Microfluidic chip

Abstract

The utility model discloses a micro-fluidic chip, and relates to the technical field of micro-fluidic chips, the micro-fluidic chip comprising a single-emulsion micro-fluidic assembly specifically comprises a first carrier, a second carrier, an inner phase tube, an outer phase tube and a receiving tube; a plurality of centering guide protrusions are annularly arranged in the hollow cavity of the outer phase pipe in the circumferential direction. A centering guide cavity is defined by the multiple centering guide protrusions. The centering guide protrusions distributed in the circumferential direction are arranged in the hollow cavity of the outer phase pipe and used for forming the centering guide cavity, so that the inner phase pipe / middle pipe is guided to be matched with the receiving pipe in a centering mode, the inner phase pipe / middle pipe and the receiving pipe after centering are supported, the coaxiality between the inner phase pipe / middle pipe and the receiving pipe is ensured, and the centering accuracy of the inner phase pipe / middle pipe and the receiving pipe is improved. And the situation of non-coaxial deviation is reduced, so that the manufacturing difficulty of the micro-fluidic chip is reduced, and the manufacturing cost is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of microfluidic chip, in particular to a microfluidic chip. BACKGROUND

[0002] The microfluidic chip is a technology platform for manipulating fluid in micron scale space, which has wide application prospect and important scientific value.

[0003] The outer phase tube is one of the fluid channels in the microfluidic chip, which is used to provide a relatively closed fluid environment, while the inner phase tube / intermediate phase tube generates droplets in the fluid environment and is received by the receiving tube.

[0004] The existing outer phase tube is usually a simple hollow tubular structure with single function. When the length of the outer phase tube is large, the inner phase tube / intermediate tube and the receiving tube located in the outer phase tube are prone to non-coaxial deviation due to lack of further support, which requires further adjustment of the coaxiality between the inner phase tube / intermediate tube and the receiving tube in the outer phase tube, thereby increasing the difficulty of chip manufacturing and increasing the manufacturing cost. CONTENT OF THE UTILITY MODEL

[0005] Therefore, the purpose of the present application is to provide a microfluidic chip which can reduce the difficulty of chip manufacturing and reduce the manufacturing cost.

[0006] To achieve the above technical purpose, the present application provides a microfluidic chip comprising a single emulsion microfluidic assembly;

[0007] The single emulsion microfluidic assembly comprises a first carrier, a second carrier, an inner phase tube, an outer phase tube and a receiving tube;

[0008] The outer phase tube is installed between the first carrier and the second carrier;

[0009] The first carrier is provided with an inner phase channel along the axial direction of itself;

[0010] The inner phase tube is installed in the inner phase channel and one end of the inner phase tube extends into the outer phase tube for forming an inner phase droplet in the outer phase tube;

[0011] The second carrier is provided with a receiving channel along the axial direction of itself;

[0012] The receiving tube is installed in the receiving channel and one end of the receiving tube extends into the outer phase tube for receiving the inner phase droplet;

[0013] A plurality of centering guide protrusions are circumferentially arranged in the hollow cavity of the outer phase tube;

[0014] The plurality of centering guide protrusions enclose a centering guide cavity.

[0015] Further, the inner phase pipe extends out of the first carrier at the other end to form an inner phase inlet, or the first carrier is provided with an inner phase inlet channel communicating with the other end of the inner phase pipe;

[0016] The outer phase pipe is provided with an outer phase inlet, or the second carrier is further provided with an outer phase channel along the axial direction of the second carrier and connected to the outer phase pipe, and the second carrier is further provided with an outer phase inlet channel communicating with the outer phase channel.

[0017] Further, the centering guide protrusions each include an intermediate support portion and two guide portions;

[0018] The two guide portions are connected to the two end portions of the intermediate support portion along the axial direction of the outer phase pipe;

[0019] The plurality of intermediate support portions enclose a support cavity;

[0020] The plurality of guide portions on the same side enclose a guide cavity;

[0021] The guide cavity gradually narrows from the end portion of the intermediate support portion to the center of the intermediate support portion.

