Recrystallization preparation equipment capable of preventing crystallization product from being damaged

Abstract

The utility model belongs to the technical field of medicine purification, and discloses recrystallization preparation equipment capable of preventing crystallization products from being damaged, which comprises a first base, the top of the first base is fixedly connected with a second base, four corners of the top of the second base are fixedly connected with first support rods, and the top ends of the first support rods are fixedly connected with a top plate. A supporting column is fixedly connected to the bottom of the top plate, a mounting frame is fixedly connected to the bottom of the supporting column, a first recrystallization kettle is mounted on the inner wall of the mounting frame, a second recrystallization kettle is arranged at the bottom of the first recrystallization kettle, a collecting tank is fixedly connected to the bottom of the second recrystallization kettle, and a coil is mounted on the inner bottom wall of the collecting tank. The recrystallization kettle is stably installed, meanwhile, it is guaranteed that the recrystallization kettle is in an unshielded environment, personnel can conveniently monitor and control the device in real time, meanwhile, the coil generates magnetic force through the controller, the stirring effect is achieved through cooperation of the coil and the conductive material, and therefore liquid is controlled to flow uniformly, and mechanical damage to crystals is avoided.

Description

[0001] Drug purification technology field

[0002] The utility model relates to the technical field of drug purification, in particular to a recrystallization preparation device for preventing a crystal product from being damaged. Background Art

[0003] Sulfonamides are a widely used class of antibacterial drugs primarily used to treat bacterial infections. These drugs exert their antibacterial effects by inhibiting bacterial folate synthesis. The synthesis of sulfonamides typically involves multiple chemical reactions, which may produce unreacted raw materials, intermediates, or byproducts. Recovering these byproducts can transform waste from the production process into reusable resources, improving production efficiency while reducing overall production costs.

[0004] Chinese Patent Authorization Publication No. CN218458761U provides a device for removing impurities from ritonavir crystals. The device includes a preparation barrel, a filtration device, and a crystallization device. The crystallization device is equipped with a crystallization plate, a motor, a capstan, a horizontal telescopic mechanism, and a horizontal push plate. A heating barrel is provided outside the crystallization device. The utility model utilizes a water bath heating method during ritonavir recrystallization to more accurately control the crystallization temperature and maintain ritonavir's stability. Furthermore, a retractable crystallization plate is provided at the bottom of the crystallization device. After ritonavir crystallizes, the capstan is controlled to raise the crystallization plate and promptly collect the ritonavir crystals, minimizing exposure to high temperatures and preventing denaturation.

[0005] In the existing technology, during the traditional recrystallization process, the crystallized product is easily affected by the external environment and improper operation, resulting in problems such as damage to the crystal structure and mixing of impurities during the crystallization process, which in turn affects the purity and yield of the product, resulting in certain limitations in the use of traditional recrystallization equipment.

[0006] Based on this, the utility model designs a recrystallization preparation equipment that avoids damage to the crystallized product to solve the above problem. Utility Model Content

[0007] In view of the above-mentioned shortcomings of the prior art, the utility model provides a recrystallization preparation device that avoids damage to the crystallized product.

[0008] In order to achieve the above objectives, the present invention is implemented through the following technical solutions:

[0009] A recrystallization preparation device for preventing damage to a crystallized product, comprising a first base, wherein the top of the first base is fixedly connected to a second base, four corners of the top of the second base are fixedly connected to a first support rod, the top of the first support rod is fixedly connected to a top plate, the bottom of the top plate is fixedly connected to a support column, the bottom of the support column is fixedly connected to a mounting frame, a first recrystallization kettle is mounted on an inner wall of the mounting frame, a second recrystallization kettle is provided at the bottom of the first recrystallization kettle, a collecting tank is fixedly connected to the bottom of the second recrystallization kettle, a coil is mounted on the inner bottom wall of the collecting tank, a controller is mounted on the front end of the outer wall of the collecting tank, and a disassembly mechanism is provided at the bottom of the first recrystallization kettle;

