Silica gel extraction and separation device for urokinase preparation

Abstract

The utility model relates to the field of urokinase preparation, and discloses a silica gel extraction and separation device for urokinase preparation, which comprises a box body, a filter assembly is arranged on the outer wall of the left side of the box body and comprises a belt pulley A. The outer wall of the belt pulley A is in transmission connection with a belt pulley B through a belt. A connecting column is slidably connected to the inner wall of the inclined face of the bottom end of the extrusion block, a swing frame is fixedly connected to the end, away from the extrusion block, of the connecting column, a wedge block is elastically connected to the surface of the box body through a reset spring, and a stirring assembly is arranged on the inner wall of the top end of the box body. According to the utility model, the elliptical block in the filter assembly rotates to drive the contact plate, the extrusion block and the connecting column to move, so that the swing frame and the filter screen move back and forth at the bottom of the box body to dynamically filter urine, the extraction effect of silica gel is further improved, and meanwhile, the silica gel is prevented from being accumulated on the surface of the filter screen to influence the subsequent filtration and extraction operation.

Description

Technical Field

[0001] The utility model relates to the field of urokinase preparation, in particular to a silica gel extraction and separation device for urokinase preparation. Background Art

[0002] Urokinase is an enzyme protein isolated from healthy human urine or obtained from human kidney tissue culture. Its primary function is to activate the body's plasminogen to convert it into plasmin, thereby dissolving blood clots. Clinically, urokinase is widely used to treat thrombotic diseases such as acute myocardial infarction, cerebral infarction, and pulmonary embolism. It can quickly clear blocked blood vessels, restore blood circulation, and save patients' lives.

[0003] In the preparation of urokinase, efficient extraction of silica gel from urine is a crucial step. Effective extraction of silica gel is directly related to the quality and efficiency of subsequent urokinase separation and purification.

[0004] The currently common silica gel extraction device for urokinase preparation has some shortcomings: on the one hand, during the filtration process, the filter screen of the traditional device is usually fixed and the impurities in the urine are easily accumulated on the filter screen surface, which not only affects the filtration effect but also hinders the subsequent filtration and extraction operations. On the other hand, most existing equipment does not have a structure to accelerate the extraction and separation of incoming urine, making the extraction efficiency of the equipment itself slow. Therefore, a silica gel extraction and separation device for urokinase preparation is proposed to solve the above problems. Utility Model Content

[0005] In order to make up for the above shortcomings, the utility model provides a silica gel extraction and separation device for the preparation of urokinase, which aims to improve the problem in the prior art that impurities in the liquid are easily accumulated on the filter surface, which not only affects the filtration effect but also hinders subsequent filtration and extraction operations.

[0006] In order to achieve the above-mentioned object, the present invention adopts the following technical solution: a silica gel extraction and separation device for preparing urokinase, comprising a box body, a filter assembly is provided on the left outer wall of the box body, and the filter assembly includes a pulley A;

[0007] The outer wall of the pulley A is connected to the pulley B through a belt drive, and the surface of the pulley B is fixedly connected to an elliptical block, the outer wall of the left side of the box is fixedly connected to a guide block, the top of the outer wall of the guide block is elastically connected to a contact plate through a limit spring, the bottom end of the outer wall of the contact plate is fixedly connected to an extrusion block, the bottom end of the extrusion block is provided with an inclined surface, the inner wall of the inclined surface of the bottom end of the extrusion block is slidably connected to a connecting column, the end of the connecting column away from the extrusion block is fixedly connected to a swing frame, the inner wall of the swing frame is detachably mounted with a filter, the surface of the box is elastically connected to a wedge through a return spring, and the inner wall of the top end of the box is provided with a stirring assembly.

[0008] As a further description of the above technical solution:

[0009] The stirring assembly includes a motor, the output shaft of the motor is fixedly connected to a rotating sleeve, and two groups of rotating sleeves are provided. The inner wall of the rotating sleeve on the left side is elastically connected to a rotating rod through a connecting spring, the inner wall of the top end of the box body is fixedly connected to a hemispherical block, and the surface of the rotating rod is fixedly connected to multiple groups of stirring rods.

