Sampling device

Abstract

The utility model provides a sampling device, and relates to the technical field of detection. The sampling device provided by the utility model comprises a base, one end of the inner needle is fixedly connected with the base, the inner needle is provided with an inner cavity, the base is provided with a first positioning hole, the first positioning hole is communicated with the inner cavity of the inner needle, and the first positioning hole is configured to be detachably connected with a first pipeline assembly; the outer needle is of a hollow structure, the outer needle is fixedly connected to the base, the outer needle is arranged on the periphery of the inner needle in a sleeving mode, and one end, away from the base, of the outer needle is fixedly connected with the inner needle. The rigidity of the inner needle in the sampling device is higher, and the sampling stability of the inner needle is better.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of detection, in particular to a sampling device. BACKGROUND

[0002] The droplet digital polymerase chain reaction (PCR) is a technique for accurately quantifying nucleic acid molecules. After amplification, the droplets generated in the reaction need to be transferred from the amplification cup into a detection assembly for detection to determine whether a target DNA or RNA sequence exists in each droplet.

[0003] In related technologies, a sampling needle is used to suck and transfer the droplets. Specifically, the sampling needle has a liquid suction cavity and is connected to a liquid path tube. The sampling needle sucks the droplets from the liquid suction cavity into the liquid path tube through the capillary action of the end portion.

[0004] However, the vertical stability of the sampling needle in related technologies is insufficient, and it is easy to deviate from the alignment with the liquid path tube, resulting in low sampling accuracy. Utility model content

[0005] The present application provides a sampling device, which has high rigidity of the inner needle and excellent sampling stability of the inner needle.

[0006] To achieve the above-mentioned purpose, the present application provides the following technical solutions:

[0007] The present application provides a sampling device, which comprises:

[0008] a base;

[0009] an inner needle, one end of the inner needle being fixedly connected to the base, the inner needle having an inner cavity, the base being provided with a first positioning hole, the first positioning hole being in communication with the inner cavity of the inner needle, and the first positioning hole being configured to be detachably connected with a first pipeline assembly;

[0010] an outer needle, which is a hollow structure, the outer needle being fixedly connected to the base, the outer needle being sleeved on the outer periphery of the inner needle and being fixedly connected to the inner needle at an end of the outer needle away from the base.

[0011] In a possible implementation manner, the first positioning hole comprises a tapered hole, the tapered hole being coaxially arranged with the inner needle and being in communication with the inner cavity of the inner needle, a small-diameter end of the tapered hole facing the inner needle, and a large-diameter end of the tapered hole being away from the inner needle;

[0012] The first pipeline assembly comprises a first liquid path tube and a first connector sleeved on the outer periphery of the first liquid path tube, an outer peripheral surface of a first section of the first connector being a tapered surface, and the tapered hole being used to be sealingly connected with the first section of the first connector to form a tapered surface seal.

[0013] In a possible implementation, the first positioning hole further comprises a first limiting hole, the first limiting hole is in communication with the tapered hole and the inner cavity of the inner needle, and the first limiting hole is coaxially arranged with the inner needle; the first end of the first liquid path tube protrudes relative to the first connector, and the first limiting hole is configured to be in sealed connection with the first end of the first liquid path tube.

[0014] In a possible implementation, the first positioning hole further comprises a threaded hole, the threaded hole is coaxially arranged with the tapered hole and located on the side of the tapered hole away from the inner needle, and the threaded hole is configured to be in threaded connection with the first connector.

[0015] In a possible implementation, the base comprises a bottom plate and a first connecting seat, the bottom plate is provided with a second limiting hole, the first connecting seat is provided with the first positioning hole and a limiting protrusion, and the limiting protrusion is clamped in the second limiting hole.

[0016] The limiting protrusion is provided with a clamping groove, the inner needle penetrates through the second limiting hole and is clamped in the clamping groove, and the clamping groove is provided with a flow guide hole in communication with the first positioning hole and the inner cavity of the inner needle.

[0017] In a possible implementation, the inner needle comprises a main body portion and a needle head portion connected with each other, the main body portion is fixedly connected to the base, the needle head portion is tapered, the large-diameter end of the needle head portion is connected with the main body portion, and the outer diameter of the large-diameter end of the needle head portion is equal to the outer diameter of the main body portion, and the ratio of the outer diameter of the large-diameter end of the needle head portion to the outer diameter of the small-diameter end of the needle head portion is 1.2:1 to 4:1.

