Liquid pipeline heating device for small gene sequencer

Abstract

The utility model discloses a liquid path pipeline heating device for a small gene sequencer. The liquid path pipeline heating device comprises a guide rod, a plurality of positioning blocks and heating patches, wherein the positioning blocks are coaxially sleeved on the guide rod and have the same structure; the heating patches wrap the outer sides of the positioning blocks; each positioning block is a rectangular positioning block, the axis direction of the guide rod is coaxial with the axis of each positioning block in the width direction, a plurality of first penetrating through holes and second penetrating through holes are formed in the two ends of each positioning block in the length direction respectively, and the axis directions of the first penetrating through holes and the second penetrating through holes are parallel to the axis direction of the guide rod; a to-be-heated liquid path pipeline penetrates through the first penetrating through hole and then is bent to penetrate out of the second penetrating through hole, the PTFE pipeline can be used in a small gene sequencer through multiple times of small-range bending, and the sequencing precision can be improved.

Description

Technical Field

[0001] The utility model relates to the field of biological experimental instruments, in particular to a liquid pipeline heating device for a small gene sequencer. Background Art

[0002] During gene sequencing, reagents flow from the test kit into the fluid channel of the sequencing chip through pipelines for biochemical reactions, and the temperature required for the biochemical reactions is controlled by a temperature control device. When the reagents flow from the pipeline into the fluid channel, if the temperature difference between the reagents and the reaction system is large, the sequencing chip is subjected to a strong impact, which will affect the service life of the chip. If the temperature distribution in the reaction system in the fluid channel is uneven, it will also affect the sequencing quality. Therefore, it is necessary to preheat the reagents in advance to reduce the time taken for the reagents to heat up in the chip channel, optimize the total sequencing time, and improve sequencing efficiency. The liquid pipelines used in small gene sequencers are mostly PTFE, which is a relatively hard material with a relatively small bending radius. Due to the size limitation of the instrument itself, it is impossible to install a very long pipeline heating platform. This application aims to propose a heating device for hard pipes to solve the above problems. Utility Model Content

[0003] In response to the above problems, the utility model provides a liquid pipeline heating device for a small gene sequencer, which has the advantages of simple structure, modular splicing, and high flexibility in use.

[0004] The technical solution of the utility model is:

[0005] A liquid pipeline heating device for a small gene sequencer includes a guide rod, a plurality of positioning blocks with the same structure coaxially sleeved on the guide rod, and a heating patch wrapped around the outer side of the positioning blocks;

[0006] Each of the positioning blocks is a rectangular positioning block, the axial direction of the guide rod is coaxial with the width axis of each positioning block, and a plurality of first through holes and second through holes are respectively provided at both ends of the length direction of each positioning block, and the axial directions of the first through holes and the second through holes are parallel to the axial direction of the guide rod.

[0007] A splicing block is provided at one end in the width direction of each positioning block, and a splicing groove corresponding to the splicing block is provided at the other end, and the depth of the splicing groove is greater than the length of the splicing block.

[0008] The splicing groove is located at one end of the positioning block in the length direction and is provided with a long strip through hole, and the length direction of the long strip through hole is parallel to the axis direction of the guide rod.

[0009] The heating patch is a C-shaped patch, and the opening side of the heating patch is the side where the long strip through hole is provided.

[0010] The outer layer of the heating patch is wrapped with thermal insulation cotton.

[0011] The number of the first through holes of each positioning block is three, and the number of the second through holes is two.

[0012] The device further comprises end plates arranged at both ends of the guide rod.

[0013] The beneficial effects of the utility model are:

[0014] The PTFE tube passes through a channel formed by multiple first through-holes and then bends at the end to pass out along a channel formed by multiple second through-holes. It does not need to be wound like a solenoid, and the bending radius can be minimized. Multiple positioning blocks form a rectangular structure, which can ensure that the sequencing reagents to be heated have sufficient heating space, ensure the reliability of sequencing, and effectively improve the sequencing quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the overall structure of a liquid pipeline heating device for a small gene sequencer according to an embodiment of the present utility model;

[0016] Figure 2 This is a schematic diagram of the exploded structure of a liquid pipeline heating device for a small gene sequencer according to an embodiment of the present utility model;

[0017] Figure 3 This is a structural schematic diagram of a positioning block of a liquid pipeline heating device for a small gene sequencer according to an embodiment of the present utility model;

[0018] Figure 4 This is a right view of a positioning block of a liquid pipeline heating device for a small gene sequencer according to an embodiment of the present utility model;

[0019] Figure 5 This is a left view of a positioning block of a liquid pipeline heating device for a small gene sequencer according to an embodiment of the present utility model;

[0020] Figure 6 It is a top view of a positioning block of a liquid pipeline heating device for a small gene sequencer described in an embodiment of the present utility model.

