Production device of D-calcium pantothenate

Abstract

The utility model discloses a D-calcium pantothenate production device, and relates to the technical field of D-calcium pantothenate production, an outlet of a fermentation liquor tank is communicated with a first flocculation tank, an outlet of the first flocculation tank is communicated with a first plate-and-frame filter press, a liquid phase outlet of the first plate-and-frame filter press is communicated with a first filtrate tank, an outlet of the first filtrate tank is communicated with an extraction tank, and the extraction tank is communicated with a second flocculation tank. An outlet at the lower end of the extraction tank is communicated with a nanofiltration membrane device, an outlet of the nanofiltration membrane device is communicated with a chromatographic column, an outlet of the chromatographic column is communicated with a reaction kettle through a pipeline, and an inlet of the reaction kettle is communicated with a calcium chloride solution tank through a pipeline; an outlet of the reaction kettle is communicated with a crystallizing tank through a pipeline, and an outlet of the crystallizing tank is communicated with a D-calcium pantothenate product tank through a pipeline. The whole reaction process is short in period, the purity of the product is up to 99.5% or above, the yield is up to 95% or above, the process is easy to operate and low in cost, and industrialization can be achieved.

Description

Technical Field

[0001] The utility model relates to the technical field of D-calcium pantothenate production, in particular to a production device of D-calcium pantothenate. Background Art

[0002] Calcium D-pantothenate is a vitamin-like drug, an essential trace substance for maintaining normal physiological functions in humans and animals. It participates in the metabolism of carbohydrates, fats, and proteins in the body. It is primarily used in pharmaceuticals, foods, and feed additives. In pharmaceuticals and food supplements, it is used to treat vitamin B deficiency conditions such as beriberi, riboflavin deficiency, pellagra, peripheral neuritis, postoperative colic, lethargy, neurasthenia, and to strengthen the body and enhance immune function. In feed additives, it is used to promote the growth and development of poultry, livestock, and fish, and to improve their reproductive and emergency adaptability.

[0003] Chinese patent CN 117510363 A discloses a method for extracting and preparing calcium D-pantothenate from a fermentation broth. The extraction steps include: filtration through a ceramic membrane, ultrafiltration membrane, cation exchange, anion adsorption, calcium chloride desorption, nanofiltration concentration, activated carbon decolorization, and methanol cooling and crystallization to obtain calcium D-pantothenate. The calcium D-pantothenate product prepared by this method has a content of approximately 98.9%, but the product has low purity and requires adsorption and desorption, resulting in cumbersome steps. Summary of the Invention

[0004] The technical problem to be solved by the utility model is: in view of the deficiencies in the prior art, a production device for calcium D-pantothenate is provided, wherein the obtained product has high purity and is suitable for industrialization.

[0005] In order to solve the above technical problems, the technical solution of the utility model is:

[0006] A production device for calcium D-pantothenate, comprising a fermentation liquid tank, the outlet of the fermentation liquid tank being connected to a first flocculation tank via a pipeline, the outlet of the first flocculation tank being connected to a first plate-and-frame filter press, the liquid phase outlet of the first plate-and-frame filter press being connected to a first filtrate tank via a pipeline, the outlet of the first filtrate tank being connected to an extraction tank via a pipeline, the lower outlet of the extraction tank being connected to a nanofiltration membrane device via a pipeline, the outlet of the nanofiltration membrane device being connected to a chromatography column via a pipeline, the outlet of the chromatography column being connected to a reactor via a pipeline, and the inlet of the reactor being connected to a calcium chloride solution tank via a pipeline.

[0007] The outlet of the reactor is connected to a crystallization tank through a pipeline, and the outlet of the crystallization tank is connected to a D-calcium pantothenate product tank through a pipeline.

[0008] As an improved technical solution, the solid phase outlet of the first plate and frame filter press is connected to a filter residue tank.

[0009] As an improved technical solution, the outlet of the first filtrate tank is connected to an ultrafiltration membrane device through a pipeline, and the clear liquid outlet of the ultrafiltration membrane device is connected to the extraction tank through a pipeline.