[0018] In a possible implementation, at least two fixed connecting portions are arranged between the inner needle and the outer needle, the fixed connecting portions connect the inner needle and the outer needle, and the at least two fixed connecting portions are arranged at intervals along the circumference of the inner needle.

[0019] In a possible implementation, a sleeve member is further included, the sleeve member is sleeved on the outer periphery of the outer needle, and the inner needle and the sleeve member have a cavity therebetween along the circumference of the inner needle; the inner needle and the outer needle have a gap flow channel in communication with the cavity therebetween; the sleeve member is provided with a liquid passage opening in communication with the cavity, and the liquid passage opening is configured to be in communication with a cleaning liquid source.

[0020] In a possible implementation, a reinforcing member is further included, the sleeve member is fixedly connected with the base through the reinforcing member.

[0021] In a possible implementation, the base further comprises a second connecting seat, and the base further comprises a second positioning hole configured to be detachably connected with a second pipeline assembly for conveying the cleaning liquid source; the liquid guide pipe is in communication between the liquid outlet and the second positioning hole, and the liquid guide pipe is in communication with the second pipeline assembly.

[0022] The sampling device provided in the application has at least the following advantages:

[0023] The sampling device comprises an inner needle fixedly connected with the base, and the inner needle is supported by an outer needle sleeved on the outer periphery of the inner needle. The base is provided with a first positioning hole, so that the end of the inner needle is fixedly connected with the base, and the inner cavity of the inner needle is in communication with the first positioning hole. In this way, the structural stability of the inner needle in the axial and radial directions is significantly enhanced, which is beneficial to the sampling stability and sampling accuracy of the inner needle for extracting the liquid sample through the inner cavity and conveying the liquid sample to the first pipeline assembly connected with the first positioning hole. That is, the structural rigidity of the inner needle is enhanced to reduce the deformation amount of the inner needle after puncturing the aluminum plastic film on the sample container, and the residual amount of the liquid in the liquid sample container is also reduced. BRIEF DESCRIPTION OF DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings in the following description are some embodiments of the application, and for those skilled in the art, other drawings can also be obtained without creative labor based on these drawings.

[0025] Figure 1 The structure schematic diagram of the sampling device provided in the embodiment of the application;

[0026] Figure 2 The sectional view of the sampling device provided in the embodiment of the application;

[0027] Figure 3 The sectional view of the sampling device provided in the embodiment of the application; Figure 2 The top view sectional structure diagram of the inner needle and the outer needle of the sampling device;

[0028] Figure 4 The sectional view of the sampling device provided in the embodiment of the application; Figure 1 The sectional view of the sampling device and the first pipeline assembly after assembly.

[0029] Explanation of reference signs:

[0030] 10, base;

[0031] 100, base plate;

[0032] 110, second limiting hole; 120, avoiding hole;

[0033] 200, first connecting seat;

[0034] 210, first positioning hole;

[0035] 211, conical hole; 212, first limiting hole; 213, threaded hole;

[0036] 220, limiting protrusion;

[0037] 221, clamping groove;

[0038] 300, inner needle;

[0039] 310, inner cavity; 320, main body part; 330, needle head part;

[0040] 400, first pipeline assembly;

[0041] 410, first liquid path pipe;

[0042] 420, first connector;

[0043] 421, first section; 422, second section;

[0044] 500, outer needle;

[0045] 510, fixed connecting part; 520, gap flow channel;

[0046] 600, sleeve joint;

[0047] 610, first part; 620, second part; 630, third part; 640, liquid passage;

[0048] 700, reinforcing member;

[0049] 800, second connecting seat; 810, second positioning hole;

[0050] 900, liquid guide tube.

