Reduced-pressure drying reaction kettle with cooling function

Abstract

The utility model relates to the technical field of reduced pressure drying reaction kettles, in particular to a reduced pressure drying reaction kettle with a cooling function, which comprises a reaction kettle, and the top end of the reaction kettle is communicated with a vacuum pipe and a pressure release valve; the cooling mechanism is arranged in the reaction kettle; wherein the cooling mechanism comprises a rotating frame rotationally connected to the inner wall of the reaction kettle; according to the device, through the rotating frame, the material pushing frame, the liquid inlet pipe and the cooling pipeline, raw materials close to the inner wall of the reaction kettle are pushed to the surface of the cooling pipeline, and the rotating cooling pipeline conveys, throws away and cools the raw materials in the middle of the reaction kettle; by means of the mode, the contact area between the raw materials and the material pushing frame and the contact area between the raw materials and the cooling pipeline are increased, so that the raw materials in the reaction kettle are evenly cooled, and the pharmaceutical production quality is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of reduced pressure drying reactors, in particular to a reduced pressure drying reactor with a cooling function. Background Art

[0002] A vacuum drying reactor with cooling function is a device specifically designed for reaction and drying processes in the chemical, pharmaceutical, or food industries. In the pharmaceutical field, vacuum drying reactors are often used to dry materials under reduced pressure in the production and synthesis of new drugs. They combine vacuuming, heating, cooling, and drying functions to ensure the safety and efficiency of the reaction process.

[0003] After searching, the Chinese patent "A reactor with cooling function" authorization announcement number "CN211537718U" realizes the cooling of the raw materials in the reactor through the coolant outlet, cooling pipe and coolant inlet, and the cooling pipe is arranged inside the reactor, thereby ensuring the production quality of the reactor.

[0004] In the above application, since the cooling pipe is arranged inside the reactor, the cooling pipe is left stationary inside the reactor, which easily causes the raw materials to accumulate on the cooling pipe, thereby causing the raw materials in the area far away from the cooling pipe to cool slower, and the raw materials in the area close to the cooling pipe to cool faster, thereby affecting the production quality.

[0005] Therefore, a reduced pressure drying reactor with a cooling function is proposed to solve the above problems. Utility Model Content

[0006] The purpose of the present invention is to provide a vacuum drying reactor with a cooling function in order to solve the above problems, thereby improving the problem that the cooling pipe is placed stationary in the reactor, which easily leads to the accumulation of raw materials on the cooling pipe, thereby causing the raw materials in the area far from the cooling pipe to cool slower and the raw materials in the area close to the cooling pipe to cool faster.

[0007] The utility model achieves the above-mentioned purpose through the following technical solutions: a reduced-pressure drying reactor with a cooling function, comprising: a reactor, the top of which is connected to a vacuum tube and a pressure relief valve; a cooling mechanism, which is arranged inside the reactor; wherein the cooling mechanism comprises a rotating frame rotatably connected to the inner wall of the reactor, the surface of the rotating frame is fixedly connected to a cooling pipe, the cooling pipe is in a spiral progressive shape as a whole, the upper surface end of the rotating frame is connected to the top of the cooling pipe, the lower surface end of the rotating frame is connected to the bottom of the cooling pipe, the surface of the rotating frame is fixedly connected to a pushing frame, the upper surface end of the rotating frame is connected to a liquid inlet pipe, the bottom end of the liquid inlet pipe is connected to the top of the pushing frame, and both sides of the pushing frame are concave in an arc shape. Through the rotating frame, pushing frame, liquid inlet pipe and cooling pipe, the raw materials close to the inner wall of the reactor are pushed to the surface of the cooling pipe. The rotating cooling pipe transports and shakes off the raw materials in the middle of the reactor and cools the raw materials. Compared with the existing cooling pipe that is stationary in the reactor, resulting in uneven cooling of the raw materials in the reactor, this method increases the contact area between the raw materials and the pushing frame and cooling pipe, thereby evenly cooling the raw materials in the reactor and improving the production quality of pharmaceuticals.