[0022] Further, the intermediate support portion has a support surface;

[0023] The support surface is a rectangular arc surface;

[0024] The guide portion has a guide surface;

[0025] The guide surface is a fan-shaped arc surface.

[0026] Further, the first carrier, the second carrier, and the outer phase pipe are prepared by 3D printing.

[0027] Another microfluidic chip is disclosed, which includes a double emulsion microfluidic assembly;

[0028] The double emulsion microfluidic assembly includes a first carrier, a second carrier, an inner phase pipe, an intermediate phase pipe, an outer phase pipe, and a receiving pipe;

[0029] The outer phase pipe is installed between the first carrier and the second carrier;

[0030] The first carrier is provided with an inner phase channel and an intermediate phase channel along the axial direction of the first carrier;

[0031] The inner phase pipe is installed in the inner phase channel and extends into the intermediate phase channel at one end to form an inner phase droplet in the intermediate phase pipe;

[0032] The intermediate phase tube is installed in the intermediate phase channel and has one end extending into the outer phase tube for forming intermediate phase droplets containing inner phase droplets in the outer phase tube;

[0033] The second carrier is provided with a receiving channel along the axial direction of the second carrier;

[0034] The receiving tube is installed in the receiving channel and has one end extending into the outer phase tube for receiving intermediate phase droplets;

[0035] A plurality of centering guide protrusions are circumferentially arranged in the hollow cavity of the outer phase tube;

[0036] The plurality of centering guide protrusions enclose a centering guide cavity.

[0037] Further, the other end of the inner phase tube extends out of the first carrier to form an inner phase liquid inlet, or the first carrier is provided with an inner phase liquid inlet channel communicating with the other end of the inner phase tube;

[0038] The first carrier is provided with an intermediate phase liquid inlet channel communicating with the intermediate phase tube;

[0039] The outer phase tube is provided with an outer phase liquid inlet, or the second carrier is further provided with an outer phase channel along the axial direction of the second carrier and connected to the outer phase tube, and the second carrier is further provided with an outer phase liquid inlet channel communicating with the outer phase channel.

[0040] Further, the centering guide protrusions each include an intermediate support portion and two guide portions;

[0041] The two guide portions are connected to the two end portions of the intermediate support portion along the axial direction of the outer phase tube;

[0042] The plurality of intermediate support portions enclose a support cavity;

[0043] The plurality of guide portions on the same side enclose a guide cavity;

[0044] The guide cavity gradually narrows in the direction from the end portion of the intermediate support portion to the center of the intermediate support portion.

[0045] Further, the intermediate support portion has a support surface;

[0046] The support surface is a rectangular arc surface;

[0047] The guide portion has a guide surface;

[0048] The guide surface is a fan-shaped arc surface.

[0049] Further, the first carrier, the second carrier, and the outer phase tube are all prepared by 3D printing.

[0050] From the above technical scheme can be seen, the microfluidic chip with single milk microfluidic component designed by the application, which adopts modular design, the first carrier and the second carrier can be prepared according to the size of the inner phase pipe, the outer phase pipe and the receiving pipe, the cooperation is more closely and reliably, which breaks the shackles of traditional glass slide, the overall volume is smaller, and the appearance is more free; At the same time, a plurality of centering guide protrusions are arranged in the hollow cavity of the outer phase pipe, which are used to form a centering guide cavity to guide the inner phase pipe / intermediate pipe and the receiving pipe to be centered and cooperated, and to support the inner phase pipe / intermediate pipe and the receiving pipe after centering, so as to ensure the coaxiality between the inner phase pipe / intermediate pipe and the receiving pipe, reduce the non-coaxial deviation, effectively reduce the manufacturing difficulty and reduce the manufacturing cost.

