper partition and a lower partition are provided in the second cavity to divide the second cavity into an upper cavity, a middle cavity and a lower cavity.

[0013] In some embodiments of the present application, a third fan and a fourth fan are arranged in an upper and lower spaced relationship in the middle cavity on a side away from the inner tank.

[0014] In some embodiments of the present application, a first temperature sensor and a second temperature sensor are provided in the inner tank, the first temperature sensor is provided on one side of the first fan, and the second temperature sensor is provided in the first heat sink.

[0015] In some embodiments of the present application, the outside of the insulation board is also covered with a cover plate, and fasteners are threadedly connected to the upper partition and the lower partition, and the ends of the fasteners abut against the cover plate to apply a pressing force to the inner tank toward the door body to further seal the first cavity.

[0016] Compared with the prior art, the present invention has the following advantages and beneficial effects: the column temperature box of the present application includes a first cavity formed by an inner liner, a cooling and heating device and a door body, a second cavity formed by an inner liner, a cooling and heating device and a box body, and a second fan and a second heat sink are arranged in the second cavity. In this way, when the cooling and heating device heats one side of the first cavity, the cold load generated on one side of the second cavity can be discharged out of the second cavity through the second fan and the second heat sink to prevent the cold load from being transferred to the first cavity, thereby keeping the temperature in the first cavity stable; when the cooling and heating device cools one side of the first cavity, the heat generated on one side of the second cavity can be discharged out of the second cavity through the second fan and the second heat sink to prevent the heat from being transferred to the first cavity, thereby keeping the temperature in the first cavity stable, thereby improving the separation accuracy of the chromatographic column.

[0017] It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The accompanying drawings, which constitute part of this document, are intended to provide a further understanding of this document. The exemplary embodiments and descriptions herein are intended to explain this document and do not constitute an improper limitation on this document. In the accompanying drawings:

[0019] Figure 1This is a schematic structural diagram of a column oven (with a hidden door and part of the box) with bidirectional temperature control provided by an exemplary embodiment of the present application;

[0020] Figure 2 is a cross-sectional view of a column oven capable of bidirectional temperature control provided by an exemplary embodiment of the present application;

[0021] Figure 3 yes Figure 2 Enlarged view in the middle dashed box;

[0022] Figure 4 It is a schematic structural diagram of a column oven capable of bidirectional temperature control provided by an exemplary embodiment of the present application.

[0023] In the picture:

[0024] 10. Box body; 101. Upper partition; 102. Lower partition; 103. Third fan; 104. Fourth fan; 20. Door body; 201. First layer door body; 202. Second layer door body; 30. Inner tank; 301. Adapter; 3011. First groove; 3012. Second groove; 302. Fixed chromatographic column housing; 303. Air guide housing; 304. Insulation board; 40. Cooling and heating device; 50. First fan; 60. First heat sink; 70. Second fan; 80. Second heat sink; 100A. First cavity; 100B. Middle cavity; 100C. Upper cavity; 100D. Lower cavity. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application. It should be noted that, in the absence of conflict, the embodiments in the present application and the features in the embodiments can be combined with each other in any way.

[0026] The temperature of the liquid chromatography column has a great influence on the adsorption and analysis results of the components therein. The temperature change and the temperature difference in the column oven will affect the accuracy of the separation results of the chromatographic column.

[0027] In traditional column ovens, due to unstable air circulation inside the oven, the heat or cold load inside the oven will be transferred to the chromatographic column reaction chamber, resulting in unstable temperature inside the chromatographic column reaction chamber, which in turn causes low accuracy of the chromatographic column separation results.

[0028] Based on this, an exemplary embodiment of the present application provides a column temperature box, which includes a first cavity formed by an inner liner, a cooling and heating device and a door body, and a second cavity formed by an inner liner, a cooling and heating device and a box body. A second fan and a second heat sink are arranged in the second cavity. In this way, when the cooling and heating device heats one side of the first cavity, the cold load generated on one side of the second cavity can be discharged out of the second cavity through the second fan and the second heat sink to prevent the cold load from being transferred to the first cavity, thereby keeping the temperature in the first cavity stable; when the cooling and heating device cools one side of the first cavity, the heat generated on one side of the second cavity can be discharged out of the second cavity through the second fan and the second heat sink to prevent the heat from being transferred to the first cavity, thereby keeping the temperature in the first cavity stable, thereby improving the separation accuracy of the chromatographic column.

