Constant-temperature box for liquid chromatographic column

Abstract

The utility model discloses a liquid chromatographic column thermotank, which relates to the technical field of liquid chromatographic column thermotanks and comprises a heating cabin and a constant temperature cabin which are hermetically connected, a heating component is mounted in the heating cabin, a second inner cabin is welded in the constant temperature cabin, the second inner cabin and an outer shell of the heating cabin form an interlayer, and a liquid circulating component is arranged in the interlayer. The liquid circulation component penetrates through the constant-temperature cabin and is connected with the heating component through a first circulation input port and a first circulation output port, the heating component further comprises a wind heat output port, the wind heat output port penetrates through the constant-temperature cabin and the second inner cabin, and a supporting component is installed on the side wall of the second inner cabin and used for clamping a liquid chromatographic column. The heating component utilizes wind heat and water heat coupling constant-temperature heating, so that the constant temperature in the second inner cabin is kept, the temperature inconsistency of all positions in the space of the second inner cabin is avoided, the stable constant-temperature environment of the liquid chromatographic column is realized, the stable environment for a certain period of time can be ensured even if a fault occurs, and the working efficiency is improved. The long-time temperature loss of the liquid chromatographic column is avoided.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography column constant temperature oven technology, and more specifically to a liquid chromatography column constant temperature oven. Background Technology

[0002] A liquid chromatography column is an instrument used for liquid chromatography analysis. The column oven, a core module of the high-performance liquid chromatograph (HPLC), provides an ideal constant temperature environment for the adsorption-desorption partitioning process. In existing technologies, an HPLC column system consists of several parts, including a reservoir, pump, injector, column, detector, and workstation. The mobile phase in the reservoir is pumped into the system by a high-pressure pump. The sample solution enters the mobile phase through the injector and is carried into the column (stationary phase). Because the components in the sample solution have different partition coefficients in the two phases, during relative motion, through repeated adsorption-desorption partitioning processes, the components develop significant differences in migration speed and are separated into individual components that elute sequentially from the column. Upon passing through the detector, the sample concentration is converted into an electrical signal and transmitted to the workstation, where the data is displayed in chromatographic form.

[0003] Existing liquid chromatography column ovens all use resistance or Peltier heating, which results in poor internal heat circulation. This leads to uneven heat distribution and slow temperature equilibration. Furthermore, when the resistance or Peltier fails, the temperature inside the column oven changes rapidly, indicating poor fault resistance.

[0004] Therefore, how to propose a liquid chromatography column constant temperature oven to achieve a stable constant temperature environment for the liquid chromatography column, and to ensure environmental stability for a certain period of time even in the event of a malfunction, thus avoiding prolonged temperature loss of the liquid chromatography column, is a problem that urgently needs to be solved by those skilled in the art. Utility Model Content

[0005] In view of this, the present invention provides a liquid chromatography column constant temperature oven to achieve a stable constant temperature environment for the liquid chromatography column. Even in the event of a malfunction, the environment can be kept stable for a certain period of time, avoiding prolonged temperature loss of the liquid chromatography column. To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A liquid chromatography column oven includes a door and a body, the door and body being sealed together. The body includes a heating chamber and a constant temperature chamber, which are sealed together. A heating element is installed in the heating chamber. A second inner chamber is welded inside the constant temperature chamber. The second inner chamber and the outer shell of the heating chamber form a sandwich structure. A liquid circulation element is installed within the sandwich structure. The liquid circulation element passes through the constant temperature chamber and is connected to the heating element through a first circulation inlet and a first circulation outlet. The heating element also includes a hot air outlet, which passes through the constant temperature chamber and the second inner chamber. A support element is installed on the side wall of the second inner chamber for clamping the liquid chromatography column.

[0007] Optionally, the liquid circulation component includes a first water-cooled circulation pipe, a second water-cooled circulation pipe, and a third water-cooled circulation pipe connected in sequence. The first, second, and third water-cooled circulation pipes are all installed in the interlayer. The second water-cooled circulation pipe passes through the constant temperature chamber and is connected to the heating component through the first circulation inlet. The third water-cooled circulation pipe passes through the constant temperature chamber and is connected to the heating component through the first circulation outlet.