[0008] Preferably, a cooler is fixedly connected to the surface of the reactor, the top of the cooler is connected to a liquid pump, the top of the liquid pump is connected to a liquid feeding pipe, the bottom end of the liquid feeding pipe passes through and extends out of the upper end of the inner wall of the rotating frame. Through the cooler, liquid feeding pump and liquid feeding pipe, the coolant in the rotating frame flows into the cooling pipe and the pushing frame respectively, so that the coolant flows in the cooling pipe and the pushing frame and absorbs heat from the raw materials.

[0009] Preferably, both sides of the pusher frame are fixedly connected to a fixing frame, the surface of which is fixedly connected to a material distribution frame distributed in equal rows, and the top of the material distribution frame is fixedly connected to an inclined plate. Through the fixing frame, the material distribution frame and the inclined plate, the amount of material flowing into the pusher frame is controlled, preventing excessive material from flowing into the pusher frame and thus affecting the cooling effect of the pusher frame on the material.

[0010] Preferably, the bottom end of the pushing frame is connected to a drain pipe, and the other end of the drain pipe is connected to the lower end of the surface of the rotating frame.

[0011] Preferably, the lower end of the surface of the cooler is connected to a liquid outlet pipe, the top end of which passes through and extends out of the lower end of the surface of the rotating frame. The liquid outlet pipe is used to discharge the coolant after absorbing heat in the pusher frame, and the liquid outlet pipe is used to transport the coolant after absorbing heat to the cooler for cooling, thereby ensuring repeated heat absorption of the coolant.

[0012] Preferably, sealed bearings are embedded in both the top and bottom ends of the rotating frame, with the inner edge of one of the sealed bearings fixedly connected to the lower surface end of the liquid supply pipe, and the inner edge of the other sealed bearing fixedly connected to the upper surface end of the liquid outlet pipe. The sealed bearings ensure that the rotating frame does not rotate the liquid supply pipe and the liquid outlet pipe, thereby preventing wear on the liquid supply pipe and the liquid outlet pipe.

[0013] Preferably, a liquid separation block is fixedly connected to the upper end of the inner wall of the rotating frame.

[0014] Preferably, both sides of the liquid separation block are fixedly connected to an inclined block, and the surface of the inclined block is fixedly connected to the upper end of the inner wall of the rotating frame. The liquid separation block and the inclined block ensure that the coolant on the upper end of the inner wall of the rotating frame flows orderly and quickly into the cooling pipe and the pusher frame.

[0015] The beneficial effects of the utility model are:

[0016] 1. Through the rotating frame, pushing frame, liquid inlet pipe and cooling pipe, the raw materials close to the inner wall of the reactor are pushed to the surface of the cooling pipe. The rotating cooling pipe transports and shakes off the raw materials in the middle of the reactor and cools the raw materials. Compared with the existing cooling pipe that is stationary in the reactor, which causes uneven cooling of the raw materials in the reactor, this method increases the contact area between the raw materials and the pushing frame and cooling pipe, thereby evenly cooling the raw materials in the reactor and improving the production quality of pharmaceuticals.

[0017] 2. Through the cooling machine, liquid delivery pump and liquid delivery pipe, the coolant in the rotating frame flows into the cooling pipe and the pushing frame respectively, so that the coolant flows in the cooling pipe and the pushing frame and absorbs heat from the raw materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0019] Figure 2 This is a schematic diagram of the cooling mechanism structure of the utility model;

[0020] Figure 3 This is a cross-sectional view of the rotating frame and the pushing frame of the present utility model;

[0021] Figure 4 This is a cross-sectional view of the rotating frame and cooling pipe of the present invention.

