Material sterile connection adding system

Abstract

The utility model relates to the technical field of material sterile equipment, and provides a material sterile connecting and adding system, which is used for adding materials into a main pipeline and comprises a movable sterile tank connected with a discharge pipeline. The system is provided with a discharging station, when the system is located at the discharging station, the system has a discharging state, in the discharging state, a discharging pipeline is connected with a sterile transfer valve, the sterile transfer valve is connected with a sterile isolator, a conveying hose with a needle head is arranged in the sterile transfer valve, a main pipeline penetrates through the sterile isolator, one end of the conveying hose is connected with the sterile transfer valve, and the other end of the conveying hose is connected with the sterile isolator. One end, with a needle head, of the conveying hose is inserted into an adding point of the main pipeline; materials in the movable sterile tank can be added into the main pipeline through the discharging pipeline and the conveying hose. According to the utility model, the heat-sensitive material can be added into the pipeline in a sterile manner through the movable tank, so that the use of a sterile material bag is avoided; and a sterile isolator is adopted to carry out sterile isolation on the adding point, so that thermal damage of the heat-sensitive material is avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of material aseptic equipment, in particular to a material aseptic connection and addition system. Background Art

[0002] Currently, more and more attention is paid to the addition of heat-sensitive elements in room temperature long-shelf-life dairy products, such as lactoferrin, probiotics, immunoglobulins, vitamins, active peptides, flavors, etc., and these additives that are positively correlated with human immunity, intestinal health and other functional ingredients as well as flavor and taste are also attracting more and more attention from consumers.

[0003] Currently, the existing adding equipment can only achieve an adding capacity of 0L / h to 30L / h, and the addition is carried out in the form of sterile bags. The maximum capacity of a disposable sterile bag is 10kg. After use, the bag and the corresponding adding syringe need to be replaced. In the long run, the consumable costs of sterile bags and corresponding disposable syringes are high. At the same time, the adding point has been using a steam mask to maintain sterility, which will cause thermal damage to heat-sensitive elements and reduce the activity and other functions of the elements. In addition, the repeated removal and insertion of the syringe at the adding point will also increase the risk of microbial contamination. Utility Model Content

[0004] The purpose of the utility model is to provide a sterile material connection and addition system, which realizes the aseptic addition of heat-sensitive materials into the pipeline through a movable tank, avoiding the use of sterile material bags, and at the same time adopts a sterile isolator to aseptically isolate the addition point to avoid thermal damage to the heat-sensitive materials.

[0005] The above technical objectives of the present invention are mainly achieved through the following technical solutions:

[0006] A material aseptic connection and addition system is used to add materials into a main pipeline. The material aseptic connection and addition system includes a movable sterile tank for containing the material, and an outlet at the bottom of the movable sterile tank is connected to a discharge pipeline;

[0007] The aseptic material connection and addition system has a discharging station. When the movable sterile tank is at the discharging station, the aseptic material connection and addition system has a discharging state. In the discharging state:

[0008] The discharge pipeline is connected to a sterile transfer valve, which is connected to a sterile isolator through a docking port. A delivery hose with a needle is provided in the sterile transfer valve. The main pipeline passes through the sterile isolator. A peristaltic pump is provided in the sterile isolator. One end of the delivery hose is connected to the inlet of the sterile transfer valve, and one end of the delivery hose with a needle extends into the sterile isolator through the docking port and is clamped into the peristaltic pump. The needle is inserted at the adding point of the main pipeline. The material in the movable sterile tank can be added into the main pipeline through the discharge pipeline and the delivery hose.

[0009] The material aseptic connection and addition system described in the utility model adds heat-sensitive materials into the main pipeline through a large-capacity movable sterile tank, avoiding the use of disposable sterile bags and the need to frequently replace sterile bags and corresponding addition pipelines, which not only reduces production operation costs but also reduces the risk of product contamination caused by frequent replacement of addition pipelines.

[0010] The aseptic material connection and addition system described in the utility model has a main pipeline that passes through an aseptic isolator, and the addition point is located in an aseptic chamber formed in the aseptic isolator. The connection operations of the conveying hose are all performed in a sterile environment, thereby reducing the risk of product contamination. At the same time, it avoids maintaining sterility through a steam shield and reduces the risk of thermal damage to heat-sensitive materials.

[0011] The material aseptic connection and addition system described in the utility model adopts an aseptic transfer valve to achieve docking with the aseptic isolator. When the movable sterile tank is transferred to the discharge station, aseptic docking can be achieved quickly, reducing the risk of possible material contamination.

[0012] In a preferred embodiment of the present invention, when the movable sterile tank is at the discharging station, the gas inlet on the top of the movable sterile tank is connected to a first gas supply line;

[0013] In the discharging state, the first gas supply line can introduce sterile gas into the movable sterile tank to drive the material to be added into the main pipeline.

[0014] In this embodiment, the first air supply line serves as the power line at the discharge station. By introducing nitrogen or compressed air of a certain pressure into the movable sterile tank, the air pressure in the movable sterile tank is increased to ensure that the material in the tank can flow smoothly into the discharge pipeline.

[0015] In a preferred embodiment of the present invention, the first air supply line is connected to a sterilization line capable of sterilizing the first air supply line.

[0016] In this embodiment, before the first gas supply line is activated, high-pressure steam is introduced into the sterilization line to sterilize the pipeline, thereby avoiding contamination of the material.

[0017] In a preferred embodiment of the present invention, a first flow meter is provided on the discharge pipeline, and a second flow meter is provided on the main pipeline. The first flow meter and the second flow meter are both connected to a control unit, and the control unit is connected to the peristaltic pump to regulate the rotational speed of the peristaltic pump.

[0018] In this embodiment, the control unit can obtain the liquid flow in the main pipeline and the discharge pipeline, and control the proportion of adding material to the main pipeline by controlling the rotation speed of the peristaltic pump.

[0019] In a preferred embodiment of the present invention, a glove operation port is provided on the side wall of the sterile isolator, and the operator can connect the delivery hose to the inlet of the sterile transfer valve and the main pipeline respectively through the glove operation port.