[0008] Optionally, the number of heating components is two, and the two heating components are connected to each other through a second circulation output port, a transmission pipe, and a second circulation input port.

[0009] Optionally, the heating component has a built-in heating pump, the output end of which is connected to a second circulation input port and the input end of which is connected to a first circulation input port. On the other side, the output end of the heating pump is connected to a second circulation output port and the input end of which is connected to the first circulation output port. The heating component also has a built-in exhaust fan, which is connected to the heat output port.

[0010] Optionally, the support component includes a support rod, a mounting bracket, and a fixing component. Multiple fixing components are sleeved and fixed on the support rod, and multiple mounting brackets are symmetrically installed on the side wall of the second inner compartment. The support rod is adapted to the symmetrically installed mounting brackets.

[0011] Optionally, the card holder includes a first base and a snap-fit ​​component. The first base is fixedly connected to the snap-fit ​​component. The first base is installed on the side wall of the second inner compartment. The snap-fit ​​component has a groove inside. The size of the groove is adapted to the size of the support rod. The opening of the groove faces upward.

[0012] Optionally, it also includes: the fixing component is adapted to install a liquid chromatography column holder, the liquid chromatography column holder is provided with a slider at the bottom, the fixing component is provided with a circumferential groove, the groove is adapted to the slider, and multiple liquid chromatography column holders are fixedly connected to the fixing component through the slider; the liquid chromatography column holder includes a main body and a cover, the main body has an opening, one end of the cover is rotatably connected to one end of the opening, and the other end of the cover is snapped into the other end of the opening.

[0013] Optionally, a buffer layer is provided on the inner wall of the main body. The buffer layer is a flexible insulating material. The curvature of the inner wall of the cover is the same as that of the inner wall of the main body. The buffer layer is provided on the inner wall of the cover.

[0014] Optionally, the side of the cover that engages with the main body is provided with a groove, and the side of the main body that engages with the cover is provided with a protrusion that matches the groove of the cover. When the cover and the main body are closed, the protrusion of the main body engages with the groove of the cover.

[0015] Optionally, a temperature sensor is included, which is mounted on the side wall of the second interior compartment for detecting the temperature inside the second interior compartment.

[0016] As can be seen from the above technical solution, compared with the prior art, the present invention discloses a liquid chromatography column constant temperature oven, which has the following beneficial effects:

[0017] This invention discloses a liquid chromatography column constant temperature chamber, comprising: a door and a chamber body, the door and the chamber body being sealed together. The chamber body includes a heating chamber and a constant temperature chamber, which are sealed together. A heating component is installed in the heating chamber. A second inner chamber is welded inside the constant temperature chamber. The second inner chamber and the outer shell of the heating chamber form a sandwich structure. A liquid circulation component is installed within the sandwich structure. The liquid circulation component penetrates the constant temperature chamber and is connected to the heating component through a first circulation inlet and a first circulation outlet. The heating component also includes a hot air outlet, which penetrates the constant temperature chamber and the second inner chamber. A support component is installed on the side wall of the second inner chamber for clamping the liquid chromatography column. This invention achieves constant temperature heating through a combination of hot air and hot water heating, maintaining a constant temperature environment within the second inner chamber. It also avoids temperature inconsistencies in different locations within the second inner chamber, achieving a stable constant temperature environment for the liquid chromatography column. Even in the event of a malfunction, it can ensure environmental stability for a certain period, preventing prolonged temperature loss of the liquid chromatography column. Meanwhile, a support component is installed on the side wall of the second inner chamber. The support component includes a support rod, a bracket, and a fixing component. Multiple fixing components are sleeved and fixed on the support rod. Multiple brackets are symmetrically installed on the side wall of the second inner chamber. The support rod is adapted to the symmetrically installed brackets. The bracket includes a first base and a snap-fit ​​component. The first base is fixedly connected to the snap-fit ​​component. The first base is installed on the side wall of the second inner chamber. The snap-fit ​​component has a groove. The size of the groove is adapted to the size of the support rod. The groove opening faces upward. It can simultaneously clamp multiple or multiple sets of liquid chromatography columns, which can be taken out and used immediately, and is easy to operate. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0019] Figure 1 A schematic diagram of a liquid chromatography column constant temperature oven provided by this utility model.

