Raw material crushing mechanism for rosuvastatin intermediate production

Abstract

The utility model relates to the technical field of rosuvastatin production equipment, and discloses a raw material crushing mechanism for rosuvastatin intermediate production. Comprising a grinding roller, a grinding cylinder, a supporting frame, a conical feeding opening, a discharging pipe, a conveying chamber, a high-pressure air pipe, a powder conveying pipe, a first separating cylinder, a second separating cylinder, a vacuum feeding machine, a conduction pipe, a screening net cover, a filter, a material returning opening and a material collecting barrel. According to the crushing mechanism, raw materials are ground through the grinding roller and the grinding cylinder, the particle diameter is gradually reduced, then the ground raw materials are screened through the first separation cylinder and the second separation cylinder, raw material powder meeting the standard is collected and stored, and raw material powder not meeting the standard enters the grinding cylinder again to be ground; the fineness and the reaction efficiency of the raw materials are improved, and the production of the rosuvastatin intermediate is facilitated.

Description

TECHNICAL FIELD

[0001] The utility model relates to rizatriptan production equipment technical field, specifically for a kind of raw material crushing mechanism for rizatriptan intermediate production. BACKGROUND

[0002] Rizatriptan is statin lipid-lowering drugs, can inhibit cholesterin synthesis enzyme activity, reduce cholesterin generation, reduce cholesterin level in blood, especially low-density lipoprotein cholesterin. It can reduce cardiovascular disease risk, also possibly stabilize atherosclerotic plaque, reduce the risk of plaque rupture and thrombosis.

[0003] Rizatriptan drug intermediate is intermediate product in synthesis process, needs further processing. Crushing intermediate raw material can increase surface area, improve reaction efficiency and product quality. Rizatriptan calcium tablet processing needs to follow strict standard, and crushing needs to ensure uniform granularity, to ensure drug quality and stability. After crushing, intermediate raw material can be more evenly distributed, improve solubility and bioavailability.

[0004] According to Chinese patent publication No. CN214288420U, a kind of rizatriptan intermediate raw material crushing device is provided, the utility model is through the setting of crushing roller, raw material enters the inside of device shell after, drop to between two crushing rollers, crushing roller is driven by motor, drives crushing roller to rotate, so that crushing work is carried out between two crushing rollers, and the raw material powder on the outer surface of crushing roller is scraped by scraper, so that the raw material can be reduced attachment, improve the working state of crushing roller.

[0005] But the above-mentioned rizatriptan intermediate raw material crushing device can only be crushed by two crushing rollers during use, cannot ensure the sufficiency of crushing, and the crushed raw material may be mixed with rizatriptan intermediate raw material that is not fully crushed, so that the crushing cannot ensure uniform granularity, thereby affecting rizatriptan production reaction efficiency and product quality.

[0006] Therefore, we propose a kind of raw material crushing mechanism for rizatriptan intermediate production to solve the problems in the above background. UTILITY MODEL CONTENTS

[0007] The utility model aims at providing a kind of raw material crushing mechanism for rizatriptan intermediate production to solve the problem that rizatriptan intermediate raw material cannot be fully crushed in the above background technology.

[0008] To solve the above technical problem, the utility model provides the following technical scheme:

[0009] The utility model provides a kind of raw material grinding mechanism for producing rosuvastatin intermediate, including grinding roller and the grinding roller matched grinding cylinder, grinding roller rotates and is connected in grinding cylinder inside, the discharge end of grinding cylinder is fixedly connected with the discharge pipe, the outlet of discharge pipe is fixedly connected with conveying chamber, one end of conveying chamber is fixedly connected with high pressure gas pipe, the other end of conveying chamber is fixedly connected with powder conveying pipe, grinding cylinder is fixedly connected with separator, the outlet of the separator is fixedly connected with vacuum feeder.

[0010] As a further scheme of the utility model: the inlet of grinding cylinder is fixedly connected with conical feed inlet, and the bottom of the conical feed inlet is tightened.

[0011] As a further scheme of the utility model: the gap between grinding roller and grinding cylinder gradually becomes smaller from the direction of feed inlet to discharge outlet.

[0012] As a further scheme of the utility model: the grinding roller is provided as double-cone shape, and the grinding surface between the grinding roller and the grinding cylinder becomes narrower and wider, and then narrower again, and the grinding surface is elongated along the axial direction of the grinding roller.

[0013] As a further scheme of the utility model: the separator includes a first separation cylinder and a second separation cylinder, the inlet of the first separation cylinder is communicated with the powder conveying pipe, the outlet of the second separation cylinder is fixedly connected with the vacuum feeder, and a through pipe is communicated between the outlet of the first separation cylinder and the inlet of the second separation cylinder.

[0014] As a further scheme of the utility model: a screening mesh cover is arranged inside the upper end of the first separation cylinder, and a filter is arranged inside the upper end of the second separation cylinder.

