Tandem combined solid-phase extraction column

Abstract

The utility model relates to a series combined solid phase extraction column, which comprises a first extraction column, a second extraction column and a sealing assembly, the first extraction column comprises a first male head, a first column body and a first female head, and the second extraction column comprises a second male head, a second column body and a second female head. The first extraction column and the second extraction column are connected in an embedded mode, meanwhile, the first sealing ring is arranged on the inner side of the first female head, and the second sealing ring is arranged on the inner side of the second female head, so that the air tightness of the embedded position is guaranteed, multiple processes of step-by-step sample loading, transferring and column passing of an existing solid-phase extraction product can be completed only through one-time column passing process, and the production efficiency is improved. The efficiency of solid-phase extraction operation is improved, the pretreatment time is saved, the loss of target components is reduced, the experimental working efficiency and the qualitative and quantitative accuracy of the target components are improved, and the use is convenient.

Description

Technical Field

[0001] This utility model relates to the field of chemical analysis and testing pretreatment devices, specifically to a series combined solid phase extraction column. Background Technology

[0002] Solid-phase extraction (SPE) is a sample pretreatment technique developed in recent years, combining liquid-solid extraction (LC) and column liquid chromatography (LC). It is primarily used for sample separation, purification, and concentration, improving analyte recovery, more effectively separating analytes from interfering components, reducing sample pretreatment steps, and offering simple, time-saving, and labor-saving operation. It is widely used in pharmaceuticals, food, environmental protection, commodity inspection, and chemical industries.

[0003] The separation, purification, and refinement of target components are crucial foundational work for the content analysis of chemical and biological samples. Currently, solid-phase extraction (SPE) used in laboratories can only perform stepwise sample pretreatment, which suffers from problems such as time consumption, inefficiency, and component transfer loss, affecting the accuracy of qualitative and quantitative analysis of target components. When samples need to undergo multiple SPE processes (such as multiple purification and drying processes), multiple SPE loadings are required, each consuming additional time and facing the risk of target component loss during collection and transfer, making it inconvenient to use. Utility Model Content

[0004] In view of the above problems, this utility model provides a series combined solid phase extraction column, which solves the problem of inconvenience in using existing solid phase extraction columns.

[0005] To achieve the above objectives, this application provides a series-connected solid-phase extraction column, including a first extraction column, a second extraction column, and a sealing assembly. The first extraction column includes a first male head, a first column body, and a first female head, with the first male head and the first female head disposed at both ends of the first column body. The first male head includes a first output end and a first flange, with the first flange disposed at the connection between the first column body and the first output end. The first female head includes a first extension edge and a first groove, with the first extension edge and the first groove coaxially arranged. The second extraction column includes a second male head, a second column body, and a second female head, with the second male head and the second female head disposed at both ends of the second column body. The second male head includes a second output end and a second flange, with the second flange disposed at the connection between the second column body and the second output end. The second female head includes a second extension edge and a second groove, with the second extension edge and the second groove coaxially arranged. The sealing assembly includes a first sealing ring and a second sealing ring, with the first sealing ring disposed within the first groove and the second sealing ring disposed within the second groove.

[0006] The first extraction column and the second extraction column can be placed in a first splicing state. In the first splicing state, the first extraction column and the second extraction column are arranged sequentially from top to bottom, the first flange is placed in the second groove, and the outer side of the first flange is fitted with a second sealing ring. The first output end is placed in the second column, and the first column and the second column are connected through the first output end. The first extraction column and the second extraction column can also be placed in a second splicing state. In the second splicing state, the second extraction column and the first extraction column are arranged sequentially from top to bottom, the second flange is placed in the first groove, and the outer side of the second flange is fitted with a first sealing ring. The second output end is placed in the first column, and the second column and the first column are connected through the second output end.

[0007] In some embodiments, the first male connector further includes a first extended edge, which is disposed at the first output end; the second female connector further includes a second extended edge, which is disposed inside the second column; in the first splicing state, the first extended edge and the second extended edge are engaged.

[0008] The second male connector also includes a third extended edge, which is located at the second output end; the first female connector also includes a fourth extended edge, which is located inside the first column; in the second splicing state, the third extended edge and the fourth extended edge engage.