[0020] Figure 2 A schematic diagram of a liquid chromatography column constant temperature oven provided by this utility model.

[0021] Figure 3 A schematic diagram of the card holder structure provided by this utility model.

[0022] Figure 4 A schematic diagram of the fixing component and the liquid chromatography column fixing connection structure provided by this utility model.

[0023] Figure 5 A schematic diagram of the fixing component structure provided by this utility model.

[0024] Figure 6 A schematic diagram of the liquid chromatography column holder structure provided by this utility model.

[0025] Among them, 1-door, 2-heating chamber, 3-constant temperature chamber, 4-first water-cooled circulation pipe, 5-second water-cooled circulation pipe, 6-third water-cooled circulation pipe, 7-first circulation inlet, 8-first circulation outlet, 9-second circulation outlet, 10-second circulation inlet, 11-heating component, 12-exhaust fan, 13-second inner chamber, 14-support rod, 15-fixing component, 16-card seat, 16-1-first base, 16-2-clamping component, 17-1-main body, 17-2-slider, 17-3-buffer layer, 17-4-groove, 17-5-protrusion, 17-6-cover. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] This utility model discloses a liquid chromatography column constant temperature oven, such as... Figure 1As shown, the system includes: a door 1 and a housing, the door 1 and the housing being sealed together. The housing includes a heating chamber 2 and a constant temperature chamber 3, which are sealed together. A heating component 11 is installed in the heating chamber 2. A second inner chamber 13 is welded inside the constant temperature chamber 3. The second inner chamber 13 and the outer shell of the heating chamber 2 form a sandwich. A liquid circulation component is installed in the sandwich. The liquid circulation component passes through the constant temperature chamber 3 and is connected to the heating component 11 through a first circulation inlet 7 and a first circulation outlet 8, respectively. The heating component 11 also includes a hot air outlet, which passes through the constant temperature chamber 3 and the second inner chamber 13. A support component is installed on the side wall of the second inner chamber 13 for clamping the liquid chromatography column.

[0028] Furthermore, the liquid circulation component includes a first water-cooled circulation pipe 4, a second water-cooled circulation pipe 5, and a third water-cooled circulation pipe 6 connected in sequence. All three pipes are installed within the interlayer. The second water-cooled circulation pipe 5 penetrates the constant temperature chamber 3 and connects to the heating component 11 via a first circulation inlet 7. The third water-cooled circulation pipe 6 penetrates the constant temperature chamber 3 and connects to the heating component 11 via a first circulation outlet 8. The circulating liquid in the liquid circulation component is a high-quality heat-conducting liquid medium.

[0029] In a specific implementation, it also includes a liquid inlet and a liquid outlet, both of which are connected to a heating pump for replacing and discharging the circulating liquid.

[0030] Furthermore, there are two heating elements 11, which are connected to each other via a second circulation output port 9, a transmission pipe, and a second circulation input port 10.

[0031] Furthermore, the heating component 11 has a built-in heating pump, the output end of which is connected to the second circulation input port 10 and the input end of which is connected to the first circulation input port 7. On the other side, the output end of the heating pump is connected to the second circulation output port 9 and the input end of which is connected to the first circulation output port 8. The heating component 11 also has a built-in heat exhaust fan 12, which is connected to the heat exhaust port.

[0032] Furthermore, the supporting component includes a support rod 14, a mounting base 16, and a fixing component 15. Multiple fixing components 15 are sleeved and fixed onto the support rod 14, and multiple mounting bases 16 are symmetrically installed on the side wall of the second inner compartment 13. The support rod 14 is adapted to the symmetrically installed mounting bases 16. The fixing component 15 is a cylindrical structure with both ends extending through it.