[0051] The specific embodiments of the present application have been shown in the above-described drawings, and will be described in more detail hereinafter. These drawings and written descriptions are not intended to limit the scope of the concept of the present application in any way, but to illustrate the concept of the present application to those skilled in the art by referring to specific embodiments. DETAILED DESCRIPTION

[0052] As described in the background, the droplet digital polymerase chain reaction (PCR) is a technique for accurately quantifying nucleic acid molecules, and the droplets generated by the reaction need to be transferred from the amplification cup into a detection assembly for detection after amplification to determine whether the target DNA or RNA sequence exists in each droplet. In the related art, a sampling needle is used to suck and transfer the droplets. Specifically, the sampling needle has a liquid suction cavity and is connected to a liquid path tube. The sampling needle sucks the droplets from the liquid suction cavity into the liquid path tube through the capillary action of the end portion. However, the vertical stability of the sampling needle in the related art is insufficient, and it is easy to deviate from the alignment with the liquid path tube, resulting in low sampling accuracy.

[0053] It should be noted that the container for storing the liquid sample is an eight-way tube, the bottom of which is conical, and the large-diameter end of the eight-way tube faces upward along the axial direction of the eight-way tube. The vertical stability of the sampling needle in the eight-way tube affects the residual amount of the droplets. In order to prevent evaporation, pollution and other problems of the droplets after amplification, the eight-way tube for storing the droplets has an aluminum plastic film. The sampling needle needs to pierce the aluminum plastic film when extracting the droplets. When the sampling needle is not parallel to the axial line of the eight-way tube, it will be further deformed under the action of the aluminum plastic film, and the degree of deformation is uncontrollable, which results in a large residual amount of the droplets when the sampling needle sucks the liquid, affecting the sampling accuracy.

[0054] In view of the above technical problems, the embodiment of the present application provides a sampling device,

[0055] The sampling device includes an outer needle fixedly connected to the base, and the outer needle supports the inner needle by being sleeved on the outer periphery of the inner needle. The base is provided with a first positioning hole, so that the end portion of the inner needle is fixedly connected to the base, and the inner cavity of the inner needle is in communication with the first positioning hole. In this way, the structural stability of the inner needle along the axial and radial directions of the inner needle is significantly enhanced, which is beneficial to the sampling stability and sampling accuracy of the inner needle for extracting the liquid sample through the inner cavity and conveying the liquid sample to the first pipeline assembly connected to the first positioning hole. That is, by enhancing the structural rigidity of the inner needle, the deformation amount of the inner needle after piercing the aluminum plastic film on the sample container is reduced, and the residual amount of the liquid in the sample container is also reduced.

[0056] In order to make the above-mentioned purposes, features and advantages of the embodiments of the present application more apparent and easy to understand, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of protection of the present application.

[0057] Reference Figure 1 , Figure 2 and Figure 4The sampling device provided by the embodiment of the application comprises a base 10, an inner needle 300 and an outer needle 500. One end of the inner needle 300 is fixedly connected with the base 10. The inner needle 300 has an inner cavity 310. The base 10 is provided with a first positioning hole 210. The first positioning hole 210 is in communication with the inner cavity 310 of the inner needle 300. The first positioning hole 210 is configured to be detachably connected with a first pipeline assembly 400. The outer needle 500 is a hollow structure. The outer needle 500 is fixedly connected with the base 10. The outer needle 500 is sleeved on the outer periphery of the inner needle 300 and is fixedly connected with the inner needle at the end of the outer needle 500 away from the base 10.

[0058] In this way, the sampling device supports the inner needle 300 through the outer needle 500 sleeved on the outer periphery of the inner needle 300. The base 10 is provided with the first positioning hole 210. The end of the inner needle 300 is fixedly connected with the base 10, and the inner cavity 310 of the inner needle 300 is in communication with the first positioning hole 210. In this way, the structural stability of the inner needle 300 along the axial direction and the radial direction is significantly enhanced. This is beneficial to the sampling stability and sampling accuracy of the inner needle 300 for extracting the liquid sample through the inner cavity 310 and conveying the liquid sample to the first pipeline assembly connected with the first positioning hole 210. That is, the structural rigidity of the inner needle 300 is enhanced to reduce the deformation amount of the inner needle 300 after puncturing the aluminum plastic film on the sample container. The liquid residue amount of the liquid sample container is also reduced.