[0010] Furthermore, the disassembly mechanism includes an external connecting ring, which is fixedly connected to the bottom of the outer wall of the first recrystallization kettle, and the outer wall of the external connecting ring is equidistantly connected to a plurality of mounting blocks, and the outer walls of the mounting blocks are provided with positioning holes, and the first recrystallization kettle and the second recrystallization kettle are connected by a pin;

[0011] Furthermore, a protective sleeve is fixedly connected to the bottom wall of the first support rod;

[0012] Furthermore, the outer wall of the first base is provided with mounting holes at both the left and right ends and the front and rear sides thereof, and the inner walls of the mounting holes are threadedly connected with mounting bolts;

[0013] Furthermore, the top of the second recrystallization kettle is fixedly connected with an insert ring, the bottom wall of the first recrystallization kettle is provided with a slot, and the insert ring is engaged with the slot;

[0014] Furthermore, a temperature sensor is installed at the front end of the outer wall of the first recrystallization kettle;

[0015] Furthermore, a second support rod is fixedly connected to the right end of the outer wall of the first base, and a control panel is installed on the top end of the second support rod;

[0016] Furthermore, the control panel is electrically connected to the controller and the temperature sensor respectively.

[0017] Beneficial effects

[0018] Compared with the prior art, the advantages of the present invention are:

[0019] (1) This solution installs the recrystallization kettle stably and ensures that it is in an unobstructed environment, which makes it easy for personnel to monitor and control the device in real time. At the same time, the controller enables the coil to generate magnetic force and cooperate with the conductive material to achieve a stirring effect, thereby controlling the uniform flow of the liquid and avoiding mechanical damage to the crystals.

[0020] (2) This solution allows the second recrystallization kettle to be installed on the bottom of the first recrystallization kettle through the coordinated use of structures such as the external ring, the mounting block, the positioning hole and the latch, thereby facilitating the removal of the crystallized product from the recrystallization tank, avoiding damage and loss of the crystals, and improving the convenience of using the device.

[0021] (3) This solution can protect the connection between the two recrystallization kettles by locking the insert ring and the slot, ensuring the tightness of the connection and the full reaction of the solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be derived from these drawings without inventive effort.

[0023] Figure 1 This is a three-dimensional diagram of the main structure of a recrystallization preparation device for preventing damage to the crystallized product according to the present invention;

[0024] Figure 2 This is a disassembly diagram of the disassembly mechanism of a recrystallization preparation device for preventing damage to the crystallized product according to the present invention;

[0025] Figure 3 This is a partial structural diagram of a recrystallization preparation device for preventing damage to the crystallized product according to the present invention;

[0026] Figure 4 This is a partially disassembled structural diagram of a recrystallization preparation device for preventing damage to the crystallized product according to the present invention;

[0027] Figure 5 This is a front view structural diagram of a recrystallization preparation device for preventing damage to the crystallized product according to the present invention.

[0028] The numbers in the figure represent:

[0029] 1. First base; 2. Disassembly mechanism; 201. External ring; 202. Mounting block; 203. Positioning hole; 204. Latch; 3. Second base; 4. First support rod; 5. Top plate; 6. Support column; 7. Mounting frame; 8. First recrystallization kettle; 9. Second recrystallization kettle; 10. Collection tank; 11. Controller; 12. Second support rod; 13. Control panel; 14. Protective sleeve; 15. Mounting hole; 16. Mounting bolt; 17. Insert ring; 18. Slot; 19. Temperature sensor. DETAILED DESCRIPTION

[0030] To make the purpose, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention.

[0031] The present invention will be further described below with reference to the embodiments.