[0020] In this embodiment, the operator can perform the connection operation of the corresponding pipelines in the sterile isolator through the sterile glove operation port, so that the exposure points of the materials are all in a sterile environment, thereby avoiding contamination of the materials.

[0021] In a preferred embodiment of the present invention, the aseptic material connection and addition system further has a feeding station, and the movable sterile tank can move between the feeding station and the discharging station. When the movable sterile tank is at the feeding station, the aseptic material connection and addition system has a feeding state. In the feeding state:

[0022] The inlet on the side wall of the movable sterile tank is connected to a feeding pipeline, and the material can enter the movable sterile tank through the feeding pipeline.

[0023] In this embodiment, the movable sterile tank is loaded at the feeding station and can be moved to the discharging station to unload, thereby forming a relatively complete operation closed loop. The movable sterile tank is used to facilitate long-distance transportation of materials.

[0024] In a preferred embodiment of the present invention, when the movable sterile tank is at the feeding station, the feeding pipeline is connected to a barrier pipeline, a first storage tank and a second storage tank are provided on the barrier pipeline, one end of the feeding pipeline is connected to the second storage tank, and the first storage tank is connected to the feeding pipeline; a barrier valve is provided at each end of the barrier pipeline, and the barrier valve is connected to a condensate pipeline;

[0025] In the feeding state, condensed water flows through the condensed water pipeline, and the material enters the movable sterile tank through the feeding pipeline, the first storage tank, the barrier pipeline, the second storage tank and the feeding pipeline.

[0026] In this embodiment, when the movable sterile tank is at the feeding station, before the material is introduced into the tank through the feed pipeline, the barrier pipeline and the feed pipeline, the two barrier valves are protected by a steam condensate barrier through the condensed water flowing through the condensate pipeline, thereby ensuring the stability of the heat-sensitive material during the feeding process and avoiding the inactivation of the heat-sensitive elements therein.

[0027] In a preferred embodiment of the present invention, when the movable sterile tank is at the feeding station, the material aseptic connection and addition system further has a cleaning state, in which:

[0028] The inlet at the top of the movable sterile tank is connected to a cleaning line, the cleaning line is connected to a liquid supply line, and the liquid supply line is connected to the condensed water line; one end of the discharge pipeline is connected to a cleaning pipe, and the cleaning pipe is connected to a waste liquid line; the cleaning liquid can pass through the liquid supply line, the cleaning line, the movable sterile tank, the discharge pipeline and the waste liquid line in sequence for cleaning, and the cleaning liquid can also pass through the liquid supply line, the condensed water line, the barrier line and the feed pipeline in sequence to enter the movable sterile tank for cleaning.

[0029] In this embodiment, when the movable sterile tank is at the feeding station, before loading, the pipeline and the tank body can be cleaned through the liquid supply line and the cleaning line to remove impurities remaining in the pipeline and the tank body to avoid contamination of the material.

[0030] In a preferred embodiment of the present invention, when the movable sterile tank is in the feeding station, the gas inlet on the top of the movable sterile tank is connected to a second gas supply line;

[0031] In the cleaning state, the second gas supply line can introduce sterile gas into the movable sterile tank to drive the cleaning liquid into the discharge line.

[0032] In this embodiment, the second air supply pipeline serves as the power pipeline at the feeding station, and its function is basically the same as that of the first air supply pipeline at the discharging station. By introducing nitrogen or compressed air of a certain pressure into the movable sterile tank, the air pressure in the movable sterile tank is increased to ensure that the cleaning liquid entering the tank can flow out smoothly.

[0033] In a preferred embodiment of the present invention, when the movable sterile tank is at the feeding station, the material aseptic connection and addition system also has a sterilization state, in which:

[0034] The second air supply line, the condensed water line and the cleaning line are all connected to the disinfection line, one end of the discharge line is connected to the sterile transfer valve, and the outlet of the sterile transfer valve is connected to the waste liquid line; the disinfectant can enter the second air supply line and the condensed water line through the disinfection line to disinfect them, and the disinfectant can also pass through the disinfection line, the cleaning line, the movable sterile tank, the discharge line, the sterile transfer valve and the waste liquid line in sequence for disinfection.

[0035] In this embodiment, when the movable sterile tank is at the feeding station, after the cleaning of the pipeline and the tank body is completed, the pipeline and the tank body can be disinfected by passing high-pressure steam into the disinfection pipeline, thereby reducing the risk of material contamination.

[0036] In a preferred embodiment of the present invention, after the disinfection treatment of the condensate pipeline is completed, the disinfection pipeline is connected to the condensate pipeline, and low-pressure steam can enter the condensate pipeline through the disinfection pipeline and liquefy so that the barrier valve forms a steam condensate barrier protection.

[0037] In this embodiment, low-pressure steam is directly introduced into the condensate line through the disinfection line connected to the condensate line, and then liquefied to form condensate in the condensate line, avoiding the need to set up a corresponding low-pressure steam pipeline separately and simplifying the pipeline structure at the feeding station.

[0038] In a preferred embodiment of the present invention, when the movable sterile tank is at the feeding station, the material aseptic connection and addition system further has a purge state, in which:

[0039] The second gas supply line can introduce sterile gas into the movable sterile tank to cool the movable sterile tank.

[0040] In this embodiment, when the movable sterile tank is at the feeding station, after the disinfection of the pipeline and the tank body is completed, nitrogen or compressed air at a certain pressure is introduced into the pipeline through the second air supply line to purge the pipeline and the tank body, so that the temperature of the tank body and the pipeline is reduced to an appropriate range, thereby avoiding affecting the activity of heat-sensitive materials.

[0041] In a preferred embodiment of the present invention, a cooling water interlayer is provided on the side wall of the movable sterile tank, and in the purge state:

[0042] Cooling water is passed through the cooling water interlayer to cool the movable sterile tank.

[0043] In this embodiment, the cooling water is introduced into the cooling water interlayer to accelerate the cooling rate of the movable sterile tank during the purging process.