[0010] As an improved technical solution, the concentrate outlet of the ultrafiltration membrane device is connected to a second flocculation tank through a pipeline, the outlet of the second flocculation tank is connected to a second plate and frame filter press, and the liquid phase outlet of the second plate and frame filter press is connected to a second filtrate tank through a pipeline.

[0011] As an improved technical solution, the lower outlet of the extraction tank is connected to a distillation kettle through a pipeline, and the top outlet of the distillation kettle is connected to an extractant recovery tank through a pipeline.

[0012] As an improved technical solution, the inlet of the chromatography column is connected to a methanol solution tank and an ammonia solution tank through pipelines respectively.

[0013] As a preferred technical solution, the outlet of the reactor is connected to a concentration tank via a pipeline, and the outlet of the concentration tank is connected to the crystallization tank via a pipeline.

[0014] As a preferred technical solution, the outlet of the crystallization tank is connected to a first suction filtration tank through a pipeline, the outlet of the first suction filtration tank is connected to a dryer, and the outlet of the dryer is connected to a D-pantothenate calcium product tank.

[0015] As a preferred technical solution, the outlet of the first suction filtration tank is connected to a washing kettle, the inlet of the washing kettle is connected to an ethanol tank through a pipeline, and the outlet of the washing kettle is connected to a D-pantothenate calcium product tank.

[0016] As a preferred technical solution, the outlet of the washing kettle is connected to a second suction filtration tank, and the outlet of the second suction filtration tank is connected to the dryer.

[0017] Due to the adoption of the above technical solution, the beneficial effects of the utility model are:

[0018] The utility model provides a production device for calcium D-pantothenate, comprising a fermentation liquid tank, wherein the outlet of the fermentation liquid tank is connected to a first flocculation tank via a pipeline, the outlet of the first flocculation tank is connected to a first plate-frame filter press, the liquid phase outlet of the first plate-frame filter press is connected to a first filtrate tank via a pipeline, the outlet of the first filtrate tank is connected to an extraction tank via a pipeline, the lower end outlet of the extraction tank is connected to a nanofiltration membrane device via a pipeline, the outlet of the nanofiltration membrane device is connected to a chromatography column via a pipeline, the outlet of the chromatography column is connected to a reactor via a pipeline, the inlet of the reactor is connected to a calcium chloride solution tank via a pipeline; the outlet of the reactor is connected to a crystallization tank via a pipeline, and the outlet of the crystallization tank is connected to a calcium D-pantothenate product tank via a pipeline. A composite flocculant consisting of bentonite, clay, and chitosan is added to the fermentation broth of calcium D-pantothenate. After flocculation, the broth is filtered using a first plate-and-frame filter press to obtain a filtrate and a filter residue. Compared to direct filtration, flocculation followed by filtration removes more solid impurities. Furthermore, the composite flocculant forms larger flocs after reaction than a single flocculant, providing clarification and preliminary decolorization of the fermentation broth, removing 50-60% of protein and residual sugars without loss of calcium D-pantothenate. This process reduces the processing pressure in subsequent purification processes. The filtrate from the first plate-and-frame filter press enters an extraction tank, undergoes 2-3 extractions, and then stands for separation. The lower layer is removed and concentrated by nanofiltration. The nanofiltration concentrate enters a chromatography column, is eluted with an eluent, and the target component containing D-pantothenic acid is collected. The concentrate is then reacted with a calcium chloride solution until the pH of the reaction solution reaches 6-8, with the reaction endpoint occurring within 30 minutes without significant pH fluctuation. The reacted solution is crystallized to obtain the calcium D-pantothenate product. The entire reaction process has a short cycle, the purity of the product is as high as over 99.5%, the yield is as high as over 95%, and the process operation is simple, the cost is low, and it can be industrialized.

[0019] The solid phase outlet of the first plate and frame filter press of the utility model is connected with a filter residue tank, and the filter residue can be used as a raw material for making fertilizers, thereby improving economic benefits and avoiding harm to the environment during the treatment process.

