Synthesis system for trihydroxymethyl glycine
The synthesis system, consisting of a premixing reactor, a microchannel reactor, and a crystallization reactor, solved the problem of continuous production in the synthesis of tris(hydroxymethyl)glycine, thereby improving production efficiency.
Patent Information
- Application Number
- CN202422079364.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-27
- Publication Date
- 2025-10-31
- Estimated Expiration
- 2034-08-27
AI Technical Summary
The existing synthesis process for tris(hydroxymethyl)glycine cannot achieve continuous production, resulting in insufficient production efficiency.
A synthesis system comprising a premixing vessel, a microchannel reactor, and a crystallization vessel is employed. Chloroacetic acid and tris(hydroxymethyl)aminomethane solutions are fed into the premixing vessel through feed pipes and reacted in the microchannel reactor. Subsequently, the mixture is cooled and crystallized in the crystallization vessel, and the product and waste liquid are separated by a filter.
This enabled the continuous production of tris(hydroxymethyl)glycine, improving production efficiency.
Smart Images
Figure CN223490939U_ABST
Abstract
Description
Technical Field
[0001] This utility model belongs to the field of trihydroxymethylglycine production technology, specifically relating to a synthesis system for trihydroxymethylglycine. Background Technology
[0002] Trimethylolglycine (Tricine) is an excellent zwitterionic buffer (also known as a Good's buffer). Compared with single acid-base buffers, it is less irritating to the human body, has a milder effect, a wider buffering range, no obvious toxic side effects, and has a wide range of applications.
[0003] Tricine has good buffering properties and can be used in alkaline cosmetics and detergents such as shampoos, perms, hair dyes, conditioning agents, soaps, and hair creams. It also has good stability and remains very stable in solutions with a pH of 3 to 12, so it can be used in strongly alkaline cosmetics and detergents.
[0004] Tricine also has antibacterial effects, effectively inhibiting the growth of Gram-positive bacteria, Gram-negative bacteria, yeasts, and molds. Therefore, it is often used as a pH stabilizer in vaccine culture media.
[0005] Therefore, as a product with high added value and broad application prospects, developing its synthetic route and production process is of great theoretical and practical significance.
[0006] Numerous studies have reported on the synthesis of tris(hydroxymethyl)glycine, with the most commonly used synthetic route currently involving the reaction of tris(hydroxymethyl)aminomethane with chloroacetic acid to obtain the target product. However, this synthesis is mostly carried out using batch reactors, which cannot achieve continuous production and suffers from disadvantages such as insufficient production efficiency. Therefore, developing a continuous production process is of great significance. Utility Model Content
[0007] To address the problems of continuous production and insufficient production efficiency in existing technologies, this invention provides a synthesis system for tris(hydroxymethyl)glycine. Chloroacetic acid and tris(hydroxymethyl)aminomethane solution are fed into a premixing vessel through a first feed pipe and a second feed pipe, respectively. The mixture is stirred and kept warm at 35-40°C to obtain a mixed solution. The mixed solution flows into a microchannel reactor, where the microchannel reaction temperature is set to 110-130°C and the reaction residence time is 20-30 minutes. Subsequently, the mixture flows into a crystallization vessel, where it is cooled and crystallized to obtain a final mixture. The mixture is then filtered to obtain the product (tris(hydroxymethyl)glycine) and waste liquid.
[0008] The objective of this utility model is achieved through the following technical solution:
[0009] A synthesis system for tris(hydroxymethyl)glycine includes a premixing vessel, a microchannel reactor, and a crystallization vessel connected in sequence. The premixing vessel is equipped with a first feed pipe, a second feed pipe, and a heating jacket. The crystallization vessel is equipped with a cooling jacket and a discharge pipe. The discharge pipe is equipped with a filter, which is connected to a product pipe and a waste liquid pipe.
[0010] Preferably, the microchannel reactor includes a reaction module and a cooling module connected in sequence.
[0011] Preferably, the premixing vessel and the microchannel reactor are connected by a first connecting pipe.
[0012] Preferably, a delivery pump is provided on the first connecting pipe.
[0013] Preferably, the microchannel reactor and the crystallization vessel are connected by a second connecting pipe.
[0014] Preferably, a first shut-off valve is provided on the first connecting pipe; and a second shut-off valve is provided on the second connecting pipe.
[0015] Preferably, a third shut-off valve is provided on the discharge pipe.
[0016] Preferably, both the premixing vessel and the crystallizing vessel are equipped with thermometers.