[0029] An exemplary embodiment of the present application provides a column oven, such as Figure 1 and 4 As shown, the column temperature box includes a box body 10 and a door body 20. The box body 10 and the door body 20 enclose a cavity, and the box body 10 is provided with air inlet and exhaust holes; an inner liner 30 and a cooling and heating device 40 are provided in the cavity. The cooling and heating device 40 is preferably a Peltier cooling and heating plate. According to the reaction temperature requirements, the cooling and heating device 40 can perform cooling or heating to adjust the reaction temperature within the range of 5°C and 90°C. The inner liner 30 is fixedly arranged on the box body 10, and the cooling and heating device 40 is fixedly arranged on the side of the inner liner 30 away from the door body 20; the inner liner 30, the cooling and heating device 40 and the door body 20 enclose a closed first cavity 100A; the inner liner 30, the box body 10 and the cooling and heating device 40 enclose a second cavity; the chromatographic column is arranged in the first cavity 100A; the first fan 50 and the first heat sink 60 are arranged in the first cavity 100A to drive the air to move in the first cavity 100A; the second fan 70 and the second heat sink 80 are arranged in the second cavity to drive the air to move in the second cavity.

[0030] like Figure 2As shown, the black bold arrows in the figure indicate the air circulation paths in the first cavity 100A and the second cavity. Preferably, the first fan 50 and the first heat sink 60 are both arranged near the middle position in the vertical direction of the first cavity 100A, and the first fan 50 and the first heat sink 60 are arranged at intervals. The first heat sink 60 has a plurality of evenly arranged heat dissipation grooves that pass through the vertical direction. When the cooling and heating device 40 is heating on one side of the first cavity 100A, the heat is transferred to the first cavity 100A through the heat sink, and the first fan 50 blows air towards the first heat sink 60. The moving airflow will move in the upward and downward directions from the heat sink, so that two upper and lower circulating airflows are formed in the first cavity 100A, so as to make the heat distribution in the first cavity 100A more uniform. At the same time, one side of the cooling and heating device 40 located in the second cavity will be cooled, and the generated cold load will be transmitted to the second cavity through the second heat sink 80. The second heat sink 80 has a plurality of evenly arranged heat dissipation grooves that pass through the vertical direction. The second fan 70 blows air to the second heat sink 80, so that two upper and lower circulating airflows are formed in the second cavity, which can quickly discharge the cold load generated by the refrigeration to the outside of the second cavity, preventing the generated cold load from being transmitted to the first cavity 100A, affecting the temperature in the first cavity 100A, and preventing the temperature in the first cavity 100A from fluctuating, affecting the separation accuracy of the chromatographic column.

[0031] When the cooling and heating device 40 cools on one side of the first cavity 100A, for example, the reaction temperature is 5°C. At this time, the cooling load generated by the cooling and heating device 40 is transferred to the first cavity 100A through the first heat sink 60, and the first fan 50 forms an up and down circulating airflow in the first cavity 100A, so that the cooling load in the first cavity 100A is more evenly distributed. At this time, the cooling and heating device 40 is heating on the second cavity side. If the heat generated in the second cavity is not discharged in time, the heat will be transferred to the first cavity 100A, making the temperature in the first cavity 100A unstable. At the same time, due to the heat transfer, the temperature in the first cavity 100A may not be able to reach the preset 5°C. In this way, the control system will always control the cooling and heating device 40 to cool. At the same time, the cooling and heating device 40 is always heating in the second cavity, and the heat generated by the heating will be always transferred to the first cavity 100A. This heat transfer will always cause the temperature in the first cavity 100A to be unable to reach the preset temperature, causing the cooling and heating device 40 to keep working, high energy consumption, and the inability to guarantee the separation accuracy of the chromatographic column. In the present application, the heat generated on one side of the second cavity can be discharged from the second cavity through the second fan 70 and the second heat sink 80 to prevent the heat from being transferred to the first cavity 100A. This not only keeps the temperature in the first cavity 100A stable, but also quickly reduces the temperature of the first cavity 100A to a preset temperature and maintains the preset temperature unchanged, thereby improving the separation accuracy of the chromatographic column.

[0032] The second chamber is provided with an upper partition 101 and a lower partition 102, dividing the second chamber into an upper chamber 100C, a middle chamber 100B, and a lower chamber 100D. To accelerate the discharge of air from the second chamber to the exterior of the housing 10, a third fan 103 and a fourth fan 104 are arranged in a vertically spaced arrangement on the side of the middle chamber 100B away from the inner liner 30. The third fan 103 and the fourth fan 104 simultaneously exhaust air to the exterior of the housing 10, accelerating the discharge of air from the middle chamber 100B.

