Multi-channel multi-joint-inspection parallel pretreatment device and POCT (Point of Care Testing) full-automatic chemiluminescence equipment

Abstract

The multi-channel multi-joint-inspection parallel pretreatment device comprises a portal frame, wherein a first driving element is arranged at the top of the portal frame; the sample extraction mechanism is arranged on the portal frame and comprises a first mounting frame, a second driving element and an extraction assembly, the second driving element can drive the first mounting frame to ascend and descend, and the second driving element can drive the extraction assembly to ascend and descend so as to suck and spit samples; the sample pretreatment mechanism is arranged on the portal frame and comprises a second mounting frame, a third driving element and a pretreatment assembly, and the first driving element drives the second mounting frame to ascend and descend; the pretreatment assembly comprises at least two rows of magnetic bars arranged side by side in the width direction of the pretreatment assembly, each row of magnetic bars comprises at least two magnetic bars, and the third driving element drives the pretreatment assembly to ascend and descend so as to transfer the magnetic particles through the at least two rows of magnetic bars. The utility model also provides POCT (Point of Care Testing) full-automatic chemiluminescence equipment. According to the utility model, the pretreatment assembly comprises at least two rows of magnetic bars for transferring magnetic particles, so that multi-joint inspection can be realized while the size of the equipment is controlled.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a multi-channel multi-joint detection parallel pre-processing device and a POCT fully automatic chemiluminescence device. Background Art

[0002] Chemiluminescent immunoassay (CLIA), a rapidly developing non-radioactive immunoassay technology, has become a key area of ​​immunology. It utilizes chemiluminescent signals to directly measure immune responses. Chemiluminescent equipment utilizing CLIA offers advantages such as high sensitivity, good repeatability, high accuracy, good specificity, and a wide linear range.

[0003] POCT (Point-Of-Care Testing) is a testing method that conducts clinical testing immediately at the sampling site, eliminating the complex processing procedures of specimens in laboratory testing and quickly obtaining test results. It has the characteristics of instrument programming, simple operation and fast reporting of results.

[0004] At present, POCT fully automatic chemiluminescence equipment has been manufactured by applying chemiluminescence immunoassay technology to POCT products. The POCT fully automatic chemiluminescence equipment generally includes a reaction chamber module and a multi-channel parallel pre-processing module. The reaction chamber module is loaded with reagent strips containing various reagents, and it moves the reagent strips to the multi-channel parallel pre-processing module for corresponding processing.

[0005] However, the current multi-channel parallel pre-processing module can only transfer magnetic particles in one well on the reagent strip at a time. If magnetic particles in multiple wells need to be transferred, multiple operations are required, which increases the risk of cross-interference and prolongs the transfer time of the magnetic particles. Moreover, since it takes a long time to transfer magnetic particles multiple times, the analysis efficiency of the equipment is affected. Utility Model Content

[0006] An embodiment of the present utility model provides a multi-channel multi-joint detection parallel pre-processing device, which aims to solve the technical problem that the existing multi-channel parallel pre-processing module can only transfer magnetic particles in one hole position at a time, and multiple operations are required to transfer magnetic particles in multiple holes, resulting in an increased risk of cross-interference, prolonged transfer time of magnetic particles and detection and analysis time of the equipment.

[0007] The embodiment of the present invention is implemented as follows: a multi-channel multi-joint detection parallel pre-processing device, comprising:

[0008] A gantry, wherein a first driving element is provided on the top of the gantry;

[0009] a sample extraction mechanism disposed on the gantry, the sample extraction mechanism comprising a first mounting frame disposed on the gantry and drivingly connected to the first driving element, a second driving element disposed on the first mounting frame, and an extraction assembly disposed on the first mounting frame and drivingly connected to the second driving element, the second driving element being capable of driving the first mounting frame to rise and fall, and the second driving element being capable of driving the extraction assembly to rise and fall to aspirate and discharge samples; and

[0010] a sample pre-processing mechanism disposed on the gantry, the sample pre-processing mechanism comprising a second mounting frame disposed on the gantry and transmission-connected to the first driving element, a third driving element disposed on the second mounting frame, and a pre-processing assembly disposed on the second mounting frame and transmission-connected to the third driving element, wherein the first driving element can drive the second mounting frame to rise and fall;

[0011] The pre-processing component includes at least two rows of magnetic bars arranged side by side along the width direction of the pre-processing component, with at least two magnetic bars in each row. The third driving element can drive the pre-processing component to rise and fall to transfer magnetic particles through at least two rows of magnetic bars.

[0012] Furthermore, the pre-processing component includes:

[0013] A magnetic bar device is provided on the second mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are provided at the bottom of the magnetic bar device, wherein the plurality of first loading heads are in one-to-one communication with the plurality of movable through holes;

[0014] a first push plate disposed above the magnetic bar device, the first push plate being in driving connection with the third driving element; and

[0015] There are multiple connecting rods arranged on the first push plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The third driving element can drive the first push plate to drive the magnetic bars to rise and fall in the corresponding movable through holes so as to be separated from or pass through the first loading head.

[0016] Furthermore, the magnetic bars are arranged in multiple rows and are evenly spaced along the width direction of the first push plate; each row has multiple magnetic bars and the multiple magnetic bars in each row are evenly spaced along the length direction of the first push plate.

[0017] Furthermore, the sample pre-processing mechanism further includes:

[0018] a first slide rail provided on the second mounting frame, the first slide rail being distributed along a height direction of the second mounting frame; and

[0019] A first sliding block is provided on the first pushing plate, and the first sliding block is slidably connected to the first sliding rail.

[0020] Furthermore, the extraction component includes:

[0021] An injection device is provided on the first mounting frame, wherein a plurality of injection cavities are formed in the injection device, and a plurality of second loading heads for loading tip heads are provided at the bottom of the injection device, wherein the plurality of second loading heads are in one-to-one communication with the plurality of injection cavities;

[0022] a second push plate disposed above the injection device, the second push plate being in transmission connection with the second driving element; and

[0023] A plurality of piston rods are provided on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The second driving element can drive the second push plate to drive the piston rods to move up and down in the syringe cavity to perform a suction and exhalation action.

[0024] Furthermore, the sample extraction mechanism further includes:

[0025] A push rod is lifted and lowered through the injection device, wherein the top end of the push rod is spaced apart from the second push plate;

[0026] an elastic element sleeved on the push rod in the injection device, wherein the elastic element is simultaneously extended or compressed when the push rod is raised or lowered relative to the injection device; and

[0027] A separation plate is provided at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

[0028] Furthermore, the plurality of syringe cavities are evenly spaced along the length direction of the injection device, the plurality of second loading heads are evenly spaced along the length direction of the injection device, and the plurality of piston rods are evenly spaced along the length direction of the second push plate.