[0044] In a preferred embodiment of the present invention, when the movable sterile tank is at the feeding station, the material aseptic connection and addition system sequentially enters the cleaning state, the disinfection state, the purging state and the feeding state.

[0045] In a preferred embodiment of the present invention, the gas inlet at the top of the movable sterile tank is provided with a switch control valve, and the first gas supply line or the second gas supply line passes through the switch control valve, and the switch control valve can control the conduction and disconnection of the first gas supply line or the second gas supply line and the movable sterile tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative work. In the drawings:

[0047] The drawings described herein are for illustrative purposes only and are not intended to limit the scope of the present invention in any way. Furthermore, the shapes and proportional dimensions of the components in the drawings are for illustrative purposes only and are intended to facilitate understanding of the present invention. They are not intended to limit the shapes and proportional dimensions of the components of the present invention. Those skilled in the art, guided by the present invention, may select various possible shapes and proportional dimensions to implement the present invention, depending on the specific circumstances.

[0048] Figure 1 This is a structural schematic diagram of the aseptic material connection and addition system of the utility model in the discharging state;

[0049] Figure 2 This is a structural schematic diagram of the material aseptic connection and addition system of the utility model in the cleaning state;

[0050] Figure 3 This is a structural schematic diagram of the aseptic material connection and addition system of the utility model in the sterilized state;

[0051] Figure 4 This is a schematic diagram of the structure of the aseptic material connection and addition system of the utility model to form a condensation water barrier protection;

[0052] Figure 5 This is a structural schematic diagram of the material aseptic connection and addition system of the utility model in the purge state;

[0053] Figure 6 This is a structural schematic diagram of the material aseptic connection and addition system of the utility model in the feeding state;

[0054] Description of reference numerals:

[0055] 10. Movable sterile tank; 11. Discharge pipeline; 12. Intake pipeline; 13. Cleaning pipeline; 14. On / off control valve; 15. Cooling water interlayer; 16. Temperature sensor; 17. Agitator; 18. Gravity sensor;

[0056] 20. Aseptic transfer valve; 21. Delivery hose; 22. Docking port;

[0057] 30. Sterile isolator; 31. Peristaltic pump; 32. Main pipeline; 33. Glove operation port; 34. First flow meter; 35. Second flow meter;

[0058] 40. First air supply line; 41. Sterilization line;

[0059] 50. Barrier pipeline; 51. First storage tank; 52. Second storage tank; 53. Barrier valve; 54. Condensate pipeline; 55. Feed pipeline;

[0060] 60. Liquid supply line; 61. Cleaning pipe; 62. Waste liquid line;

[0061] 70. Second air supply line; 71. Sterile filter; 72. Pressure sensor;

[0062] 80. Disinfection pipelines;

[0063] 001, first valve; 002, second valve; 003, third valve; 004, fourth valve; 005, fifth valve; 006, sixth valve; 007, seventh valve; 008, eighth valve; 009, ninth valve; 010, tenth valve; 011, eleventh valve; 012, twelfth valve; 013, thirteenth valve; 014, fourteenth valve; 015, fifteenth valve; 016, sixteenth valve; 017, seventeenth valve; 018, eighteenth valve; 019, nineteenth valve. DETAILED DESCRIPTION

[0064] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the following will be combined with the drawings of the embodiments of the present invention to clearly and completely describe the technical solutions of the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0065] It should be noted that when an element is referred to as being "disposed on" another element, it may be directly on the other element or there may be an element centered thereon. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an element centered thereon. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only embodiments.

[0066] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used herein in the specification of this invention are for the purpose of describing specific embodiments only and are not intended to limit the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0067] like Figure 1 As shown, the utility model provides a material aseptic connection and addition system for adding materials into the main pipeline 32. The material aseptic connection and addition system includes a movable sterile tank 10 for containing materials. The outlet at the bottom of the movable sterile tank 10 is connected to a discharge pipeline 11. The material aseptic connection and addition system has a discharge station. When the movable sterile tank 10 is in the discharge station, the material aseptic connection and addition system has a discharge state. In the discharge state, the discharge pipeline 11 is connected to a sterile transfer valve 20, and the sterile transfer valve 20 is connected to the sterile transfer valve 20 through the docking port 22. It is connected to a sterile isolator 30, a delivery hose 21 with a needle is provided in the sterile transfer valve 20, a main pipeline 32 passes through the sterile isolator 30, a peristaltic pump 31 is provided in the sterile isolator 30, one end of the delivery hose 21 is connected to the inlet of the sterile transfer valve 20, and one end of the delivery hose 21 with a needle extends into the sterile isolator 30 through the docking port 22 and is clamped into the peristaltic pump 31, and the needle is inserted at the adding point of the main pipeline 32; the material in the movable sterile tank 10 can be added into the main pipeline 32 through the discharge pipeline 11 and the delivery hose 21.

[0068] The aseptic material connection and addition system described in the present invention adds heat-sensitive materials to the main pipeline 32 through a large-capacity movable sterile tank 10, avoiding the use of disposable sterile bags and the need to frequently replace sterile bags and corresponding addition pipelines, which not only reduces production operation costs but also reduces the risk of product contamination caused by frequent replacement of addition pipelines.

[0069] In the aseptic material connection and addition system described in the present invention, the main pipeline 32 is arranged in the aseptic isolator 30, and the addition point is located in the aseptic chamber formed in the aseptic isolator 30. The connection operation of the conveying hose 21 is carried out in a sterile environment, reducing the risk of material contamination. At the same time, it avoids maintaining sterility through a steam shield and reduces the risk of thermal damage to heat-sensitive materials.

[0070] The material aseptic connection and addition system described in the present invention adopts an aseptic transfer valve 20 to achieve docking with the aseptic isolator 30. When the movable sterile tank 10 is transferred to the discharge station, aseptic docking can be achieved quickly, reducing the risk of possible material contamination.

[0071] The following will further describe the specific structure of each part of the aseptic material connection and addition system of the present invention, as well as the pipeline connection relationship between the parts.