[0059] In other examples, the base 10 can have a split structure. Specifically, the base 10 comprises a bottom plate 100 and a first connecting seat 200. The bottom plate 100 can be a rectangular bottom plate 100 or a circular bottom plate 100. The first connecting seat 200 is fixedly connected with the bottom plate 100. The first connecting seat 200 can be a cylindrical structure which is welded to the bottom plate 100. One end of the inner needle 300 penetrates through the bottom plate 100 and is fixedly connected with the first connecting seat 200. For example, the bottom plate 100 is provided with a through hole. The first connecting seat 200 is provided with a slot. One end of the inner needle 300 penetrates through the through hole and is fixedly connected with the first connecting seat 200 by insertion. The inner needle 300 has an inner cavity 310. The first connecting seat 200 is provided with a first positioning hole 210. The first positioning hole 210 is in communication with the inner cavity 310 of the inner needle 300. The first positioning hole 210 is configured to be detachably connected with the first pipeline assembly 400. For example, the first positioning hole 210 is internally threaded. The first positioning hole 210 is threadedly connected with a threaded connector in the first pipeline assembly 400. The outer needle 500 is a hollow structure. The outer needle 500 is fixedly connected with the bottom plate 100. The outer needle 500 is sleeved on the outer periphery of the inner needle 300 and is fixedly connected with the inner needle 300. For example, the outer needle 500 is welded to the outer periphery of the inner needle 300.

[0060] In this way, the inner needle 300 is supported by the outer needle 500 sleeved on the outer periphery of the inner needle 300, and the first connecting seat 200 fixed to the bottom plate 100 is provided with the first positioning hole 210, so that the end of the inner needle 300 is fixedly connected with the first connecting seat 200, and the inner cavity 310 of the inner needle 300 is in communication with the first positioning hole 210. In this way, the structural stability of the inner needle 300 along the axial and radial directions is significantly enhanced, which is beneficial to the sampling stability and sampling accuracy of the inner needle 300 for extracting the liquid sample through the inner cavity 310 and conveying the liquid sample to the first pipeline assembly 400 connected to the first positioning hole 210. That is, by enhancing the structural rigidity of the inner needle 300, the deformation amount of the inner needle 300 after puncturing the aluminum plastic film on the sample container is reduced, and the liquid residue amount of the liquid sample container is also reduced.

[0061] With reference to the foregoing Figure 2 and Figure 4 In some embodiments, the first positioning hole 210 includes a tapered hole 211 coaxially arranged with the inner needle 300 and in communication with the inner cavity 310 of the inner needle 300 in the axial direction of the inner needle 300. The small-diameter end of the tapered hole 211 faces the inner needle 300, and the large-diameter end of the tapered hole 211 faces away from the inner needle 300. The first pipeline assembly 400 includes a first liquid path tube 410 and a first connector 420 sleeved on the first liquid path tube 410. The tapered hole 211 is used for sealingly connecting the first segment 421 of the first connector 420. Illustratively, the first connector 420 has a connecting cavity for connecting the first liquid path tube 410. In the axial direction of the first connector 420, a portion on the side of the first connector 420 facing the inner needle 300 is the first segment 421. The outer peripheral surface of the first segment 421 is a tapered surface for being inserted into the tapered hole 211 to form a tapered surface seal. This not only improves the sealing between the first liquid path tube 410 and the first connecting seat 200, but also facilitates the axial alignment of the first liquid path tube 410 and the inner needle 300, thereby reducing the leakage of the liquid sample transmitted by the inner needle 300 to the first liquid path tube 410.

[0062] With reference to the foregoing Figure 2 and Figure 4 In some embodiments, the first positioning hole 210 further includes a first limiting hole 212 in communication with the tapered hole 211 and the inner cavity 310 of the inner needle 300, and the first limiting hole 212 is coaxially arranged with the inner needle 300. The first end of the first liquid path tube 410 protrudes relative to the first connector 420. The first limiting hole 212 is configured to sealingly connect with the first end of the first liquid path tube 410. Illustratively, the first limiting hole 212 is a straight hole, and the straight hole is perpendicular to the end surface of the first connecting seat 200 on the side close to the inner needle 300. In this way, the end sealing and perpendicularity of the first liquid path tube 410 are ensured.

[0063] That is, compared with the prior art sampling needle and pipeline which adopts end face sealing connection, the centering error of the needle and the pipeline in the embodiment is small, and the taper face sealing can ensure the centering of the inner needle 300 and the first liquid path pipeline 410 and reduce the loss in the droplet transfer process.