[0033] Furthermore, the card holder 16 includes a first base 16-1 and a snap-fit ​​component 16-2. The first base 16-1 is fixedly connected to the snap-fit ​​component 16-2. The first base 16-1 is installed on the side wall of the second inner compartment 13. The snap-fit ​​component 16-2 has a groove inside. The size of the groove is adapted to the size of the support rod 14. The opening direction of the groove is upward.

[0034] Furthermore, it also includes: the fixing component 15 is adapted to install a liquid chromatography column holder, the bottom of the liquid chromatography column holder is provided with a slider 17-2, the fixing component 15 is provided with a circumferential groove, the number of the grooves is set according to the circumference of the cylinder, the number of the grooves can be 5 or 6, the grooves are adapted to the slider 17-2 and are interference fitted, and multiple liquid chromatography column holders are fixedly connected to the fixing component 15 through the slider 17-2; the liquid chromatography column holder includes a main body 17-1 and a cover 17-6, the main body 17-1 has an opening, one end of the cover 17-6 is rotatably connected to one end of the opening, and the other end of the cover 17-6 is snapped into the other end of the opening. This invention sets a corresponding number of liquid chromatography column holders according to the number of liquid chromatography columns, thereby improving the effective utilization rate of the internal space of the second inner chamber 13. At the same time, by inserting the liquid chromatography column holders into the slides at different positions, the liquid chromatography columns are separated, avoiding wear between different types of liquid chromatography columns, and realizing intentional grouping or partitioning.

[0035] Furthermore, a buffer layer 17-3 is provided on the inner wall of the main body 17-1. The buffer layer 17-3 is a flexible insulating material. The curvature of the inner wall of the cover 17-6 is the same as the curvature of the inner wall of the main body 17-1. A buffer layer is provided on the inner wall of the cover 17-6.

[0036] The cover 17-6 has an arc-shaped cross-section. This structure effectively reduces damage to the liquid chromatography column. It ensures a good fit during column fixation, and a buffer layer is provided on the concave end face of the cover 17-6. A buffer layer 17-3, made of flexible insulating material, is provided on the inner wall of the main body 17-1 to prevent damage to the liquid chromatography column caused by vibration, thus effectively protecting the column.

[0037] Furthermore, the side of the cover 17-6 that engages with the main body 17-1 has a groove 17-4, and the side of the main body 17-1 that engages with the cover 17-6 has a protrusion 17-5 that matches the groove 17-4 of the cover 17-6. When the cover 17-6 and the main body 17-1 are closed, the protrusion 17-5 of the main body 17-1 engages with the groove 17-4 of the cover 17-6. That is, after the cover 17-6 and the main body 17-1 are engaged and fixed, the cover 17-6 and the main body 17-1 form a closed ring, thereby fixing the liquid chromatography column inside the main body 17-1 and making the liquid chromatography column less likely to fall out. When it is necessary to remove the liquid chromatography column, simply open the cover 17-6 on the main body 17-1. After the liquid chromatography column is fixed, the protrusion 17-5 and the groove 17-4 cooperate with each other, providing positioning and stabilization, and bringing greater safety.

[0038] Furthermore, it also includes a temperature sensor, which is installed on the side wall of the second inner compartment 13 to detect the temperature inside the second inner compartment 13.

[0039] Furthermore, it also includes an audible and visual alarm, which will trigger an audible and visual alarm when the temperature inside the second inner chamber 13 exceeds the threshold range, and when the constant temperature chamber is powered off.