[0020] Nanofiltration supernatant can be used as a diluent for methanol and ammonia water, and can also be used for the preparation of culture medium during the fermentation process.

[0021] The outlet of the first filtrate tank is connected to an ultrafiltration membrane device through a pipeline, and the clear liquid outlet of the ultrafiltration membrane device is connected to an extraction tank through a pipeline. The ultrafiltration membrane can further remove impurities and improve the purity of the product.

[0022] The concentrate outlet of the ultrafiltration membrane device is connected to a second flocculation tank via a pipeline. The outlet of the second flocculation tank is connected to a second plate-and-frame filter press. The liquid phase outlet of the second plate-and-frame filter press is connected to a second filtrate tank via a pipeline. The filtrate from the ultrafiltration membrane concentrate after filtration serves as a diluent for the subsequent dilution of the eluents methanol and ammonia, saving costs and avoiding waste.

[0023] The lower outlet of the extraction tank is connected to a distillation kettle via a pipeline, and the top outlet of the distillation kettle is connected to the extractant recovery tank via a pipeline. The upper layer liquid of the extraction tank is distilled, and the obtained extract is used as the extractant for the next extraction, saving costs.

[0024] The inlet of the chromatography column is connected to a methanol solution tank and an ammonia solution tank through pipelines, respectively. Through gradient elution, the extraction effect of the target component containing D-pantothenic acid is better, which greatly improves the yield and purity of the product.

[0025] The outlet of the reactor is connected to a concentration tank via a pipeline, and the outlet of the concentration tank is connected to the crystallization tank via a pipeline. By pre-concentrating, the time required for subsequent crystallization is saved and the production cycle is shortened.

[0026] The outlet of the crystallizer is connected to a first suction filtration tank via a pipeline, the outlet of the first suction filtration tank is connected to a dryer, and the outlet of the dryer is connected to a D-calcium pantothenate product tank. By suction filtering the solid phase after crystallization, the purity of the product is higher.

[0027] The outlet of the first suction filtration tank is connected to a washing kettle, the inlet of the washing kettle is connected to an ethanol tank through a pipeline, and the outlet of the washing kettle is connected to a D-calcium pantothenate product tank. Washing with ethanol improves the purity of the product.

[0028] The outlet of the washing kettle is connected to a second suction filtration tank, and the outlet of the second suction filtration tank is connected to the dryer. The purity of the product is further improved through secondary suction filtration. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0030] Figure 1 It is a structural schematic diagram of an embodiment of the utility model;

[0031] Wherein: 1. fermentation liquid tank; 2. first flocculation tank; 3. first plate and frame filter press; 4. first filtrate tank; 5. extraction tank; 6. nanofiltration membrane device; 7. chromatography column; 8. reactor; 9. calcium chloride solution tank; 10. crystallization tank; 11. D-calcium pantothenate product tank; 12. filter residue tank; 13. ultrafiltration membrane device; 14. second flocculation tank; 15. second plate and frame filter press; 16. second filtrate tank; 17. distillation kettle; 18. extractant recovery tank; 19. methanol solution tank; 20. ammonia solution tank; 21. concentration tank; 22. first suction tank; 23. dryer; 24. washing kettle; 25. ethanol tank; 26. second suction tank. DETAILED DESCRIPTION