[0029] Furthermore, the sample extraction mechanism further includes:

[0030] a second slide rail provided between the injection device and the second push plate; and

[0031] A second sliding block is provided on the second pushing plate, and the second sliding block is slidably connected to the second slide rail.

[0032] Furthermore, the sample extraction mechanism is opposite to the sample pre-processing mechanism, and the sample extraction mechanism is located in front of the sample pre-processing mechanism, and the first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

[0033] Furthermore, a movable space is provided on the gantry, a transmission shaft of the first driving element passes through the movable space, a transmission plate is sleeved on the transmission shaft, and the transmission plate can be raised and lowered in the movable space when the transmission shaft moves;

[0034] A first connecting portion is provided on a side of the first mounting frame facing the gantry, and a second connecting portion is provided on a side of the second mounting frame facing the gantry. Both the first connecting portion and the second connecting portion are connected to the transmission plate.

[0035] Furthermore, a third slider is provided on a side of the first mounting frame facing the gantry, and a third slide rail is provided on a side of the gantry facing the first mounting frame, the third slide rail extending along the height direction of the gantry, and the third slider is slidably connected to the third slide rail;

[0036] A fourth slider is provided on the side of the second mounting frame facing the gantry, and a fourth slide rail is provided on the side of the gantry facing the second mounting frame. The fourth slide rail extends along the height direction of the gantry, and the fourth slider is slidably connected to the fourth slide rail.

[0037] Furthermore, a first sensing member is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame, and the first sensing member can generate or disconnect induction with the first detector as the first mounting frame rises and falls;

[0038] A second induction member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second induction member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

[0039] The present invention also provides a multi-detection POCT fully automatic chemiluminescence device, comprising:

[0040] Install the frame;

[0041] a reaction chamber device provided on the mounting frame, the reaction chamber device being reciprocally movable along the length direction of the mounting frame, the reaction chamber device being used for loading a reagent strip;

[0042] a PMT device disposed at the rear end of the mounting frame and located above the reaction chamber device, the reaction chamber device being used to move the reagent strip to the PMT device, and the PMT device being used to detect the luminescence value of the detection position of the reagent strip; and

[0043] According to any of the above-mentioned multi-channel multi-joint detection parallel pre-processing devices, the multi-channel multi-joint detection parallel pre-processing device is used to aspirate and discharge samples of the reagents in the reagent strip and transfer magnetic particles.

[0044] In the multi-channel multi-joint detection parallel pre-processing device of the embodiment of the present invention, the pre-processing component includes at least two rows of magnetic rods for transferring magnetic particles, and each row of magnetic rods has at least two magnetic rods, that is, the pre-processing component can simultaneously transfer the magnetic particles in at least two reagent wells on a single reagent strip, and transfer the magnetic particles in at least two reagent strips arranged in parallel, thereby realizing the detection of at least two items, realizing multi-channel parallel processing and multi-joint detection at the same time, reducing the risk of cross infection, shortening the time and equipment volume for transferring magnetic particles, and ensuring the equipment's analysis efficiency for multiple items. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 This is a three-dimensional schematic diagram of a POCT fully automatic chemiluminescence device according to an embodiment of the present invention;

[0046] Figure 2 It is a three-dimensional schematic diagram of a POCT fully automatic chemiluminescence device which is part of an embodiment of the present utility model;

[0047] Figure 3 This is a three-dimensional schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0048] Figure 4 This is a three-dimensional disassembled schematic diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present utility model;

[0049] Figure 5 This is a schematic structural diagram of a multi-channel multi-joint inspection parallel pre-processing device according to an embodiment of the present invention;

[0050] Figure 6 It is a three-dimensional schematic diagram of the gantry frame of the embodiment of the utility model;

[0051] Figure 7 This is another perspective schematic diagram of the gantry frame according to an embodiment of the present utility model;

[0052] Figure 8 It is a three-dimensional schematic diagram of the sample extraction mechanism of an embodiment of the utility model;

[0053] Figure 9 It is a three-dimensional schematic diagram of the sample pre-processing mechanism of an embodiment of the present utility model.

[0054] Description of main component symbols:

[0055] Multi-channel multi-joint detection parallel pre-processing device-10; gantry-11; movable space-111; transmission plate-112; third slide rail-113; fourth slide rail-114; first detector-115; first drive element-12; sample extraction mechanism-13; first mounting frame-131; second drive element-132; extraction assembly-133; injection device-1331; second loading head-1332; second push plate-1333; piston rod-1334; push rod-1335; elastic element-1336; separation plate-1337; second slide rail- 134; second slider-135; third slider-136; first sensing element-137; sample pre-processing mechanism-14; second mounting frame-141; third driving element-142; pre-processing assembly-143; magnetic rod device-1431; first loading head-1432; first push plate-1433; connecting rod-1434; magnetic rod-1435; first slide rail-144; first slider-145; fourth slider-146; mounting frame-20; reaction chamber device-30; PMT device-40; POCT fully automatic chemiluminescence equipment-100. DETAILED DESCRIPTION

[0056] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. Examples of the embodiments are shown in the accompanying drawings, in which the same or similar reference numerals throughout represent the same or similar elements or elements with the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and are not to be construed as limiting the present invention. In addition, it should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0057] In the description of the present invention, it should be understood that the orientation or positional relationship indicated in the description of the direction and positional relationship is based on the orientation or positional relationship shown in the accompanying drawings, which is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0058] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the described features. In the description of this utility model, "plurality" means two or more, unless otherwise specifically defined.

[0059] The disclosure below provides many different embodiments or examples for realizing different structures of the present invention. In order to simplify the disclosure of the present invention, the components and settings of specific examples are described below. Of course, they are merely examples and are not intended to limit the present invention. In addition, the present invention may repeat reference numbers and / or reference letters in different examples. Such repetition is for the purpose of simplicity and clarity and does not in itself indicate the relationship between the various embodiments and / or settings discussed. In addition, the present invention provides examples of various specific processes and materials, but a person of ordinary skill in the art will appreciate the application of other processes and / or the use of other materials.

[0060] See also Figures 1 to 9 The multi-channel multi-joint inspection parallel pre-processing device 10 of the embodiment of the present invention includes:

[0061] A gantry 11, with a first driving element 12 provided on the top of the gantry 11;

[0062] A sample extraction mechanism 13 is provided on the gantry 11. The sample extraction mechanism 13 includes a first mounting frame 131 provided on the gantry 11 and in transmission connection with the first driving element 13, a second driving element 132 provided on the first mounting frame 131, and an extraction assembly 133 provided on the first mounting frame 131 and in transmission connection with the second driving element 132. The second driving element 132 can drive the first mounting frame 131 to move upward and downward, and the second driving element 132 can drive the extraction assembly 133 to move upward and downward to aspirate and discharge samples; and

[0063] A sample pre-processing mechanism 14 is mounted on the gantry 11 and includes a second mounting frame 141 mounted on the gantry 11 and in transmission connection with the first drive element 12, a third drive element 142 mounted on the second mounting frame 141, and a pre-processing assembly 143 mounted on the second mounting frame 141 and in transmission connection with the third drive element 142. The first drive element 13 can drive the second mounting frame 141 to move upward and downward.

