Detection unit and detection disc thereof

Abstract

The utility model discloses a detection unit and a detection disc thereof, the detection unit comprises a detection groove and at least one accommodating groove which are arranged on a disc body and are sequentially connected along the flowing direction of detection liquid, and the depth of the detection groove is smaller than that of the accommodating groove. The device can be applied to detection of detection objects with different detection quantities, and can realize quantification of detection liquid at the detection grooves due to the adoption of the detection grooves with the same structure, and meanwhile, the influence on detection data due to the structural change of the detection grooves can be avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of biochemical detection, in particular to a detection unit and a detection disc thereof. Background Art

[0002] With the development of detection technology, microfluidic chip technology has been widely used in many fields due to its advantages such as high throughput, integration, convenience, ease of operation, and low cost. However, in the actual detection process, different detection targets require different amounts of detection fluid, which puts different requirements on the detection tank capacity. The configuration of detection tanks with different capacities will affect the uniformity of optical detection data. Therefore, in the existing technology, the detection of different detection targets requires different detection volumes on different discs, resulting in wasted discs. Summary of the Invention

[0003] In order to overcome the shortcomings of the existing technology, the purpose of the present invention is to provide a detection unit that can be used for the detection of detection targets with different detection quantities. Since the detection tanks with the same structure are used, the quantification of the detection liquid in the detection tanks can be achieved. At the same time, the influence of the detection data due to changes in the detection tank structure can be avoided.

[0004] In order to solve the above problems, the solution adopted by the present invention is as follows:

[0005] A detection unit comprises a detection groove and at least one accommodating groove which are arranged on a disc body and are sequentially connected along the flow direction of a detection liquid. The depth of the detection groove is smaller than the depth of the accommodating groove.

[0006] Preferably, there are two receiving tanks, including a first receiving tank connected to the detection tank for receiving the detection liquid overflowing from the detection tank, and a second receiving tank connected to the first receiving tank and for receiving the detection liquid overflowing from the first receiving tank. The depth of the detection tank is less than the depth of the first receiving tank, and the depth of the first receiving tank is not greater than the depth of the second receiving tank.

[0007] Preferably, the second accommodating groove, the first accommodating groove and the detection groove are arranged in sequence along the radial direction of the disc body from the rotation center to the circumferential direction.

[0008] Preferably, a slope inclined toward the first accommodating groove is provided at the connection between the detection groove and the first accommodating groove.

[0009] Preferably, a partition is provided between the first accommodating groove and the second accommodating groove, and the height of the partition is smaller than the depth of the first accommodating groove.

[0010] Preferably, the depth of the detection groove is 1.5-3.5 mm.

[0011] Preferably, the depth of the first accommodating groove is 2.5-4.5 mm.

[0012] Preferably, a vent hole is provided on the second accommodating groove.

[0013] The utility model also includes a detection disc, which includes a disc body and a micro-channel structure of the detection unit described above and arranged on the disc body.

[0014] Preferably, it further comprises a sample adding tank, a separation tank and at least one liquid injection tank, wherein one end of the separation tank is connected to the sample adding tank and the other end is connected to the detection unit via a microchannel, and the liquid injection tank is connected to the detection unit.

[0015] Compared with the prior art, the beneficial effects of the present invention are:

[0016] The detection disc in the present invention adopts detection grooves of uniform specifications and sizes, which can achieve quantitative detection liquid in the detection groove and avoid the influence of detection data due to changes in the detection groove structure; multiple accommodating grooves are used to receive excess overflow detection liquid in the previous detection groove, and by setting different depths, the backflow of detection liquid is avoided, thereby ensuring the stability of detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a structural diagram of the detection unit in a preferred embodiment of the present utility model;

[0018] Figure 2 for Figure 1 Schematic diagram of the microfluidic channel structure;

[0019] Figure 3 for Figure 2 Schematic diagram of the structure of the detection unit;

[0020] Figure 4 for Figure 3 A cross-sectional view of the detection unit;

[0021] Figure 5-Figure 6 Schematic diagrams of the structures of detection discs in different embodiments;

[0022] Figure 7 A schematic structural diagram of a microfluidic channel structure in a specific embodiment;

[0023] Figure 8 for Figure 7 Schematic diagram of the structure of the detection unit.

[0024] Among them, the figure marks are as follows: 1 is the disk body, 10 is the rotation center, 11 is the first positioning groove, 2 is the microfluidic structure, 21 is the sample adding groove, 22 is the separation groove, 23 is the storage groove, 24 is the first liquid injection groove, 25 is the second liquid injection groove, 26a / 26b is the detection unit, 261a / 261b is the detection groove, 262a / 262b is the first accommodating groove, 263a / 263b is the second accommodating groove, 264a / 264b is the vent, 265 is the inclined surface, and 266 is the partition. DETAILED DESCRIPTION

[0025] The present invention will be described in further detail below with reference to the accompanying drawings.