[0009] In some embodiments, there are multiple first extension edges, which are distributed circumferentially at intervals along the first output end, and the gap between two adjacent first extension edges is greater than the width of a single second extension edge; there are multiple second extension edges, which are distributed circumferentially at intervals along the inner side of the second column, and the gap between two adjacent second extension edges is greater than the width of a single first extension edge.

[0010] And / or, there are multiple third extension edges, which are distributed circumferentially along the second output end, and the gap between two adjacent third extension edges is greater than the width of a single fourth extension edge; there are multiple fourth extension edges, which are distributed circumferentially along the inner side of the first column, and the gap between two adjacent fourth extension edges is greater than the width of a single third extension edge.

[0011] In some embodiments, the edges of the first extended edge and / or the second extended edge and / or the third extended edge and / or the fourth extended edge are arc-shaped.

[0012] In some embodiments, the first male connector further includes a third extension edge disposed above the first flange, wherein in the first splicing state, the projection of the third extension edge and the second extension edge in the vertical direction coincides; the second male connector further includes a fourth extension edge disposed above the second flange, wherein in the second splicing state, the projection of the fourth extension edge and the first extension edge in the vertical direction coincides.

[0013] In some embodiments, a first protrusion is provided on the side of the first extension edge facing the first column, a second protrusion is provided on the side of the second extension edge facing the second column, a third protrusion is provided on the side of the third extension edge facing the first column, and a fourth protrusion is provided on the side of the fourth extension edge facing the second column. The series-connected solid-phase extraction column also includes a first fastener and a second fastener. The first fastener has a U-shaped structure. In the first splicing state, the first fastener is fastened to the third protrusion and the second protrusion. The second fastener has a U-shaped structure. In the second splicing state, the second fastener is fastened to the fourth protrusion and the first protrusion.

[0014] In some embodiments, the sealing assembly further includes a third sealing ring and a fourth sealing ring, wherein the third sealing ring is disposed inside the first fastener and the fourth sealing ring is disposed inside the second fastener.

[0015] In some embodiments, the periphery of the first column and / or the periphery of the second column are provided with anti-slip textures.

[0016] In some embodiments, the outer surface of the first column and / or the outer surface of the second column are provided with scale lines.

[0017] In some embodiments, the first extraction column and / or the second extraction column are made of polystyrene, a polymer matrix material.

[0018] Unlike existing technologies, the above technical solution includes a series-connected solid-phase extraction column comprising a first extraction column, a second extraction column, and a sealing assembly. The first extraction column includes a first male head, a first column body, and a first female head. The second extraction column includes a second male head, a second column body, and a second female head. The first and second extraction columns are in a first spliced ​​state and a second spliced ​​state. In the first spliced ​​state, the first and second extraction columns are arranged from top to bottom, and the first male head and the second female head are sealed together, facilitating multiple solid-phase extractions. In the second spliced ​​state, the second extraction column and the first extraction column are arranged from top to bottom, and the second male head and the first female head are sealed together, facilitating multiple solid-phase extractions. This technical solution connects the first extraction column and the second extraction column through a mating method. A first sealing ring is provided inside the first female head, and a second sealing ring is provided inside the second female head to ensure airtightness at the mating point. This allows the process of multiple steps—sample loading, transfer, and column passage—required in existing solid-phase extraction methods to be completed in a single column pass. This improves the efficiency of solid-phase extraction operations, saves pretreatment time, reduces target component loss, and enhances experimental efficiency and the accuracy of qualitative and quantitative analysis of target components. It is also convenient to use.

[0019] The above description of the utility model is merely an overview of the technical solution of this utility model. In order to enable those skilled in the art to better understand the technical solution of this utility model and to implement it based on the description and drawings, and to make the above-mentioned objectives and other objectives, features and advantages of this utility model easier to understand, the following description is provided in conjunction with the specific embodiments and drawings of this utility model. Attached Figure Description

[0020] The accompanying drawings are only used to illustrate the principles, implementation methods, applications, features, and effects of the present invention and other related contents, and should not be considered as limitations on the present invention.

[0021] In the accompanying drawings of the instruction manual:

[0022] Figure 1 A schematic diagram of the first extraction column for a specific implementation method;

[0023] Figure 2 This is a schematic diagram of an embodiment of the first extraction column and the second extraction column in a first splicing state;

[0024] Figure 3 This is a schematic diagram of another embodiment of the first extraction column and the second extraction column in a second splicing state;

[0025] Figure 4 for Figure 3 Cross-sectional schematic diagram of the third and fourth extension edges;

[0026] Figure 5 This is a schematic diagram illustrating the connection between the first fastener and the third and second protruding strips in a specific implementation.