[0064] The pre-processing component 143 includes at least two rows of magnetic rods 1435 arranged side by side along the width direction of the pre-processing component 143 , with at least two magnetic rods 1435 in each row. The third driving element 142 can drive the pre-processing component 143 to rise and fall to transfer magnetic particles through at least two rows of magnetic rods 1435 .

[0065] In the multi-channel multi-joint detection parallel pre-processing device 10 of an embodiment of the present invention, the pre-processing component 143 includes at least two rows of magnetic rods 1435 for transferring magnetic particles, and there are at least two magnetic rods 1435 in each row, that is, the pre-processing component 143 can simultaneously transfer the magnetic particles in at least two reagent wells on a single reagent strip, and transfer the magnetic particles in at least two reagent strips arranged in parallel, thereby realizing the detection of at least two items, realizing multi-joint detection while realizing multi-channel parallel processing, realizing the multi-channel multi-joint detection function of the multi-channel multi-joint detection parallel pre-processing device 10, which can reduce the risk of cross infection, control the time and equipment volume for transferring magnetic particles, and ensure the equipment's analysis efficiency for multiple items.

[0066] Specifically, the gantry 11 spans the width direction of the POCT fully automatic chemiluminescence device 100, so that the sample extraction mechanism 13 and the sample pre-processing mechanism 14 can span above the reaction chamber device 30 to achieve multi-channel parallel pre-processing.

[0067] In the embodiment of the present invention, the sample extraction mechanism 13 is used to combine with the tip head on the reagent strip to transfer the sample or reagent and break the sealing film of each well. The sample pre-treatment mechanism 14 is used to combine with the disposable magnetic separation sleeve on the reagent strip to adsorb, mix, clean and transfer magnetic particles.

[0068] The sample pretreatment mechanism 14 and the sample extraction mechanism 13 are located on opposite sides of the gantry 11. This can avoid the problem that the sample pretreatment mechanism 14 and the sample extraction mechanism 13 are arranged on the same side of the gantry 11, which will cause the space on one side of the gantry 11 to be crowded and the load to be heavy, thereby causing inconvenience in operation and unstable structure of the gantry 11. In addition, the sample extraction mechanism 13 and the sample pretreatment mechanism 14 can be made to correspond to reagent holes with different functions on the reagent strip respectively. For example, the front section of the reagent strip requires more participation of the sample extraction mechanism 13, while the back half requires more participation of the sample pretreatment mechanism 14, which can further improve the pretreatment speed of the multi-channel multi-test parallel pretreatment device 10 on the reagent strip.

[0069] When the reagent strip is used for multiple detection items and the length of the reagent strip becomes longer, the reaction chamber device does not need to move the reagent strip a long distance but only needs to move the reagent strip to the corresponding position. The sample extraction mechanism 13 and the sample pre-processing mechanism 14 that are relatively separately arranged can be used to process the reagent strip separately. For example, the sample can be aspirated and the magnetic particles can be transferred separately, thereby shortening the time required to transfer the reagent strip in the reaction chamber device.

[0070] Taking a reagent strip for multiplex testing as an example, the strip may be provided with a sample well, a tip well, multiple disposable magnetic separation wells, multiple magnetically labeled ligand wells, multiple enzyme-labeled ligand wells, multiple wash solution wells, and multiple substrate reading wells (detection sites) in the order from one end to the other. The number of disposable magnetic separation wells, magnetically labeled ligand wells, enzyme-labeled ligand wells, and substrate reading wells is the same. Ligands include, but are not limited to, haptens, antigens, monoclonal antibodies, polyclonal antibodies, and nucleic acid ligands.

[0071] The sample hole is used to add blood samples, the tip hole is provided with a tip head, the disposable magnetic separation sleeve hole is provided with a disposable magnetic separation sleeve, the magnetic labeled ligand hole contains a magnetic labeled ligand, the enzyme labeled ligand hole contains an enzyme labeled ligand, the cleaning liquid hole contains a cleaning liquid, and the substrate reading hole contains a substrate reading.

[0072] Specifically, the tip is a hollow structure with a sharp end and a perforation, allowing it to be used to transfer samples or reagents and to remove the film seals at each well. The disposable magnetic separation sleeve is also hollow and can be used to adsorb, mix, clean, and transfer magnetic particles. The cleaning solution well can be used to clean the magnetic particles. The substrate reading well is used to perform a chemiluminescent reaction and read the luminescence value.

[0073] In one embodiment, the first drive element 12 may be a lead screw motor. The lead screw motor has high motion precision and more accurate and stable position adjustment. The first drive element 12, located at the top of the gantry 11, drives the sample extraction mechanism 13 and the sample pre-processing mechanism 14 to rise and fall on the gantry 11, allowing the sample extraction mechanism 13 and the sample pre-processing mechanism 14 to smoothly and accurately approach or move away from the reagent strip.

[0074] In this embodiment, the first drive element 12 drives the first mounting frame 131 to rise and fall, thereby driving the sample extraction mechanism 13 to rise and fall, thereby performing corresponding processing such as aspirating and discharging the sample from the reagent strip. Specifically, the first mounting frame 131 can be roughly L-shaped, comprising two parts, such as a horizontally extending plate and a vertically extending plate. The second drive element 132 can be mounted on the horizontally extending plate to ensure a stable installation, thereby providing stable power for the lifting and lowering of the extraction assembly 133.

[0075] The extraction component 133 is arranged on the vertical extension plate, and the second driving element 132 can be a screw motor. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the extraction component 133. The transmission connection between the two can be a threaded connection, which can not only ensure the stability of the connection between the two, but also the second driving element 132 can drive the extraction component 133 in the vertical direction smoothly and accurately through threaded driving, so as to smoothly and accurately aspirate the sample after contacting the sample.

[0076] In this embodiment, the first drive element 12 drives the second mounting frame 141 to rise and fall, thereby driving the sample pre-processing mechanism 14 to perform corresponding processing on the reagent strip, such as transferring magnetic particles. The second mounting frame 141 can be roughly L-shaped, comprising two parts, such as a horizontally extending plate and a vertically extending plate. The third drive element 142 can be mounted on the horizontally extending plate to ensure a stable installation, thereby providing stable power for the raising and lowering of the pre-processing assembly 143.

[0077] The pre-processing component 143 is arranged on the vertical extension plate, and the third driving element 142 can be a screw motor. Its transmission shaft (i.e., transmission screw) passes through the horizontal extension plate and extends downward to be connected to the pre-processing component 143. The transmission connection between the two can be a threaded connection, which can not only ensure the stability of the connection between the two, but also the third driving element 142 can be driven by a thread to make the pre-processing component 143 move smoothly and accurately in the vertical direction, so as to smoothly and accurately adsorb the magnetic particles in the reagent strip and then transfer them.