[0022] In the figure: 1. Reactor; 2. Pressure relief valve; 3. Vacuum tube; 4. Cooling mechanism; 41. Rotating frame; 42. Cooling pipe; 43. Cooling machine; 44. Liquid feeding pump; 45. Liquid feeding pipe; 46. Liquid inlet pipe; 47. Fixed frame; 48. Inclined block; 49. Material distribution frame; 410. Liquid outlet pipe; 411. Pushing frame; 412. Liquid distribution block; 413. Inclined plate; 414. Liquid discharge pipe; 415. Sealed bearing. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0024] When implementing: Figure 1-4 As shown, a reduced-pressure drying reactor with a cooling function comprises: a reactor 1, the top of the reactor 1 is connected to a vacuum tube 3 and a pressure relief valve 2; a cooling mechanism 4, the cooling mechanism 4 is arranged inside the reactor 1; wherein, the cooling mechanism 4 comprises a rotating frame 41 rotatably connected to the inner wall of the reactor 1, the surface of the rotating frame 41 is fixedly connected to a cooling pipe 42, the cooling pipe 42 is in a spiral progressive shape as a whole, the upper surface of the rotating frame 41 is connected to the top of the cooling pipe 42, the lower surface of the rotating frame 41 is connected to the bottom of the cooling pipe 42, the surface of the rotating frame 41 is fixedly connected to a pushing frame 411, the upper surface of the rotating frame 41 is connected to a liquid inlet pipe 46, the bottom end of the liquid inlet pipe 46 is connected to the top of the pushing frame 411, and both sides of the pushing frame 411 are concave in an arc shape.

[0025] The top of the reactor 1 is connected to a feed pipe, and a sealing cover is provided at the top opening of the feed pipe. The bottom end of the reactor 1 is connected to a discharge pipe, and a solenoid valve is embedded in the surface of the discharge pipe. The top of the reactor 1 is fixedly connected to a servo motor, and the output shaft of the servo motor is fixedly connected to a first gear. The bottom end of the first gear is rotatably connected to the top of the reactor 1. The upper surface of the rotating frame 41 is fixedly connected to a second gear, and the first gear is meshed with the second gear.

[0026] When synthesizing a new drug, such as an anti-tumor drug, the vacuum tube 3 is connected to the vacuum pump and manually activated. The vacuum pump cooperates with the pressure relief valve 2 to achieve an appropriate pressure reduction value in the reactor 1 and heat the reactor 1 to a suitable reaction temperature. 6-dichloro-5-methoxypyrimidine, a catalyst, and other raw materials are then poured into the reactor 1. The servo motor is manually activated, and the servo motor's output shaft rotates through the first and second gears, driving the rotating frame 41. The rotating frame 41 drives the cooling pipe 42 and the pushing frame 411 to stir the raw materials in the reactor 1. When the reaction is complete, the heating and pressure reduction are stopped, and the reactor 1 is cooled to room temperature by the cooling mechanism 4. Since 6-dichloro-5-methoxypyrimidine can serve as a key intermediate for drug molecules, it can be synthesized into a pharmacologically active structure through the Kjeldahl reaction, thus producing the raw materials into an anti-tumor drug. After preparation is complete, the servo motor is manually deactivated.

[0027] like Figure 2 As shown, a cooler 43 is fixedly connected to the surface of the reactor 1, the top of the cooler 43 is connected to a liquid feeding pump 44, the top of the liquid feeding pump 44 is connected to a liquid feeding pipe 45, and the bottom end of the liquid feeding pipe 45 passes through and extends out of the upper end of the inner wall of the rotating frame 41.