[0051] From the above technical scheme can be seen, the microfluidic chip with single milk microfluidic component designed by the application, which adopts modular design, the first carrier and the second carrier can be prepared according to the size of the inner phase pipe, the outer phase pipe and the receiving pipe, the cooperation is more closely and reliably, which breaks the shackles of traditional glass slide, the overall volume is smaller, and the appearance is more free; At the same time, a plurality of centering guide protrusions are arranged in the hollow cavity of the outer phase pipe, which are used to form a centering guide cavity to guide the inner phase pipe / intermediate pipe and the receiving pipe to be centered and cooperated, and to support the inner phase pipe / intermediate pipe and the receiving pipe after centering, so as to ensure the coaxiality between the inner phase pipe / intermediate pipe and the receiving pipe, reduce the non-coaxial deviation, effectively reduce the manufacturing difficulty and reduce the manufacturing cost. BRIEF DESCRIPTION OF DRAWINGS

[0052] In order to more clearly illustrate the technical scheme in the embodiments of the application or the prior art, the drawings needed to be used in the following embodiment or prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the application, and those skilled in the art can also obtain other drawings according to these drawings without creative labor.

[0053] Figure 1 The cross-sectional view of the single-milk microfluidic chip with coaxial adjustment mechanism provided in the application;

[0054] Figure 2 The cross-sectional view of the double-milk microfluidic chip with coaxial adjustment mechanism provided in the application;

[0055] Figure 3 The cross-sectional view of the outer phase pipe provided in the application;

[0056] Figure 4 The side view of the outer phase pipe provided in the application;

[0057] Figure 5 The exploded schematic view of the coaxial adjustment mechanism provided in the application;

[0058] In the figure: 1, outer phase tube; 2, hollow cavity; 3, centering guide protrusion; 31, support part; 32, guide part; 4, first carrier; 41, inner phase passage; 42, groove; 43, intermediate phase passage; 44, intermediate phase liquid inlet passage; 5, second carrier; 51, receiving passage; 52, outer phase passage; 53, outer phase liquid inlet passage; 61, outer phase tube; 62, inner phase tube; 63, receiving tube; 64, intermediate phase tube; 7, mechanism main body; 71, first center hole; 72, chute; 73, extension tube part; 8, adjusting disc; 81, second center hole; 82, track groove; 83, knob part; 9, adjusting block; 91, limiting protrusion. DETAILED DESCRIPTION

[0059] The technical solutions of the embodiments of the present application will be described clearly and completely below with reference to the drawings. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0060] In the description of the embodiments of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship shown in the drawings, and are only for the purpose of facilitating the description of the embodiments of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the embodiments of the present application. In addition, the terms "first", "second", "third" are only for the purpose of description, and cannot be understood as indicating or implying relative importance.

[0061] In the description of the embodiments of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connection" should be understood broadly, for example, it can be fixedly connected, or replaceably connected, or integrally connected, it can be mechanically connected, or electrically connected, it can be directly connected, or indirectly connected through an intermediate medium, it can be the communication inside two elements. For those skilled in the art, the specific meaning of the above terms in the embodiments of the present application can be understood according to the specific circumstances.

[0062] As shown in Figure 1 , Figure 3 and Figure 4 , the present application discloses a single-milk microfluidic chip, comprising a single-milk microfluidic assembly.

[0063] The single emulsion microfluidic assembly comprises a first carrier 4, a second carrier 5, an inner phase tube 62, an outer phase tube 61 and a receiving tube 63.

[0064] The outer phase tube 61 is mounted between the first carrier 4 and the second carrier 5. As shown in Figure 3 and Figure 4 , a plurality of centering guide protrusions 3 are circumferentially arranged in the hollow cavity 2 of the outer phase tube 61, which form a centering guide cavity. By arranging the plurality of circumferentially distributed centering guide protrusions 3 in the hollow cavity 2 of the outer phase tube 61, a centering guide cavity is formed to guide the inner phase tube 62 / intermediate tube and the receiving tube 63 to be centered, and to support the centered inner phase tube 62 / intermediate tube and the receiving tube 63, ensuring the coaxiality between the inner phase tube 62 / intermediate tube and the receiving tube 63, reducing the occurrence of non-coaxial deviation, thereby reducing the manufacturing difficulty and cost.