[0078] Pre-processing assembly 143 includes at least two rows of magnetic rods 1435 arranged side by side along its width. This means that pre-processing assembly 143 can transfer magnetic particles from at least two reagent wells on a single reagent strip to perform tests on at least two items, thus enabling multi-channel testing. The presence of at least two magnetic rods 1435 in each row means that pre-processing assembly 143 can simultaneously transfer magnetic particles from at least two parallel reagent strips, enabling multi-channel parallel processing.

[0079] Correspondingly, the reagent strip corresponding to the multi-channel multi-test parallel pre-processing device 10 of the embodiment of the present invention is a multi-test reagent strip, which is provided with disposable magnetic separation sleeves, reagent holes containing magnetic particles, and detection positions containing substrate readings, which are equal to the number of rows of magnetic rods 1435. For example, if there are two rows of magnetic rods, the number of disposable magnetic separation sleeves, reagent holes containing magnetic particles, and detection positions containing substrate readings on the reagent strip are all two.

[0080] In the embodiment of the present utility model, the sample extraction mechanism 13 is opposite to the sample pre-processing mechanism 14 on the gantry 11, and the sample extraction mechanism 13 is located in front of the sample pre-processing mechanism 14. The first driving element 12, the second driving element 132 and the third driving element 142 are arranged linearly on the top of the gantry 11, so that the top structure of the multi-channel multi-joint inspection parallel pre-processing device 10 is regularly distributed, and the three driving elements are basically concentrated in the middle position of the gantry 11 when exerting force, so that the gantry 11 is evenly stressed and not prone to shaking or displacement.

[0081] See also Figure 9 Furthermore, the pre-processing component 14 includes:

[0082] A magnetic rod device 1431 is provided on the second mounting frame 141. A plurality of movable through holes are formed in the magnetic rod device 1431. A plurality of first loading heads 1432 for loading disposable magnetic separation sleeves are provided at the bottom of the magnetic rod device 1431. The plurality of first loading heads 1432 are in one-to-one communication with the plurality of movable through holes.

[0083] a first push plate 1433 disposed above the magnetic bar device 1431 , the first push plate 1433 being in driving connection with the third driving element 142 ; and

[0084] Multiple connecting rods 1434 are provided on the first pushing plate 1433, and at least two rows of magnetic bars 1435 are provided on the free ends of the multiple connecting rods 1434 in a one-to-one correspondence. The third driving element 142 can drive the first pushing plate 1433 to drive the magnetic bars 1435 to rise and fall in the corresponding movable through holes so as to be separated from or pass through the first loading head 1432.

[0085] Specifically, the magnetic rod components are distributed along the width of the second mounting frame 141, allowing the active through-holes therein to be distributed along the width of the pre-processing assembly 143 to correspond to the location of the reagent strip. When the disposable magnetic separation sleeve needs to be loaded, the first drive element 12 drives the second mounting frame 141 down to the second loading head 1432, where it contacts the disposable magnetic separation sleeve for loading. The interference fit between the two ensures the stability of the disposable magnetic separation sleeve when loaded on the second loading head 1432, while also facilitating separation.

[0086] The second loading head 1432 is connected to the movable through-hole, thereby connecting the movable through-hole to the disposable magnetic separation sleeve. When the third driving element 142 drives the connecting rod 1434 to drive the magnetic rod 1435 through the second loading head 1432 and into the disposable magnetic separation sleeve, the disposable magnetic separation sleeve can attract magnetic particles. When the disposable magnetic separation sleeve needs to be separated, the third driving element 142 is controlled to drive the magnetic rod 1435 downward until it contacts the bottom of the disposable magnetic separation sleeve, thereby removing the disposable magnetic separation sleeve from the second loading head 1432. When the third driving element 142 drives the connecting rod 1434 to drive the magnetic rod 1435 away from the second loading head 1432 and separate from the disposable magnetic separation sleeve, the magnetic particles can be separated from the disposable magnetic separation sleeve and transferred.

[0087] In addition, based on the transfer of magnetic particles, the pre-treatment component 143 can also be used to transfer the magnetic particles to the reagent for reaction mixing, or to separate the magnetic particles in the reaction solution into the cleaning solution, or to transfer the magnetic particles to the substrate reading for reaction and complete luminescence detection.

[0088] The transmission shaft of the third driving element 142 extends downward through the top of the second mounting frame 141 and the second push plate 1433. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the second push plate 1433 can be fixed on the fixing piece. When the transmission shaft of the third driving element 142 moves, the fixing piece can be used to drive the second push plate 1433 to rise and fall, thereby realizing the rise and fall of the magnetic rod 1435.

[0089] Alternatively, a screw hole can be set on the second push plate 1433, and a thread can be set on the transmission shaft of the third driving element 142. The transmission shaft is threadedly connected to the second push plate 1433. This can ensure the stability of the connection between the two, and the third driving element 142 can also drive the second push plate 1433 to rise and fall by thread driving.

[0090] See also Figure 5 and Figure 9 Furthermore, the magnetic bars 1435 are arranged in multiple rows, evenly spaced along the width of the first push plate 1433. The number of rows of magnetic bars 1435 equals the number of substrate reading wells and reagent wells containing magnetic particles on the reagent strip, thereby enabling the testing of multiple items, i.e., multi-item testing. Each row of magnetic bars 1435 has multiple magnetic bars 1435, evenly spaced along the length of the first push plate 1433. The number of magnetic bars 1435 in each row equals the number of reagent strips, thereby enabling multi-channel parallel processing of multiple reagent strips.

[0091] In an embodiment of the present invention, there are three rows of magnetic rods 1435, that is, the sample pretreatment mechanism 14 can simultaneously transfer the magnetic particles in the three reagent holes of the reagent strip, and can realize the detection of three items. The space occupied by the three rows of magnetic rods 1435 is not large, and three tests can be realized, and multiple tests can be realized while controlling the volume of the POCT fully automatic chemiluminescence device 100.

[0092] Of course, in other embodiments, the magnetic bars 1435 can also be arranged in 2 rows, 4 rows, or even more rows to enable detection of different numbers of items.

[0093] Exemplarily, the process of transferring magnetic particles by the sample pre-processing mechanism 14 is roughly as follows:

[0094] After the sample is injected into the corresponding reagent hole of the reagent strip, the reaction chamber device 30 drives the reagent strip to move so that the sample pretreatment mechanism 14 is located directly above the disposable magnetic separation sleeve. At this time, the first driving element 12 drives the second mounting bracket 141 to descend to a certain height until the disposable magnetic separation sleeve is loaded on the second loading head 1432. The first driving element 12 drives the second mounting bracket 141 to rise, and the disposable magnetic separation sleeve is driven by the second loading head 1432 to rise to a certain height.