[0072] like Figure 1 As shown, the material aseptic connection and addition system described in the present invention is provided with a movable sterile tank 10, which is used to temporarily store the material to be added to the main pipeline 32. The material to be added is usually a heat-sensitive material with high requirements for the addition environment (pressure, temperature, cleanliness, etc.). The movable sterile tank 10 is a cylindrical tank structure, which can be flexibly transported by providing walking wheels on each leg, or by placing the entire tank on a wheelbarrow, so as to conveniently move the movable sterile tank 10 to any location where material needs to be added. A material chamber for holding materials is formed in the movable sterile tank 10. The volume of the material chamber is usually several hundred liters to several thousand liters, which is much larger than a disposable material bag of several tens of liters.

[0073] Furthermore, the outlet at the bottom of the movable sterile tank 10 is connected to a discharge pipeline 11 , and a first valve 001 is provided at the bottom outlet of the movable sterile tank 10 . The first valve 001 is used to control the conduction and shutoff of the discharge pipeline 11 .

[0074] like Figure 1As shown, the aseptic material connection and addition system of the present invention has a discharge station arranged at the addition point. The discharge station is arranged at the actual addition position of the main pipeline 32 in the production workshop. At the actual addition position, a pipeline and equipment matching the movable sterile tank 10 are provided for conveying the material contained in the movable sterile tank 10 into the main pipeline 32. The specific location and number of the discharge station can be selected according to the needs of the production workshop and are not specifically limited here.

[0075] Furthermore, a sterile isolator 30 is provided at the discharge station, and a sterile chamber is formed in the sterile isolator 30. The main pipeline 32 passes through the sterile isolator 30 and has a section located in the above-mentioned sterile chamber. An adding point is provided on the part of the main pipeline 32 located in the sterile chamber, and the adding point is the position where the material liquid in the movable sterile tank 10 needs to be added into the main pipeline 32.

[0076] When it is necessary to add material to the main pipeline 32 at the discharge station, the movable sterile tank 10 containing the material is moved to the discharge station, and a sterile transfer valve 20 is connected to the free end of the discharge line 11. The sterile transfer valve 20 is a tank body with an inlet and an outlet. One end of the tank body is provided with an interface that can be docked with the sterile isolator 30. One end of the discharge line 11 is connected to the inlet of the sterile transfer valve 20. A disposable delivery hose 21 and a needle are provided inside the sterile transfer valve 20, and the needle is connected to one end of the delivery hose 21. When the movable sterile tank 10 is moved to the discharge station, the interface of the sterile transfer valve 20 is connected to the opening in the side wall of the sterile isolator 30, thereby connecting the sterile chamber in the sterile isolator 30 with the space in the sterile transfer valve 20. The sterile transfer valve 20 and the sterile isolator 30 are sealed to ensure a sterile environment in the sterile isolator 30. The end of the conveying hose 21 without a needle is connected to the inlet of the sterile transfer valve 20, that is, one end of the conveying hose 21 is connected to the discharge pipeline 11; the end of the conveying hose 21 with a needle passes through the opening on the side wall of the sterile isolator 30 and extends into the sterile chamber, and the conveying hose 21 bypasses the peristaltic pump 31 in the sterile isolator 30, and the end of the conveying hose 21 with a needle is inserted into the adding point of the main pipeline 32. The rotation of the peristaltic pump 31 can control the material in the conveying hose 21 to be transported toward the main pipeline 32.

[0077] The connection state of the above pipelines and devices is the discharge state mentioned above, such as Figure 1 As shown, in the discharging state, the first valve 001 is opened, the discharging pipeline 11 is connected, the peristaltic pump 31 is turned on, and the material in the movable sterile tank 10 can flow into the main pipeline 32 through the discharging pipeline 11 and the conveying hose 21 in the sterile transfer valve 20, thereby realizing the addition of material.

[0078] Since the movable sterile tank 10 has a large capacity, a large amount of materials to be added can be stored in it in advance, so long-term addition without replacement can be achieved at the discharge station; and a sterile environment is formed at the addition point of the main pipeline 32 through the sterile isolator 30 and the sterile transfer valve 20, which can effectively avoid contamination of the material.

[0079] The structure and corresponding technical effects of the preferred embodiment of the aseptic material connection and addition system of the present invention will be further described below.

[0080] According to one embodiment of the present invention, Figure 1 As shown, when the movable sterile tank 10 is in the discharging position, the gas inlet at the top of the movable sterile tank 10 is connected to the first gas supply line 40; in the discharging state, the first gas supply line 40 can introduce sterile gas into the movable sterile tank 10 to drive the material to be added into the main pipeline 32.

[0081] The first air supply line 40 serves as a power line at the discharge station. It increases the air pressure inside the movable sterile tank 10 by introducing nitrogen or compressed air of a certain pressure into the movable sterile tank 10 to ensure that the material in the tank can flow smoothly into the discharge pipeline 11.

[0082] Specifically, such as Figure 1 As shown, the first gas supply line 40 is a complete set of gas supply lines installed at the discharge station. When the movable sterile tank 10 moves to the discharge station, the first gas supply line 40 is connected to the gas inlet on the tank top. During the discharge process, it can pass sterile nitrogen or air at a certain pressure into the movable sterile tank 10 to assist in the discharge. The specific pipeline structure of the first gas supply line 40 will be described in detail below.

[0083] According to one embodiment of the present invention, Figure 1 As shown, a sterilization line 41 capable of sterilizing the first air supply line 40 is connected to the first air supply line 40. Before the first air supply line 40 is activated, high-pressure steam is introduced into the sterilization line 41 to sterilize the pipeline, thereby avoiding contamination of the material.

[0084] According to one embodiment of the present invention, Figure 1 As shown, a first flow meter 34 is provided on the discharge pipeline 11, and a second flow meter 35 is provided on the main pipeline 32. Both the first flow meter 34 and the second flow meter 35 are connected to a control unit, which is connected to the peristaltic pump 31 to regulate the speed of the peristaltic pump 31. The control unit can obtain the liquid flow in the main pipeline 32 and the discharge pipeline 11, and control the proportion of material added to the main pipeline 32 by controlling the speed of the peristaltic pump 31.