[0027] The reference numerals used in the above figures are explained as follows:

[0028] 1. First extraction column;

[0029] 11. The first male head;

[0030] 111. First output terminal;

[0031] 112. First flange;

[0032] 113. First extension edge;

[0033] 114. Third extension edge;

[0034] 115. Third convex strip;

[0035] 12. First female head;

[0036] 121. First extension edge;

[0037] 122. First groove;

[0038] 123. Fourth extension edge;

[0039] 124. First convex strip;

[0040] 13. The first column;

[0041] 2. Second extraction column;

[0042] 21. Second male head;

[0043] 211. Second output terminal;

[0044] 212. Second flange;

[0045] 213. Third extension edge;

[0046] 214. Fourth extension edge;

[0047] 215. Fourth convex strip;

[0048] 22. Second female head;

[0049] 221. Second extension edge;

[0050] 222. Second groove;

[0051] 223. Second extension edge;

[0052] 224. Second convex strip;

[0053] 23. The second column;

[0054] 3. First sealing ring;

[0055] 4. Second sealing ring;

[0056] 5. First fastener;

[0057] 6. Second fastener. Detailed Implementation

[0058] To illustrate in detail the possible application scenarios, technical principles, implementable specific solutions, and achievable objectives and effects of this utility model, the following description, in conjunction with the listed specific embodiments and accompanying drawings, provides a detailed explanation. The embodiments described herein are merely illustrative of the technical solutions of this utility model and are therefore intended to limit the scope of protection of this utility model.

[0059] In this document, the term "embodiment" means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this utility model. The term "embodiment" appearing in various places throughout the specification does not necessarily refer to the same embodiment, nor does it specifically limit its independence or connection with other embodiments. In principle, in this utility model, as long as there are no technical contradictions or conflicts, the technical features mentioned in each embodiment can be combined in any way to form corresponding implementable technical solutions.

[0060] Unless otherwise defined, the technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains; the use of related terms herein is merely for the purpose of describing particular embodiments and is not intended to limit the invention.

[0061] In the description of this utility model, the term "and / or" is used to describe the logical relationship between objects, indicating that three relationships can exist. For example, A and / or B means: A exists, B exists, and A and B exist simultaneously. Additionally, the character " / " generally indicates that the preceding and following objects have an "or" logical relationship.

[0062] In this invention, terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any actual quantity, hierarchy, or order between these entities or operations.

[0063] Without further limitations, the use of terms such as “comprising,” “including,” “having,” or other similar expressions in this invention is intended to cover non-exclusive inclusion, which does not exclude the presence of additional elements in a process, method, or product that includes the stated elements, such that a process, method, or product that includes a series of elements may include not only those defined elements but also other elements not expressly listed, or elements inherent to such a process, method, or product.

[0064] Similar to the understanding in the Examination Guidelines, in this utility model, expressions such as "greater than," "less than," and "exceeding" are understood to exclude the stated number; expressions such as "above," "below," and "within" are understood to include the stated number. Furthermore, in the description of the embodiments of this utility model, "multiple" means two or more (including two), and similar expressions related to "multiple" are also understood in this way, such as "multiple groups" and "multiple times," unless otherwise explicitly specified.

[0065] In the description of the embodiments of this utility model, the space-related expressions used, such as "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "vertical," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," and "circumferential," indicate the orientation or positional relationship based on the orientation or positional relationship shown in the specific embodiments or drawings. They are only for the convenience of describing the specific embodiments of this utility model or for the reader's understanding, and do not indicate or imply that the device or component referred to must have a specific position, a specific orientation, or be constructed or operated in a specific orientation. Therefore, they should not be construed as limitations on the embodiments of this utility model.

[0066] Unless otherwise expressly specified or limited, the terms "installation," "connection," "linking," "fixing," and "setting," as used in the description of the embodiments of this utility model, should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral setting; it can be a mechanical connection, an electrical connection, or a communication connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be the internal connection of two components or the interaction between two components. For those skilled in the art to which this utility model pertains, the specific meaning of the above terms in the embodiments of this utility model can be understood according to the specific circumstances.