[0017] Preferably, the heating jacket is provided with a heating inlet pipe and a heating outlet pipe; the cooling jacket is provided with a cooling inlet pipe and a cooling outlet pipe.
[0018] Preferably, a first temperature regulating valve is provided on the heating inlet pipe, and a second temperature regulating valve is provided on the cooling inlet pipe.
[0019] The beneficial effects of this technical solution are as follows:
[0020] I. This utility model provides a synthesis system for tris(hydroxymethyl)glycine. Chloroacetic acid and tris(hydroxymethyl)aminomethane solution are fed into a premixing vessel through a first feed pipe and a second feed pipe, respectively. The mixture is stirred and kept at 35-40°C to obtain a mixed solution. The mixed solution flows into a microchannel reactor, where the microchannel reaction temperature is set to 110-130°C and the reaction residence time is 20-30 minutes. Subsequently, it flows into a crystallization vessel, where it is cooled and crystallized to obtain a mixture. The mixture is then filtered to obtain the product (tris(hydroxymethyl)glycine) and waste liquid. This utility model enables continuous production with high efficiency.
[0021] II. The present invention provides a synthesis system for trihydroxymethylglycine, wherein the setting of the first and second shut-off valves can ensure the reaction time of the microchannel reactor and improve the reaction rate.
[0022] III. The present invention provides a synthesis system for tris(hydroxymethyl)glycine, which includes a thermometer, a first temperature regulating valve, and a second temperature regulating valve, enabling rapid and effective temperature regulation within the premixing vessel and the crystallizing vessel. Attached Figure Description
[0023] Figure 1 This is a schematic diagram of the structure of this utility model;
[0024] Figure 2 This is a schematic diagram of the internal structure of the reaction module in the microchannel reactor of this utility model;
[0025] The components are as follows: 1. Premixing vessel; 2. Microchannel reactor; 21. Reaction module; 22. Cooling module; 3. Crystallization vessel; 4. First feed pipe; 5. Second feed pipe; 6. Heating jacket; 61. Heating inlet pipe; 62. Heating outlet pipe; 63. First temperature regulating valve; 7. Cooling jacket; 71. Cooling inlet pipe; 72. Cooling outlet pipe; 73. Second temperature regulating valve; 8. Discharge pipe; 9. Filter; 10. Product pipe; 11. Waste liquid pipe; 12. First connecting pipe; 13. Transfer pump; 14. Second connecting pipe; 15. First shut-off valve; 16. Second shut-off valve; 17. Third shut-off valve; 18. Thermometer. Detailed Implementation
[0026] The present invention will be further described in detail below with reference to the embodiments, but the implementation of the present invention is not limited thereto.
[0027] Example 1
[0028] like Figure 1 As shown, a synthesis system for tris(hydroxymethyl)glycine includes a premixing vessel 1, a microchannel reactor 2, and a crystallization vessel 3 connected in sequence. The premixing vessel 1 is equipped with a first feed pipe 4, a second feed pipe 5, and a heating jacket 6. The crystallization vessel 3 is equipped with a cooling jacket 7 and a discharge pipe 8. A filter 9 is installed on the discharge pipe 8, and the filter 9 is connected to a product pipe 10 and a waste liquid pipe 11. Both the premixing vessel 1 and the crystallization vessel 3 are equipped with stirring devices, which are existing technologies and will not be described in detail here. The filter 9 uses a centrifugal device for filtration, and the centrifugal drying process can be completed within the same equipment. The product pipe 10 and the waste liquid pipe 11 are connected to the product tank and the waste liquid tank, respectively.
[0029] Example 2
[0030] The difference between this embodiment and Embodiment 1 is that, as Figure 2As shown, the microchannel reactor 2 includes a reaction module 21 and a cooling module 22 connected in sequence. The microchannel reactor 2 is a Corning G1 silicon carbide reactor manufactured by Corning (Shanghai) Management Co., Ltd.; the reaction module 21 is a silicon carbide reactor module, and the cooling module 22 is an aluminum alloy heat exchange module.
[0031] The premixing vessel 1 and the microchannel reactor 2 are connected by a first connecting pipe 12.
[0032] The first connecting pipe 12 is equipped with a delivery pump 13.
[0033] The microchannel reactor 2 and the crystallization vessel 3 are connected by a second connecting pipe 14.
[0034] The first connecting pipe 12 is provided with a first shut-off valve 15; the second connecting pipe 14 is provided with a second shut-off valve 16.
[0035] The discharge pipe 8 is equipped with a third shut-off valve 17.