[0085] According to one embodiment of the present invention, Figure 1 As shown, a glove access port 33 is provided on the side wall of the sterile isolator 30. Through this port, an operator can connect the delivery hose 21 to the inlet of the sterile transfer valve 20 and the main pipeline 32, respectively. This port allows the operator to connect the corresponding pipelines within the sterile isolator 30, ensuring that all material exposure points are in a sterile environment, thereby preventing material contamination. The glove access port 33 is a common feature on sterile equipment and will not be described in detail here.

[0086] According to one embodiment of the present invention, Figures 2 to 6 As shown, the aseptic material connection and addition system also has a feeding station, at which at least one operation among cleaning operation, disinfection operation, purging operation and feeding operation can be performed.

[0087] At the feeding station, the above different operations require connecting different pipelines or conducting different pipelines, so each operation corresponds to a different pipeline status. Figure 2 As shown, the cleaning operation corresponds to the cleaning state, which is used to clean the corresponding pipelines and the movable sterile tank 10; Figure 3 As shown, the disinfection operation corresponds to the disinfection state, which is used to disinfect and sterilize the corresponding pipelines and the movable sterile tank 10; Figure 5 As shown, the purging operation corresponds to the purging state, which is used to purge and cool the corresponding pipelines and the movable sterile tank 10; Figure 6 As shown, the feeding operation corresponds to the feeding state, realizing the feeding of materials into the tank.

[0088] In one embodiment of the present invention, the aseptic material connection and addition system can have only the aforementioned feeding state, that is, it can also have at least one of the aforementioned cleaning state, disinfection state, and purge state. In other words, during the process, the pipeline structure of this application can be used to achieve cleaning, disinfection, and purge operations, and other structures or methods can also be used to achieve the aforementioned process.

[0089] The following will explain in detail the pipeline connection structure and conduction conditions of the cleaning state, disinfection state, purge state and feeding state according to the sequential operation sequence of each state at the feeding station.

[0090] like Figure 1 As shown, the material aseptic connection and addition system described in the present invention has a cleaning state. Before the material liquid addition operation is performed, the pipeline and the tank body need to be pretreated, and the pretreatment process includes a cleaning operation.

[0091] First, move the movable sterile tank 10 to the feeding station. The movable sterile tank 10 can move between the feeding station and the discharging station. The feeding station refers to the position for pre-processing the movable sterile tank 10. Various pipelines that can be connected to the movable sterile tank 10 to perform various pre-processing operations are arranged at this position.

[0092] like Figure 2 As shown, after the movable sterile tank 10 is moved into place, the cleaning line 13 is connected to the inlet at the top of the movable sterile tank 10. A third valve 003 is provided at the inlet at the top of the movable sterile tank 10. The third valve 003 is used to control the conduction and shutoff of the cleaning line 13; Figure 2 and Figure 6 As shown, a feed line 12 is connected to the inlet of the side wall of the movable sterile tank 10, and the material can enter the movable sterile tank 10 through the feed line 12. A second valve 002 is provided at the inlet of the side wall of the movable sterile tank 10, and the second valve 002 is used to control the conduction and shutoff of the feed line 12.

[0093] Better, such as Figure 2 and Figure 6 As shown, the feed pipeline 12 is connected to the barrier pipeline 50, and the barrier pipeline 50 is provided with a first storage tank 51 and a second storage tank 52. One end of the feed pipeline 12 is connected to the second storage tank 52, and the first storage tank 51 is connected to the feed pipeline 55; a barrier valve 53 is provided at each end of the barrier pipeline 50, and the barrier valve 53 is connected to the condensate pipeline 54. Among them, the feed pipeline 55 includes a feed pipe and a return pipe connected to the first storage tank 51; the condensate line 54 includes a main pipe and two branch pipes, the two branch pipes are arranged in parallel and located in the middle of the main pipe, along the flow direction of the condensate in the condensate line 54, there are two branch pipes in the main pipe, the two branch pipes pass through two barrier valves 53 respectively and then converge into the main pipe again, the main pipe is provided with an eighth valve 008, the eighth valve 008 is used to control the conduction and shutdown of the main pipe, one of the branch pipes (close to the first storage tank 51) is provided with a seventh valve 007, the seventh valve 007 is used to control the conduction and shutdown of the branch pipe.

[0094] like Figure 2As shown, in the cleaning state: one end of the cleaning line 13 is connected to the liquid supply line 60, which is equipped with a one-way valve. The liquid supply line 60 is also connected to the condensate line 54 via the ninth valve 009. The ninth valve 009 is a three-way valve that controls the flow between the liquid supply line 60, the cleaning line 13, and the condensate line 54. One end of the discharge line 11 is connected to the cleaning pipe 61, which is a U-shaped pipe. The outlet of the cleaning pipe 61 is equipped with a fifth valve 005, which is used to control the flow and shutoff of the cleaning pipe 61. The cleaning pipe 61 is also connected to the waste liquid line 62, which is equipped with a twelfth valve 012, which is used to control the flow and shutoff of the waste liquid line 62.

[0095] When the cleaning operation is performed in the cleaning state, cleaning liquid is introduced into the liquid supply line 60; the ninth valve 009 is opened to connect the liquid supply line 60, the cleaning line 13 and the condensate line 54; the third valve 003, the first valve 001, the fifth valve 005 and the twelfth valve 012 are opened, and the cleaning liquid passes through the liquid supply line 60, the cleaning line 13, the movable sterile tank 10, the discharge line 11 and the waste liquid line 62 in turn for cleaning; at the same time, the barrier valve 53 is opened, the condensate line 54 is connected to the barrier line 50, the eighth valve 008 and the second valve 002 are opened, and the cleaning liquid passes through the liquid supply line 60, the condensate line 54, the barrier line 50 and the feed line 12 in turn into the movable sterile tank 10 for cleaning. When the movable sterile tank 10 is at the feeding station, before the material is fed into the tank, the pipeline and the tank body can be cleaned through the liquid supply line 60 and the cleaning line 13 to remove impurities remaining in the pipeline and the tank body to avoid contamination of the material.