[0040] In use, multiple card holders 16 are symmetrically installed on the side wall of the second inner chamber 13. The support rod 14 is adapted to the symmetrically installed card holders 16. The first base 16-1 is fixedly connected to the snap-fit ​​component 16-2. The first base 16-1 is installed on the side wall of the second inner chamber 13. The snap-fit ​​component 16-2 has a groove, the size of which is adapted to the size of the support rod 14. The groove opens upward. The support rod 14 is snapped into the groove of a set of symmetrically installed snap-fit ​​components 16-2. The fixing component 15 is a cylindrical structure with both ends through. Multiple fixing components 15 are sleeved and fixed on the support rod 14. The fixing component 15 can be set at any position on the support rod 14. Generally, multiple fixing components 15 are adapted to one support rod 14 and adjusted according to the length of the liquid chromatography column.

[0041] The bottom of the liquid chromatography column holder is provided with a slider 17-2, and the fixing component 15 is provided with a circumferential groove. The groove is adapted to the slider 17-2 and is interference-fitted. A corresponding number of liquid chromatography column holders are set according to the number of liquid chromatography columns. By inserting the liquid chromatography column holders into the grooves at different positions, the liquid chromatography columns are separated to avoid wear between different types of liquid chromatography columns and to achieve intentional grouping or partitioning.

[0042] The liquid chromatography columns are sequentially inserted into the liquid chromatography column holder through the opening of the main body 17-1, and then the cover 17-6 is closed. The remaining liquid chromatography columns can be stored and secured using the same method described above. Various sizes of liquid chromatography columns can be individually inserted into the main body 17-1, offering convenience and ease of operation. It also allows for the separate securing of different sizes of liquid chromatography columns, improving column stability. The column holder separates the columns, preventing wear. The fixing component 15 is selected according to the number of liquid chromatography columns, ensuring ease of use. The column holder is plugged into the fixing component 15 for easy disassembly.

[0043] The liquid circulation component includes a first water-cooled circulation pipe 4, a second water-cooled circulation pipe 5, and a third water-cooled circulation pipe 6 connected in sequence. All three pipes are installed within the interlayer. The second water-cooled circulation pipe 5 penetrates the constant temperature chamber 3 and connects to the heating element 11 via a first circulation inlet 7. The third water-cooled circulation pipe 6 penetrates the constant temperature chamber 3 and connects to the heating element 11 via a first circulation outlet 8. There are two heating elements 11 connected by a second circulation outlet 9. The heating component 11 is connected to the transmission pipeline and the second circulation inlet 10; the heating component 11 has a built-in heating pump, the output end of which is connected to the second circulation inlet 10 and the input end of which is connected to the first circulation inlet 7. The output end of the heating pump on the other side is connected to the second circulation outlet 9 and the input end of which is connected to the first circulation outlet 8. The heating component 11 has a built-in exhaust fan 12, which is connected to the air heat outlet. The liquid is circulated and heated by the heating pump. The constant temperature environment inside the heating component 11 is introduced into the second inner chamber 13 through the air heat outlet by the exhaust fan 12 for coupled heating.

[0044] Temperature sensors are installed on the side wall of the second inner compartment 13 to detect the temperature inside the second inner compartment 13. When the temperature inside the second inner compartment 13 exceeds the threshold range, an audible and visual alarm will be triggered. An audible and visual alarm will also be triggered when the constant temperature chamber is powered off.

[0045] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on its differences from other embodiments. Similar or identical parts between embodiments can be referred to interchangeably. For the apparatus disclosed in the embodiments, since it corresponds to the method disclosed in the embodiments, the description is relatively simple; relevant parts can be referred to the method section.

[0046] The above description of the disclosed embodiments enables those skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A liquid chromatography column constant temperature oven, characterized in that, include: The enclosure includes a door (1) and a body, which are sealed together. The body includes a heating chamber (2) and a constant temperature chamber (3) that are sealed together. A heating component (11) is installed in the heating chamber (2). A second inner chamber (13) is welded inside the constant temperature chamber (3). The second inner chamber (13) and the outer shell of the heating chamber (2) form a sandwich. A liquid circulation component is installed in the sandwich. The liquid circulation component passes through the constant temperature chamber (3) and is connected to the heating component (11) through the first circulation inlet (7) and the first circulation outlet (8) respectively. The heating component (11) also includes a hot air outlet. The hot air outlet passes through the constant temperature chamber (3) and the second inner chamber (13). A support component is installed on the side wall of the second inner chamber (13) for clamping the liquid chromatography column.