[0010] As a further description of the above technical solution:

[0011] The pulley A is rotatably connected to the outer wall of the top left side of the box body, and the pulley B is rotatably connected to the outer wall of the left side of the box body.

[0012] As a further description of the above technical solution:

[0013] The bottom end of the outer wall of the elliptical block contacts the top end of the outer wall of the contact plate, and the extrusion block penetrates and is slidably connected to the inner wall of the guide block.

[0014] As a further description of the above technical solution:

[0015] One end of the limit spring is fixedly connected to both sides of the bottom end of the contact plate, and the other end of the limit spring is fixedly connected to the top of the outer wall of the guide block. The connecting column passes through and is slidably connected to the inner wall of the box, and the swing frame is slidably connected to the inner wall of the bottom end of the box.

[0016] As a further description of the above technical solution:

[0017] The filter is slidably connected to the inner wall of the box, one end of the return spring is fixedly connected to the inner side wall of the wedge, and the other end of the return spring is fixedly connected to the surface of the box. The wedge passes through and is slidably connected to the inner wall of the box surface, and the outer wall of the wedge is connected to the outer wall of the filter.

[0018] As a further description of the above technical solution:

[0019] The motor is fixedly connected to the outer wall of the top of the box body, the two groups of rotating sleeves are rotatably connected to the side walls of the top of the box body, both sides of the outer wall of the rotating rod are slidably connected to the inner wall of the rotating sleeve, and the rotating sleeve on the right side is fixedly connected to the rotation center axis of the pulley A.

[0020] As a further description of the above technical solution:

[0021] One end of the connecting spring is fixedly connected to the inner wall of the left rotating sleeve, and the other end of the connecting spring is fixedly connected to the outer wall of the left side of the rotating rod. The stirring rod is in contact with the outer wall of the hemispherical block.

[0022] The utility model has the following beneficial effects:

[0023] 1. In the present invention, the rotation of the elliptical block in the filter assembly drives the contact plate, the extrusion block and the connecting column to move, thereby causing the swing frame and the filter screen to move back and forth at the bottom of the box body, dynamically filtering the urine, further improving the extraction effect of silica gel, while also avoiding accumulation on the surface of the filter screen, affecting subsequent filtering and extraction operations.

[0024] 2. In the present invention, the motor in the stirring assembly drives the rotating sleeve and the rotating rod to rotate, so that the stirring rod stirs the urine. At the same time, the rotating rod moves up and down under the action of the hemispherical block, which increases the sufficiency of stirring and greatly improves the extraction efficiency of silica gel in urine. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a schematic diagram of the overall three-dimensional structure of a silica gel extraction and separation device for preparing urokinase proposed in the present invention;

[0026] Figure 2 This is a schematic diagram of a partial cross-sectional structure of the top of a housing of a silica gel extraction and separation device for preparing urokinase proposed in the present invention;

[0027] Figure 3 The utility model proposes a silica gel extraction and separation device for preparing urokinase Figure 2 A schematic diagram of the enlarged structure of part A;

[0028] Figure 4 This is a schematic structural diagram of the separation state of the extrusion block and the connecting column of a silica gel extraction and separation device for preparing urokinase proposed by the present invention;

[0029] Figure 5 The utility model provides a schematic diagram of the partial cross-sectional structure of the top of the housing and the rotating sleeve of a silica gel extraction and separation device for preparing urokinase.

[0030] Legend:

[0031] 1. Box body; 2. Filter assembly; 21. Pulley A; 22. Elliptical block; 23. Contact plate; 24. Pulley B; 25. Extrusion block; 26. Guide block; 27. Limit spring; 28. Connecting column; 29. ​​Swing frame; 210. Filter screen; 211. Return spring; 212. Wedge block; 3. Stirring assembly; 31. Motor; 32. Rotating sleeve; 33. Connecting spring; 34. Rotating rod; 35. Stirring rod; 36. Hemispherical block. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0033] Reference Figure 1-Figure 3 The present invention provides an embodiment of a silica gel extraction and separation device for preparing urokinase, comprising a box body 1, a discharge port being provided at the bottom end of the box body 1, so as to discharge the liquid after filtering the urine entering the box body, a filter assembly 2 being provided on the left outer wall of the box body 1, the filter assembly 2 comprising a pulley A21, the pulley A21 being rotatably connected to the outer wall of the left top end of the box body 1, the pulley B24 being rotatably connected to the outer wall of the left side of the box body 1, the outer wall of the pulley A21 being connected to the pulley B24 via a belt drive, and the pulley A21 being driven by the belt when rotating, so that the pulley B24 can follow the pulley A21 rotates synchronously, and the surface of the pulley B24 is fixedly connected to an elliptical block 22. When the pulley B24 rotates synchronously with the pulley A21, it will drive the elliptical block 22 on its surface to rotate synchronously with it. The outer wall on the left side of the box body 1 is fixedly connected to a guide block 26, and the top of the outer wall of the guide block 26 is elastically connected to the contact plate 23 through a limit spring 27. One end of the limit spring 27 is fixedly connected to both sides of the bottom end of the contact plate 23, and the other end of the limit spring 27 is fixedly connected to the top of the outer wall of the guide block 26. The function of the limit spring 27 is to automatically reset the position of the contact plate 23 after being squeezed and moved by the elliptical block 22.

[0034] Reference Figure 2-Figure 3 The connecting column 28 passes through and is slidably connected to the inner wall of the box body 1, and the swing frame 29 is slidably connected to the inner wall of the bottom end of the box body 1. A guide groove is provided on the outer side wall of the box body 1, so that the connecting column 28 can move on its inner wall, and at the same time, it will push the swing frame 29 to move on its inner wall. A cavity is provided at the bottom end of the box body 1 corresponding to the swing frame 29, so that the swing frame 29 can move back and forth on the inner wall of the cavity. At the same time, the size of the inner wall of the box body 1 is smaller than the width of the swing frame 29. The bottom end of the outer wall of the elliptical block 22 contacts the top end of the outer wall of the contact plate 23. The contact between the two can drive the extrusion block 25 to move downward on the inner wall of the guide block 26 by the rotation of the elliptical block 22.

[0035] Reference Figure 3-Figure 4The extrusion block 25 passes through and is slidably connected to the inner wall of the guide block 26. The bottom end of the outer wall of the contact plate 23 is fixedly connected to the extrusion block 25. The bottom end of the extrusion block 25 is provided with an inclined surface. The inner wall of the inclined surface of the bottom end of the extrusion block 25 is slidably connected to a connecting column 28. The front end of the connecting column 28 is provided with a guide groove that fits the bottom end of the extrusion block 25, so that the extrusion block 25 will synchronously drive the connecting column 28 to move in its inclined groove when it moves up and down. The end of the connecting column 28 away from the extrusion block 25 is fixedly connected to a swing frame 29. The inner wall of the swing frame 29 is detachably mounted with a filter screen 210. The surface of the filter screen 210 is provided with a handle. The inner wall of the swing frame 29 is provided with a cavity corresponding to the filter screen 210, so that the position of the filter screen 210 is placed, thereby extracting the silica gel in the urine entering its interior from the top of the box body 1. The surface of the box body 1 is elastically connected by a return spring 211 The wedge block 212 is provided with a wedge block 212, and the filter screen 210 is slidably connected to the inner wall of the box body 1. One end of the return spring 211 is fixedly connected to the inner side wall of the wedge block 212, and the other end of the return spring 211 is fixedly connected to the surface of the box body 1. The function of the return spring 211 is to automatically reset the position of the inclined surface of the wedge block 212 after being squeezed and moved. The wedge block 212 passes through and is slidably connected to the inner wall of the surface of the box body 1. The outer wall of the wedge block 212 contacts the outer wall of the filter screen 210. The contact between the two fixes the position of the filter screen 210 installed on the inner wall of the swing frame 29. At the same time, when the swing frame 29 drives the filter screen 210 to move horizontally, the wedge block 212 will always fit with the outer wall of the filter screen 210 to prevent the filter screen 210 from escaping from the inside of the swing frame 29 during use. The inner wall of the top of the box body 1 is provided with a stirring assembly 3.