[0065] The first carrier 4 is provided with an inner phase channel 41 along the axial direction of the first carrier 4; the inner phase tube 62 is mounted in the inner phase channel 41 and extends into the outer phase tube 61 at one end, for forming an inner phase droplet in the outer phase tube 61.

[0066] The second carrier 5 is provided with a receiving channel 51 along the axial direction of the second carrier 5; the receiving tube 63 is mounted in the receiving channel 51 and extends into the outer phase tube 61 at one end, for receiving the inner phase droplet.

[0067] In order to improve the convenience of installation and maintenance, the first carrier 4 and the outer phase tube 61 are designed to be detachably connected, specifically, one side of the first carrier 4 facing the outer phase tube 61 is provided with a groove 42 for the one end of the outer phase tube 61 to be clamped into, the outer phase tube 61 and the groove 42 are in interference fit, and a sealing ring can also be arranged between the end of the outer phase tube 61 and the bottom of the groove 42 to improve the sealing performance of the fit. The inner hole of the sealing ring is used for the inner phase tube 62 to movably pass through and seal with the inner phase tube 62, thereby sealing the outer phase tube 61. The detachable connection between the outer phase tube 61 and the second carrier 5 can refer to the above design, and details are not described herein.

[0068] The sealing connection is realized by the sealing ring and the interference fit, which is simpler to assemble than the glue sealing method, and the damaged parts can be disassembled and maintained at any time.

[0069] Of course, the outer phase tube 61 can also be designed to be integrally formed with the first carrier 4 and the second carrier 5, so that a sealing ring for sealing one end of the outer phase tube 61 and for the inner phase tube 62 to pass through can be arranged in the first carrier 4, and a sealing ring for sealing the other end of the outer phase tube 61 and for the receiving tube 63 to pass through can be arranged in the second carrier 5, to realize the sealing arrangement of the outer phase tube 61.

[0070] Further, as shown in Figure 1As shown, the other end of the inner phase pipe 62 extends out of the first carrier 4 to form an inner phase inlet.

[0071] Or the first carrier 4 is provided with an inner phase inlet channel communicating with the other end of the inner phase pipe 62. At this time, the first carrier 4 (designed as a three-way structure) can be changed and designed by those skilled in the art according to actual needs, and the specific design is not limited.

[0072] The outer phase pipe 61 is provided with an outer phase inlet.

[0073] Or as Figure 1 shown, the second carrier 5 is further provided with an outer phase channel 52 connected and communicated with the outer phase pipe 61 along the axial direction of the second carrier 5, and the second carrier 5 is further provided with an outer phase inlet channel 53 (designed as a three-way structure) communicating with the outer phase channel 52.

[0074] Further, as Figure 3 and Figure 4 shown, the specific structure design of the centering guide protrusion 3 includes an intermediate support part 31 and two guide parts 32; the two guide parts 32 are connected to the two end parts of the intermediate support part 31 along the axial direction of the outer phase pipe 61.

[0075] The plurality of intermediate support parts 31 enclose a support cavity, which plays a supporting role.

[0076] The plurality of guide parts 32 located on the same side enclose a guide cavity, which gradually narrows from the end part of the intermediate support part 31 to the center of the intermediate support part 31, and plays a role of guiding the centering.

[0077] In use, the inner phase pipe 62, the intermediate phase pipe 64 or the receiving pipe 63 extends into the outer phase pipe 61, and enters the support cavity under the guidance of the guide cavity, so as to be supported and fixed by each support part 31, thereby ensuring the centering effect.

[0078] Further, the intermediate support part 31 has a support surface to realize support by surface, which has a better support effect than point and line support.

[0079] The support surface is a rectangular arc surface, which is an arc surface with a rectangular contour edge (projected contour). The rectangular arc surface can better fit the inner phase pipe 62, the intermediate phase pipe 64 and the receiving pipe 63.