[0067] Please see Figures 1 to 5 This embodiment provides a series-connected solid-phase extraction column, including a first extraction column 1, a second extraction column 2, and a sealing assembly. The first extraction column 1 includes a first male connector 11, a first column body 13, and a first female connector 12. The first male connector 11 and the first female connector 12 are located at both ends of the first column body 13. The first male connector 11 includes a first output end 111 and a first flange 112, which is located at the connection between the first column body 13 and the first output end 111. The first female connector 12 includes a first extension edge 121 and a first groove 122, which are coaxially arranged. The second extraction column 2 includes... The assembly includes a second male connector 21, a second column 23, and a second female connector 22. The second male connector 21 and the second female connector 22 are located at both ends of the second column 23. The second male connector 21 includes a second output end 211 and a second flange 212, which is located at the connection between the second column 23 and the second output end 211. The second female connector 22 includes a second extension edge 221 and a second groove 222, which are coaxially arranged. The sealing assembly includes a first sealing ring 3 and a second sealing ring 4, which are located in the first groove 122 and the second sealing ring 4 are located in the second groove 222.

[0068] The first extraction column 1 and the second extraction column 2 can be placed in a first splicing state. In the first splicing state, the first extraction column 1 and the second extraction column 2 are arranged sequentially from top to bottom. The first flange 112 is placed in the second groove 222, and the outer side of the first flange 112 is fitted with a second sealing ring 4. The first output end 111 is placed in the second column 23, and the first column 13 and the second column 23 are connected through the first output end 111. The first extraction column 1 and the second extraction column 2 can be placed in a second splicing state. In the second splicing state, the second extraction column 2 and the first extraction column 1 are arranged sequentially from top to bottom. The second flange 212 is placed in the first groove 122, and the outer side of the second flange 212 is fitted with a first sealing ring 3. The second output end 211 is placed in the first column 13, and the second column 23 and the first column 13 are connected through the second output end 211.

[0069] In this embodiment, the first extraction column 1 and the second extraction column 2 may have the same structure. To facilitate the description of their positional relationship in the spliced ​​state, they are divided into the first extraction column 1 and the second extraction column 2. The first extraction column 1 will be described in detail. The structure of the second male head 21, the second female head 22 and the second column body 23 of the second extraction column 2 can be understood by referring to the first male head 11, the first female head 12 and the first column body 13.

[0070] Specifically, the first extraction column 1 includes a first male connector 11, a first column body 13, and a first female connector 12. The first column body 13 can be a cylindrical structure, with the first male connector 11 at one end and the first female connector 12 at the other end. The diameter of the first column body 13 can be the same as the diameter of the second column body 23. The first male connector 11 includes a first output end 111 and a first flange 112, wherein the first flange 112 is located at the connection between the first output end 111 and the first column body 13, such as... Figure 1 as well as Figure 3 As shown, the second flange 212 can be referenced accordingly. Figure 2 To understand this, the first output end 111 can be understood by referring to the injection end of a syringe. The first output end 111 has a pointed structure, which facilitates the collection of the extracted liquid and the execution of subsequent analysis steps.

[0071] The first female head 12 includes a first extension edge 121 and a first groove 122. The diameter of the first groove 122 is larger than the diameter of the second flange 212, so the second flange 212 can be placed inside the first groove 122. The diameter of the second flange 212 is the outer diameter of the second column 23. When the diameters of the first column 13 and the second column 23 are the same, the inner diameter of the first column 13 is smaller than the outer diameter of the second column 23, so the second flange 212 will engage with the first groove 122. The structure of the first extension edge 121 can be set according to actual needs. For example, the first extension edge 121 can be understood with reference to the structure of the push end of a syringe. The first extension edge 121 can also be disc-shaped to facilitate the user's structural splicing of the first extraction column 1 and the second extraction column 2.

[0072] The first extraction column 1 and the second extraction column 2 are used for solid-phase extraction, and a certain degree of sealing is required. This embodiment adds a sealing assembly, which includes a first sealing ring 3 and a second sealing ring 4, both of which can be O-rings. The first sealing ring 3 is disposed within a first groove 122, and the second sealing ring 4 is disposed within a second groove 222. Both the first sealing ring 3 and the second sealing ring 4 are detachably connected to each other. This facilitates the sterilization of the first sealing ring 3 and the second sealing ring 4, and also facilitates the sterilization process after disassembly of the first extraction column 1 and the second extraction column 2.