[0028] The liquid feeding pump 44 and the cooling machine 43 are manually turned on. The liquid feeding pump 44 extracts the cooling liquid stored in the cooling machine 43 and transports it to the chamber at the upper end of the rotating frame 41 through the liquid feeding pipe 45. The cooling liquid in the chamber at the upper end of the rotating frame 41 flows into the cooling pipe 42 and the liquid inlet pipe 46 respectively. Because the cooling pipe 42 is in a bolt progressive shape, the cooling liquid flows evenly in the cooling pipe 42, and the cooling liquid in the liquid inlet pipe 46 flows into the pushing frame 411. Because both sides of the pushing frame 411 are concave in an arc shape, the rotation of the rotating frame 41 drives the cooling pipe 42 and the pushing frame 411 to rotate. During the rotation of the pushing frame 411, the raw materials near the inner wall of the reactor 1 are pushed toward the cooling pipe 42 under the operation of centrifugal force. The cooling pipe 42 transports the raw materials in the middle of the reactor 1 and throws them out to the surrounding areas, so that the raw materials in the reactor 1 are dispersed and contact the cooling pipe 42 and the pushing frame 411, thereby evenly cooling the raw materials in the reactor 1. After cooling is completed, the liquid delivery pump 44 is manually turned off. After the cooler 43 cools the coolant therein for a period of time, the coolant is manually turned off.

[0029] like Figure 3 As shown, both sides of the pusher frame 411 are fixedly connected with fixing frames 47 , the surface of the fixing frames 47 are fixedly connected with equally distributed material distribution frames 49 , and the top of the material distribution frames 49 is fixedly connected with an inclined plate 413 .

[0030] The material distribution frame 49 is in the shape of a prism and there is a certain distance between the three adjacent material distribution frames 49. The rotation of the pushing frame 411 drives the fixed frame 47, the material distribution frame 49 and the inclined plate 413 to rotate. Because the material distribution frame 49 is located in the front side of the pushing frame 411, less raw materials in the reactor 1 flow into the pushing frame 411 during rotation, so that the raw materials can better contact with the side of the pushing frame 411 for cooling and better guide the raw materials to the middle of the reactor 1.

[0031] like Figure 4 As shown, the bottom end of the pushing frame 411 is connected to a drain pipe 414, the other end of the drain pipe 414 is connected to the lower end of the surface of the rotating frame 41, the lower end of the surface of the cooler 43 is connected to a liquid outlet pipe 410, the top end of the liquid outlet pipe 410 passes through and extends out of the lower end of the surface of the rotating frame 41, and the top and bottom ends of the rotating frame 41 are embedded with sealed bearings 415, the inner edge of one sealed bearing 415 is fixedly connected to the lower end of the surface of the liquid feeding pipe 45, and the inner edge of the other sealed bearing 415 is fixedly connected to the upper end of the surface of the liquid outlet pipe 410.

[0032] like Figure 3As shown, a liquid separation block 412 is fixedly connected to the upper end of the inner wall of the rotating frame 41 , and both sides of the liquid separation block 412 are fixedly connected to inclined blocks 48 . The surfaces of the inclined blocks 48 are fixedly connected to the upper end of the inner wall of the rotating frame 41 .

[0033] When the utility model is in use, the liquid feeding pump 44 and the cooling machine 43 are manually turned on, and the liquid feeding pump 44 extracts the cooling liquid stored in the cooling machine 43 and transports it to the chamber at the upper end of the rotating frame 41 through the liquid feeding pipe 45. The cooling liquid in the chamber at the upper end of the rotating frame 41 flows into the cooling pipe 42 and the liquid inlet pipe 46 respectively. Because the cooling pipe 42 is in a progressive shape of bolts, the cooling liquid flows evenly in the cooling pipe 42, and the cooling liquid in the liquid inlet pipe 46 flows into the pushing frame 411. Because both sides of the pushing frame 411 are concave in an arc shape, the rotation of the rotating frame 41 drives the cooling pipe 42 and the pushing frame 411 to rotate, and the distribution frame 49 is in a prism shape and has three distribution frames There is a certain distance between adjacent parts 49, and the rotation of the pushing frame 411 drives the fixed frame 47, the dividing frame 49 and the inclined plate 413 to rotate. Since the dividing frame 49 is located in the front side of the pushing frame 411, less raw materials in the reactor 1 flow into the pushing frame 411 during rotation, so that the raw materials can better contact with the side of the pushing frame 411 for cooling and better guide the raw materials to the middle of the reactor 1. Under the operation of centrifugal force, the cooling pipe 42 transports the raw materials in the middle of the reactor 1 and throws them out to the surroundings, so that the raw materials in the reactor 1 are dispersed and contact with the cooling pipe 42 and the pushing frame 411, thereby evenly cooling the raw materials in the reactor 1.