[0080] Further, the guide part 32 has a guide surface to realize guidance by surface, which has a better guidance effect than line guidance.

[0081] The guide surface is a fan-shaped arc surface, which is an arc surface with a triangular contour edge (projected contour). The fan-shaped arc surface can connect the rectangular arc surface and better fit the inner phase pipe 62, the intermediate phase pipe 64 and the receiving pipe 63.

[0082] In order to facilitate the formation of the centering guide protrusion 3 in the outer phase tube 61, the outer phase tube 61 can be prepared by using a 3D printing technology, and the outer phase tube 61 is prepared from a transparent material or has a visible window to facilitate observation of the droplet formation in the outer phase tube 61.

[0083] Further, the first carrier 4, the second carrier 5 and the outer phase tube 61 are all prepared by 3D printing. The 3D printing preparation design greatly reduces the manufacturing difficulty and improves the success rate. Moreover, the size can be freely controlled to better fit the inner phase tube 62, the outer phase tube 61 and the receiving tube 63.

[0084] As can be seen from the above technical solutions, the microfluidic chip with a single-lactation microfluidic assembly designed by the present application adopts a modular design. The first carrier 4 and the second carrier 5 can be prepared according to the size of the inner phase tube 62, the outer phase tube 61 and the receiving tube 63, and are more closely and reliably matched. The present application breaks away from the constraints of traditional glass slides, has a smaller overall volume and a more free shape. At the same time, through the design of the centering guide protrusion 3 of the outer phase tube 61, the manufacturing difficulty is effectively reduced and the manufacturing cost is reduced.

[0085] As shown in Figure 2 to Figure 4 , the present application also discloses a double-lactation microfluidic chip, which comprises a double-lactation microfluidic assembly.

[0086] The double-lactation microfluidic assembly comprises a first carrier 4, a second carrier 5, an inner phase tube 62, an intermediate phase tube 64, an outer phase tube 61 and a receiving tube 63.

[0087] The outer phase tube 61 is installed between the first carrier 4 and the second carrier 5. As shown in Figure 3 and Figure 4 , a plurality of centering guide protrusions 3 are circumferentially arranged in the hollow cavity 2 of the outer phase tube 61, and the plurality of centering guide protrusions 3 form a centering guide cavity. By arranging the plurality of circumferentially distributed centering guide protrusions 3 in the hollow cavity 2 of the outer phase tube 61, a centering guide cavity is formed to guide the inner phase tube 62 / intermediate tube and the receiving tube 63 to be centered and matched, and to support the inner phase tube 62 / intermediate tube and the receiving tube 63 after being centered, so as to ensure the coaxiality between the inner phase tube 62 / intermediate tube and the receiving tube 63, reduce the non-coaxial deviation, and thus reduce the manufacturing difficulty and the manufacturing cost.

[0088] The first carrier 4 is provided with an inner phase channel 41 and an intermediate phase channel 43 along the axial direction of the first carrier 4; the inner phase tube 62 is installed in the inner phase channel 41 and extends into the intermediate phase channel 43 at one end to form an inner phase droplet in the intermediate phase tube 64; and the intermediate phase tube 64 is installed in the intermediate phase channel 43 and extends into the outer phase tube 61 at one end to form an intermediate phase droplet containing the inner phase droplet in the outer phase tube 61.

[0089] The second carrier 5 is provided with a receiving channel 51 along the axial direction of the second carrier 5; the receiving tube 63 is installed in the receiving channel 51 and extends into the outer phase tube 61 at one end for receiving the intermediate phase liquid droplets.