[0073] In this embodiment, the first extraction column 1 and the second extraction column 2 include a first spliced ​​state and a second spliced ​​state. For example... Figure 2 As shown, in the first splicing state, the first extraction column 1 and the second extraction column 2 are spliced ​​sequentially from top to bottom, that is, the first extraction column 1 is placed above the second extraction column 2, so the first female head 12 is set upwards, the first male head 11 is placed inside the second female head 22, and the second male head 21 is suspended downwards, that is, the first flange 112 is placed inside the second groove 222, and a second sealing ring 4 is provided at the splicing point of the first flange 112 and the second groove 222. The first output end 111 is placed inside the second column 23, so the first extraction column 1 and the second extraction column 2 are connected through the first output end 111; Figure 3 As shown, in the second splicing state, the second extraction column 2 and the first extraction column 1 are spliced ​​from top to bottom, that is, the second extraction column 2 is placed above the first extraction column 1, the second female head 22 is set upwards, the second male head 21 is set inside the first female head 12, and the first male head 11 is suspended downwards, that is, the second flange 212 is placed inside the first groove 122, the splicing point of the second flange 212 and the first groove 122 is provided with a first sealing ring 3, and the second output end 211 is placed inside the first column 13, so the second extraction column 2 and the first extraction column 1 are connected through the second output end 211.

[0074] It should be noted that the number of first extraction columns 1 and second extraction columns 2 shown in this embodiment can be multiple. Depending on actual needs, multiple first extraction columns 1 or multiple second extraction columns 2 can be assembled into a single unit. This embodiment describes the process of assembling first extraction columns 1 and second extraction columns 2, and does not limit the number of first extraction columns 1 and second extraction columns 2 that can be assembled. In use, the corresponding number of first extraction columns 1 and second extraction columns 2 can be pre-assembled, and then the liquid is input from the uppermost first female connector 12 or second female connector 22, and finally collected from the lowermost first male connector 11 or second male connector 21.

[0075] This embodiment connects the first extraction column 1 and the second extraction column 2 in a nested manner. At the same time, a first sealing ring 3 is provided inside the first female head 12 and a second sealing ring 4 is provided inside the second female head 22 to ensure the airtightness of the nested joint. It can complete the multiple processes of sample loading, transfer and column passage required by existing solid phase extraction products in a single column passage process, which improves the efficiency of solid phase extraction operation, saves pretreatment time, reduces the loss of target components, improves experimental efficiency and the qualitative and quantitative accuracy of target components, and is convenient to use.

[0076] Please see Figure 3 In some embodiments, the first male connector 11 further includes a first extension edge 113, which is disposed at the first output terminal 111; the second female connector 22 further includes a second extension edge 223, which is disposed inside the second pillar 23; in the first splicing state, the first extension edge 113 and the second extension edge 223 are engaged; the second male connector 21 further includes a third extension edge 213, which is disposed at the second output terminal 211; the first female connector 12 further includes a fourth extension edge 123, which is disposed inside the first pillar 13; in the second splicing state, the third extension edge 213 and the fourth extension edge 123 are engaged.

[0077] In this embodiment, the first extension edge 113 is disposed on the periphery of the first output end 111; the second extension edge 223 is disposed on the inner side of the second column 23. Thus, the first extension edge 113 and the second extension edge 223 can achieve the engaging connection between the first extraction column 1 and the second extraction column 2 in the first splicing state, thereby improving the splicing stability of the first extraction column 1 and the second extraction column 2.

[0078] Correspondingly, such as Figure 3 As shown, the third extension edge 213 is located on the periphery of the second output end 211, and the fourth extension edge 123 is located on the inner side of the first column 13. Thus, the third extension edge 213 and the fourth extension edge 123 can achieve the engaging connection between the first extraction column 1 and the second extraction column 2 in the second splicing state, thereby improving the splicing stability of the first extraction column 1 and the second extraction column 2.

[0079] For further details, please refer to Figure 3 and Figure 4 In some embodiments, there are multiple first extension edges 113, which are distributed circumferentially along the first output end 111, and the gap between two adjacent first extension edges 113 is greater than the width of a single second extension edge 223; there are multiple second extension edges 223, which are distributed circumferentially along the inner side of the second column 23, and the gap between two adjacent second extension edges 223 is greater than the width of a single first extension edge 113; and / or, there are multiple third extension edges 213, which are distributed circumferentially along the second output end, and the gap between two adjacent third extension edges 213 is greater than the width of a single fourth extension edge 123; there are multiple fourth extension edges 123, which are distributed circumferentially along the inner side of the first column 13, and the gap between two adjacent fourth extension edges 123 is greater than the width of a single third extension edge 213.