[0095] Afterwards, the reaction chamber device 30 moves to the sample pretreatment mechanism 14 loaded with the disposable magnetic separation sleeve and moves to above the corresponding hole position of the reagent strip. The third driving element 142 drives the magnetic rod 1435 to descend until the magnetic rod 1435 contacts the bottom of the disposable magnetic separation sleeve. At this time, the first driving element 12 drives the second mounting bracket 141 to descend to a certain height, so that the disposable magnetic separation sleeve extends into the liquid containing magnetic particles until the disposable magnetic separation sleeve contacts the bottom of the magnetic label ligand hole, so that the magnetic particles are gradually adsorbed to the end of the disposable magnetic separation sleeve. The adsorption of the magnetic particles can be fully completed by slowly lifting and lowering multiple times.

[0096] After the adsorption of the magnetic particles is completed, the first driving element 12 is controlled to drive the second mounting bracket 141 to rise. At this time, all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve. The reaction chamber device 30 is controlled to move until the disposable magnetic separation sleeve is located above the cleaning liquid. The first driving element 12 drives the second mounting bracket 141 to descend until the disposable magnetic separation sleeve extends into the cleaning liquid. After that, the third driving element 142 drives the magnetic rod 1435 to rise from the disposable magnetic separation sleeve and the magnetic field disappears. The magnetic particles are separated from the outer wall of the disposable magnetic separation sleeve and fall off and enter the cleaning liquid.

[0097] To accelerate the separation of the magnetic particles, the first drive element 12 drives the second mounting frame 141 up and down repeatedly at varying frequencies, causing the magnetic particles to repeatedly move within the cleaning solution, thereby ensuring thorough mixing and suspension of the magnetic particles and the cleaning solution. After the magnetic particles have completely detached from the outer wall of the disposable magnetic separation sleeve, the first drive element 12 drives the second mounting frame 141 up to its initial height, completing the separation, cleaning, and mixing operations. Repeating these steps can be performed multiple times if magnetic separation and cleaning are required.

[0098] Similarly, if it is necessary to transfer the magnetic particles to other hole positions, just control the first driving element 12 to drive the second mounting bracket 141 to descend until the disposable magnetic separation sleeve extends into the bottom of the corresponding liquid surface, and then control the third driving element 142 to drive the magnetic rod 1435 to descend until it contacts the bottom end of the disposable magnetic separation sleeve, so that all the magnetic particles are adsorbed on the outer wall of the disposable magnetic separation sleeve, and control the first driving element 12 to drive the second mounting bracket 141 to rise.

[0099] Afterwards, the reaction chamber device 30 is controlled to move until the disposable magnetic separation sleeve with adsorbed magnetic particles moves to the top of the target hole, and then the first driving element 12 is controlled to drive the second mounting bracket 141 to descend until the disposable magnetic separation sleeve extends into the target liquid. At this time, the third driving element 142 is controlled to drive the magnetic rod 1435 to rise so that the magnetic field disappears, and the magnetic particles can be gradually separated into the target liquid. The first driving element 12 can be controlled to repeatedly drive the second mounting bracket 141 to rise and fall, so that the disposable magnetic separation sleeve repeatedly moves in the target liquid to accelerate the separation and mixing of the magnetic particles.

[0100] See also Figure 9 Furthermore, the sample pre-processing mechanism 14 further includes:

[0101] A first slide rail 144 is provided on the second mounting frame 141 , and the first slide rail 144 is distributed along the height direction of the second mounting frame 141 ; and

[0102] The first sliding block 145 is disposed on the first pushing plate 1433 and is slidably connected to the first sliding rail 144 .

[0103] Furthermore, in order to ensure that the first push plate 1433 can smoothly drive at least two rows of magnetic rods 1435 to rise and fall, a first slide rail 144 extending in the vertical direction is provided on the second mounting frame 141, and a first slider 145 adapted to the first slide rail 144 is provided on the first push plate 1433. The stable movement of the first push plate 1433 relative to the second mounting frame 141 is achieved through the cooperation between the first slide rail 144 and the first slider 145.

[0104] Furthermore, the first slide rail 144 and the first slider 145 are divided into two groups and are respectively disposed on the left and right sides of the sample pre-processing mechanism 14 to further ensure the smooth lifting and lowering of the first push plate 1433 .

[0105] See also Figure 8 , further, the extraction component 133 includes:

[0106] An injection device 1331 is mounted on the first mounting frame 131. The injection device 1331 has a syringe cavity formed therein. A first loading head 1332 for loading a tip is provided at the bottom of the injection device 1331. The first loading head 1332 is in communication with the syringe cavity.

[0107] a second push plate 1333 disposed above the injection device 1331 , the second push plate 1333 being in transmission connection with the second driving element 132 ; and

[0108] The piston rod 1334 is provided on the second push plate 1333 and is movably and sealedly connected to the syringe cavity. The second driving element 132 can drive the first push plate 1333 to drive the piston rod 1334 to rise and fall in the syringe cavity to perform a suction and exhalation action.

[0109] Specifically, the injection components are distributed along the width of first mounting bracket 131, allowing the syringe cavities therein to be distributed across the width of extraction assembly 133 to correspond to the location of the reagent strip. Injection components 1331 also have a certain height to ensure that the syringe cavities are sufficiently spacious, allowing piston rod 1334 to generate sufficient suction and discharge force when moving within the syringe cavities.

[0110] The first loading head 1332 and the tip are fitted with an interference fit, ensuring the tip's stability when mounted on the first loading head 1332. When the first drive element 12 drives the first mounting frame 131, which in turn lowers the extraction assembly 133, the tip mounted on the first loading head 1332 can break the corresponding sealing film on the reagent strip. The first loading head 1332 is connected to the syringe cavity, allowing the syringe cavity to communicate with the tip. When the piston rod 1334 is pushed up and down within the syringe cavity, the sample can be aspirated and discharged through the tip.

[0111] The transmission shaft of the second driving element 132 extends downward through the top of the first mounting frame 131 and the first push plate 1333. A fixing piece threadedly connected to the transmission shaft can be set on the transmission shaft, and the first push plate 1333 can be fixed on the fixing piece. When the transmission shaft of the second driving element 132 moves, the first push plate 1333 can be driven to rise and fall through the fixing piece to realize the rise and fall of the piston rod 1334.

[0112] Alternatively, a screw hole can be set on the first push plate 1333, and a thread can be set on the transmission shaft of the second driving element 132. The transmission shaft is threadedly connected to the first push plate 1333. This can ensure the stability of the connection between the two, and the second driving element 132 can also drive the first push plate 1333 to rise and fall by thread driving.