[0032] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0033] like Figure 1As shown, a production device for calcium D-pantothenate includes a fermentation liquid tank 1, the outlet of the fermentation liquid tank 1 is connected to a first flocculation tank 2 through a pipeline, the outlet of the first flocculation tank 2 is connected to a first plate and frame filter press 3, the liquid phase outlet of the first plate and frame filter press 3 is connected to a first filtrate tank 4 through a pipeline, the outlet of the first filtrate tank 4 is connected to an extraction tank 5 through a pipeline, the lower end outlet of the extraction tank 5 is connected to a nanofiltration membrane device 6 through a pipeline, the outlet of the nanofiltration membrane device 6 is connected to a chromatography column 7 through a pipeline, the outlet of the chromatography column 7 is connected to a reactor 8 through a pipeline, the inlet of the reactor 8 is connected to a calcium chloride solution tank 9 through a pipeline; the outlet of the reactor 8 is connected to a crystallization tank 10 through a pipeline, and the outlet of the crystallization tank 10 is connected to a calcium D-pantothenate product tank 11 through a pipeline. After the flocculation is completed, a composite flocculant composed of bentonite, clay, and chitosan is added to the fermentation broth of calcium D-pantothenate. After flocculation, the filtrate is filtered using a first plate-and-frame filter press 3 to obtain a filtrate and a filter residue. Compared with direct filtration, flocculation followed by filtration can remove more solid impurities. At the same time, the composite flocculant produces larger flocs after the reaction than a single flocculant, which can clarify and initially decolorize the fermentation broth of calcium D-pantothenate, removing 50-60% of the protein and residual sugar in the fermentation broth without losing calcium D-pantothenate. This process reduces the processing pressure in the subsequent purification process. The filtrate from the first plate-and-frame filter press 3 enters an extraction tank 5, is extracted 2-3 times, and then allowed to stand and separate. The lower layer is removed and concentrated by nanofiltration. The nanofiltration supernatant is used as a diluent in the subsequent preparation of methanol and ammonia water as eluents, and can also be used for the preparation of the culture medium during the fermentation process. The nanofiltration concentrate enters a chromatography column 7, where it is eluted with an eluent to collect the target component containing D-pantothenic acid. The target component is then reacted with a calcium chloride solution until the pH of the reaction solution reaches 6-8. The reaction endpoint is achieved within 30 minutes, with no significant pH fluctuation. The reacted liquid is crystallized to obtain the calcium D-pantothenate product. The entire reaction process is short, the product purity is as high as over 99.5%, and the yield is as high as over 95%. The process is simple to operate, low-cost, and can be industrialized.

[0034] The solid phase outlet of the first plate-frame filter press 3 is connected to a filter residue tank 12 , and the filter residue can be used as a raw material for making fertilizer, thereby improving economic benefits and avoiding harm to the environment during the treatment process.

[0035] The outlet of the first filtrate tank 4 is connected to the ultrafiltration membrane device 13 through a pipeline, and the clear liquid outlet of the ultrafiltration membrane device 13 is connected to the extraction tank 5 through a pipeline. The ultrafiltration membrane can further remove impurities and improve the purity of the product.

[0036] The concentrate outlet of the ultrafiltration membrane device 13 is connected to a second flocculation tank 14 via a pipeline. The outlet of the second flocculation tank 14 is connected to a second plate-and-frame filter press 15. The liquid phase outlet of the second plate-and-frame filter press 15 is connected to a second filtrate tank 16 via a pipeline. The filtrate from the ultrafiltration membrane concentrate after filtration serves as a diluent for the subsequent dilution of the eluents methanol and ammonia, saving costs and avoiding waste.

[0037] The lower outlet of the extraction tank 5 is connected to a distillation kettle 17 via a pipeline, and the top outlet of the distillation kettle 17 is connected to the extractant recovery tank 18 via a pipeline. The upper layer liquid of the extraction tank 5 is distilled, and the obtained extract is used as the extractant for the next extraction, saving costs.

[0038] The inlet of the chromatography column 7 is connected to the methanol solution tank 19 and the ammonia solution tank 20 through pipelines. Through gradient elution, the extraction effect of the target component containing D-pantothenic acid is better, which greatly improves the yield and purity of the product.

[0039] The outlet of the reactor 8 is connected to the concentration tank 21 through a pipeline, and the outlet of the concentration tank 21 is connected to the crystallization tank 10 through a pipeline. By pre-concentration, the time required for subsequent crystallization is saved and the production cycle is shortened.