[0036] Reference Figure 1 and Figure 5The stirring assembly 3 includes a motor 31, which is fixedly connected to the outer wall of the top of the box body 1, and two sets of rotating sleeves 32 are rotatably connected to the side walls of the top of the box body 1. Both sides of the outer wall of the rotating rod 34 are slidably connected to the inner wall of the rotating sleeve 32. The inner wall of the rotating sleeve 32 is provided with guide grooves that fit on both sides of the rotating rod 34, so that the rotating rod 34 can only move up and down on the inner wall of the rotating sleeve 32. At the same time, the rotating rod 34 will also drive the rotating sleeve 32 to rotate synchronously when it rotates. The right rotating sleeve 32 is fixedly connected to the rotation center axis of the pulley A21, and the output shaft of the motor 31 is fixedly connected to the rotating sleeve 32. The rotating sleeve 32 is provided with two groups. The inner wall of the left rotating sleeve 32 is elastically connected to the rotating rod 34 through a connecting spring 33. The connecting spring 3 One end of 3 is fixedly connected to the inner wall of the left rotating sleeve 32, and the other end of the connecting spring 33 is fixedly connected to the outer wall of the left side of the rotating rod 34. The function of the connecting spring 33 is to automatically reset the position of the rotating rod 34 after it moves on the inner wall of the rotating sleeve 32. The stirring rod 35 contacts the outer wall of the hemispherical block 36. The contact between the two makes the rotating sleeve 32 drive the multiple groups of stirring rods 35 on its surface to rotate synchronously when driving the rotating rod 34 to rotate, and is squeezed by the hemispherical block 36 to make the rotating rod 34 move on the inner wall of the left rotating sleeve 32, and the connecting spring 33 is elastically compressed. The inner wall of the top of the box body 1 is fixedly connected with the hemispherical block 36, and the surface of the rotating rod 34 is fixedly connected with multiple groups of stirring rods 35.

[0037] Working Principle: First, urine enters the device from the top of the box 1. The filter assembly 2 on the left outer wall of the box 1 starts to work, and the pulley A21 rotates, driving the pulley B24 to rotate synchronously through the belt. When the pulley B24 rotates, the elliptical block 22 on its surface rotates synchronously.

[0038] When the elliptical block 22 rotates to contact the top of the outer wall of the contact plate 23, the contact plate 23 is squeezed to move downward, compressing the limit spring 27. The contact plate 23 moves downward, driving the squeezing block 25 to move downward on the inner wall of the guide block 26. Since the bottom end of the squeezing block 25 is provided with a slope and the inner wall of the slope is slidably connected to the guide groove at the front end of the connecting column 28, the downward movement of the squeezing block 25 will push the connecting column 28 to move in its slope. The swing frame 29 fixedly connected to the end of the connecting column 28 away from the squeezing block 25 also moves back and forth in the cavity on the inner wall of the bottom end of the box body 1. The inner wall of the swing frame 29 is detachably installed with a filter 210 to extract silica gel in the urine entering the inside of the box body 1.

[0039] At the same time, when the filter 210 is installed on the inner wall of the swing frame 29, the wedge block 212 contacts the outer wall of the filter 210 under the action of the return spring 211, fixing the position of the filter 210 on the inner wall of the swing frame 29, and when the swing frame 29 drives the filter 210 to move horizontally, the wedge block 212 will always fit with the outer wall of the filter 210, preventing the filter 210 from escaping from the inside of the swing frame 29 during use.

[0040] At the same time, on the inner wall at the top of the box body 1, the stirring assembly 3 starts to work, the motor 31 starts, and drives the rotating sleeve 32 on the right to rotate. The rotating sleeve 32 on the right is fixedly connected to the rotating center axis of the pulley A21, so the rotation of the rotating sleeve 32 will drive the pulley A21 to rotate, thereby affecting the operation of the filter assembly 2. When the lever 32 is unlocked, the lever 33 is unlocked and the spring 33 is unlocked, so that the lever 33 can be unlocked and the spring 33 can be unlocked.