[0034] It should be noted that the reactor 1, pressure relief valve 2, cooler 43, liquid feeding pump 44, sealed bearing 415 and servo motor in the above description are all relatively mature devices in existing technology. The specific models can be selected according to actual needs. At the same time, the reactor 1, pressure relief valve 2, liquid feeding pump 44 and servo motor can be powered by a built-in power supply or by AC power. The specific power supply method is selected according to the situation and will not be elaborated here.

[0035] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A vacuum drying reactor with cooling function, characterized in that: include: A reactor (1), the top of which is connected to a vacuum tube (3) and a pressure relief valve (2); A cooling mechanism (4), the cooling mechanism (4) being arranged inside the reaction kettle (1); The cooling mechanism (4) comprises a rotating frame (41) rotatably connected to the inner wall of the reactor (1); a cooling pipe (42) is fixedly connected to the surface of the rotating frame (41); the cooling pipe (42) is spirally progressive in shape as a whole; the upper surface end of the rotating frame (41) is connected to the top of the cooling pipe (42); the lower surface end of the rotating frame (41) is connected to the bottom of the cooling pipe (42); a pushing frame (411) is fixedly connected to the surface of the rotating frame (41); the upper surface end of the rotating frame (41) is connected to a liquid inlet pipe (46); the bottom end of the liquid inlet pipe (46) is connected to the top of the pushing frame (411); and both sides of the pushing frame (411) are concave in an arc shape.

2. The vacuum drying reactor with cooling function according to claim 1, characterized in that: A cooler (43) is fixedly connected to the surface of the reactor (1), the top of the cooler (43) is connected to a liquid delivery pump (44), the top of the liquid delivery pump (44) is connected to a liquid delivery pipe (45), and the bottom end of the liquid delivery pipe (45) passes through and extends out of the upper end of the inner wall of the rotating frame (41).

3. The vacuum drying reactor with cooling function according to claim 1, characterized in that: Both sides of the pushing frame (411) are fixedly connected to a fixing frame (47), the surface of the fixing frame (47) is fixedly connected to a material distribution frame (49) distributed in equal rows, and the top of the material distribution frame (49) is fixedly connected to an inclined plate (413).

4. The vacuum drying reactor with cooling function according to claim 1, characterized in that: The bottom end of the pushing frame (411) is connected to a drain pipe (414), and the other end of the drain pipe (414) is connected to the lower end of the surface of the rotating frame (41).

5. The vacuum drying reactor with cooling function according to claim 2, characterized in that: The lower end of the surface of the cooling machine (43) is connected to a liquid outlet pipe (410), and the top end of the liquid outlet pipe (410) passes through and extends out of the lower end of the surface of the rotating frame (41).

6. The vacuum drying reactor with cooling function according to claim 1, characterized in that: Sealed bearings (415) are embedded and installed at the top and bottom ends of the rotating frame (41), wherein the inner edge of one of the sealed bearings (415) is fixedly connected to the lower end of the surface of the liquid delivery pipe (45), and the inner edge of the other sealed bearing (415) is fixedly connected to the upper end of the surface of the liquid outlet pipe (410).

7. The vacuum drying reactor with cooling function according to claim 1, characterized in that: A liquid separation block (412) is fixedly connected to the upper end of the inner wall of the rotating frame (41).

8. The vacuum drying reactor with cooling function according to claim 7, characterized in that: Both sides of the liquid separation block (412) are fixedly connected with inclined blocks (48), and the surface of the inclined blocks (48) is fixedly connected to the upper end of the inner wall of the rotating frame (41).

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