[0090] In order to improve the installation and maintenance convenience, the first carrier 4 and the outer phase tube 61 are designed to be detachably connected, specifically, one side of the first carrier 4 facing the outer phase tube 61 is provided with a groove 42 for clamping one end of the outer phase tube 61, the outer phase tube 61 is in interference fit with the groove 42, and a sealing ring can be further arranged between the end of the outer phase tube 61 and the bottom of the groove 42 to improve the sealing performance of the fit; the inner hole of the sealing ring is movably arranged through the intermediate phase tube 64 and in sealing contact with the intermediate phase tube 64, thereby sealing the outer phase tube 61. The detachable connection between the outer phase tube 61 and the second carrier 5 can refer to the above design, and details are not described herein.

[0091] The sealing connection is realized by the sealing ring and the interference fit, which is simpler to assemble and can be disassembled and maintained at any time compared with the glue sealing method.

[0092] Of course, the outer phase tube 61 can also be designed to be integrally formed with the first carrier 4 and the second carrier 5, so that a sealing ring for sealing one end of the outer phase tube 61 and for the intermediate phase tube 64 to pass through can be arranged in the first carrier 4, and a sealing ring for sealing the other end of the outer phase tube 61 and for the receiving tube 63 to pass through can be arranged in the second carrier 5, thereby realizing the sealing arrangement of the outer phase tube 61.

[0093] Further, as shown in Figure 4 , the other end of the inner phase tube 62 extends out of the first carrier 4 to form an inner phase liquid inlet.

[0094] Or the first carrier 4 is provided with an inner phase liquid inlet channel communicating with the other end of the inner phase tube 62.

[0095] As shown in Figure 4 , the first carrier 4 is provided with an intermediate phase liquid inlet channel 44 communicating with the intermediate phase tube 64 (at this time, the first carrier 4 is designed as a three-way structure).

[0096] The outer phase tube 61 is provided with an outer phase liquid inlet.

[0097] Or as shown in Figure 4 , the second carrier 5 is further provided with an outer phase channel 52 along the axial direction of the second carrier 5 and connected to the outer phase tube 61, and the second carrier 5 is further provided with an outer phase liquid inlet channel 53 communicating with the outer phase channel 52 (at this time, the second carrier 5 is designed as a three-way structure).

[0098] Further, as shown in Figure 3 and Figure 4As shown, for the specific structure design of the centering guide protrusion 3, both include the intermediate support part 31 and the two guide parts 32; the two guide parts 32 are connected to the two end parts of the intermediate support part 31 along the axial direction of the outer phase tube 61.

[0099] The plurality of intermediate support parts 31 enclose a support cavity and play a supporting role.

[0100] The plurality of guide parts 32 on the same side enclose a guide cavity, which gradually narrows from the end part of the intermediate support part 31 to the center of the intermediate support part 31, and plays a role of guiding the centering.

[0101] In use, the inner phase tube 62, the intermediate phase tube 64 or the receiving tube 63 extends into the outer phase tube 61 and enters the support cavity under the guidance of the guide cavity to be supported and fixed by each support part 31, thereby ensuring the centering effect.

[0102] Further, the intermediate support part 31 has a support surface to realize support by the surface, which has a better support effect than point or line support.

[0103] The support surface is a rectangular arc surface, which is an arc surface with a rectangular contour edge (projected contour). The rectangular arc surface can better fit the inner phase tube 62, the intermediate phase tube 64 and the receiving tube 63.

[0104] Further, the guide part 32 has a guide surface to realize guidance by the surface, which has a better guidance effect than line guidance.

[0105] The guide surface is a fan-shaped arc surface, which is an arc surface with a triangular contour edge (projected contour). The fan-shaped arc surface can connect the rectangular arc surface and better fit the inner phase tube 62, the intermediate phase tube 64 and the receiving tube 63.

[0106] In order to facilitate the formation of the centering guide protrusion 3 in the outer phase tube 61, the outer phase tube 61 can be prepared by using 3D printing technology, and the outer phase tube 61 is prepared from transparent material or has a viewing window to facilitate observation of the droplet formation in the outer phase tube 61.