[0113] In this embodiment, the end of the piston rod 1334 in the syringe cavity can be sealed with the syringe cavity by a sealing ring (such as a rubber ring or plastic ring). When the piston rod 1334 is driven upward by the first push plate 1333 and rises in the syringe cavity, negative pressure is generated in the syringe cavity, causing the tip to absorb the sample. When the piston rod 1334 is pushed downward by the first push plate 1333 and descends in the syringe cavity, positive pressure is generated in the syringe cavity, causing the tip to discharge the sample.

[0114] Furthermore, a photoelectric switch can be provided on the top of the first mounting frame 131, and a baffle can be provided on the corresponding side of the first push plate 1333. When the first push plate 1333 drives the baffle to move to the photoelectric switch so that the photoelectric switch disconnects the sensing, it indicates that the first push plate 1333 has moved to the set height, that is, it indicates that the piston rod 1334 has been reset. At this time, the power supply of the second driving element 132 can be disconnected to prevent the second driving element 132 from being damaged by overload due to continuous operation.

[0115] Please continue reading Figure 8 Furthermore, the sample extraction mechanism 13 also includes:

[0116] A push rod 1335 is liftably disposed through the injection device 1331 , with the top end of the push rod 1335 spaced apart from the first push plate 1333 ;

[0117] an elastic element 1336 sleeved on a push rod 1335 located in the injection device 1331, and the elastic element 1336 is simultaneously stretched or compressed when the push rod 1335 is raised or lowered relative to the injection device 1331; and

[0118] A separation plate 1337 is provided at the bottom of the injection device 1331 , and the first loading head 1332 passes through the separation plate 1337 . The bottom end of the push rod 1335 is connected to the separation plate 1337 , and the push rod 1335 can drive the separation plate 1337 to rise and fall relative to the first loading head 1332 .

[0119] In an embodiment of the present invention, a through hole is provided on the separation plate 1337, the size of which is smaller than the size of the connection between the tip head and the first loading head 1332. Therefore, the tip head loaded on the first loading head 1332 can be removed by setting the separation plate 1337.

[0120] Specifically, since the top end of the push rod 1335 is spaced from the first push plate 1333, when the first push plate 1333 is pushed down a certain height by the second driving element 132 to contact the top end of the push rod 1335, the first push plate 1333 pushes the push rod 1335 to descend in the injection device 1331, thereby pushing the separation plate 1337 located at the bottom of the injection device 1331 to descend and collide with the tip head, so as to push the tip head to separate from the first loading head 1332.

[0121] After the tip is separated, the second driving element 132 stops driving, and the elastic element 1336 expands, exerting an upward force on the push rod 1335, thereby returning the separation plate 1337 to its original position. The compression of the elastic element 1336 provides a certain buffer for the descent of the push rod 1335, preventing the push rod 1335 from descending too quickly and causing damage to the tip, or preventing the tip from pressing against the test strip and causing the strip to shift or shake.

[0122] In an embodiment of the present invention, there are two push rods 1335 and elastic elements 1336, which are respectively arranged on both sides of the injection device 1331 to ensure that the push rod 1335 pushes the separation plate 1337 smoothly, thereby ensuring the separation effect of the tip head, and ensuring that the elastic element 1336 smoothly resets the separation plate 1337.

[0123] See also Figure 5 and Figure 8Furthermore, there are multiple syringe cavities, and the multiple syringe cavities are evenly distributed in the injection device 1331 along the length direction of the injection device 1331; there are multiple first loading heads 1332, and the multiple first loading heads 1332 are evenly distributed at the bottom of the injection device 1331 along the length direction of the injection device 1331; there are multiple piston rods 1334, and the multiple piston rods 1334 are evenly distributed on the first push plate 1333 along the length direction of the first push plate 1333.

[0124] That is, the multiple piston rods 1334, the multiple syringe cavities and the multiple piston rods 1334 correspond one to one, thereby achieving multi-channel parallel processing of multiple reagent strips.

[0125] See also Figure 8 Furthermore, the sample extraction mechanism 13 also includes:

[0126] a second slide rail 134 disposed between the injection device 1331 and the second push plate 1333 ; and

[0127] The second slider 135 is disposed on the second push plate 1333 and is slidably connected to the second slide rail 134 .

[0128] Furthermore, in order to ensure that the second push plate 1333 can smoothly drive the piston rod 1334 to rise and fall, a second slide rail 134 extending in the vertical direction is provided on the injection device 1331, and a second slider 135 adapted to the second slide rail 134 is provided on the second push plate 1333. The stable movement of the second push plate 1333 relative to the first mounting frame 131 is achieved through the cooperation between the second slide rail 134 and the second slider 135.

[0129] The second slide rail 134 and the second slider 135 are two sets, respectively disposed on the left and right sides of the sample extraction mechanism 13 , to further ensure the smooth lifting of the second push plate 1333 .

[0130] See also Figure 3 、 Figure 6 and Figure 7 Furthermore, a movable space 111 is provided on the gantry 11, and the transmission shaft of the first driving element 12 passes through the movable space 111. A transmission plate 112 is sleeved on the transmission shaft, and a thread is provided on the transmission shaft, and a screw hole is provided on the transmission plate 112. Therefore, when the transmission shaft moves, the transmission plate 112 can be synchronously raised and lowered in the movable space 111 by thread transmission.

[0131] A first connecting portion is provided on the side of the first mounting frame 131 facing the gantry 11, and the first connecting portion is formed by a vertical extension plate of the first mounting frame 131 extending toward the gantry 11. A second connecting portion is provided on the side of the second mounting frame 141 facing the gantry 11, and the second extension portion is formed by a vertical extension plate of the second mounting frame 141 extending toward the gantry 11. The first connecting portion and the second connecting portion are both connected to the transmission plate 112 by fasteners (such as screws). Therefore, when the transmission plate 112 is raised and lowered along with the transmission shaft of the first driving element 12, it can drive the first mounting frame 131 and the second mounting frame 141 to rise and fall, thereby realizing the lifting and lowering of the sample extraction mechanism 13 and the sample pre-processing mechanism 14 on the gantry 11.

[0132] Exemplarily, the process of the sample extraction mechanism 13 aspirating and discharging the sample (and transferring / mixing the reagent) is roughly as follows:

[0133] When the reaction chamber device 30 drives the reagent strip to move to the corresponding position, the first driving element 12 drives the first mounting frame 131 to descend to the first loading head 1332 to cooperate with and fix the tip head on the reagent strip.

[0134] After the tip head is loaded, the reaction chamber device 30 drives the reagent strip to move until the tip head moves above the sample hole. At the same time, the second driving element 132 first drives the piston rod 1334 to descend a certain height or to the lowest point in the syringe cavity. Then, the first driving element 12 drives the first mounting frame 131 to descend a certain height until the tip of the tip head extends into the sample. The second driving element 132 drives the piston rod 1334 to rise to absorb the sample through the tip head. Then, the first driving element 12 drives the first mounting frame 131 to rise to separate the tip head from the sample liquid surface. The reaction chamber device 30 drives the reagent strip to move until the tip head with the sample absorbed moves to directly above the target hole position.