[0080] The engagement method between the first extended edge 113 and the second extended edge 223 can be understood by referring to the engagement method between the third extended edge 213 and the fourth extended edge 123. Figure 3 and Figure 4 When there are multiple third extension edges 213, there is a gap between two adjacent third extension edges 213; when there are multiple fourth extension edges 123, there is a gap between two adjacent fourth extension edges 123. During the assembly process, the second extraction column 2 can be rotated at an angle so that the third extension edge 213 enters below the fourth extension edge 123 through the gap. Then, the second extraction column 2 is rotated in the opposite direction so that the third extension edge 213 and the fourth extension edge 123 are aligned as follows: Figure 3 The engagement shown improves the stability of the connection between the first extraction column 1 and the second extraction column 2, and also makes it easier for the third extension edge 213 and the fourth extension edge 123 to abut, thus making it easier to assemble and disassemble the first extraction column 1 and the second extraction column 2.

[0081] Please see Figure 3 In some embodiments, the edges of the first extension edge 113 and / or the second extension edge 223 and / or the third extension edge 213 and / or the fourth extension edge 123 are arc-shaped. This facilitates the guidance of the first extension edge 113 and the second extension edge 223 during the assembly process, as well as the guidance of the third extension edge 213 and the fourth extension edge 123 during the assembly process, making the first extraction column 1 and the second extraction column 2 easy to assemble and disassemble.

[0082] Please see Figure 3In some embodiments, the first male head 11 further includes a third extension edge 114, which is disposed above the first flange 112. In the first splicing state, the projection of the third extension edge 114 and the second extension edge 221 in the vertical direction coincides. The second male head 21 also includes a fourth extension edge 214, which is disposed above the second flange 212. In the second splicing state, the projection of the fourth extension edge 214 and the first extension edge 121 in the vertical direction coincides. This method facilitates the user in positioning the splicing state of the first extraction column 1 and the second extraction column 2. In particular, when the aforementioned first extension edge 113 and second extension edge 223 are rotated and spliced, the arrangement of the third extension edge 114 and the fourth extension edge 214 facilitates the adjustment and verification of the rotation angle of the first extraction column 1 and the second extraction column 2.

[0083] For further details, please refer to Figure 3 and Figure 5 In some embodiments, the first extension edge 121 has a first protrusion 124 on the side facing the first column 13, the second extension edge 221 has a second protrusion 224 on the side facing the second column 23, the third extension edge 114 has a third protrusion 115 on the side facing the first column 13, and the fourth extension edge 214 has a fourth protrusion 215 on the side facing the second column 23. The series-connected solid-phase extraction column also includes a first fastener 5 and a second fastener 6. The first fastener 5 has a U-shaped structure. In the first splicing state, the first fastener 5 is fastened to the third protrusion 115 and the second protrusion 224. The second fastener 6 has a U-shaped structure. In the second splicing state, the second fastener 6 is fastened to the fourth protrusion 215 and the first protrusion 124.

[0084] In this embodiment, a first protrusion 124 is provided on the first extension edge 121. Optionally, there are two first protrusions 124, which are arranged opposite to each other on both sides of the first extension edge 121. Correspondingly, a second protrusion 224 is provided on the second extension edge 221, and a third protrusion 115 is provided on the third extension edge 114, such as... Figure 4 As shown, the fourth protrusion 215 is disposed on the fourth extension edge 214. The positional distribution of the second protrusion 224, the third protrusion 115 and the fourth protrusion 215 can be understood with reference to the positional distribution of the first protrusion 124.

[0085] This embodiment also includes a first fastener 5 and a second fastener 6. The first fastener 5 and the second fastener 6 have a certain elastic deformation capability. The first fastener 5 can be fastened to the third protrusion 115 and the second protrusion 224 in the first splicing state, and the second fastener 6 can be fastened to the first protrusion 124 and the fourth protrusion 215 in the second splicing state.