[0041] Finally, it should be noted that the above is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or make equivalent replacements for some of the technical features therein. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A silica gel extraction and separation device for preparing urokinase, comprising a housing (1), characterized in that: A filter assembly (2) is provided on the left outer wall of the box body (1), and the filter assembly (2) includes a pulley A (21); The outer wall of the pulley A (21) is connected to the pulley B (24) through a belt transmission, and the surface of the pulley B (24) is fixedly connected to an elliptical block (22). The outer wall of the left side of the box (1) is fixedly connected to a guide block (26), and the top end of the outer wall of the guide block (26) is elastically connected to a contact plate (23) through a limit spring (27). The bottom end of the outer wall of the contact plate (23) is fixedly connected to an extrusion block (25), and the bottom end of the extrusion block (25) is provided with an inclined surface. The inner wall of the inclined surface of the bottom end of the extrusion block (25) is slidably connected to a connecting column (28). The end of the connecting column (28) away from the extrusion block (25) is fixedly connected to a swing frame (29), and the inner wall of the swing frame (29) is detachably mounted with a filter screen (210). The surface of the box (1) is elastically connected to a wedge block (212) through a return spring (211). The inner wall of the top end of the box (1) is provided with a stirring assembly (3).

2. The silica gel extraction and separation device for preparing urokinase according to claim 1, characterized in that: The stirring assembly (3) comprises a motor (31), the output shaft of the motor (31) is fixedly connected to a rotating sleeve (32), and the rotating sleeve (32) is provided with two groups. The inner wall of the left rotating sleeve (32) is elastically connected to a rotating rod (34) via a connecting spring (33). The inner wall of the top end of the box (1) is fixedly connected to a hemispherical block (36), and the surface of the rotating rod (34) is fixedly connected to multiple groups of stirring rods (35).

3. The silica gel extraction and separation device for preparing urokinase according to claim 1, characterized in that: The pulley A (21) is rotatably connected to the outer wall of the top left side of the box body (1), and the pulley B (24) is rotatably connected to the outer wall of the left side of the box body (1).

4. The silica gel extraction and separation device for preparing urokinase according to claim 1, characterized in that: The bottom end of the outer wall of the elliptical block (22) contacts the top end of the outer wall of the contact plate (23), and the extrusion block (25) penetrates and is slidably connected to the inner wall of the guide block (26).

5. The silica gel extraction and separation device for preparing urokinase according to claim 1, characterized in that: One end of the limit spring (27) is fixedly connected to both sides of the bottom end of the contact plate (23), and the other end of the limit spring (27) is fixedly connected to the top end of the outer wall of the guide block (26). The connecting column (28) passes through and is slidably connected to the inner wall of the box body (1), and the swing frame (29) is slidably connected to the inner wall of the bottom end of the box body (1).

6. The silica gel extraction and separation device for preparing urokinase according to claim 1, characterized in that: The filter (210) is slidably connected to the inner wall of the box (1), one end of the return spring (211) is fixedly connected to the inner side wall of the wedge (212), and the other end of the return spring (211) is fixedly connected to the surface of the box (1). The wedge (212) penetrates and is slidably connected to the inner wall of the surface of the box (1), and the outer wall of the wedge (212) contacts the outer wall of the filter (210).

7. The silica gel extraction and separation device for preparing urokinase according to claim 2, characterized in that: The motor (31) is fixedly connected to the outer wall of the top of the box (1), the two sets of rotating sleeves (32) are rotatably connected to the side walls of the top of the box (1), both sides of the outer wall of the rotating rod (34) are slidably connected to the inner wall of the rotating sleeve (32), and the rotating sleeve (32) on the right side is fixedly connected to the rotation center axis of the pulley A (21).

8. The silica gel extraction and separation device for preparing urokinase according to claim 2, characterized in that: One end of the connecting spring (33) is fixedly connected to the inner wall of the left rotating sleeve (32), and the other end of the connecting spring (33) is fixedly connected to the outer wall of the left side of the rotating rod (34). The stirring rod (35) contacts the outer wall of the hemispherical block (36).

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