[0135] The first driving element 12 drives the first mounting frame 131 to descend, driving the tip head with the sample absorbed to descend until its tip is inserted below the liquid surface of the reagent. The second driving element 132 drives the piston rod 1334 to descend to inject the sample in the tip head into the reagent. Then, the first driving element 12 drives the first mounting frame 131 to rise until the tip head is separated from the reagent. The second driving element 132 drives the piston rod 1334 to rise to its original position, realizing the suction and transfer of the sample, and then retracting the tip head into the tip head hole on the reagent strip.

[0136] The reagent transfer process is the same as the sample transfer process and will not be described in detail here.

[0137] If multiple pipetting operations are required, the tip can be repeatedly loaded and the suction and injection operations can be repeated. In addition, the sample extraction mechanism 13 can also be used to mix the reagents. The second drive element 132 is controlled to drive the piston rod 1334 to repeatedly rise and fall in the syringe cavity, so that the tip repeatedly sucks and discharges below the reagent liquid level, thereby fully mixing the reagents or samples to be reacted.

[0138] Furthermore, a third slider 136 may be provided on the side of the first mounting frame 131 facing the gantry 11, and a third slide rail 113 extending along the height direction of the gantry 11 may be provided on the side of the gantry 11 facing the first mounting frame 131. The third slider 136 is slidably connected to the third slide rail 113, and the third slider 136 and the third slide rail 113 are two groups, which are respectively provided on the left and right sides of the gantry 11 and the first mounting frame 131. Through the cooperation of the two groups of third sliders 136 and the third slide rail 113, it can be ensured that the first driving element 12 drives the first mounting frame 131 on the gantry 11 to rise and fall smoothly, thereby ensuring that the sample extraction mechanism 13 rises and falls smoothly and accurately.

[0139] In addition, a fourth slider 146 may be provided on the side of the second mounting frame 141 facing the gantry 11, and a fourth slide rail 114 extending along the height direction of the gantry 11 may be provided on the side of the gantry 11 facing the second mounting frame 141. The fourth slider 146 is slidably connected to the fourth slide rail 114, and the fourth slider 146 and the fourth slide rail 114 are two groups, which are respectively provided on the left and right sides of the gantry 11 and the second mounting frame 141. Through the cooperation of the two groups of fourth sliders 146 and the fourth slide rail 114, it can be ensured that the first driving element 12 drives the second mounting frame 141 on the gantry 11 to rise and fall smoothly, thereby ensuring that the sample pre-processing mechanism 14 rises and falls smoothly and accurately.

[0140] A first detector 115 (e.g., a photoelectric switch) can be installed on one side of the top of the gantry 11, and a first sensor 137 (e.g., a baffle) can be installed on one side of the top of the first mounting bracket 131. The first sensor 137 can be inductively coupled to or decoupled from the first detector 115 as the first mounting bracket 131 rises and falls. When the first mounting bracket 131 drives the first sensor 137 to the first detector 115, decoupling it from the sensor, indicating that the sample extraction mechanism 13 has reached the desired height, the power supply to the first drive element 12 can be disconnected to prevent overload and damage to the first drive element 12.

[0141] In addition, a second detector (e.g., a photoelectric switch) can be disposed on the other side of the top of the gantry 11, and a second sensing element (e.g., a baffle) can be disposed on one side of the top of the second mounting bracket 141. The second sensing element can be inductively coupled to or decoupled from the second detector as the second mounting bracket 141 is raised or lowered. When the second mounting bracket 141 drives the second sensing element to the second detector, decoupling the sensing element, indicating that the sample pre-processing mechanism 14 has reached the desired height, the power supply to the third drive element 142 can be disconnected to prevent overload and damage to the third drive element 142.

[0142] See also Figures 1 to 9 The POCT fully automatic chemiluminescence device 100 of an embodiment of the present invention includes: a mounting frame 20; a reaction chamber device 30 provided on the mounting frame 20, the reaction chamber device 30 can move back and forth along the length direction of the mounting frame 20, and the reaction chamber device 30 is used to load a reagent strip; a PMT device 40 provided at the rear end of the mounting frame 20 and located above the reaction chamber device 30, the reaction chamber device 30 is used to move the reagent strip to the PMT device 40, and the PMT device 40 is used to detect the luminescence value of the detection position of the reagent strip; and a multi-channel multi-joint detection parallel pre-processing device 10 according to any of the above items, the multi-channel multi-joint detection parallel pre-processing device 10 is used to aspirate samples of reagents in the reagent strip and transfer magnetic particles.

[0143] In the POCT fully automatic chemiluminescence equipment 100 of the embodiment of the present invention, the pre-treatment component 143 in the multi-channel multi-joint detection parallel pre-treatment device 10 includes at least two rows of magnetic rods 1435 for transferring magnetic particles, and there are at least two magnetic rods 1435 in each row, that is, the pre-treatment component 143 can simultaneously transfer the magnetic particles in at least two reagent wells on a single reagent strip, and transfer the magnetic particles in at least two reagent strips arranged in parallel, thereby realizing the detection of at least two items, realizing multi-joint detection while realizing multi-channel parallel processing, and realizing the multi-channel multi-joint detection function of the multi-channel multi-joint detection parallel pre-treatment device 10, which can reduce the risk of cross infection, control the time and equipment volume for transferring magnetic particles, and ensure the analysis efficiency of the equipment for multiple items.

[0144] In an embodiment, the reaction chamber device 30 can be arranged on the bottom plate of the mounting frame 20, and driving elements such as a motor and a guide rail extending along the length direction of the mounting frame 20 can be arranged on the bottom plate. A slide corresponding to the guide rail can be provided at the bottom of the reaction chamber device 30. Through the cooperation between the slide and the guide rail, the reaction chamber device 30 can be slidably arranged on the mounting frame 20 to realize reciprocating movement, and then the reagent strip can be moved to the corresponding position for corresponding detection and analysis.

[0145] Since the reaction chamber device 30 is arranged on the bottom plate of the mounting frame 20, the PMT device 40 can be arranged above the bottom plate through a bracket or other structure, that is, the PMT device 40 is located relatively above the reaction chamber device 30. To ensure that the PMT device 40 can detect the luminescence values ​​of all reagent strips in the reaction chamber device 30, the PMT device 40 can move up and down and left and right on the bracket, that is, it can move in the vertical direction and horizontal direction (the width direction of the mounting frame 20), thereby approaching or moving away from the reagent strip and moving back and forth between multiple reagent strips to achieve corresponding detection.

[0146] The reaction chamber device 30 and the PMT device 40 do not relate to the practical features of the present invention and will not be described in detail here.