[0064] In some embodiments, as shown in Figure 4 The first positioning hole 210 further includes a threaded hole 213 coaxially arranged with the tapered hole 211 and located on the side of the tapered hole 211 away from the inner needle 300. The threaded hole 213 is used for threaded connection with the second section 422 of the first joint 420. The connection stability of the first joint 420 and the first connecting seat 200 is high, which ensures the stability of the liquid sample extraction.

[0065] In some embodiments, the bottom plate 100 is provided with a second limiting hole 110, and the first connecting seat 200 is provided with a limiting protrusion 220 which is clamped in the second limiting hole 110. The limiting protrusion 220 is provided with a clamping groove 221, and the inner needle 300 penetrates through the second limiting hole 110 and is clamped in the clamping groove 221. Further, the end of the inner needle 300 is laser welded to the clamping groove 221. The clamping groove 221 is provided with a flow guide hole which communicates the first positioning hole 210 and the inner cavity 310 of the inner needle 300. In this way, through the clamping cooperation of the limiting protrusion 220 and the second limiting hole 110 on the bottom plate 100, the connection structure strength of the first connecting seat 200 and the bottom plate 100 is strengthened. At the same time, the clamping groove 221 for clamping the inner needle 300 is arranged on the limiting protrusion 220, which improves the compactness and stability of the overall structure.

[0066] In some embodiments, the inner needle 300 includes a main body part 320 and a needle head part 330 connected with each other. The main body part 320 is fixedly connected to the bottom plate 100 through the first connecting seat 200. The needle head part 330 is tapered. The large-diameter end of the needle head part 330 is connected with the main body part 320, and the outer diameter of the large-diameter end of the needle head part 330 is equal to the outer diameter of the main body part 320. The ratio of the outer diameter of the large-diameter end of the needle head part 330 to the outer diameter of the small-diameter end of the needle head part 330 is 1.2:1 to 4:1. For example, the ratio of the outer diameter of the large-diameter end of the needle head part 330 to the outer diameter of the small-diameter end of the needle head part 330 is 1.5:1, or the ratio of the outer diameter of the large-diameter end of the needle head part 330 to the outer diameter of the small-diameter end of the needle head part 330 is 4:1. In this way, the partial structure of the inner needle 300 is designed to be thickened, which not only improves the structural stiffness, but also controls the small size range of the small-diameter end of the tapered needle head part 330, thereby ensuring the good capillary liquid absorption performance of the inner needle 300.

[0067] Further, the inner diameter of the main body part 320 of the inner needle 300 is the same as the inner diameter of the first liquid path pipeline 410 connected to the first positioning hole 210, so as to reduce the loss in the droplet transfer process from the inner cavity 310 of the inner needle 300 to the first liquid path pipeline 410.

[0068] In combination Figure 2 And Figure 3 In some embodiments, at least one fixed connection part 510 is arranged between the inner needle 300 and the outer needle 500, the fixed connection part 510 connects the inner needle 300 and the outer needle 500, for example, the inner needle 300 is welded with the outer needle 500 to form a welded connection part, the welded connection part can be two or three, and the plurality of welded connection parts are arranged at intervals along the circumference of the inner needle 300, thereby strengthening the radial stability of the inner needle 300 to ensure the perpendicularity thereof and ensure that the deformation of the inner needle 300 is small when the inner needle 300 pierces the aluminum-plastic film.

[0069] In some embodiments, the sleeve part 600 is further included, the sleeve part 600 is sleeved on the outer circumference of the outer needle 500, the inner needle 300 and the sleeve part 600 have a cavity therebetween along the circumference of the inner needle 300, the inner needle 300 and the outer needle 500 have a gap flow channel 520 communicated with the cavity, and the sleeve part 600 is provided with a liquid inlet 640 communicated with the cavity, the liquid inlet 640 is configured to be communicated with a cleaning liquid source, so that the structural design of the cleaning channel in the sampling device can be realized, and the liquid sample remaining on the outer side wall of the inner needle 300 and the inner side wall of the outer needle 500 can be cleaned, thereby ensuring the precision of multiple sampling of the sampling device.