[0096] Preferably, when the cleaning operation is performed in the cleaning state, the upper agitator 17 of the movable sterile tank 10 is intermittently opened and closed to improve the cleaning effect of the movable sterile tank 10.

[0097] Preferably, in order to improve the cleaning effect of the barrier pipeline 50, when performing the cleaning operation in the cleaning state, the barrier valve 53 and the seventh valve 007 can be intermittently opened and closed, and when the barrier valve 53 is opened, the seventh valve 007 is closed.

[0098] Furthermore, in order to improve the cleaning effect of the pipes and tanks, CIP cleaning can be adopted, that is, during the cleaning operation, clean water, alkaline solution, clean water, acidic solution and clean water are successively introduced into the liquid supply line 60, and the above cleaning operation is realized in five steps.

[0099] According to one embodiment of the present invention, Figure 2As shown, when the movable sterile tank 10 is in the feeding station, the gas inlet at the top of the movable sterile tank 10 is connected to the second gas supply line 70; when the cleaning operation is performed in the cleaning state, the second gas supply line 70 can introduce sterile gas into the movable sterile tank 10 to drive the cleaning liquid into the discharge pipeline 11.

[0100] The second air supply line 70 serves as the power line at the inlet station. Its function is essentially the same as that of the first air supply line 40 at the outlet station. By introducing nitrogen or compressed air at a certain pressure into the movable sterile tank 10, the air pressure within the movable sterile tank 10 is increased, ensuring that the cleaning liquid entering the tank can flow out smoothly. The pipeline structure of the second air supply line 70 is essentially the same as that of the first air supply line 40 and will be described in detail below.

[0101] like Figure 3 As shown, the aseptic material connection and addition system described in the present invention also has a disinfection state. Before the material liquid addition operation is performed, the pipeline and the tank body need to be pretreated. The pretreatment process also includes a disinfection operation, which is usually performed after the cleaning operation.

[0102] like Figure 3 As shown, after the cleaning operation is completed, the material aseptic connection adding system enters the disinfection state. In the disinfection state: the second air supply line 70, the condensed water line 54 and the cleaning line 13 are all connected to the disinfection line 80. The disinfection line 80 has a main pipe and two branch pipes, one of which is connected to the second air supply line 70. The branch pipe is provided with an eleventh valve 011, which is used to control the conduction and shutoff of the branch pipe. The other branch pipe is connected to the liquid supply line 60. The branch pipe is provided with a tenth valve 010 and a one-way valve. The tenth valve 010 is used to control the conduction and shutoff of the branch pipe. One end of the discharge line 11 is connected to a sterile transfer valve 20, that is, the cleaning pipe 61 connected to the discharge line 11 in the cleaning state is replaced with the sterile transfer valve 20. One end of the discharge line 11 is connected to the inlet of the sterile transfer valve 20, and the outlet of the sterile transfer valve 20 is provided with a nineteenth valve 019, which is used to control the opening and closing of the sterile transfer valve 20; the outlet of the sterile transfer valve 20 is connected to the waste liquid pipeline 62, and the waste liquid pipeline 62 is provided with a twelfth valve 012, which is used to control the conduction and shutoff of the waste liquid pipeline 62. The specific structure of the sterile transfer valve 20 has been described in detail above and will not be repeated here.

[0103] When performing disinfection operations in the disinfection state, high-pressure steam is introduced into the disinfection line 80 as a disinfectant; the eleventh valve 011 is opened, and the high-pressure steam enters the second air supply line 70 through the disinfection line 80 to disinfect and sterilize the second air supply line 70; at the same time, the ninth valve 009, the second valve 002, the seventh valve 007, the eighth valve 008, and the barrier valve 53 are opened, and the high-pressure steam enters the condensate line 54, the barrier line 50, and the feed line 12 through the disinfection line 80 to disinfect and sterilize; at the same time, the third valve 003, the first valve 001, the nineteenth valve 019, and the twelfth valve 012 are opened, and the high-pressure steam passes through the disinfection line 80, the cleaning line 13, the movable sterile tank 10, the discharge line 11, the sterile transfer valve 20, and the waste liquid line 62 in sequence to disinfect and sterilize. After the pipelines and tank bodies are cleaned, the pipelines and tank bodies are disinfected by introducing high-pressure steam into the disinfection line 80, thereby reducing the risk of material contamination.

[0104] According to one embodiment of the present invention, Figure 4 As shown, after completing the disinfection and sterilization operations of the pipeline and the tank body, low-pressure steam can be directly introduced into the condensate line 54 using the disinfection line 80 connected to the condensate line 54, thereby forming liquefied condensate in the condensate line 54, avoiding the need to separately set up a corresponding low-pressure steam pipeline and simplifying the pipeline structure at the feeding station.

[0105] Specifically, such as Figure 4 As shown, two parallel branch pipes are provided at the inlet of the disinfection pipeline 80, one of which is connected to a high-pressure steam source, and a thirteenth valve 013 is provided on the branch pipe. The thirteenth valve 013 is used to control the conduction and shutoff of the branch pipe. When performing disinfection and sterilization operations, the thirteenth valve 013 is opened; the other branch pipe is connected to a low-pressure steam source, and a fourteenth valve 014 is provided on the branch pipe. The fourteenth valve 014 is used to control the conduction and shutoff of the branch pipe.

[0106] After completing the high-pressure steam disinfection and sterilization operation, open the ninth valve 009 to connect the disinfection pipeline 80 with the condensate pipeline 54. At the same time, open the fourteenth valve 014. The low-pressure steam can enter the condensate pipeline 54 through the disinfection pipeline 80 and liquefy to form a steam condensate barrier protection for the barrier valve 53, providing protection for the subsequent process of transporting materials into the tank through the barrier pipeline 50.