[0086] Optional, Figure 5The diagram illustrates a splicing configuration of a first fastener 5 with a second protruding strip 224 and a third protruding strip 115. The second protruding strip 224 has a second guide slope, and the third protruding strip 115 has a third guide slope. The second and third guide slopes are arranged on the same side. Therefore, the first fastener 5 can be spliced ​​according to… Figure 5 The component is cut laterally in the direction shown and finally snapped onto the outside of the second protrusion 224 and the third protrusion 115. This method can reduce the difficulty of disassembling and assembling the first fastener 5 and make the whole splicing process more convenient.

[0087] In this embodiment, by setting the first fastener 5 and the second fastener 6, the splicing stability of the first extraction column 1 and the second extraction column 2 can be increased, and the sealing performance at the splicing point of the first extraction column 1 and the second extraction column 2 can be improved.

[0088] In some embodiments, the sealing assembly further includes a third sealing ring and a fourth sealing ring, wherein the third sealing ring is disposed inside the first fastener 5; and the fourth sealing ring is disposed inside the second fastener 6. The third and fourth sealing rings can further improve the sealing performance at the joint between the first extraction column 1 and the second extraction column 2. Optionally, the third and fourth sealing rings are detachable, allowing them to be sterilized to maintain the cleanliness of the joint between the first extraction column 1 and the second extraction column 2.

[0089] In some embodiments, the outer periphery of the first column 13 and / or the outer periphery of the second column 23 are provided with anti-slip textures. These textures facilitate user gripping of the first column 13 and the second column 23, and facilitate the assembly and disassembly of the first extraction column 1 and the second extraction column 2. It is understood that the anti-slip textures may not completely cover the outer surfaces of the first column 13 and the second column 23, and may avoid scale lines or observation areas, to facilitate the use of the first extraction column 1 and the second extraction column 2.

[0090] In some embodiments, the outer surface of the first column 13 and / or the outer surface of the second column 23 are provided with scale lines. Optionally, the scale lines can be coated with a fluorescent material on the outer surface of the first column 13 and the second column 23 to avoid affecting the internal liquid. The fluorescent material can improve the visibility of the scale lines in dim light.

[0091] In some embodiments, the first extraction column 1 and / or the second extraction column 2 are made of polystyrene or a polymer matrix material. Polystyrene and polymer matrices have better chemical compatibility and are suitable for processing polar or heat-sensitive samples. Different materials can be selected according to actual needs, and this embodiment does not impose any limitations on this.

[0092] In the above technical solution, the tandem combined solid-phase extraction column includes a first extraction column 1, a second extraction column 2, and a sealing assembly. The first extraction column 1 includes a first male head 11, a first column body 13, and a first female head 12. The second extraction column 2 includes a second male head 21, a second column body 23, and a second female head 22. The first extraction column 1 and the second extraction column 2 have a first splicing state and a second splicing state. In the first splicing state, the first extraction column 1 and the second extraction column 2 are arranged from top to bottom, and the first male head 11 and the second female head 22 are sealed together, which facilitates multiple solid-phase extractions. In the second splicing state, the second extraction column 2 and the first extraction column 1 are arranged from top to bottom, and the second male head 21 and the first female head 12 are sealed together, which also facilitates multiple solid-phase extractions. This technical solution connects the first extraction column 1 and the second extraction column 2 through a mating method. At the same time, a first sealing ring 3 is provided inside the first female head 12 and a second sealing ring 4 is provided inside the second female head 22 to ensure the airtightness of the mating point. It can complete the multiple processes of sample loading, transfer and column passage required by existing solid phase extraction products in a single column passage process, which improves the efficiency of solid phase extraction operation, saves pretreatment time, reduces the loss of target components, improves experimental efficiency and the accuracy of qualitative and quantitative analysis of target components, and is convenient to use.

[0093] Finally, it should be noted that although the above embodiments have been described in the text and drawings of this utility model, this should not limit the scope of patent protection of this utility model. Any technical solutions resulting from equivalent structural or procedural substitutions or modifications made based on the essential concept of this utility model and utilizing the content described in the text and drawings of this utility model, as well as the direct or indirect application of the technical solutions of the above embodiments to other related technical fields, are all included within the scope of patent protection of this utility model.