[0015] As a further scheme of the utility model: a return port is arranged at the lower end of the first separation cylinder, the outlet of the return port is directed towards the conical feed inlet, and a collecting barrel is arranged below the outlet of the second separation cylinder.

[0016] Compared with the prior art, the utility model achieves the following beneficial effects:

[0017] The utility model discloses a grinding mechanism for swissvalet intermediate raw material, which comprises a grinding roller, a grinding cylinder, a conical feeding port, a discharge pipe, a conveying chamber, a high-pressure air pipe, a powder conveying pipe, a separator, a vacuum feeding machine, a screening mesh cover, a filter, a return port and a material collecting barrel. BRIEF DESCRIPTION OF DRAWINGS

[0018] Fig. 1 It is the whole structure schematic diagram of the utility model;

[0019] Fig. 2 It is the powder conveying pipe connecting structure schematic diagram of the utility model;

[0020] Fig. 3 It is the whole cross section structure schematic diagram of the utility model.

[0021] 1, grinding roller;2, grinding cylinder;3, conical feeding port;4, discharge pipe;5, conveying chamber;6, high-pressure air pipe;7, powder conveying pipe;8, separator;81, first separating cylinder;82, second separating cylinder;83, lead-through pipe;9, vacuum feeding machine;10, screening mesh cover;11, filter;12, return port;13, material collecting barrel. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the utility model will be clearly and completely described below with reference to the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments in the utility model, all the other embodiments obtained by those skilled in the art without creative labor fall within the protection scope of the utility model.

[0023] Embodiment one:

[0024] Referring to Figs. 1-3 The utility model provides a technical scheme:

[0025] A raw material crushing mechanism for rosuvastatin intermediate production, including grinding roller 1 and with grinding roller 1 cooperate grinding cylinder 2, the outside fixed connection of grinding cylinder 2 has support frame, grinding roller 1 is rotationally connected in grinding cylinder 2 inside, the inlet of grinding cylinder 2 is fixedly connected with conical feed inlet 3, and the motor is installed on grinding cylinder 2, and the motor drives grinding roller 1 to rotate;

[0026] Further, the gap between the grinding roller 1 and the grinding cylinder 2 gradually decreases from the feed inlet to the discharge outlet, and the rosuvastatin intermediate production raw material enters between the rotating grinding roller 1 and the fixed grinding cylinder 2 from the conical feed inlet 3, and the rosuvastatin intermediate production raw material is ground and the particle diameter is gradually reduced.

[0027] Further, the grinding roller 1 is in the shape of a double cone, and the grinding surface between the grinding roller 1 and the grinding cylinder 2 changes from narrow to wide and then from wide to narrow. The grinding surface is elongated along the axial direction of the grinding roller 1, so that the rosuvastatin intermediate production raw material is repeatedly ground between the rotating grinding roller 1 and the fixed grinding cylinder 2, increasing the grinding thoroughness and allowing the rosuvastatin intermediate production raw material to meet the screening standard, facilitating the next step of screening.

[0028] The discharge end of the grinding cylinder 2 is fixedly connected with a discharge pipe 4, the outlet of the discharge pipe 4 is fixedly connected with a conveying chamber 5, one end of the conveying chamber 5 is fixedly connected with a high-pressure gas pipe 6, the other end of the conveying chamber 5 is fixedly connected with a powder conveying pipe 7, and the grinding cylinder 2 is fixedly connected with a separator 8. The separator 8 includes a first separation cylinder 81 and a second separation cylinder 82. The first separation cylinder 81 and the second separation cylinder 82 are fixedly connected. The inlet of the first separation cylinder 81 is communicated with the powder conveying pipe 7. The outlet of the second separation cylinder 82 is fixedly connected with a vacuum feeder 9. A communication pipe 83 is connected between the outlet of the first separation cylinder 81 and the inlet of the second separation cylinder 82.

[0029] A screening mesh cover 10 is arranged inside the upper end of the first separation cylinder 81, and a filter 11 is arranged inside the upper end of the second separation cylinder 82. The mesh of the screening mesh cover 10 can pass powders of a set particle size, which are used to screen the rosuvastatin intermediate raw powder that is sufficiently ground and meets the standard.

[0030] A return port 12 is arranged at the lower end of the first separation cylinder 81, and the outlet of the return port 12 faces the conical feed inlet 3. A collection barrel 13 is arranged below the outlet of the second separation cylinder 82, which is used to collect the rosuvastatin intermediate raw powder that is ground and meets the standard.

[0031] The inside of the conveying chamber 5 is ventilated by the high-pressure air pipe 6, and the ground and crushed rosuvastatin intermediate raw material powder is sent into the first separation cylinder 81 by the powder conveying pipe 7 under the action of air power, and the vacuum feeding machine 9 is opened, since the first separation cylinder 81 and the second separation cylinder 82 are communicated, negative pressure suction is generated at the outlets of the first separation cylinder 81 and the second separation cylinder 82 at the same time, and the first separation is carried out in the first separation cylinder 81;

[0032] The rosuvastatin intermediate raw material powder that does not meet the standard is sent into the conical feeding port 3 again through the lower end return port 12 of the first separation cylinder 81, and is ground again between the grinding roller 1 and the grinding cylinder 2, so that the powder is finer, and the reaction is rapid and sufficient during the production of the rosuvastatin intermediate, and the production efficiency of the rosuvastatin intermediate is improved.