[0107] Further, the first carrier 4, the second carrier 5 and the outer phase tube 61 are all prepared by 3D printing. The 3D printing preparation design greatly reduces the manufacturing difficulty and improves the success rate. Moreover, the size can be freely controlled to better fit the inner phase tube 62, the intermediate phase tube 64, the outer phase tube 61 and the receiving tube 63.

[0108] As shown in Figure 1 , Figure 2 and Figure 5 , in order to improve the convenience of coaxial adjustment, the single-milk microfluidic chip and the double-milk microfluidic chip of the present application are both provided with a coaxial adjustment module.

[0109] The coaxial adjustment module is arranged between the first carrier 4 and the outer phase tube 61, and specifically includes a mechanism body 7, an adjustment disc 8, and at least one adjustment block 9.

[0110] The mechanism body 7 is provided with a first central hole 71 penetrating through the mechanism body 7 in the center of the axial direction of the mechanism body 7; the adjustment disc 8 is rotationally installed on one side surface of the mechanism body 7, and is provided with a second central hole 81 penetrating through the adjustment disc 8 and coaxially communicated with the first central hole 71.

[0111] The adjustment block 9 is slidingly installed on the mechanism body 7 along a radial direction of the first central hole 71, and one end of the adjustment block 9 can extend into the first central hole 71 or can extend into an axial extension area of the first central hole 71; specifically, as shown in the drawings, a sliding groove 72 is arranged on one side surface of the mechanism body 7, one end of the sliding groove 72 penetrates out of the outer circumferential surface of the mechanism body 7, and the other end of the sliding groove 72 is communicated with the first central hole 71. Figure 5

[0112] The adjustment block 9 is provided with a limiting protrusion 91, the limiting protrusion 91 can be integrally formed with the adjustment block 9 to reduce assembly procedures; the shape of the limiting protrusion 91 can be a square block, a cylindrical state, etc., and is not limited.

[0113] The adjustment disc 8 is provided with a track groove 82 for clamping the limiting protrusion 91 and slidingly connecting with the limiting protrusion 91, the track groove 82 is arranged in the rotation process of the adjustment disc 8, and the track groove 82 is relatively displaced with the limiting protrusion 91 to drive the adjustment block 9 to slide.

[0114] The length shape of the track groove 82 is related to the adjustment range and accuracy of the final adjustment block 9, as shown in the drawings, the track groove 82 of the present application is in a spiral shape, and the distance difference between the two ends of the track groove 82 and the center of the first central hole 71 is also the adjustable range of the adjustment block 9. Figure 5

[0115] The number of the limiting protrusions 91 can be multiple, and the corresponding track grooves 82 are also multiple, the limiting protrusions 91 of the present application are two, and the corresponding track grooves 82 are also two, and the two track grooves 82 can be connected to form a continuous track groove. Those skilled in the art can make changes and designs according to actual needs, and the changes are not limited.

[0116] The microfluidic chip provided by the present application is described in detail above, and for those skilled in the art, the specific implementation manners and application ranges can be changed according to the idea of the embodiments of the present application, and the content of the specification should not be understood as a limitation of the present application.​​

Claims

1. A microfluidic chip, characterized by, The single emulsion microfluidic component comprises a first carrier (4), a second carrier (5), an inner phase tube (62), an outer phase tube (61) and a receiving tube (63); The outer phase tube (61) is installed between the first carrier (4) and the second carrier (5); The first carrier (4) is provided with an inner phase channel (41) in the axial direction of itself; The inner phase tube (62) is installed in the inner phase channel (41) and one end thereof extends into the outer phase tube (61) for forming an inner phase droplet in the outer phase tube (61); The second carrier (5) is provided with a receiving channel (51) in the axial direction of itself; The receiving tube (63) is installed in the receiving channel (51) and one end thereof extends into the outer phase tube (61) for receiving the inner phase droplet; A plurality of the centering guide protrusions (3) surround a centering guide cavity. The other end of the inner phase tube (62) extends out of the first carrier (4) to form an inner phase liquid inlet, or the first carrier (4) is provided with an inner phase liquid inlet channel communicating with the other end of the inner phase tube (62); The outer phase tube (61) is provided with an outer phase liquid inlet, or the second carrier (5) is further provided with an outer phase channel (52) in the axial direction of itself and connected to the outer phase tube (61), and the second carrier (5) is further provided with an outer phase liquid inlet channel (53) communicating with the outer phase channel (52).