[0021] Description of reference numerals:

[0022] 1 is a guide rod, 2 is a positioning block, 3 is a heating patch, 4 is a heat-insulating cotton, 5 is an end plate, 21 is a first through hole, 22 is a second through hole, 23 is a splicing block, 24 is a splicing groove, and 25 is a long strip through hole. DETAILED DESCRIPTION

[0023] The embodiments of the present invention will be further described below with reference to the accompanying drawings. Example

[0024] like Figures 1-6 As shown, a liquid pipeline heating device for a small gene sequencer includes a guide rod 1, a plurality of positioning blocks 2 with the same structure coaxially sleeved on the guide rod 1, and a heating patch 3 wrapped around the outer side of the positioning block 2;

[0025] Each positioning block 2 is a rectangular positioning block, the axial direction of the guide rod 1 is coaxial with the width axis of each positioning block 2, and a plurality of first through holes 21 and second through holes 22 are respectively provided at both ends in the length direction of each positioning block 2, and the axial directions of the first through holes 21 and the second through holes 22 are parallel to the axial direction of the guide rod 1.

[0026] The working principle of the above technical solution is as follows:

[0027] Multiple positioning blocks 2 are spliced ​​into a whole along the guide rod 1. The first through holes 21 on each positioning block 2 are connected in sequence to form a channel, and the second through holes 22 on each positioning block 2 are connected in sequence to form a channel. The PTFE pipe passes through the first through hole 21, passes out at the end and bends, and then passes out along the second through hole 22 to form a U shape, and then passes through another group of first through holes 21, and circulates in sequence. After meeting the specified requirements, the insertion and exit action is stopped, and the PTFE is heated by the heating patch 3 to ensure that the temperature of the sequencing reagent meets the requirements and improve the sequencing quality.

[0028] A splicing block 23 is provided at one end of each positioning block 2 in the width direction, and a splicing groove 24 corresponding to the splicing block 23 is provided at the other end. The depth of the splicing groove 24 is greater than the length of the splicing block 23. A long strip through hole 25 is provided at one end of the splicing groove 24 in the length direction of the positioning block 2. The length direction of the long strip through hole 25 is parallel to the axial direction of the guide rod 1. The heating patch 3 is a C-shaped patch. The opening side of the heating patch 3 is the side with the long strip through hole 25. The reliability of the connection between the positioning blocks 2 can be ensured by the splicing groove 24 and the splicing block 23. The long strip through hole 25 is provided at the splicing groove 24. After the PTFE is bent to the required length, the reagent is folded out from the long strip through hole 25 to introduce it into the subsequent sequencer module, which can be flexibly adjusted according to the size of the instrument.

[0029] The outer layer of the heating patch 3 is wrapped with thermal insulation cotton 4 to ensure the reliability of heating.

[0030] The number of first through holes 21 of each positioning block 2 is three, and the number of second through holes 22 is two. The device also includes end plates 5 arranged at both ends of the guide rod 2. The three groups of first through holes and two groups of second through holes can meet the PTFE bending requirements. The end plates 5 can ensure the stability and safety of the entire heating device. The temperature sensing probe can be connected to the end plates to further ensure the reliability of the reagent pipeline heating.

[0031] The above-described embodiments merely represent specific implementations of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make numerous variations and improvements without departing from the scope of the present invention, all of which fall within the scope of protection of the present invention.

Claims

1. A liquid pipeline heating device for a small gene sequencer, characterized in that: It includes a guide rod, a plurality of positioning blocks with the same structure coaxially sleeved on the guide rod, and a heating patch wrapped around the outer side of the positioning block; Each positioning block is a rectangular positioning block, the axis direction of the guide rod is coaxial with the width axis of each positioning block, and a plurality of positioning blocks are respectively provided at both ends of the length direction of each positioning block. The first through hole and the second through hole, wherein the axis directions of the first through hole and the second through hole are parallel to the axis direction of the guide rod.

2. The liquid pipeline heating device for a small gene sequencer according to claim 1, characterized in that: A splicing block is provided at one end in the width direction of each positioning block, and a splicing groove corresponding to the splicing block is provided at the other end, and the depth of the splicing groove is greater than the length of the splicing block.

3. The liquid pipeline heating device for a small gene sequencer according to claim 2, characterized in that: The splicing groove is located at one end of the positioning block in the length direction and is provided with a long strip through hole, and the length direction of the long strip through hole is parallel to the axis direction of the guide rod.

4. The liquid pipeline heating device for a small gene sequencer according to claim 3, characterized in that: The heating patch is a C-shaped patch, and the opening side of the heating patch is the side where the long strip through hole is provided.

5. The liquid pipeline heating device for a small gene sequencer according to claim 1, characterized in that: The outer layer of the heating patch is wrapped with thermal insulation cotton.

6. The liquid pipeline heating device for a small gene sequencer according to claim 1, characterized in that: The number of the first through holes of each positioning block is three, and the number of the second through holes is two.

7. The liquid pipeline heating device for a small gene sequencer according to claim 1, characterized in that: The device further comprises end plates arranged at both ends of the guide rod.

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