[0107] like Figure 5 As shown, the aseptic material connection and addition system described in the present invention also has a purging state. Since high-pressure steam is used in the sterilization process, the movable sterile tank 10 needs to be purged after the disinfection and sterilization treatment to quickly cool it to the required temperature.

[0108] When performing the purge operation in the purge state, Figure 5 As shown, the second gas supply line 70 is opened, so that the second gas supply line 70 is connected to the movable sterile tank 10. The second gas supply line 70 introduces sterile gas into the movable sterile tank 10 to purge and cool the movable sterile tank 10 and the sterilized pipeline. The temperature of the movable sterile tank 10 is monitored by the temperature sensor 16 on the movable sterile tank 10. Nitrogen gas or compressed air at a certain pressure is introduced into the pipeline through the second gas supply line 70 to purge the pipeline and the tank body, so that the temperature of the tank body and the pipeline is reduced to an appropriate range, thereby avoiding affecting the activity of heat-sensitive materials.

[0109] According to one embodiment of the present invention, Figure 5 As shown, a cooling water interlayer 15 is provided on the side wall of the movable sterile tank 10. When cooling and purging are performed in the purging state, cooling water is simultaneously introduced into the cooling water interlayer 15 to cool the movable sterile tank 10, so as to speed up the cooling rate of the movable sterile tank 10 during the cooling and purging process.

[0110] like Figure 6 As shown, the aseptic material connection and addition system described in the present invention also has a feeding state. After completing the pretreatment operations such as cleaning, disinfection and purging described above, the material to be added is passed into the movable sterile tank 10 at the feeding station.

[0111] The structures of feed line 55, barrier line 50, feed line 12, and condensate line 54 required for feeding have been described above and will not be repeated here. The steam condensate barrier protection formed by condensate line 54 and barrier valve 53 has been described above and will not be repeated here. Condensate formed in condensate line 54 provides steam condensate barrier protection for the two barrier valves 53, thereby ensuring the stability of heat-sensitive materials during the feeding process and preventing the inactivation of heat-sensitive elements.

[0112] Specifically, when the feeding operation is performed in the feeding state, the second valve 002 is opened, and the material enters the first storage tank 51 through the feed pipe of the feed line 55. Some of the material in the first storage tank 51 is refluxed through the reflux pipe. The material in the first storage tank 51 enters the second storage tank 52 through the barrier line 50, and the material in the second storage tank 52 enters the movable sterile tank 10 through the feed line 12. During the feeding process, the amount of material entering the movable sterile tank 10 is monitored by the gravity sensor 18 on the movable sterile tank 10.

[0113] According to one embodiment of the present invention, Figure 5As shown, the gas inlet at the top of the movable sterile tank 10 is provided with a switch control valve 14, and the first gas supply line 40 or the second gas supply line 70 passes through the switch control valve 14. The switch control valve 14 can control the conduction and shutdown of the first gas supply line 40 or the second gas supply line 70 and the movable sterile tank 10.

[0114] The structure of the second air supply line 70 will be described below as an example. The structure of the first air supply line 40 is substantially the same as that of the second air supply line 70 , and therefore will not be described in detail.

[0115] like Figure 5 As shown, Figure 1 As shown, the second gas supply line 70 includes a main pipe and two parallel branch pipes. The main pipe is equipped with multiple sterilizing filters 71 for filtering the gas. Each sterilizing filter 71 is connected to a discharge line, which is equipped with a seventeenth valve 017 for controlling the flow of the discharge line. The main pipe is also equipped with a fifteenth valve 015 for controlling the flow of the main pipe.

[0116] Furthermore, a branch pipe connected to the main pipe is connected to the on-off control valve 14. A sixth valve 006 is installed at one end of this branch pipe, passing through the on-off control valve 14. This valve is used to control the flow of this branch pipe. Another branch pipe connected to the main pipe has a protective pipe and a discharge pipe connected in parallel at one end. Both the protective pipe and the discharge pipe are connected to this branch pipe. The protective pipe is equipped with an eighteenth valve 018, a pressure protection valve. When the pressure in the second gas supply line 70 exceeds the rated pressure, this valve opens to release air and relieve pressure. The discharge pipe is equipped with a sixteenth valve 016, which controls the flow of the discharge pipe.

[0117] When the first air supply line 40 is sterilized and disinfected via the sterilization line 41 or the second air supply line 70 is sterilized and disinfected via the sterilization line 80, the sixteenth valve 016, the seventeenth valve 017, and the sixth valve 006 are opened, and high-pressure steam enters the corresponding pipeline for steam sterilization. When sterile air with a certain pressure needs to be introduced into the movable sterile tank 10 via the first air supply line 40 or the second air supply line 70, the on-off control valve 14 and the fifteenth valve 015 are opened, and the sixth valve 006 is closed, so that the second air supply line 70 is connected to the chamber in the movable sterile tank 10.

[0118] Further, such as Figure 5As shown, a pressure sensor 72 is provided on the branch pipe connecting the second gas supply line 70 and the switch control valve 14. The pressure sensor 72 is connected to the controller, and the controller is respectively connected to the fifteenth valve 015 and the sixteenth valve 016. The controller can adjust the opening of the fifteenth valve 015 and the sixteenth valve 016 according to the gas pressure value detected by the pressure sensor 72, thereby stabilizing the air pressure in the second gas supply line 70 within a suitable range.

[0119] According to one embodiment of the present invention, Figure 1 As shown, a fourth valve 004 is provided on the top of the movable sterile tank 10. The fourth valve 004 is a pressure protection valve. When the air pressure in the movable sterile tank 10 exceeds the rated pressure, the fourth valve 004 opens to release air and relieve pressure.