[0040] The outlet of the crystallization tank 10 is connected to the first suction filtration tank 22 through a pipeline, the outlet of the first suction filtration tank 22 is connected to the dryer 23, and the outlet of the dryer 23 is connected to the D-pantothenate calcium product tank 11. By filtering the solid phase after crystallization, the purity of the product is higher.

[0041] The outlet of the first suction filtration tank 22 is connected to a washing tank 24, the inlet of the washing tank 24 is connected to an ethanol tank 25 through a pipeline, and the outlet of the washing tank 24 is connected to the D-calcium pantothenate product tank 11. Washing with ethanol improves the purity of the product.

[0042] The outlet of the washing tank 24 is connected to a second suction filtration tank 26, and the outlet of the second suction filtration tank 26 is connected to the dryer 23. The purity of the product is further improved by the secondary suction filtration.

[0043] It should be understood that these embodiments are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the contents of the present invention, those skilled in the art may make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of this application.

Claims

1. A production device for calcium D-pantothenate, comprising a fermentation liquid tank, characterized in that: The outlet of the fermentation liquid tank is connected to a first flocculation tank via a pipeline, the outlet of the first flocculation tank is connected to a first plate-frame filter press, the liquid phase outlet of the first plate-frame filter press is connected to a first filtrate tank via a pipeline, the outlet of the first filtrate tank is connected to an extraction tank via a pipeline, the lower end outlet of the extraction tank is connected to a nanofiltration membrane device via a pipeline, the outlet of the nanofiltration membrane device is connected to a chromatography column via a pipeline, the outlet of the chromatography column is connected to a reactor via a pipeline, and the inlet of the reactor is connected to a calcium chloride solution tank via a pipeline; The outlet of the reactor is connected to a crystallization tank through a pipeline, and the outlet of the crystallization tank is connected to a D-calcium pantothenate product tank through a pipeline.

2. A production device for calcium D-pantothenate as claimed in claim 1, characterized in that: The solid phase outlet of the first plate-frame filter press is connected to a filter residue tank.

3. A production device for calcium D-pantothenate as claimed in claim 1, characterized in that: The outlet of the first filtrate tank is connected to an ultrafiltration membrane device through a pipeline, and the clear liquid outlet of the ultrafiltration membrane device is connected to the extraction tank through a pipeline.

4. A production device for calcium D-pantothenate as claimed in claim 3, characterized in that: The concentrated liquid outlet of the ultrafiltration membrane device is connected to the second flocculation tank through a pipeline, the outlet of the second flocculation tank is connected to the second plate and frame filter press, and the liquid phase outlet of the second plate and frame filter press is connected to the second filtrate tank through a pipeline.

5. The production device of calcium D-pantothenate according to claim 1, wherein: The lower outlet of the extraction tank is connected to a distillation kettle through a pipeline, and the top outlet of the distillation kettle is connected to an extractant recovery tank through a pipeline.

6. The production device of calcium D-pantothenate according to claim 1, wherein: The inlet of the chromatography column is connected to a methanol solution tank and an ammonia solution tank through pipelines respectively.

7. A production device for calcium D-pantothenate as claimed in claim 1, characterized in that: The outlet of the reactor is connected to a concentration tank through a pipeline, and the outlet of the concentration tank is connected to the crystallization tank through a pipeline.

8. The production device of calcium D-pantothenate according to claim 1, wherein: The outlet of the crystallization tank is connected to a first suction filtration tank through a pipeline, the outlet of the first suction filtration tank is connected to a dryer, and the outlet of the dryer is connected to a D-pantothenate calcium product tank.

9. A production device for calcium D-pantothenate as claimed in claim 8, characterized in that: The outlet of the first suction filtration tank is connected to a washing kettle, the inlet of the washing kettle is connected to an ethanol tank through a pipeline, and the outlet of the washing kettle is connected to a D-pantothenate calcium product tank.

10. The production device of calcium D-pantothenate according to claim 9, wherein: The outlet of the washing kettle is connected to a second suction filtration tank, and the outlet of the second suction filtration tank is connected to the dryer.

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