[0036] The thermometer 18 is installed on both the premixing vessel 1 and the crystallizing vessel 3.
[0037] The heating jacket 6 is provided with a heating inlet pipe 61 and a heating outlet pipe 62; the cooling jacket 7 is provided with a cooling inlet pipe 71 and a cooling outlet pipe 72.
[0038] The heating inlet pipe 61 is provided with a first temperature regulating valve 63, and the cooling inlet pipe 71 is provided with a second temperature regulating valve 73.
[0039] The beneficial effects of this technical solution are as follows:
[0040] I. This utility model provides a synthesis system for tris(hydroxymethyl)glycine. Chloroacetic acid and tris(hydroxymethyl)aminomethane solution are fed into a premixing vessel 1 through a first feed pipe 4 and a second feed pipe 5, respectively. The mixture is stirred and kept at 35-40°C to obtain a mixed solution. The mixed solution flows into a microchannel reactor 2 (equipped with a dedicated temperature control system capable of relatively precise temperature control within ±3°C). The microchannel reaction temperature is set to 110-130°C, and the reaction residence time is 20-30 minutes. Subsequently, the mixture flows into a crystallization vessel 3, where it is cooled and crystallized to obtain a final mixture (cooled to 10-20°C). The mixture is then filtered through a filter 9 to obtain the product (tris(hydroxymethyl)glycine) and waste liquid. This utility model enables continuous production with high efficiency.
[0041] II. The present invention provides a synthesis system for tris(hydroxymethyl)glycine, wherein the setting of the first shut-off valve 15 and the second shut-off valve 16 can ensure the reaction time of the microchannel reactor 2 and improve the reaction rate.
[0042] III. The present invention provides a synthesis system for tris(hydroxymethyl)glycine, which includes a thermometer 18, a first temperature regulating valve 63, and a second temperature regulating valve 73, enabling rapid and effective temperature regulation within the premixing vessel 1 and the crystallizing vessel 3.
[0043] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any way. Any simple modifications or equivalent changes made to the above embodiments based on the technical essence of the present utility model shall fall within the protection scope of the present utility model.
Claims
1. A synthesis system for tris(hydroxymethyl)glycine, characterized in that: The reactor includes a premixing vessel (1), a microchannel reactor (2), and a crystallizing vessel (3) connected in sequence. The premixing vessel (1) is equipped with a first feed pipe (4), a second feed pipe (5), and a heating jacket (6). The crystallizing vessel (3) is equipped with a cooling jacket (7) and a discharge pipe (8). The discharge pipe (8) is equipped with a filter (9), which is connected to a product pipe (10) and a waste liquid pipe (11).
2. The synthesis system for tris(hydroxymethyl)glycine according to claim 1, characterized in that: The microchannel reactor (2) includes a reaction module (21) and a cooling module (22) connected in sequence.
3. The synthesis system for tris(hydroxymethyl)glycine according to claim 1, characterized in that: The premixing vessel (1) and the microchannel reactor (2) are connected by a first connecting pipe (12).
4. The synthesis system for tris(hydroxymethyl)glycine according to claim 3, characterized in that: A delivery pump (13) is installed on the first connecting pipe (12).
5. The synthesis system for tris(hydroxymethyl)glycine according to claim 4, characterized in that: The microchannel reactor (2) and the crystallizing vessel (3) are connected by a second connecting pipe (14).
6. The synthesis system for tris(hydroxymethyl)glycine according to claim 5, characterized in that: A first shut-off valve (15) is provided on the first connecting pipe (12); a second shut-off valve (16) is provided on the second connecting pipe (14).
7. The synthesis system for tris(hydroxymethyl)glycine according to claim 6, characterized in that: A third shut-off valve (17) is provided on the discharge pipe (8).
8. The synthesis system for tris(hydroxymethyl)glycine according to claim 1, characterized in that: The thermometer (18) is installed on both the premixing vessel (1) and the crystallizing vessel (3).
9. The synthesis system for tris(hydroxymethyl)glycine according to claim 8, characterized in that: The heating jacket (6) is provided with a heating inlet pipe (61) and a heating outlet pipe (62); the cooling jacket (7) is provided with a cooling inlet pipe (71) and a cooling outlet pipe (72).
10. The synthesis system for tris(hydroxymethyl)glycine according to claim 9, characterized in that: A first temperature regulating valve (63) is provided on the heating inlet pipe (61), and a second temperature regulating valve (73) is provided on the cooling inlet pipe (71).