2. The liquid chromatography column constant temperature oven according to claim 1, characterized in that, The liquid circulation component includes a first water-cooled circulation pipe (4), a second water-cooled circulation pipe (5), and a third water-cooled circulation pipe (6) connected in sequence. The first water-cooled circulation pipe (4), the second water-cooled circulation pipe (5), and the third water-cooled circulation pipe (6) are all installed in the interlayer. The second water-cooled circulation pipe (5) passes through the constant temperature chamber (3) and is connected to the heating component (11) through the first circulation inlet (7). The third water-cooled circulation pipe (6) passes through the constant temperature chamber (3) and is connected to the heating component (11) through the first circulation outlet (8).

3. The liquid chromatography column constant temperature oven according to claim 1, characterized in that, The number of heating components (11) is two, and the two heating components (11) are connected to each other through a second circulation output port (9), a transmission pipe and a second circulation input port (10).

4. The liquid chromatography column constant temperature oven according to claim 1, characterized in that, The heating component (11) has a built-in heating pump. The output end of the heating pump is connected to the second circulation input port (10), and the input end is connected to the first circulation input port (7). The output end of the heating pump on the other side is connected to the second circulation output port (9), and the input end is connected to the first circulation output port (8). The heating component (11) has a built-in heat exhaust fan (12), and the heat exhaust fan (12) is connected to the heat exhaust port.

5. A liquid chromatography column constant temperature oven according to claim 1, characterized in that, The support component includes a support rod (14), a mounting bracket (16), and a fixing component (15). Multiple fixing components (15) are sleeved and fixed on the support rod (14). Multiple mounting brackets (16) are symmetrically installed on the side wall of the second inner compartment (13). The support rod (14) is adapted to the symmetrically installed mounting brackets (16).

6. A liquid chromatography column constant temperature oven according to claim 5, characterized in that, The card holder (16) includes a first base (16-1) and a snap-fit ​​component (16-2). The first base (16-1) is fixedly connected to the snap-fit ​​component (16-2). The first base (16-1) is installed on the side wall of the second inner compartment (13). The snap-fit ​​component (16-2) has a groove inside. The size of the groove is adapted to the size of the support rod (14). The opening direction of the groove is upward.

7. A liquid chromatography column constant temperature oven according to claim 5, characterized in that, Also includes: The fixing component (15) is adapted to install a liquid chromatography column holder. The bottom of the liquid chromatography column holder is provided with a slider (17-2). The fixing component (15) is provided with a circumferential groove. The groove is adapted to the slider (17-2). Multiple liquid chromatography column holders are fixedly connected to the fixing component (15) through the slider (17-2). The liquid chromatography column holder includes a main body (17-1) and a cover (17-6). The main body (17-1) has an opening. One end of the cover (17-6) is rotatably connected to one end of the opening. The other end of the cover (17-6) is snapped into the other end of the opening.

8. A liquid chromatography column constant temperature oven according to claim 7, characterized in that, The inner wall of the main body (17-1) is provided with a buffer layer (17-3), which is a flexible insulating material. The curvature of the inner wall of the cover (17-6) is the same as that of the inner wall of the main body (17-1), and the inner wall of the cover (17-6) is provided with a buffer layer.

9. A liquid chromatography column constant temperature oven according to claim 7, characterized in that, The cover (17-6) has a groove (17-4) on one side that engages with the main body (17-1), and the main body (17-1) has a protrusion (17-5) on one side that engages with the cover (17-6) that matches the groove (17-4) of the cover (17-6). When the cover (17-6) and the main body (17-1) are closed, the protrusion (17-5) of the main body (17-1) engages with the groove (17-4) of the cover (17-6).

10. A liquid chromatography column constant temperature oven according to claim 1, characterized in that, It also includes a temperature sensor, which is installed on the side wall of the second inner compartment (13) to detect the temperature inside the second inner compartment (13).

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