[0120] The specific embodiments described above further illustrate the purpose, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A sterile material connection and addition system for adding materials into a main pipeline (32), characterized in that: The system comprises a movable sterile tank (10) for containing the material, and an outlet at the bottom of the movable sterile tank (10) is connected to a discharge pipeline (11); The aseptic material connection and addition system has a discharge station. When the movable sterile tank (10) is at the discharge station, the aseptic material connection and addition system has a discharge state. In the discharge state: The discharge pipeline (11) is connected to a sterile transfer valve (20), and the sterile transfer valve (20) is connected to a sterile isolator (30) through a docking port (22). A delivery hose (21) with a needle is provided in the sterile transfer valve (20), and the main pipeline (32) passes through the sterile isolator (30). A peristaltic pump (31) is provided in the sterile isolator (30). One end of the delivery hose (21) is connected to the inlet of the sterile transfer valve (20), and one end of the delivery hose (21) with a needle extends into the sterile isolator (30) through the docking port (22) and is clamped into the peristaltic pump (31). The needle is inserted at the adding point of the main pipeline (32); the material in the movable sterile tank (10) can be added into the main pipeline (32) through the discharge pipeline (11) and the delivery hose (21).

2. The material aseptic connection and addition system according to claim 1, characterized in that: When the movable sterile tank (10) is at the discharge station, the gas inlet at the top of the movable sterile tank (10) is connected to a first gas supply line (40); In the discharge state, the first gas supply line (40) can introduce sterile gas into the movable sterile tank (10) to drive the material to be added into the main pipeline (32).

3. The material aseptic connection and addition system according to claim 2, characterized in that: The first air supply line (40) is connected to a sterilization line (41) capable of sterilizing the first air supply line (40).

4. The material aseptic connection and addition system according to claim 1, characterized in that: A first flow meter (34) is provided on the discharge pipeline (11), and a second flow meter (35) is provided on the main pipeline (32). The first flow meter (34) and the second flow meter (35) are both connected to a control unit, and the control unit is connected to the peristaltic pump (31) to regulate the rotation speed of the peristaltic pump (31).

5. The material aseptic connection and addition system according to claim 1, characterized in that: A glove operation port (33) is provided on the side wall of the sterile isolator (30).

6. The material aseptic connection and addition system according to claim 1, characterized in that: The aseptic material connection and addition system further comprises a feeding station, and the movable sterile tank (10) can be moved between the feeding station and the discharging station. When the movable sterile tank (10) is at the feeding station, the aseptic material connection and addition system has a feeding state. In the feeding state: The inlet on the side wall of the movable sterile tank (10) is connected to a feeding pipeline (12), and materials can enter the movable sterile tank (10) through the feeding pipeline (12).

7. The material aseptic connection and addition system according to claim 6, characterized in that: When the movable sterile tank (10) is at the feeding station, the feeding pipeline (12) is connected to a barrier pipeline (50), a first storage tank (51) and a second storage tank (52) are provided on the barrier pipeline (50), one end of the feeding pipeline (12) is connected to the second storage tank (52), and the first storage tank (51) is connected to a feed pipeline (55); a barrier valve (53) is provided at each end of the barrier pipeline (50), and the barrier valve (53) is connected to a condensate pipeline (54); In the feeding state, condensed water flows through the condensed water pipeline (54), and the material enters the movable sterile tank (10) through the feeding pipeline (55), the first storage tank (51), the barrier pipeline (50), the second storage tank (52) and the feeding pipeline (12).

8. The aseptic material connection and addition system according to claim 7, characterized in that: When the movable sterile tank (10) is at the feeding station, the material aseptic connection and addition system also has a cleaning state, in which: The inlet at the top of the movable sterile tank (10) is connected to a cleaning line (13), the cleaning line (13) is connected to a liquid supply line (60), and the liquid supply line (60) is connected to the condensed water line (54); one end of the discharge line (11) is connected to a cleaning pipe (61), and the cleaning pipe (61) is connected to a waste liquid line (62); the cleaning liquid can pass through the liquid supply line (60), the cleaning line (13), the movable sterile tank (10), the discharge line (11) and the waste liquid line (62) in sequence for cleaning, and the cleaning liquid can also pass through the liquid supply line (60), the condensed water line (54), the barrier line (50) and the feed line (12) in sequence to enter the movable sterile tank (10) for cleaning.

9. The aseptic material connection and addition system according to claim 8, characterized in that: When the movable sterile tank (10) is at the feeding station, the gas inlet at the top of the movable sterile tank (10) is connected to a second gas supply line (70); In the cleaning state, the second gas supply line (70) can introduce sterile gas into the movable sterile tank (10) to drive the cleaning liquid into the discharge line (11).

10. The aseptic material connection and addition system according to claim 9, characterized in that: When the movable sterile tank (10) is at the feeding station, the material aseptic connection and addition system also has a sterilization state, in which: The second air supply line (70), the condensed water line (54) and the cleaning line (13) are all connected to the disinfection line (80), one end of the discharge line (11) is connected to the sterile transfer valve (20), and the outlet of the sterile transfer valve (20) is connected to the waste liquid line (62); the disinfectant can enter the second air supply line (70) and the condensed water line (54) through the disinfection line (80) to disinfect them, and the disinfectant can also pass through the disinfection line (80), the cleaning line (13), the movable sterile tank (10), the discharge line (11), the sterile transfer valve (20) and the waste liquid line (62) in sequence to disinfect them.

11. The aseptic material connection and addition system according to claim 1, characterized in that: A cooling water interlayer (15) is provided on the side wall of the movable sterile tank (10), and cooling water is passed into the cooling water interlayer (15) to cool the movable sterile tank (10).

12. The aseptic material connection and addition system according to claim 2, characterized in that: The gas inlet at the top of the movable sterile tank (10) is provided with a switch control valve (14), and the first gas supply line (40) passes through the switch control valve (14). The switch control valve (14) can control the conduction and shutoff of the first gas supply line (40) and the movable sterile tank (10).

13. The material aseptic connection and addition system according to claim 9, characterized in that: The gas inlet at the top of the movable sterile tank (10) is provided with a switch control valve (14), and the second gas supply line (70) passes through the switch control valve (14). The switch control valve (14) can control the conduction and shutoff of the second gas supply line (70) and the movable sterile tank (10).

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