[0033] like Figure 3 As shown, the inner tank 30 includes an air guide housing 303, a fixed chromatographic column housing 302 and an adapter 301; the adapter 301 is fixed to the box body 10, the fixed chromatographic column housing 302 is fixedly connected to the side of the adapter 301 away from the door body 20, and the air guide housing 303 is fixedly connected to the side of the fixed chromatographic column housing 302 away from the door body 20. Figure 1As shown, the chromatographic column housing 302 includes a mounting plate located in the middle of the first cavity 100A. The mounting plate is provided with through holes in shapes such as elongated strips and arcs to facilitate airflow circulation within the first cavity 100A. Furthermore, a chromatographic column clamp is provided on the side of the mounting plate close to the door 20, and the chromatographic column is fixed to the chromatographic column clamp. The first fan 50 is mounted on the side of the mounting plate away from the door 20. Preferably, a plurality of elongated and arc-shaped through holes are provided at the location where the first fan 50 is mounted. These through holes facilitate the circulation of airflow into the interior of the first fan 50, thereby ensuring stable air circulation and more uniform temperature distribution within the first cavity 100A.

[0034] The outer portion of the inner liner 30 is covered with an insulation board 304. Preferably, the top, sides, bottom, and the area near the second cavity of the inner liner 30 are all covered with insulation boards 304 to prevent heat or cold load in the second cavity from being transferred to the first cavity 100A. The insulation board 304 is preferably made of EVA.

[0035] In one embodiment, in order to facilitate the reverse circulation of the air in the first cavity 100A and make the temperature in the first cavity 100A more uniform, the air guide housing 303 includes an inclined air guide surface, such as Figure 3 As shown in the figure, the setting of the upper and lower air guide surfaces makes the opening of the first cavity 100A gradually increase from the cooling and heating device 40 toward the door body 20. Therefore, the air guide surface can guide the air movement in the main cavity and accelerate the circulation of the air in the main cavity. Under the action of the first fan 50, the airflow emitted from the upper and lower ends of the first heat sink 60 turns at the air guide surface to flow toward the door body 20, so that a circulating airflow is formed in the upper and lower parts of the first cavity 100A, which can make the temperature in the first cavity 100A more uniform.

[0036] like Figure 2 and 3As shown, one side of the adapter 301 is in contact with the housing 10 and the door 20, and the other side is in contact with the fixed chromatographic column housing 302. Preferably, the adapter 301 is made of ABS. On the basis of having a certain strength, the thermal conductivity of ABS is lower than that of metal. Therefore, it can prevent the formation of a cold bridge between the fixed chromatographic column housing 302, the housing, and the door 20, thereby avoiding the loss of more heat or cooling load. A first groove 3011 and a second groove 3012 are provided on the side of the adapter 301 close to the door 20. The first groove 3011 and the second groove 3012 together form a convex groove facing the side of the fixed chromatographic column housing 302. A plurality of mounting holes for achieving a threaded connection with the fixed chromatographic column housing 302 are spaced apart in the first groove 3011, and a sealing member is provided in the convex groove. In this way, the fastener is sealed within the groove by the seal, preventing the fastener from contacting the door 20 and the cabinet 10, thereby preventing the formation of a cold bridge. This reduces the transfer of heat or cooling load, and maintains a stable temperature within the first cavity 100A. At the same time, the side of the seal that enters the door 20 protrudes slightly from the outside of the groove. Therefore, when the door 20 is closed, the door 20 presses against the seal, forming a close contact between the door 20 and the seal, improving the sealing between the first cavity 100A and the door 20, and reducing the loss of heat or cooling load within the first cavity 100A.

[0037] The upper partition 101 and lower partition 102 provided within the second cavity can prevent the temperature of the upper cavity 100C and the lower cavity 100D from being too low or too high, thereby preventing the excessively high or low temperature from affecting the regulating valve provided in the upper cavity 100C and the lower wall. The insulation board 304 is also covered with a cover plate. Fasteners are threadedly connected to the upper partition 101 and the lower partition 102. The ends of the fasteners abut against the cover plate to apply a compressive force to the inner liner 30 in the direction of the door body 20, further sealing the first cavity 100A. The insulation board 304 has a certain degree of elasticity. Therefore, by adjusting the length between the fasteners and the cover plate, the compressive force of the fasteners on the cover plate can be adjusted, thereby further sealing the inner liner 30 and the door body 20.

[0038] In one embodiment, if Figure 3 As shown, the door body 20 is a double-layer door body 20, which includes a first-layer door body 201 and a second-layer door body 202. The first-layer door body 201 is sealed on the outside of the first cavity 100A, and the second-layer door body 202 is sealed on the outside of the first-layer door body 201. The second-layer door body 202 seals the upper cavity 100C and the lower cavity 100D at the same time. In this way, when it is necessary to operate the regulating valves arranged in the upper cavity 100C and the lower cavity 100D, it is only necessary to open the second-layer door body 202 without opening the first-layer door body 201. This ensures the sealing of the first cavity 100A and avoids heat transfer between the first cavity 100A and the outside world, which affects the temperature inside the first cavity 100A.