[0026] Reference Figure 1-4 , which is a detection unit in a preferred embodiment of the present invention, includes a detection groove 261a, a first accommodating groove 262a, and a second accommodating groove 263a arranged on the disc body 1 and connected in sequence along the flow direction of the detection liquid. The first accommodating groove 262a is connected to the detection groove 261a and is used to receive excess overflow detection liquid in the detection groove 261a; the second accommodating groove 263a is connected to the first accommodating groove 262a and is used to receive excess overflow detection liquid in the first accommodating groove 262a; the depth of the detection groove 261a is less than the depth of the first accommodating groove 262a, and the depth of the first accommodating groove 262a is not greater than the depth of the second accommodating groove 263a; due to the higher surface tension in the shallower groove body, the surface tension of the detection liquid in the detection groove 261a is the largest, and the detection liquid in the detection groove 261a can stay stably in the detection groove 261a without moving, thereby ensuring stable detection results.

[0027] For details, please refer to Figure 3 In one embodiment, the second receiving slot 263a, the first receiving slot 262a, and the detection slot 261a are sequentially arranged along the radial direction of the disk 1 from the rotation center 10 toward the circumference. The detection units 26a arranged radially along the disk 1 can significantly reduce the occupied area, facilitating the installation of more microfluidic channel structures 2 on the disk 1.

[0028] For details, please refer to Figure 4 To better ensure the stability of test data and prevent the movement of the testing liquid in the first accommodating groove 262a from disturbing the testing liquid in the testing groove 261a, a slope 265 is provided at the junction of the testing groove 261a and the first accommodating groove 262a, inclined toward the first accommodating groove 262a. Furthermore, a partition 266 is provided between the first accommodating groove 262a and the second accommodating groove 263a. The height of the partition 266 is less than the depth of the first accommodating groove 262a. The first accommodating groove 262a and the second accommodating groove 263a are connected by a channel above the partition 266, which helps reduce disturbances between the testing liquids in each compartment.

[0029] Specifically, the depth of the detection groove 2621 may be 1.5-3.5 mm, and the depth of the first accommodating groove 262a may be 2.5-4.5 mm.

[0030] Specifically, in order to balance the air pressure in the micro-channel structure 2 , a vent hole 264 a is provided on the second receiving groove 263 a .

[0031] Reference Figure 5 、 Figure 6 , which is a schematic diagram of the structure of the detection disk in different embodiments. The detection disk includes a disk body 1 and a micro-channel structure 2 using the above-mentioned detection unit 26a disposed on the disk body 1. The detection disk can be a sector disk (such as Figure 5 As shown) or a disc (as Figure 6 shown).

[0032] For details, please refer to Figure 2 The microfluidic structure 2 also includes a sample loading tank 21, a separation tank 22, a first liquid injection tank 24, and a second liquid injection tank 25. One end of the separation tank 22 is connected to the sample loading tank 21, and the other end is connected to the detection unit 26a via a microfluidic channel. The two liquid injection tanks are connected to the detection unit 26a. A storage tank 23 is also connected to the bottom of the separation tank 22 for storing the centrifuged material.

[0033] Reference Figure 7 、 Figure 8 , is a structural diagram of a microfluidic structure in a specific embodiment. Different from the above embodiment, the detection groove 261b, the first accommodating groove 262b and the second accommodating groove 263b in the microfluidic structure are distributed circumferentially, and the vent 264b is connected to the second accommodating groove 263b.

[0034] In the above embodiment, the number of the containing tanks is only for illustration. In actual application, the number of the containing tanks is not specifically limited and can be designed according to the maximum amount of the detection liquid.

[0035] The embodiments of this specific implementation method are all preferred embodiments of the present utility model, and are not intended to limit the scope of protection of the present utility model. Therefore, any equivalent changes made based on the structure, shape, and principle of the present utility model should be included in the scope of protection of the present utility model.

Claims

1. A detection unit, characterized in that: It comprises a detection groove and at least one accommodating groove which are arranged on the disc body and are sequentially connected along the flow direction of the detection liquid. The depth of the detection groove is smaller than the depth of the accommodating groove.

2. The detection unit according to claim 1, wherein There are two receiving tanks, including a first receiving tank connected to the detection tank for receiving the detection liquid overflowing from the detection tank, and a second receiving tank connected to the first receiving tank and for receiving the detection liquid overflowing from the first receiving tank. The depth of the detection tank is less than the depth of the first receiving tank, and the depth of the first receiving tank is not greater than the depth of the second receiving tank.

3. The detection unit according to claim 1, wherein The second accommodating groove, the first accommodating groove and the detection groove are sequentially arranged along the radial direction of the disc body from the rotation center to the circumferential direction. 4 . The detection unit according to claim 2 , wherein a slope inclined toward the first accommodating groove is provided at a connection between the detection groove and the first accommodating groove.

5. The detection unit according to claim 2, wherein: A partition is provided between the first accommodating groove and the second accommodating groove, and the height of the partition is smaller than the depth of the first accommodating groove.

6. The detection unit according to claim 2, wherein: The depth of the detection groove is 1.5-3.5 mm.

7. The detection unit according to claim 2, wherein: The depth of the first accommodating groove is 2.5-4.5 mm.

8. The detection unit according to claim 2, wherein: The second accommodating groove is provided with a vent hole.

9. A detection disc, characterized in that: The invention comprises a disc body and a microfluidic channel structure provided on the disc body and adopting the detection unit according to any one of claims 1 to 7.

10. The detection disc according to claim 9, wherein: It also includes a sample adding tank, a separation tank and at least one liquid injection tank. One end of the separation tank is connected to the sample adding tank, and the other end is connected to the detection unit through a microchannel. The liquid injection tank is connected to the detection unit.

Images