[0147] In this specification, references to terms such as "Example 1" and "Example 2" indicate that specific features, structures, materials, or characteristics described in conjunction with an embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0148] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A multi-channel multi-joint inspection parallel pre-processing device, characterized in that: include: A gantry, wherein a first driving element is provided on the top of the gantry; A sample extraction mechanism is provided on the gantry, comprising a first mounting frame provided on the gantry and in transmission connection with the first driving element, a second driving element provided on the first mounting frame, and an extraction assembly provided on the first mounting frame and in transmission connection with the second driving element, wherein the second driving element can drive the first mounting frame to rise and fall, and the second driving element can drive the extraction assembly to rise and fall to aspirate and discharge samples; as well as a sample pre-processing mechanism disposed on the gantry, the sample pre-processing mechanism comprising a second mounting frame disposed on the gantry and transmission-connected to the first driving element, a third driving element disposed on the second mounting frame, and a pre-processing assembly disposed on the second mounting frame and transmission-connected to the third driving element, wherein the first driving element can drive the second mounting frame to rise and fall; The pre-processing component includes at least two rows of magnetic bars arranged side by side along the width direction of the pre-processing component, with at least two magnetic bars in each row. The third driving element can drive the pre-processing component to rise and fall to transfer magnetic particles through at least two rows of magnetic bars.

2. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The pre-processing component includes: A magnetic bar device is provided on the second mounting frame, wherein a plurality of movable through holes are formed in the magnetic bar device, and a plurality of first loading heads for loading disposable magnetic separation sleeves are provided at the bottom of the magnetic bar device, wherein the plurality of first loading heads are in one-to-one communication with the plurality of movable through holes; a first push plate disposed above the magnetic bar device, the first push plate being in driving connection with the third driving element; and There are multiple connecting rods arranged on the first push plate, and at least two rows of magnetic bars are arranged one by one on the free ends of the multiple connecting rods. The third driving element can drive the first push plate to drive the magnetic bars to rise and fall in the corresponding movable through holes so as to be separated from or pass through the first loading head.

3. The multi-channel multi-joint inspection parallel pre-processing device according to claim 2, characterized in that: The magnetic bars are arranged in multiple rows, and the magnetic bars in the multiple rows are evenly distributed along the width direction of the first push plate; There are multiple magnetic bars in each row, and the multiple magnetic bars in each row are evenly distributed along the length direction of the first push plate.

4. The multi-channel multi-joint inspection parallel pre-processing device according to claim 2, characterized in that: The sample pre-processing mechanism also includes: a first slide rail provided on the second mounting frame, the first slide rail being distributed along a height direction of the second mounting frame; and A first sliding block is provided on the first pushing plate, and the first sliding block is slidably connected to the first sliding rail.

5. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The extraction component includes: An injection device is provided on the first mounting frame, wherein a plurality of injection cavities are formed in the injection device, and a plurality of second loading heads for loading tip heads are provided at the bottom of the injection device, wherein the plurality of second loading heads are in one-to-one communication with the plurality of injection cavities; a second push plate disposed above the injection device, the second push plate being in transmission connection with the second driving element; and A plurality of piston rods are provided on the second push plate, and the piston rods are movably and sealedly connected to the syringe cavity. The second driving element can drive the second push plate to drive the piston rods to move up and down in the syringe cavity to perform a suction and exhalation action.

6. The multi-channel multi-joint inspection parallel pre-processing device according to claim 5, characterized in that: The sample extraction mechanism further includes: A push rod is lifted and lowered through the injection device, wherein the top end of the push rod is spaced apart from the second push plate; an elastic element sleeved on the push rod in the injection device, wherein the elastic element is simultaneously stretched or compressed when the push rod is raised or lowered relative to the injection device; and A separation plate is provided at the bottom of the injection device, the second loading head passes through the separation plate, the bottom end of the push rod is connected to the separation plate, and the push rod can drive the separation plate to rise and fall relative to the second loading head.

7. The multi-channel multi-joint inspection parallel pre-processing device according to claim 5, characterized in that: The plurality of syringe cavities are evenly distributed along the length direction of the injection device, the plurality of second loading heads are evenly distributed along the length direction of the injection device, and the plurality of piston rods are evenly distributed along the length direction of the second push plate.

8. The multi-channel multi-joint inspection parallel pre-processing device according to claim 5, characterized in that: The sample extraction mechanism further includes: a second slide rail provided between the injection device and the second push plate; and A second sliding block is provided on the second pushing plate, and the second sliding block is slidably connected to the second slide rail.

9. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The sample extraction mechanism is opposite to the sample pre-processing mechanism and is located in front of the sample pre-processing mechanism. The first driving element, the second driving element and the third driving element are linearly arranged on the top of the gantry.

10. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: The gantry is provided with an activity space, the transmission shaft of the first driving element passes through the activity space, and a transmission plate is sleeved on the transmission shaft. When the transmission shaft moves, the transmission plate can be raised and lowered in the activity space; A first connecting portion is provided on a side of the first mounting frame facing the gantry, and a second connecting portion is provided on a side of the second mounting frame facing the gantry. Both the first connecting portion and the second connecting portion are connected to the transmission plate.

11. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: A third slider is provided on a side of the first mounting frame facing the gantry frame, and a third slide rail is provided on a side of the gantry frame facing the first mounting frame. The third slide rail extends along the height direction of the gantry frame, and the third slider is slidably connected to the third slide rail. A fourth slider is provided on the side of the second mounting frame facing the gantry, and a fourth slide rail is provided on the side of the gantry facing the second mounting frame. The fourth slide rail extends along the height direction of the gantry, and the fourth slider is slidably connected to the fourth slide rail.

12. The multi-channel multi-joint inspection parallel pre-processing device according to claim 1, characterized in that: A first sensing member is provided on one side of the top of the first mounting frame, and a first detector is provided on one side of the top of the gantry frame. The first sensing member can generate or disconnect induction with the first detector as the first mounting frame rises or falls; A second induction member is provided on one side of the top of the second mounting frame, and a second detector is provided on one side of the top of the gantry frame. The second induction member can generate or disconnect induction with the second detector as the second mounting frame rises and falls.

13. A POCT fully automatic chemiluminescence device, characterized in that: include: Install the frame; a reaction chamber device provided on the mounting frame, the reaction chamber device being reciprocally movable along the length direction of the mounting frame, the reaction chamber device being used for loading a reagent strip; a PMT device disposed at the rear end of the mounting frame and located above the reaction chamber device, the reaction chamber device being used to move the reagent strip to the PMT device, and the PMT device being used to detect the luminescence value of the detection position of the reagent strip; as well as The multi-channel multi-test parallel pre-processing device according to any one of claims 1 to 12, wherein the multi-channel multi-test parallel pre-processing device is used to aspirate samples and transfer magnetic particles from the reagent strip.

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