[0032] In some embodiments, please refer to the appendix of the specification. Figure 1 and Figure 5 , a recrystallization preparation equipment for avoiding damage to the crystallized product, comprises a first base 1, the top of the first base 1 is fixedly connected to the second base 3, the four corners of the top of the second base 3 are fixedly connected to the first support rod 4, the top of the first support rod 4 is fixedly connected to the top plate 5, the bottom of the top plate 5 is fixedly connected to the support column 6, the bottom of the support column 6 is fixedly connected to the mounting bracket 7, the inner wall of the mounting bracket 7 is installed with a first recrystallization kettle 8, the bottom of the first recrystallization kettle 8 is provided with a second recrystallization kettle 9, the bottom of the second recrystallization kettle 9 is fixedly connected with a collecting tank 10, the inner bottom wall of the collecting tank 10 is installed with a coil, the front end of the outer wall of the collecting tank 10 is installed with a controller 11, and the bottom of the first recrystallization kettle 8 is provided with a disassembly mechanism 2; the right end of the outer wall of the first base 1 is fixedly connected to the second support rod 12, and the top of the second support rod 12 is installed with a control panel 13; the control panel 13 is electrically connected to the controller 11 and the temperature sensor 19 respectively.

[0033] In this solution, the first recrystallization kettle 8 and the second recrystallization kettle 9 are installed on the bottom of the top plate 5 through the mounting frame 7 and the support column 6, so that the recrystallization kettle is in an unobstructed working environment, which is convenient for personnel to monitor and control the device in real time, and at the same time convenient for pouring the crystallization material in proportion. After the relevant operations, the controller 11 coil is conductive, and the conductive liquid begins to move under the influence of electromagnetic force. The moving liquid will form a circulation, thereby achieving stirring and avoiding mechanical damage to the crystals; the device can be stably controlled by the control panel 13, and the current can be automatically adjusted as needed to maintain the best stirring effect.

[0034] In some embodiments, as Figure 2 and Figure 3As shown, as a preferred embodiment of the present invention, the disassembly mechanism 2 includes an external ring 201, which is fixedly connected to the bottom of the outer wall of the first recrystallization kettle 8, and the outer wall of the external ring 201 is equidistantly connected to a plurality of mounting blocks 202, and the outer wall of the mounting block 202 is provided with a positioning hole 203, and the first recrystallization kettle 8 and the second recrystallization kettle 9 are connected by a pin 204; the top of the second recrystallization kettle 9 is fixedly connected with an insert ring 17, and the bottom wall of the first recrystallization kettle 8 is provided with a slot 18, and the insert ring 17 and the slot 18 are engaged.

[0035] In this solution, the second recrystallization kettle 9 is installed on the bottom of the first recrystallization kettle 8 through the mounting block 202. The engagement of the insert ring 17 and the slot 18 can ensure the tightness of the connection between the two recrystallization kettles and the sufficiency of the reaction. At the same time, it is convenient for personnel to quickly disassemble and assemble the second recrystallization kettle 9, thereby improving the convenience of using the device. The crystallized product can be collected through the collection tank 10 to further avoid damage to the crystallized product.

[0036] In some embodiments, as Figure 1 、 Figure 4 and Figure 5 As shown, as a preferred embodiment of the present invention, the bottom wall of the first support rod 4 is fixedly connected with a protective sleeve 14; the front and rear sides of the left and right ends of the outer wall of the first base 1 are provided with mounting holes 15, and the inner walls of the mounting holes 15 are threadedly connected with mounting bolts 16; the front end of the outer wall of the first recrystallization kettle 8 is installed with a temperature sensor 19.

[0037] This solution can ensure the stability of the connection of the first support rod 4 through the protective sleeve 14; the first base 1 is installed on the platform through the mounting hole 15 and the mounting bolt 16 to ensure the overall stability of the device; the temperature sensor 19 is installed at the front end of the outer side of the first recrystallization kettle 8 to monitor the temperature in the recrystallization kettle in real time to avoid excessively high or low temperature affecting the crystallization effect.