[0070] In some embodiments, the sleeve part 600 has a first part 610, a second part 620 and a third part 630 connected in sequence along the axial direction of the sleeve part 600, the third part 630 is located between the first part 610 and the second part 620, the first part 610 and the second part 620 are both in sealed connection with the inner needle 300, and the third part 630 has the cavity with the inner needle 300.

[0071] In combination Figure 1 And Figure 2 In some embodiments, the reinforcing part 700 is further included, the reinforcing part 700 has a first end surface and a first side surface, the first end surface is connected to the bottom plate 100, the first side surface is connected to the side surface of the sleeve part 600, and the first side surface is orthogonal to the bottom plate 100, for example, the reinforcing part 700 is a cylindrical part.

[0072] In another example, the reinforcing part 700 includes two reinforcing blocks, the two reinforcing blocks are arranged on opposite sides of the sleeve part 600 along the radial direction of the sleeve part 600, and the reinforcing blocks are connected between the sleeve part 600 and the bottom plate 100, and the structure is simple.

[0073] In some embodiments, a second connecting seat 800 is further included, the second connecting seat 800 is fixedly connected to the bottom plate 100, the second connecting seat 800 is provided with a second positioning hole 810, the second positioning hole 810 is configured to be detachably connected with a second pipeline assembly, the second pipeline assembly is connected with a cleaning liquid source, and is used to transport the cleaning liquid source; a liquid guide pipe 900 is in communication between the liquid passage 640 and the second positioning hole 810, and the liquid guide pipe 900 is communicated with the second pipeline assembly through the second connecting seat 800. In this way, the structural compactness between the liquid guide pipe used to transport the cleaning liquid and the inner needle 300 is improved, and the connection stability of the second pipeline assembly in the sampling device is ensured. Figure 2 In the embodiment shown, the structure of the second connecting seat is the same as that of the first connecting seat, and the fixing mode of the second connecting seat to the bottom plate is also the same. In other embodiments, the structure of the second connecting seat can also be different from that of the first connecting seat.

[0074] In some embodiments, the bottom plate 100 is further provided with a relief hole 120 in communication with the second positioning hole 810, the relief hole 120 is spaced apart from the second limiting hole 110, and the liquid guide pipe 900 penetrates through the relief hole 120, further improving the space utilization of the whole sampling device.

[0075] For example, the assembly sequence of the sampling device of the embodiment of the application can be as follows: the inner needle 300 is connected and then fixed on the first connecting seat 200, the perpendicularity of the inner needle 300 and the bottom plate 100 is ensured by using a clamp, the first connecting seat 200 is fixed on the bottom plate 100, then the perpendicularity of the bottom plate 100 and the axis of the eight-way pipe in which the liquid sample to be taken is stored is ensured, and further, the needle sleeve, the sleeve piece 600 and the reinforcing piece 700 are sequentially assembled and fixed. In this way, the rigidity of the inner needle 300 is ensured, and the perpendicularity of the inner needle 300 relative to the eight-way pipe is improved.

[0076] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements indicated must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application.

[0077] In addition, the terms "first" and "second" are only for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined with "first" and "second" can explicitly or implicitly include at least one of the features. In the description of the present application, the meaning of "a plurality of" is at least two, for example, two, three, etc., unless otherwise specifically limited.

[0078] In this application, unless otherwise specified or limited, the terms "installed," "connected," "connect," "fixed," etc. should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integration; mechanical connection or electrical connection; direct connection or indirect connection through an intermediate medium; internal communication between two elements or interaction between two elements, unless otherwise specified. Those skilled in the art will understand the specific meanings of the above terms in this application based on specific circumstances.

[0079] In this application, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Furthermore, when a first feature is "above," "above," or "above" a second feature, it may mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is at a higher level than the second feature. When a first feature is "below," "below," or "below" a second feature, it may mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is at a lower level than the second feature.

[0080] The various embodiments or implementation methods in this specification are described in a progressive manner. Each embodiment focuses on the differences from other embodiments, and the same or similar parts between the various embodiments can be referenced to each other.