2. The microfluidic chip of claim 1, wherein, The centering guide protrusions (3) each comprise a middle support part (31) and two guide parts (32); The two guide parts (32) are connected to the two end parts of the middle support part (31) in the axial direction of the outer phase tube (61); 3. The microfluidic chip of claim 1, wherein, A plurality of the middle support parts (31) surround a support cavity; A plurality of the guide parts (32) on the same side surround a guide cavity; The guide cavity gradually narrows in the direction from the end part of the middle support part (31) to the center of the middle support part (31). The middle support part (31) has a support surface; The support surface is a rectangular arc surface; 4. The microfluidic chip of claim 3, wherein, The guide part (32) has a guide surface; The guide surface is a fan-shaped arc surface. The first carrier (4), the second carrier (5) and the outer phase tube (61) are all prepared by 3D printing. The double emulsion microfluidic component comprises a first carrier (4), a second carrier (5), an inner phase tube (62), an intermediate phase tube (64), an outer phase tube (61) and a receiving tube (63); 5. The microfluidic chip of claim 1, wherein, The outer phase tube (61) is installed between the first carrier (4) and the second carrier (5); 6. A microfluidic chip, characterized by The first carrier (4) is provided with an inner phase channel (41) and an intermediate phase channel (43) in the axial direction of itself; The inner phase tube (62) is installed in the inner phase channel (41) and one end thereof extends into the intermediate phase channel (43) for forming an inner phase droplet in the intermediate phase tube (64); ​ ​ ​ The intermediate phase tube (64) is mounted in the intermediate phase channel (43) and extends into the outer phase tube (61) at one end for forming intermediate phase droplets containing inner phase droplets in the outer phase tube (61); The second carrier (5) is provided with a receiving channel (51) in the axial direction of the second carrier (5); The receiving tube (63) is mounted in the receiving channel (51) and extends into the outer phase tube (61) at one end for receiving intermediate phase droplets; A plurality of centering guide protrusions (3) are circumferentially arranged around the hollow cavity (2) of the outer phase tube (61); The plurality of centering guide protrusions (3) enclose a centering guide cavity.

7. The microfluidic chip of claim 6, wherein, The other end of the inner phase tube (62) extends out of the first carrier (4) to form an inner phase inlet, or the first carrier (4) is provided with an inner phase inlet channel (44) connected to the other end of the inner phase tube (62); The first carrier (4) is provided with an intermediate phase inlet channel (44) connected to the intermediate phase tube (64); The outer phase tube (61) is provided with an outer phase inlet, or the second carrier (5) is further provided with an outer phase channel (52) connected to the outer phase tube (61) in the axial direction of the second carrier (5), and the second carrier (5) is further provided with an outer phase inlet channel (53) connected to the outer phase channel (52).

8. The microfluidic chip of claim 6, wherein, The centering guide protrusion (3) includes an intermediate support portion (31) and two guide portions (32); The two guide portions (32) are connected to the two end portions of the intermediate support portion (31) in the axial direction of the outer phase tube (61); A plurality of intermediate support portions (31) enclose a support cavity; A plurality of guide portions (32) on the same side enclose a guide cavity; The guide cavity gradually narrows in the direction from the end portion of the intermediate support portion (31) to the center of the intermediate support portion (31).

9. The microfluidic chip of claim 8, wherein, The intermediate support portion (31) has a support surface; The support surface is a rectangular arc surface; The guide portion (32) has a guide surface; The guide surface is a fan-shaped arc surface.

10. The microfluidic chip of claim 6, wherein, The first carrier (4), the second carrier (5), and the outer phase tube (61) are all prepared by 3D printing.

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