[0038] The working principle of the present invention is: when it is necessary to recover by-products of sulfonamide drugs, etc., the raw materials are poured into the first recrystallization kettle 8 and the second recrystallization kettle 9, and the first recrystallization kettle 8 and the second recrystallization kettle 9 are installed at the bottom of the top plate 5 through the mounting frame 7 and the support column 6. The above design can facilitate the proportioning and pouring of the relevant materials for recrystallization. After the relevant operations, the control panel 13 is started to drive the controller 11 to work, and the coil is made conductive, so that the coil generates magnetic force, and the electromagnetic stirring is used to control the uniform liquid flow in the reactor to avoid mechanical damage to the crystals. The second recrystallization kettle 9 is installed at the bottom of the first recrystallization kettle 8 through the mounting block 202, and the plug ring 17 is inserted into the slot 18 to ensure the tightness of the connection between the two recrystallization kettles. At the same time, it is convenient for personnel to quickly disassemble and assemble the second recrystallization kettle 9, thereby improving the convenience of using the device. After the reaction is completed, the crystallized product is collected from the collection tank 10 by disassembling it to avoid damage, thereby further ensuring the integrity of the crystallized product.

[0039] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. A recrystallization preparation device for preventing damage to a crystallized product, comprising a first base (1), characterized in that: The top of the first base (1) is fixedly connected to the second base (3), the four corners of the top of the second base (3) are fixedly connected to the first support rod (4), the top of the first support rod (4) is fixedly connected to the top plate (5), the bottom of the top plate (5) is fixedly connected to the support column (6), the bottom of the support column (6) is fixedly connected to the mounting frame (7), the inner wall of the mounting frame (7) is installed with the first recrystallization kettle (8), the bottom of the first recrystallization kettle (8) is provided with the second recrystallization kettle (9), the bottom of the second recrystallization kettle (9) is fixedly connected to the collecting tank (10), the inner bottom wall of the collecting tank (10) is installed with a coil, the front end of the outer wall of the collecting tank (10) is installed with a controller (11), and the bottom of the first recrystallization kettle (8) is provided with a disassembly mechanism (2).

2. The recrystallization preparation equipment for avoiding damage to the crystallized product according to claim 1, characterized in that: The disassembly mechanism (2) comprises an external connecting ring (201), the external connecting ring (201) being fixedly connected to the bottom of the outer wall of the first recrystallization kettle (8), the outer wall of the external connecting ring (201) being equidistantly connected to a plurality of mounting blocks (202), the outer walls of the mounting blocks (202) being provided with positioning holes (203), and the first recrystallization kettle (8) and the second recrystallization kettle (9) being connected via a latch (204).

3. The recrystallization preparation equipment for avoiding damage to the crystallized product according to claim 1, characterized in that: A protective sleeve (14) is fixedly connected to the bottom wall of the first support rod (4).

4. The recrystallization preparation equipment for avoiding damage to the crystallized product according to claim 1, characterized in that: The outer wall of the first base (1) is provided with mounting holes (15) at the left and right ends and the front and rear sides thereof, and the inner walls of the mounting holes (15) are threadedly connected with mounting bolts (16).

5. The recrystallization preparation equipment for avoiding damage to the crystallized product according to claim 1, characterized in that: The top of the second recrystallization kettle (9) is fixedly connected with an insert ring (17), and the bottom wall of the first recrystallization kettle (8) is provided with a slot (18), and the insert ring (17) and the slot (18) are engaged.

6. The recrystallization preparation equipment for avoiding damage to the crystallized product according to claim 1, characterized in that: A temperature sensor (19) is installed at the front end of the outer wall of the first recrystallization kettle (8).

7. The recrystallization preparation equipment for avoiding damage to the crystallized product according to claim 1, characterized in that: The right end of the outer wall of the first base (1) is fixedly connected to a second support rod (12), and a control panel (13) is installed on the top end of the second support rod (12).

8. The recrystallization preparation equipment for preventing the crystallized product from being damaged according to claim 7, characterized in that: The control panel (13) is electrically connected to the controller (11) and the temperature sensor (19) respectively.

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