[0081] It should be noted that phrases such as "one embodiment," "an embodiment," "exemplary embodiments," and "some embodiments" in this specification may indicate embodiments that may include a particular feature, structure, or characteristic, but not every embodiment necessarily includes that particular feature, structure, or characteristic. Furthermore, such phrases do not necessarily refer to the same embodiment. Furthermore, when a particular feature, structure, or characteristic is described in conjunction with an embodiment, it is within the knowledge of those skilled in the art to implement such feature, structure, or characteristic in conjunction with other embodiments, whether explicitly described or not.

[0082] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some or all of the technical features therein. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A sampling device, characterized in that, The utility model relates to a kind of needle set, including: Base; Inner needle, one end of the inner needle is fixedly connected with the base, the inner needle has inner cavity, the base is equipped with first positioning hole, the first positioning hole is communicated with the inner cavity of the inner needle, the first positioning hole is configured as being detachably connected with first pipeline assembly; Outer needle, which is a hollow structure, is fixedly connected to the base, the outer needle is sleeved on the outer periphery of the inner needle and is fixedly connected with the inner needle at the end away from the base.

2. The sampling device of claim 1, wherein, The first positioning hole includes a tapered hole coaxially arranged with the inner needle and communicated with the inner cavity of the inner needle, the small-diameter end of the tapered hole faces the inner needle, and the large-diameter end of the tapered hole faces away from the inner needle. The first pipeline assembly includes a first liquid path tube and a first connector sleeved on the outer periphery of the first liquid path tube, the outer peripheral surface of the first segment of the first connector is a tapered surface, and the tapered hole is used to sealably connect with the first segment of the first connector to form a tapered surface seal.

3. The sampling device of claim 2, wherein, The first positioning hole further includes a first limiting hole, the first limiting hole communicates the tapered hole and the inner cavity of the inner needle, and the first limiting hole is coaxially arranged with the inner needle, the first end of the first liquid path tube protrudes relative to the first connector, and the first limiting hole is configured to be sealably connected with the first end of the first liquid path tube.

4. The sampling device of claim 2, wherein, The first positioning hole further includes a threaded hole coaxially arranged with the tapered hole and located on the side of the tapered hole away from the inner needle, and the threaded hole is used to threadedly connect with the first connector.

5. The sampling device of any one of claims 1-4, wherein, The base includes a base plate and a first connecting seat, the base plate is provided with a second limiting hole, the first connecting seat is provided with the first positioning hole and has a limiting protrusion, and the limiting protrusion is clamped in the second limiting hole. The limiting protrusion is provided with a clamping groove, the inner needle penetrates through the second limiting hole and is clamped in the clamping groove, the clamping groove is provided with a flow guide hole, and the flow guide hole communicates the first positioning hole and the inner cavity of the inner needle.

6. The sampling device of any one of claims 1-4, wherein, The inner needle includes a main body portion and a needle head portion connected thereto, the main body portion is fixedly connected to the base, the needle head portion is tapered, the large-diameter end of the needle head portion is connected to the main body portion, and the outer diameter of the large-diameter end of the needle head portion is equal to the outer diameter of the main body portion, the ratio of the outer diameter of the large-diameter end of the needle head portion to the outer diameter of the small-diameter end of the needle head portion is 1.2:1 to 4:

1.

7. The sampling device of any one of claims 1-4, wherein, At least two fixed connecting portions are provided between the inner needle and the outer needle, the fixed connecting portions connect the inner needle and the outer needle, and the at least two fixed connecting portions are spaced apart along the circumference of the inner needle.

8. The sampling device of any one of claims 1-4, wherein, Further comprising a sleeve connector, the sleeve connector is sleeved on the outer periphery of the outer needle along the circumference of the inner needle, the inner needle and the sleeve connector have a cavity therebetween, the inner needle and the outer needle have a gap flow channel communicated with the cavity therebetween, the sleeve connector is provided with a liquid passage communicated with the cavity, and the liquid passage is configured to be communicated with a cleaning liquid source.

9. The sampling device of claim 8, wherein, Further comprising a reinforcing member, the sleeve connector is fixedly connected with the base through the reinforcing member.

10. The sampling device of claim 8, wherein, The base is further provided with a second positioning hole configured to be detachably connected with a second pipeline assembly for conveying the cleaning liquid source; the liquid guide pipe is communicated between the liquid passage and the second positioning hole and communicated with the second pipeline assembly.

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