[0039] In one embodiment, a first temperature sensor and a second temperature sensor are disposed within the inner chamber 30. The first temperature sensor is disposed on one side of the first blower 50, and the second temperature sensor is disposed within the first heat sink 60. The temperature of the heat sink and the temperature of the air within the first chamber 100A are simultaneously detected. Based on the data collected by the first and second temperature sensors, the control system can precisely regulate the temperature within the first pump chamber, thereby improving the separation accuracy of the chromatographic column.

[0040] In order to further improve the measurement accuracy of the first temperature sensor and the second temperature sensor, for example, the first temperature sensor and the second temperature sensor both adopt Kelvin sensors, that is, the outer shells of the first temperature sensor and the second temperature sensor are removed. Because the outer shell can affect the detection accuracy of the sensor, the first temperature sensor and the second temperature sensor with the outer shell removed can measure more accurately; at the same time, in order to increase the heat conduction efficiency, the first temperature sensor and the second temperature sensor are coated with copper foil on the outside. Since the heat conduction efficiency of copper foil is high, the detection sensitivity of the first temperature sensor and the second temperature sensor can be improved, and the temperature accuracy in the first cavity 100A can be further improved.

[0041] The temperature adjustment range of the column oven of the present application is 5°C to 90°C, the temperature accuracy can reach 0.01, and the temperature stability can reach ±0.05°C; when set to 35°C, the heating time is 2 minutes.

[0042] In this application, the terms "comprises," "comprising," or any other variations thereof are intended to encompass non-exclusive inclusion, such that an article or device comprising a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such article or device. In the absence of further limitations, an element defined by the phrase "comprising..." does not exclude the presence of additional identical elements in the article or device comprising the element.

[0043] Although the preferred embodiments of the present application have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the present application.

[0044] Obviously, those skilled in the art may make various changes and modifications to the present application without departing from the spirit and scope of the present application. Thus, if such changes and modifications of the present application fall within the scope of the claims of the present application and their equivalents, the present application is intended to include such changes and modifications.

Claims

1. A column oven, characterized in that It includes a box body and a door body, wherein the box body and the door body enclose a cavity; An inner container and a cooling and heating device are provided in the cavity, the inner container is fixedly provided on the box body, and the cooling and heating device is fixedly provided on a side of the inner container away from the door body; The inner tank, the cooling and heating device and the door body form a closed first cavity; the inner tank, the box body and the cooling and heating device form a second cavity; the chromatographic column is arranged in the first cavity; the second cavity is provided with a second fan and a second heat sink to drive air to move in the second cavity.

2. The column oven according to claim 1, characterized in that A first fan and a first heat sink are provided in the first cavity to drive air to move in the first cavity.

3. The column oven according to claim 1, characterized in that The inner tank includes an air guide shell, a fixed chromatographic column shell and an adapter; the adapter is fixed on the box body, the fixed chromatographic column shell is fixedly connected to the side of the adapter away from the door body, and the air guide shell is fixedly connected to the side of the fixed chromatographic column shell away from the door body; the air guide shell includes an inclined air guide surface, which can guide the air movement in the main cavity and accelerate the circulation of air in the main cavity.

4. The column oven according to claim 3, characterized in that A first groove and a second groove are connected to each other on one side of the adapter close to the door body. The first groove and the second groove together form a convex groove facing the side of the fixed chromatography column housing. A plurality of mounting holes for realizing threaded connection with the fixed chromatography column housing are spaced apart in the first groove.

5. The column oven according to claim 4, characterized in that A sealing member is arranged in the convex groove.

6. The column oven according to claim 1, characterized in that The outer portion of the inner container is covered with a heat preservation plate to prevent the heat or cold load in the second cavity from being transferred to the first cavity.

7. The column oven according to claim 1, characterized in that An upper partition and a lower partition are provided in the second cavity, dividing the second cavity into an upper cavity, a middle cavity and a lower cavity.

8. The column oven according to claim 7, characterized in that A third fan and a fourth fan are arranged in an upper and lower interval manner on a side of the middle cavity away from the inner container.

9. The column oven according to claim 2, characterized in that A first temperature sensor and a second temperature sensor are arranged in the inner tank. The first temperature sensor is arranged on one side of the first fan, and the second temperature sensor is arranged in the first heat sink.

10. The column oven according to claim 6, characterized in that The outside of the insulation board is also covered with a cover plate, and fasteners are threadedly connected to the upper and lower partitions. The ends of the fasteners abut against the cover plate to apply a pressing force to the inner tank toward the door body to further seal the first cavity.

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