[0033] The powder reaching the set particle fineness is sent into the second separation cylinder 82 through the screening mesh cover 10 at the upper end of the first separation cylinder 81, and is subjected to the second separation through the filter 11 at the upper end of the second separation cylinder 82, the filter 11 discharges air, the rosuvastatin intermediate raw material powder meeting the standard is retained in the second separation cylinder 82, and is collected and stored in the material collecting barrel 13 from the outlet of the second separation cylinder 82.

[0034] The working principle of the utility model is as follows:

[0035] The rosuvastatin intermediate raw material is sent into the grinding cylinder 2 from the conical feeding port 3, is ground between the grinding roller 1 and the grinding cylinder 2, the double-cone shape and the gradually changed grinding surface of the grinding roller 1 make the raw material be repeatedly ground in the grinding process, the particle diameter gradually becomes smaller, and the ground raw material is sent into the conveying chamber 5 through the discharging pipe 4;

[0036] The high-pressure air pipe 6 ventilates the conveying chamber 5, so that the raw material powder is sent into the first separation cylinder 81 through the powder conveying pipe 7 under the action of air power, the vacuum feeding machine 9 is opened, negative pressure suction is generated at the outlets of the first separation cylinder 81 and the second separation cylinder 82, the raw material powder that does not meet the standard is sent into the grinding cylinder 2 again through the return port 12 in the first separation cylinder 81, and is ground again.

[0037] The raw material powder meeting the standard is sent into the second separation cylinder 82 through the screening mesh cover 10, in the second separation cylinder 82, the filter 11 discharges air, the raw material powder meeting the standard is retained in the inside, and is collected and stored in the material collecting barrel 13 from the outlet.

[0038] Through the above working principle, the crushing mechanism can crush and screen the raw material for the production of rosuvastatin intermediate, improve the fineness and reaction efficiency of the raw material, and be beneficial to the production of rosuvastatin intermediate.

[0039] Although the specific embodiments of the present application have been shown and described, it is to be understood that for the purpose of the present application, the specific embodiments can be changed, modified, replaced and varied in many ways without departing from the principles and spirit of the present application, and the scope of the present application is defined by the appended claims and their equivalents.

Claims

1. A raw material pulverizing mechanism for producing a rosuvastatin intermediate, comprising a grinding roller (1) and a grinding cylinder (2) matched with the grinding roller (1), wherein the grinding roller (1) is rotatably connected to the interior of the grinding cylinder (2), and a discharge end of the grinding cylinder (2) is fixedly connected to a discharge pipe (4), characterized in that: The outlet of the feeding pipe (4) is fixedly connected to a conveying chamber (5), one end of the conveying chamber (5) is fixedly connected to a high-pressure air pipe (6), and the other end of the conveying chamber (5) is fixedly connected to a powder conveying pipe (7). A separator (8) is fixedly connected to the grinding cylinder (2), and the outlet of the separator (8) is fixedly connected to a vacuum feeder (9).

2. The raw material crushing mechanism for producing a rosuvastatin intermediate according to claim 1, characterized in that: The inlet of the grinding cylinder (2) is fixedly connected with a conical feed port (3).

3. The raw material crushing mechanism for producing a rosuvastatin intermediate according to claim 1, characterized in that: The gap between the grinding roller (1) and the grinding cylinder (2) gradually decreases from the feed port to the discharge port.

4. The raw material crushing mechanism for producing a rosuvastatin intermediate according to claim 3, characterized in that: The grinding roller (1) is configured in a double cone shape.

5. The raw material crushing mechanism for producing a rosuvastatin intermediate according to claim 1, characterized in that: The separator (8) comprises a first separation cylinder (81) and a second separation cylinder (82), wherein the inlet of the first separation cylinder (81) is connected to a powder conveying pipe (7), the outlet of the second separation cylinder (82) is fixedly connected to a vacuum loader (9), and a conducting pipe (83) is connected between the outlet of the first separation cylinder (81) and the inlet of the second separation cylinder (82).

6. The raw material crushing mechanism for producing a rosuvastatin intermediate according to claim 5, characterized in that: A screening mesh cover (10) is provided inside the upper end of the first separation cylinder (81), and a filter (11) is provided inside the upper end of the second separation cylinder (82).

7. The raw material crushing mechanism for producing a rosuvastatin intermediate according to claim 6, characterized in that: A return port (12) is provided at the lower end of the first separation cylinder (81), the outlet of the return port (12) faces the conical feed port (3), and a collection bucket (13) is provided below the outlet of the second separation cylinder (82).

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