Claims

1. A series-connected solid-phase extraction column, characterized in that, include: The first extraction column includes a first male head, a first column body, and a first female head. The first male head and the first female head are disposed at both ends of the first column body. The first male head includes a first output end and a first flange. The first flange is disposed at the connection between the first column body and the first output end. The first female head includes a first extension edge and a first groove. The first extension edge and the first groove are coaxially disposed. The second extraction column includes a second male head, a second column body, and a second female head. The second male head and the second female head are disposed at both ends of the second column body. The second male head includes a second output end and a second flange. The second flange is disposed at the connection between the second column body and the second output end. The second female head includes a second extension edge and a second groove. The second extension edge and the second groove are coaxially disposed. A sealing assembly includes a first sealing ring and a second sealing ring, wherein the first sealing ring is disposed in the first groove and the second sealing ring is disposed in the second groove; The first extraction column and the second extraction column can be placed in a first splicing state. In the first splicing state, the first extraction column and the second extraction column are arranged sequentially from top to bottom. The first flange is placed in the second groove, and the second sealing ring is sleeved on the outside of the first flange. The first output end is placed in the second column, and the first column and the second column are connected through the first output end. The first extraction column and the second extraction column can be placed in a second splicing state. In the second splicing state, the second extraction column and the first extraction column are arranged sequentially from top to bottom. The second flange is placed in the first groove, and the first sealing ring is sleeved on the outside of the second flange. The second output end is placed in the first column body, and the second column body and the first column body are connected through the second output end.

2. The tandem combined solid-phase extraction column according to claim 1, characterized in that, The first male head also includes: The first extension edge is disposed at the first output terminal; The second female head also includes: The second extension edge is disposed inside the second column body; In the first splicing state, the first extended edge and the second extended edge are engaged; The second male head also includes: The third extension edge is located at the second output terminal; The first female head also includes: The fourth extension edge is disposed inside the first column body; In the second splicing state, the third extension edge engages with the fourth extension edge.

3. The tandem combined solid-phase extraction column according to claim 2, characterized in that, The number of first extension edges is multiple, and they are distributed circumferentially along the first output end. The gap between two adjacent first extension edges is greater than the width of a single second extension edge. There are multiple second extension edges, which are distributed circumferentially along the inner side of the second column, and the gap between two adjacent second extension edges is greater than the width of a single first extension edge; And / or, the number of the third extension edges is multiple, distributed circumferentially along the second output end, and the gap between two adjacent third extension edges is greater than the width of a single fourth extension edge; There are multiple fourth extension edges, which are distributed circumferentially along the inner side of the first column, and the gap between two adjacent fourth extension edges is greater than the width of a single third extension edge.

4. The tandem combined solid-phase extraction column according to claim 2 or 3, characterized in that, The edges of the first extended edge and / or the second extended edge and / or the third extended edge and / or the fourth extended edge are arc-shaped.

5. The tandem combined solid-phase extraction column according to claim 1, characterized in that, The first male head also includes: The third extension edge is disposed above the first flange. In the first splicing state, the projection of the third extension edge and the second extension edge in the vertical direction coincide. The second male head also includes: The fourth extension edge is disposed above the second flange. In the second splicing state, the projection of the fourth extension edge and the first extension edge in the vertical direction coincide.

6. The tandem combined solid-phase extraction column according to claim 5, characterized in that, The first extension edge has a first protrusion on the side facing the first column, the second extension edge has a second protrusion on the side facing the second column, the third extension edge has a third protrusion on the side facing the first column, and the fourth extension edge has a fourth protrusion on the side facing the second column. The tandem solid-phase extraction column further includes: The first fastener has a U-shaped structure and, in the first splicing state, the first fastener is fastened to the third protrusion and the second protrusion; The second fastener has a U-shaped structure. In the second splicing state, the second fastener is fastened to the fourth protrusion and the first protrusion.

7. The tandem combined solid-phase extraction column according to claim 6, characterized in that, The sealing assembly further includes: The third sealing ring is disposed inside the first fastener; The fourth sealing ring is located inside the second fastener.

8. The tandem combined solid-phase extraction column according to claim 1, characterized in that, The outer periphery of the first column and / or the outer periphery of the second column are provided with anti-slip textures.

9. The tandem combined solid-phase extraction column according to claim 1, characterized in that, The outer surface of the first column and / or the outer surface of the second column are provided with scale lines.

10. The tandem combined solid-phase extraction column according to claim 1, characterized in that, The first extraction column and / or the second extraction column are made of polystyrene or a polymer matrix material.

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